The Brain Tumor Resource Lab strives to generate and distribute patient-derived mouse models and cell lines. Our focus is on pediatric brain tumors.
The figure on the right depicts the best characterized models for model comparison.
Please note that the tissue culture lines should not be implanted into mice and patient derived xenograft cell lines should not be used for tissue culture.
These resources are for academic use only. Please contact us if you are interested in other uses.
Similar to ATCC, the only way to obtain these lines is to place an order through this site. This ensures that we can contact you if important information needs to be conveyed, that you understand that the lines cannot be shared, that a material transfer agreement is in place, and that we can track how these lines are used to benefit science and medicine.
We gratefully acknowledge funding from the National Institutes of Health, Seattle Run of Hope, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
BTRL Cell Line Detailed Information by Disease or Genetics(xls file)
Models maintained by other institutions
Note: Please check the order sheet to see availibility for the cell lines below. Some cell lines might not be immediately available and will be processed on an as-available basis, with requests for currently unavailable lines to be added to a waitlist.
Mouse Model: 17p, Group 3, Medulloblastoma, MYC
Link to details here: Med-114FH_P2
Tissue Culture Line: Available
Med-114FH grown in mice then passaged in tissue culture to transduce mCherry/Luciferase
In Mouse Model: Group 4, MYCN
Link to details here: Med-1512FH_P2
In Mouse Model: 9q, PTCH1, SHH
Link to details here: Med-1712FH_P1
In Mouse Model: 17p, Group 3, MYC
Link to details here: Med-1911FH_P2
In Mouse Models: 17q, 9q, Group 3
Link to details here: Med-210FH_P2
In Mouse Models: 17p, 17q, 9q, Group 3, MYC
Link to details here: Med-2112FH_P2
Tissue culture line available
Med-2112FH grown in mice then passaged in tissue culture to transduce mCherry/Luciferase
In Mouse Models: GFI1B, Group 3, MYC
Link to details here: Med-211FH_P2
In Mouse Models: 17p, 17q, 9q, Group 4
Link to details here: Med-2312FH_P2
In Mouse Models: 17p, 17q, 9q, GLI2, MYCN, SHH, TP53
Link to details here: Med-314FH_P2
Med-314FH grown in mice then passaged in tissue culture to transduce mCherry/Luciferase
In Mouse Models: 17p, 17q, Group 3, MYC
Link to details here: Med-411FH_P2
Tissue culture line available
Med-411FH grown in mice, then quickly passaged in tissue culture to transduce mCherry/Luciferase
In Mouse Models: 17q, Group 4, PRDM6
Link to details here: Med-610FH_P2
Has not yet been characterized
In Mouse Models: 17p, 17q, 9q, GLI2, MYCN, SHH, TP53
Link to details here: Med-813FH_P1
In Mouse Models: CTNNB1,WNT
Link to details here: Med-913FH_P1
In Mouse Line: 17p, 17q, 9q, Group 3, KBTBD4, Medulloblastoma
Link to details: PBT-07FH_P2
Mouse Model: EGFR, H3FA/HIST1H3B, High Grade Glioma, K27
Link to details here: PBT-01FH_P2
In Mouse Model: ATRX, H3FA/HIST1H3B, High Grade Glioma, K27, SETD1A, TP53
Link to details here: PBT-03FH_P1
In Mouse Model: High Grade Glioma, ID2, MYCN, MYCN
Link to details here: PBT-04FH_P2
In Mouse Model: EGFR, High Grade Glioma, ID2, MGMT Methylation, MYCN, MYCN, PIK3R1
Link to details here: PBT-05FH_P2
In Tissue Culture: EGFR, High Grade Glioma, ID2, MGMT Methylation, MYCN, MYCN, PIK3R1
Link to details here: PBT-05FHTC_P13
Tissue culture cell line available.
In Mouse Model: CDK4, High Grade Glioma, PDGFRA, pedRTK1, TERT, TP53
Link to details here: PBT-06FH_P2
In Mouse Models: ATRX, EGFR, FGFR1-4, High Grade Glioma, Hypermutator, MGMT Methylation, MSH2, pedRTK1
Link to details: GBM-311FH_P2
Tissue Culture: CDKN2A/B, High Grade Glioma, pedRTK1
Link to details here: GBM-511FHTC_P6
In Mouse Model: ATRX, EGFR, FGFR1-4, High Grade Glioma, Hypermutator, MSH2, pedRTK1
Link to details here: GBM-611FH_P1
High Grade Glioma
Has not been characterized, TC line only
Has not been characterized, TC line only
Tissue Culture Line: BRAF, CDKN2A/B, High Grade Glioma, pedRTK2
Link to details here: GBM-110FHTC_P5
Tissue Culture Line: DIPG/DMG H3.3 K27M
Link to details here: PBT-22FHTC
Tissue Culture Line: DIPG H3wt
Link to details here: PBT-24FHTC
Tissue Culture Line: DIPG/DMG H3.1 K27M
Link to details here: PBT-27FHTC
Tissue Culture Line: DIPG/DMG H3.3 K27M
Link to details here: PBT-29FHTC
In Mouse Model: 1q, Ependymoma, PFA
Link to details here: EPD-210FH_P2
Tissue Culture Line: Available
Link to details here: EPD-210FHTC_P3
Both Tissue Culture and PDX cell lines available
PDX Cell line available
In Mouse Model: 1q, Ependymoma, PFA
Link to details here: EPD-710FH_P1
Link to details here: PBT-08FH_P2
Patient Derived Xenograft grown in Flank.
In Mouse Model: SHH, SMARCB1
Link to details here: ATRT-310FH_cP10
Tissue Culture Line: Available
Link to details here: ATRT-310FHTC_P4
Tissue Culture Line: Atypical Teratoid Rhabdoid Tumor, SHH, SMARCB1
Link to details here: ATRT-311FHTC_P6
In Mouse Model: Atypical Teratoid Rhabdoid Tumor, MYC, SMARCB1
Link to details here: ATRT-312FH_P2