BayesSpace - a tool for spatial transcriptomics analysis

Edward Zhao

In recent years, there has been rapid development of spatial gene expression technology. The most mature of these are the closely related Spatial Transcriptomics and Visium platforms from 10X Genomics, which allow for gene expression profiling to be done with morphological context. Already, these spatial technologies have shown promise to generate novel biological insights in diverse areas such as cancer immunology and prefrontal cortex cytoarchitecture. However, the spatial technology is limited to resolution on the order of 10 cells per spot (the unit of observation for these data). In the meantime, development of analytical tools that effectively utilize the available spatial information and enhance the gene expression maps to higher resolution have lagged behind...