Motivated by our mission to prevent disease, advance treatment, and increase patient survival, the Bielas Laboratory pursues a broad-based methodological approach to elucidate the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the pathogenesis of cancer and age-related disease.
In our laboratory, the majority of projects set out to address long-standing intractable questions in mutation research that have remained unanswered largely due to technical limitations. Thus, our first step toward their resolution typically involves the development of new methods and technologies (featured examples highlighted below) to sensitively measure biological information. The application of these tools to the question at hand, more often than not, reveals new insights into biology that exceed the scope of the hypothesis being tested, driving us down new and exciting pathways of discovery in pursuit of our overarching mission.
As such, while mutagenesis remains at the core of our research program, the focus of the laboratory continues to diversify and expand. Current and ongoing areas of interest include nuclear and mitochondrial genomics, DNA repair, transcriptomics, metabolomics, single cell biology, tumor immunology, cancer therapeutics and diagnostics.