Our Research

Welcome to the Kensler Lab. We study adaptive responses to endogenous and exogenous stress as targets for cancer prevention with a primary focus on the KEAP1-NRF2 signaling pathway. Our work includes the discovery and translation of small molecule activators of the pathway, murine models to probe the functional reach of the pathway alone and through cross-talk with other signaling networks, and the conduct of clinical trials of NRF2 inducers, such as the broccoli-derived compound sulforaphane, in populations unavoidably exposed to high levels of environmental carcinogens.