Corey Lab

Corey Lab

Corey lab group photo

Our Research

Welcome to the Corey Lab. Our lab focuses on the pathogenesis of chronic viral infections and host immune responses. This includes herpes simplex virus type 2 (HSV-2) and HIV, and most recently SARS-CoV-2. We use HSV as a model to study the tissue based immune system of the genital tract. Our studies indicate a diverse and unique set of tissue resident cells populate the genital tract and our work is devoted to identifying and understanding the role of these cells in disease pathogenesis. The ultimate goal for these projects is to develop immunotherapeutic methods to control subclinical HSV-2 reactivation and reduce the transmission to sexual partners. Our lab has also initiated several preclinical studies to use adoptive transfer of genetically engineered T cells to traffic to and be effectors in lymphoid follicles with a goal to eradicate HIV infections.



JAMA 2020

Changes in SARS-CoV-2 Positivity Rate in Outpatients in Seattle and Washington State, March 1-April 16, 2020. Randhawa AK, Fisher LH, Greninger AL, Li SS, Andriesen J, Corey L, Jerome KR. 

AIDS Res Hum Retroviruses. 2020

Real-Time Killing Assays to Assess the Potency of a New Anti-Simian Immunodeficiency Virus Chimeric Antigen Receptor T Cell. Haeseleer F, Eichholz K, Tareen SU, Iwamoto N, Roederer M, Kirchhoff F, Park H, Okoye AA, Corey L.

The Journal of Virology 2019

Acute Infection and Subsequent Subclinical Reactivation of Herpes Simplex Virus 2 after Vaginal Inoculation of Rhesus Macaques. Lo M, Zhu J, Hansen SG, Carroll T, Farr Zuend C, Nöel-Romas L, Ma ZM, Fritts L, Huang ML, Sun S, Huang Y, Koelle DM, Picker LJ, Burgener A, Corey L, Miller CJ.

Recent News

Q&A: Dr. Larry Corey at the center of COVID-19 vaccine research

Hutch News Stories | Sabin Russell | June 4, 2020

CoVPN team leads campaign to ensure diversity in COVID-19 vaccine trials

Hutch News Stories | FRED HUTCH NEWS SERVICE STAFF | Sept. 29, 2020 

HIV antibody trial results offer 'proof of concept'

Hutch News Stories | Sabin Russell | Jan. 26, 2021