Publications

2020

Anderson, D.A. III, Murphy, T.L., Eisenman, R.N., Murphy, K.M. (2020) The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells. Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.1915060117. PMCID: PMC7060746

Lafita-Navarro, M.C., Liaño-Pons, J., Quintanilla, A., Varela, I., Blanco, R., Ourique, F., Bretones, G., Aresti, J., Molina, E., Carroll, P., Eisenman, R.N., Delgado, D. Leon, J. (2020). The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells. The Journal of biological chemistry 295, 2001-2017. PMID: 31919096 PMCID: PMC7029127 [Available on 2021-02-14] DOI: 10.1074/jbc.RA119.010389.

Augert A, Mathsyaraja H, Ibrahim AH, Freie B, Geuenich MJ, Cheng PF, Alibeckoff SP, Wu N, Hiatt JB, Basom R, Gazdar A, Sullivan LB, Eisenman RN, MacPherson D. (2020) MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer. Cancer Cell (1878-3686 (Electronic)). doi: 10.1016/j.ccell.2020.04.016, NIHMSID: PMID: 32470392.

2019

Hsieh AL, Zheng X, Yue Z, Stine ZE, Mancuso A, Rhoades SD, Brooks R, Weljie AM, Eisenman RN, Sehgal A, Dang CV. (2019). Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism. Cell Reports  29, (2211-1247 (Electronic)):1778-88.  doi: 10.1016/j.celrep.2019.10.022, NIHMSID: PMC6910219

Haritha Mathsyaraja, Brian Freie, Pei-Feng Cheng, Ekaterina Babaeva, Derek Janssens, Steven Henikoff, Robert N Eisenman (2019) Max deletion destabilizes MYC protein and abrogates Eµ-Myc lymphomagenesis. Genes Dev. published on-line: doi:10.1101/gad.325878.119

Neves, A., and Eisenman, R.N. (2019). Distinct gene-selective roles for a network of core promoter factors in Drosophila neural stem cell identity.  Biol Open 8:  bio042168 doi: 10.1242/bio.042168

2018

Carroll, P.A., Freie, B.W., Mathsyaraja, H. and Eisenman, R.N. (2018) The MYC: Transcription Factor Network: Balancing Metabolism, Proliferation and Oncogenesis. Frontiers of Medicine 12: 412-425.

Poudel KR, Roh-Johnson M, Su A, Ho T, Mathsyaraja H, Anderson S, Grady WM, Moens CB, Conacci-Sorrell M, Eisenman RN, Bai J. (2018) Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis. Developmental Cell 45(6):738-52.e6.
PMCID: PMC6095624 doi: 10.1016/j.devcel.2018.05.021.

Swygert, S.G., Kim, S., Wu, X., Fu, T., Hsieh, T.H., Rando, O.J., Eisenman, R.N., Shendure, J., McKnight, J.N., and Tsukiyama, T. (2018). Condensin-Dependent Chromatin Compaction Represses Transcription Globally during Quiescence.  Molecular Cell. 73, 533-546.
PMCID: PMC6368455; doi: 10.1016/j.molcel.2018.11.020

Schaub FX, Dhankani V, Berger AC, Trivedi M, Richardson AB, Shaw R, Zhao W, Zhang X, Ventura A, Liu Y, Ayer DE, Hurlin PJ, Cherniack AD, Eisenman RN, Bernard B, and C. Grandori. (2018) Pan-Cancer Alterations of the MYC Oncogene and its Proximal Network Across the Cancer Genome AtlasCell Systems 6: 282-300.

2016

Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M. C., Altamura, S., Reyes, A., Prendergast, A. M., Baumgartner, D., Carnevalli, L. S., Atzberger, A., Haas, S., von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A (2016). Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell 164, 668-680.  doi: 10.1016/j.cell.2015.12.033.

