The goal of the Hsieh Lab at the Fred Hutchinson Cancer Research Center is to comprehensively delineate the fundamental role of mRNA translation in normal cell physiology, cancer etiology, and cancer progression. Armed with this knowledge we are defining the next generation of therapeutic vulnerabilities in disorders associated with translation deregulation such as cancer.
mRNA translation is a therapeutic vulnerability necessary for efficient bladder epithelial transformation. Jana S, Deo R, Hough R, Liu Y, Horn JL, Wright JL, Lam H, Webster K, Chiang GC, Sonenberg N, Hsieh AC. (2021).
Androgen receptor regulates a druggable translational regulon in advanced prostate cancer. Liu Y, Horn JL, Banda K, Goodman AZ, Lim Y, Jana S, Arora S, Germanos AA, Wen L, Hardin WR, Yang YC, Coleman IM, Tharakan RG, Cai EY, Uo T, Pillai SPS, Corey E, Morrissey C, Chen Y, Carver BS, Plymate SR, Beronja S, Nelson PS, Hsieh AC. (2019).
Genomic distinctions between metastatic lower and upper tract urothelial carcinoma revealed through rapid autopsy. Winters BR, De Sakar N, Arora S, Bolouri H, Jana S, Vakar-Lopez F, Cheng HH, Schweizer MT, Yu EY, Grivas, P, Lee JK, Kollath L, Holt SK, McFerrin L, Ha G, Nelson PS, Montgomery RB, Wright JL, Lam H, Hsieh AC. (2019).
Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors. Hsieh AC, Nguyen HG, Wen L, Edlind MP, Carroll P, Kim W, Ruggero D. (2015).