The Arimura Lab was just launched in February 2024. We are currently looking for lab members to help establish an inclusive, innovative, and collaborative research team. 

Email Yasu Arimura (yarimura@fredhutch.org) with any questions.

Research Technician: We are not currently hiring research technicians.

PostDoctoral Fellow: We currently have openings for postdoctoral fellows. The candidate must have a keen interest in chromatin and structural biology. No prior research experience in structural biology is required, as we are more than happy to assist in developing your structural biology skills from scratch.

Please email Arimura Yasuhiro:

1. Your CV, with publications and contact information for three references
2. A one page cover letter that includes:

• A summary of your past research experience and accomplishments
• Your research interests and explanation of why your background and interests are a good fit for our lab
• Your broader goals for your postdoctoral training period and career, including your ideal timeframe
• Your potential start date.

Graduate Students: We expect to recruit one graduate student to join the lab this academic year.

The mission of the Arimura Lab is to achieve the structural elucidation of biological events occurring in eukaryotic chromosomes, such as the transcription regulation in euchromatin and heterochromatin, the mitosis-specific mechanisms that compact chromosomes and assemble kinetochores, and the accessible chromatin formation around transcription start sites. 

The lab currently possesses unique technology to determine the high-resolution cryo-EM structures of chromatin-related complexes isolated from interphase and M phase chromosomes formed in Xenopus (frog) egg extract and Magnetic Isolation and Concentration (MagIC)-cryo-EM, a technique enabling direct structural analysis of targets captured on nanomagnetic beads, which allows for the structural determination of scarce macromolecules (< 0.0005 mg/mL: 100 to 1000-fold lower than conventional cryo-EM) in heterogeneous samples. 

By using these unique technologies and furthering their development, we are revealing the structural basis of biological events on eukaryotic chromosomes.