Kim, D.-W., Wu, N., Kim, Y.C., Cheng,P.F., Basom, R., Kim, D., Dunn, C.T., Lee, A.Y., Kim, K., Lee, C.S., Singh, A., Gazdar, A.F., Harris, C.R., Eisenman, R.N., Park, K.-S. and MacPherson, D. (2016) Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer. Genes Dev. 30, 1289-1299.  doi: 10.1101/gad.279307.116

Anderson, S., Raj poudel, K., Roh-Johnson, M., Brabletz, T., Yu, M., Borenstein-Auerbach, N., Grady, W.M., Bai, J., Moens, C.B., *Eisenman, R.N., and *Conacci-Sorrell, M. (2016). MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activationPNAS  113(37):E5481-90. doi:10.1073/pnas.1610994113.

Kanatsu-Shinohara, M., Tanaka, T., Ogonuki, N., Ogura, Hiroko Morimoto, H., Cheng, P.F., Eisenman, R.N., Trumpp, A, and T. Shinohara (2016) Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal. Genes Dev. 30: 2637-2648; doi:10.1101/gad.287045.116. 

2015

Carroll, P. A., D. Diolaiti, L. McFerrin, H. Gu, D. Djukovic, J. Du, P. F. Cheng, S. Anderson, M. Ulrich, J. B. Hurley, D. Raftery, D. E. Ayer and R. N. Eisenman (2015). Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis. Cancer Cell 27:271-285.  doi: 10.1016/j.ccell.2014.11.024 

Gu, H., Du, J., Carnevale Neto, F., Carroll, P.A., Turner, S.J., Chiorean, E.G., Eisenman, R.N., and Raftery, D. (2015). Metabolomics method to comprehensively analyze amino acids in different domains. The Analyst 140, 2726-2734. doi: 10.1039/c4an02386b 

Hiler, D., Chen, X., Hazen, J., Kupriyanov, S., Carroll, P. A., Qu, C., Xu, B., Johnson, D., Griffiths, L., Frase, S., Rodriguez, A. R., Martin, G., Zhang, J. ,Jeon, J., Fan, Y. , Finkelstein, D., Eisenman, R. N., Baldwin, K. and Dyer, M. A. (2015). Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors. Cell Stem Cell 17, 101-115. Epub 2015/07/04. doi: 10.1016/j.stem.2015.05.015. 

Hunt, L.C., Xu, B., Finkelstein, D., Fan, Y., Carroll, P.A., Cheng, P.-F., Eisenman, R.N. and Demontis, F. The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling. (2015). Genes Dev. 29: 2479-2485. doi: 10.1101/gad.267419.115.

2014

Conacci-Sorrell M, McFerrin L, Eisenman RN. An overview of MYC and its interactome. Cold Spring Harb Perspect Med. 4(1):a014357. doi: 10.1101/cshperspect.a014357.  PMID: 24384812. 2014.

Dang CV and Eisenman RN, editors. Myc and the Pathway to Cancer. Cold Spring Harbor, N.Y.: Cold Spring Harbor Press; 2014.

Conacci-Sorrell M, Ngouenet C, Anderson S, Brabletz T, Eisenman RN. Stress-induced cleavage of Myc promotes cancer cell survival. Genes Dev. 28(7):689-707. doi: 10.1101/gad.231894.113. PubMed PMID: 24696454; PMCID: in process. 2014

Diolaiti D, McFerrin L, Carroll PA, Eisenman RN. Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis. Biochim Biophys Acta. doi: 10.1016/j.bbagrm. PMCID: PMC4241192. 2014.

