The Molecular Phenotypes of Null Alleles in Cells (MorPhiC) program is a consortium managed by the National Human Genome Research Institute (NHGRI). The long-term goal of MorPhiC is to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene, using in vitro multicellular systems.
Phase 1 of the MorPhiC program, which was launched in 2022, focuses on studying ~1000 protein-coding. MorPhiC includes four Data Production Research and Development Centers (DPCs), three Data Analysis and Validation Centers (DAVs) and the Data Resource and Administrative Coordination Center (DRACC). Our group is one of the DAVs.