Brain Tumor Resource Lab
The Brain Tumor Resource Lab strives to generate and distribute patient-derived mouse models and cell lines. Our focus is on pediatric brain tumors.
The figure on the right depicts the best characterized models for model comparison.
Please note that the tissue culture lines should not be implanted into mice and patient derived xenograft cell lines should not be used for tissue culture.
These resources are for academic use only. Please contact us if you are interested in other uses.
Similar to ATCC, the only way to obtain these lines is to place an order through this site. This ensures that we can contact you if important information needs to be conveyed, that you understand that the lines cannot be shared, that a material transfer agreement is in place, and that we can track how these lines are used to benefit science and medicine.
We gratefully acknowledge funding from the National Institutes of Health, Seattle Run of Hope, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Resources
BTRL Cell Line Detailed Information by Disease or Genetics(xls file)
Models maintained by other institutions
BTRL Cell Line Information
Note: Please check the order sheet to see availibility for the cell lines below. Some cell lines might not be immediately available and will be processed on an as-available basis, with requests for currently unavailable lines to be added to a waitlist.
Medulloblastoma Lines
Med-113FH
Med-114FH
Mouse Model: 17p, Group 3, Medulloblastoma, MYC
Link to details here: Med-114FH_P2
Tissue Culture Line: Available
Med-114FH mCherry/luciferase
Med-114FH grown in mice then passaged in tissue culture to transduce mCherry/Luciferase
Med-1512FH
In Mouse Model: Group 4, MYCN
Link to details here: Med-1512FH_P2
Med-1712FH
In Mouse Model: 9q, PTCH1, SHH
Link to details here: Med-1712FH_P1
Med-1911FH
In Mouse Model: 17p, Group 3, MYC
Link to details here: Med-1911FH_P2
Med-210FH
In Mouse Models: 17q, 9q, Group 3
Link to details here: Med-210FH_P2
Med-2112FH
In Mouse Models: 17p, 17q, 9q, Group 3, MYC
Link to details here: Med-2112FH_P2
Tissue culture line available
Med2112FH mCherry/luciferase
Med-2112FH grown in mice then passaged in tissue culture to transduce mCherry/Luciferase
Med-211FH
In Mouse Models: GFI1B, Group 3, MYC
Link to details here: Med-211FH_P2
Med-2312FH
In Mouse Models: 17p, 17q, 9q, Group 4
Link to details here: Med-2312FH_P2
Med-314FH
In Mouse Models: 17p, 17q, 9q, GLI2, MYCN, SHH, TP53
Link to details here: Med-314FH_P2
Med-314FH mCherry/luciferase
Med-314FH grown in mice then passaged in tissue culture to transduce mCherry/Luciferase
Med-411FH
In Mouse Models: 17p, 17q, Group 3, MYC
Link to details here: Med-411FH_P2
Tissue culture line available
Med-411FH mCherry/Luciferase
Med-411FH grown in mice, then quickly passaged in tissue culture to transduce mCherry/Luciferase
Med-610FH
In Mouse Models: 17q, Group 4, PRDM6
Link to details here: Med-610FH_P2
Med-615FH
Has not yet been characterized
Med-813FH
In Mouse Models: 17p, 17q, 9q, GLI2, MYCN, SHH, TP53
Link to details here: Med-813FH_P1
Med-913FH
In Mouse Models: CTNNB1,WNT
Link to details here: Med-913FH_P1
PBT-07FH (was Neo-113FH)
In Mouse Line: 17p, 17q, 9q, Group 3, KBTBD4, Medulloblastoma
Link to details: PBT-07FH_P2
High Grade Glioma Lines
PBT-01FH (was Astro-110FH)
Mouse Model: EGFR, H3FA/HIST1H3B, High Grade Glioma, K27
Link to details here: PBT-01FH_P2
PBT-02FH (was Astro-412FH)
PBT-03FH (was Astro-413FH)
In Mouse Model: ATRX, H3FA/HIST1H3B, High Grade Glioma, K27, SETD1A, TP53
Link to details here: PBT-03FH_P1
PBT-04FH (was Med-311FH)
In Mouse Model: High Grade Glioma, ID2, MYCN, MYCN
Link to details here: PBT-04FH_P2
PBT-05FH (was PNET-109FH)
In Mouse Model: EGFR, High Grade Glioma, ID2, MGMT Methylation, MYCN, MYCN, PIK3R1
Link to details here: PBT-05FH_P2
In Tissue Culture: EGFR, High Grade Glioma, ID2, MGMT Methylation, MYCN, MYCN, PIK3R1
Link to details here: PBT-05FHTC_P13
PBT-05FHTC
Tissue culture cell line available.
PBT-06FH (was PNET-212FH)
In Mouse Model: CDK4, High Grade Glioma, PDGFRA, pedRTK1, TERT, TP53
Link to details here: PBT-06FH_P2
GBM-311FH
In Mouse Models: ATRX, EGFR, FGFR1-4, High Grade Glioma, Hypermutator, MGMT Methylation, MSH2, pedRTK1
Link to details: GBM-311FH_P2
GBM-511FHTC
Tissue Culture: CDKN2A/B, High Grade Glioma, pedRTK1
Link to details here: GBM-511FHTC_P6
GBM-611FH
In Mouse Model: ATRX, EGFR, FGFR1-4, High Grade Glioma, Hypermutator, MSH2, pedRTK1
Link to details here: GBM-611FH_P1
GBM-711FH
High Grade Glioma
Astro-111FHTC
Has not been characterized, TC line only
GBM-109FHTC
Has not been characterized, TC line only
GBM-110FHTC
Tissue Culture Line: BRAF, CDKN2A/B, High Grade Glioma, pedRTK2
Link to details here: GBM-110FHTC_P5
PBT-22FHTC
Tissue Culture Line: DIPG/DMG H3.3 K27M
Link to details here: PBT-22FHTC
PBT-24FHTC
Tissue Culture Line: DIPG H3wt
Link to details here: PBT-24FHTC
PBT-27FHTC
Tissue Culture Line: DIPG/DMG H3.1 K27M
Link to details here: PBT-27FHTC
PBT-29FHTC
Tissue Culture Line: DIPG/DMG H3.3 K27M
Link to details here: PBT-29FHTC
Ependymoma Lines
EPD-210FH
In Mouse Model: 1q, Ependymoma, PFA
Link to details here: EPD-210FH_P2
Tissue Culture Line: Available
Link to details here: EPD-210FHTC_P3
EPD-313FH
Both Tissue Culture and PDX cell lines available
EPD-410FH
PDX Cell line available
EPD-613FH
EPD-710FH
In Mouse Model: 1q, Ependymoma, PFA
Link to details here: EPD-710FH_P1
Pineoblastoma Cell Lines
PBT-08FH (was Med-313FH)
Link to details here: PBT-08FH_P2
Neuroblastoma Cell Lines
Neuro-211FH Flank
Patient Derived Xenograft grown in Flank.
Atypical Teratoid Rhabdoid Tumor Cell Lines
ATRT-310FH / ATRT-333FH
In Mouse Model: SHH, SMARCB1
Link to details here: ATRT-310FH_cP10
Tissue Culture Line: Available
Link to details here: ATRT-310FHTC_P4
ATRT-311FHTC
Tissue Culture Line: Atypical Teratoid Rhabdoid Tumor, SHH, SMARCB1
Link to details here: ATRT-311FHTC_P6
ATRT-312FH
In Mouse Model: Atypical Teratoid Rhabdoid Tumor, MYC, SMARCB1
Link to details here: ATRT-312FH_P2
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