2013

Li, L., Anderson, S.A., Secombe, J., and Eisenman, R.N. The Drosophila ubiqutin-specific protease Puffyeye regulates dMyc-mediated growth.Development 140, 4776-4787. doi: 10.1242/dev.096941. PubMed Central PMCID: 3833434. 2013

2011

Young, S., Diolaiti, D., Conacci-Sorrell, M., Ruiz-Trillo, I., Eisenman, R.N., and King, N. M. Premetazoan ancestry of the Myc-Max network. Molecular Biology & Evolution. May 13. PMID: 21571926. 2011

2010

Li, L., Greer, C., Eisenman, R.N., and Secombe. Essential functions of the histone demethylase Lid. PloS Genetics 6: e1001221 PMID: 21124823. 2010
Conacci-Sorrell, M., Ngouenet, C. and R.N. Eisenman. Myc-nick: A cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Cell, 142:480-493. PMID: 20691906. 2010

Mendrysa, S.M., Akagi, K., Roayaei, J.,  Lien, W.-H.,  Copeland, N.G.,  Jenkins, N.A., and R.N. Eisenman. An integrated genetic-genomic approach for the identification of novel cancer loci in mice sensitized to c-Myc-induced apoptosis. Genes & Cancer 1: 465-479. PMID: 20927200. 2010

Conerly, M. L., Teves, S. S., Diolaiti, D., Ulrich, M., Eisenman, R. N., and Henikoff, S. Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis. Genome Res. 20:1383-1390.PMID: 20709945. 2010

2009

Lin CH, Jackson AL, Guo J, Linsley PS, Eisenman RN Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J 28: 3157-3170. 2009.

2008

Freie, B.W. and Eisenman, R.N. Ratcheting Myc. Cancer Cell 22:2755-2766. 2008

Eilers, M., and Eisenman, R.N. Myc’s Broad Reach. Genes Dev. 22:2755-2766. 2008

Laurenti, E., Varnum-Finney, B., Wilson, A., Ferrero, I., Blanco-Rose, W., Ehninger, A., Knoepfler, P., Cheng, P.-F., MacDonald, R., Eisenman, R., Bernstein, I, and Trumpp, A. Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell 3:611-624. 2008

Martins, R.A., Zindy, F., Donovan, S., Zhang, J., Pounds, S., Wey, A., Knoepfler, P.S., Eisenman, R.N., Roussel, M.F., and Dyer, M.A. N-myc coordinates retinal growth with eye size during mouse development. Genes Dev 22(2): 179-193. 2008

2007

Pierce, S.B., Yost, C., Anderson, S.A., Flynn, E.M., Delrow, J., and Eisenman, R.N. Drosophila growth and development in the absence of dMyc and dMnt. Dev Biol 315(2): 303-316. 2007

Secombe, J. et al. The Trithorax group protein Lid is a trimethyl histone H3-K4 demethylase required for dMyc-induced cell growth., Genes & Development, 21, 537. 2007

2006

Knoepfler, P. S. et al. Myc influences global chromatin structure, EMBO Journal, 25, 2723. 2006

Hatton, BA; et al. N-myc Is an Essential Downstream Effector of Shh Signaling during both Normal and Neoplastic Cerebellar Growth, Cancer Research, 66, 8655. 2006

Zindy, F. et al. N-Myc and the cyclin-dependent kinase inhibitors, p18Ink4c and p27Kip1, coordinately regulate cerebellar development, PNAS, 103, 11579. 2006

Mendrysa, S.M., O’Leary, K.A., McElwee, M.K., Michalowski, J., Eisenman, R.N., Powell, D.A. and Perry, M.E. Tumor Suppression and Normal Aging in Mice with Constitutively High p53 Activity. Genes Dev. 20: 16-21 2006.

Shiio Y., Rose D. W., Donohoe S., Aebersold R., and Eisenman R. N. Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex. Mol. Cell Biol. 26: 1386-1397. 2006.

