Ph.D., Human Molecular Genetics
Fudan University, Shanghai, P. R. China
Zhejiang University, Hangzhou, P. R. China
Guangxi Normal University, Guilin, P. R. China
My work focuses on the pathogenesis and treatment of mucinous cystic neoplasms (MCN) in the pancreas. MCN have an unusual predilection for women (20:1 female-to-male prevalence) and a pathognomonic "ovarian stroma." Combining in vivo and in vitro studies based on a genetically engineered mouse model of the disease, I am investigating the unique signaling relationships between tumor cells and stromal cells and developing ways to exploit them therapeutically.
Whittle MC, Izeradjene K, Rani PG, Feng L, Carlson MA, DelGiorno KE, Wood LD, Goggins M, Hruban RH, Chang AE, Calses P, Thorsen SM, Hingorani SR. RUNX3 controls a metastatic switch in pancreatic ductal adenocarcinoma. Cell. 2015 Jun 4;161(6):1345-60. PMCID: PMC4458240
Feng L, Cooper JA. Dual functions of Dab1 during brain development. Molecular & Cellular Biology. 2009 Jan;29(2):324-32. PMCID: PMC2612505
Feng L, Allen NS, Simo S, Cooper JA. Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development. Genes & Development. 2007 Nov 1; 21(21): 2717-30.
Cooper JA, Allen NS, Feng L. Protein kinases and signaling pathways that are activated by Reelin. In: Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. S. H. Fatemi, ed. Springer Press, New York, NY, pp. 193–216, 2008.
Feng L, Guedes S, Wang T. Atrophin-1-interacting protein 4/human Itch is an ubiquite E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways. The Journal of Biological Chemistry. 2004 Jul 9;279(28):29681-90.
Yang L, Feng L, Huang L, Wan M, Zhou W, Zhao S, Li C. Identification of the binding domain of signal transduction related proteins on c-Mpl. Biochemical Genetics. 2003 Jun;41(5-6):201-8.
Feng L, Yang L, Zhou W, Zhao S, Li C. SGK and 14-3-3 protein involved in the serine/threonine phosphorylation mechanism of the TPO/MPL signal transduction pathway. Chinese Science Bulletin. 2001 Nov;46(22):1880-4.
Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C. Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. Molecular Biology Reports. 2002 Sep;29(3):317-23.
Zhao X, Feng L, Zhou W, Li C, Zhao S. Screening of proteins that interact with human thrombopoietin receptor c-Mpl using yeast two-hybrid system. Science in China: Series C, Life Sciences. 2000 Jun;43(3):239-244.
Zhou W, Feng L, Zhao X, Dai W, Li C, Zhao S. Preliminary study of proteins that interact with human thrombopoietin receptor c-Mpl screened by yeast two-hybrid system. Journal of Fudan University (Nature Science). 1999 Oct;38(5):329-33.
Feng L, Wang X, Su S. Dependent relations between IQ and EEG. Journal of Guangxi Normal University (Natural Science). 1997;15(1):82-86.
Wang X, Feng L. The preliminary study of the even-related potential and short time memory. Science in Guangxi. 1997;3(2):42-5.
Wang X, Li J, Feng L. Relationship between short time memory capacity and event-related potenial of left and right hemispheres. Acta Academiae Medicinae Guangxi. 1996;13(4):24-7.
Feng L, Wang X, Li J. A study of event-related potential between left and right hemisphere during the procedure of memory. Acta Academiae Medicinae Guangxi. 1995 Dec;12(4):484-8.
Feng L, Xian J, Zhu A. A cellular mitosis CAI system. Journal of Guangxi Normal University (Natural Science). 1995;13(4):68-72.
Wang X, Feng L. The inputs from the 5th nerve of dorsal raphe nucleus depress the activity of cerebellar cortex purkinje. Journal of Guangxi Normal University (Natural Science). 1995;13(3): 83-8.