2005

Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ, C-Myc Binds to Human Ribosomal DNA and Stimulates Transcription of RRNA Genes By RNA Polymerase I., Nature Cell Biology, 7(3):311-8, Mar 2005

Orian, A., Grewal, S.S., Knoepfler, P.S., Edgar, B.A., Parkhurst, S.M. and Eisenman, R.N. Genomic Binding and Transcriptional Regulation by the Drosophila Myc and Mnt Transcription Factors.  Cold Spring Harbor Symp. Quant. Biol.70.  2005

Grewal SS, Li L, Orian A, Eisenman RN, Edgar BA, Myc-dependent Regulation of Ribosomal RNA Synthesis During Drosophila Development., Nature Cell Biology, 7(3):295-302, Mar 2005

Okubo T, Knoepfler PS, Eisenman RN, Hogan BL, Nmyc Plays An Essential Role During Lung Development As a Dosage-sensitive Regulator of Progenitor Cell Proliferation and Differentiation., Development (cambridge, England), 132(6):1363-74, Mar 2005

2004

Welcker M, Orian A, Grim JA, Eisenman RN, Clurman BE, A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates C-Myc and Cell Size., Current Biology : Cb, 14(20):1852-7, Oct 2004

Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I, HBP1 and Mad1 Repressors Bind the Sin3 Corepressor PAH2 Domain With Opposite Helical Orientations., Nat Struct Mol Biol, 11(8):738-46, Aug 2004

Welcker M, Orian A, Jin J, Grim JA, Harper JW, Eisenman RN, Clurman BE, The Fbw7 Tumor Suppressor Regulates Glycogen Synthase Kinase 3 Phosphorylation-dependent C-Myc Protein Degradation., Proceedings of the National Academy of Sciences of the United States of America., 101(24):9085-90, Jun 2004

Pierce SB, Yost C, Britton JS, Loo LW, Flynn EM, Edgar BA, Eisenman RN, DMyc Is Required for Larval Growth and Endoreplication in Drosophila., Development (cambridge, England), 131(10):2317-27, May 2004

Cowley SM, Kang RS, Frangioni JV, Yada JJ, DeGrand AM, Radhakrishnan I, Eisenman RN, Functional Analysis of the Mad1-mSin3A Repressor-corepressor Interaction Reveals Determinants of Specificity, Affinity, and Transcriptional Response., Molecular and Cellular Biology, 24(7):2698-709, Apr 2004
Secombe J, Pierce SB, Eisenman RN, Myc: a Weapon of Mass Destruction., Cell, 117(2):153-6, Apr 2004

2003

Gomez-Roman N, Grandori C, Eisenman RN, White RJ, Direct activation of RNA polymerase III transcription by c-Myc, Nature, 421(6920):290-4, January 2003

2002

Shiio Y, Donohoe S, Yi EC, Goodlett DR, Aebersold R, Eisenman RN, Quantitative proteomic analysis of Myc oncoprotein function, The Embo Journal, 21(19):5088-96, October 2002

Iritani BM, Delrow J, Grandori C, Gomez I, Klacking M, Carlos LS, Eisenman RN, Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1, The Embo Journal, 21(18):4820-30, September 2002

McArthur GA, Foley KP, Fero ML, Walkley CR, Deans AJ, Roberts JM, Eisenman RN, MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity, Molecular and Cellular Biology, 22(9):3014-23, May 2002

2001

Eisenman RN, Deconstructing myc, Genes and Development, 15(16):2023-30, August 2001

2000

Brubaker K, Cowley SM, Huang K, Loo L, Yochum GS, Ayer DE, Eisenman RN, Radhakrishnan I, Solution structure of the interacting domains of the Mad-Sin3 complex: Implications for recruitment of a chromatin-modifying complex, Cell, 103(4):655-65, 2000

1999

Hurlin PJ, Steingrimsson E, Copeland NG, Jenkins NA, Eisenman RN, Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif, Embo Journal, 18(24):7019-28, December 1999

Johnston LA, Prober DA, Edgar BA, Eisenman RN, Gallant P, Drosophila myc regulates cellular growth during development, Cell, 98(6):779-90, September 1999

1998

Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN, SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors, Molecular Cell, 2(1):33-42, July 1998

Foley KP, McArthur GA, Queva C, Hurlin PJ, Soriano P, Eisenman RN, Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation, Embo Journal, 17(3):774-85, February 1998

1997

Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN, Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression, Cell, 89(3):349-56, May 1997