Publications
2024
Freie, B, Carroll, PA, Varnum-Finney, BJ, Ramsey, EL, Ramani, V, Bernstein, I and Eisenman, RN (2024) A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies. Genes Dev 38(5-6): 253-272,
Suzuki, A, Uranishi, K, Nishimoto, M, Mizuno, Y, Mizuno, S, Takahashi, S, Eisenman, RN and Okuda, A (2024) MAX controls meiotic entry in sexually undifferentiated germ cells. Sci Rep 14(1): 5236, PMC10909893.
2022
Wang, H, Lu, J, Alencastro, F, Roberts, A, Fiedor, J, Carroll, P, Eisenman, RN, Ranganathan, S, Torbenson, M, Duncan, AW and Prochownik, EV (2022) Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia. Cell Mol Gastroenterol Hepatol 13(6): 1785-1804, PMC9046243.
2021
Mathsyaraja, H., Catchpole, J., Freie, B., Eastwood, E., Babaeva, E., Geuenich, M., Cheng, P.F., Ayers, J., Yu, M., Wu, N., Moorthi, S.,Poudel, K.R., Koehne, A., Houghton, A.M., Berger, A.H., Shiio, Y., *MacPherson, D. and *Eisenman, R.N (2021). Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness. eLife 10, e64212. doi: 10.7554/eLife.64212.
Wu, X and Eisenman, RN (2021) MYC and TFEB Control DNA Methylation and Differentiation in AML. Blood Cancer Discov 2(2): 116-118, PMC8447267.
Carroll, P.A., Freie, B.W., Cheng, P.F., Kasinathan, S., Gu, H., Hedrich, T., Dowdle, J.A., Venkataramani, V., Ramani, V., Wu, X., Raftery, D., Shendure, J., Ayer, D.E., Muller, C.H. and Eisenman, R.N. (2021). The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis. PLOS Biology 19, e3001085. 10.1371/journal.pbio.3001085.
2020
Anderson, D.A. III, Murphy, T.L., Eisenman, R.N., Murphy, K.M. (2020) The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells. Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.1915060117. PMCID: PMC7060746
Lafita-Navarro, M.C., Liaño-Pons, J., Quintanilla, A., Varela, I., Blanco, R., Ourique, F., Bretones, G., Aresti, J., Molina, E., Carroll, P., Eisenman, R.N., Delgado, D. Leon, J. (2020). The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells. The Journal of biological chemistry 295, 2001-2017. PMID: 31919096 PMCID: PMC7029127 [Available on 2021-02-14] DOI: 10.1074/jbc.RA119.010389.
Augert A, Mathsyaraja H, Ibrahim AH, Freie B, Geuenich MJ, Cheng PF, Alibeckoff SP, Wu N, Hiatt JB, Basom R, Gazdar A, Sullivan LB, Eisenman RN, MacPherson D. (2020) MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer. Cancer Cell (1878-3686 (Electronic)). doi: 10.1016/j.ccell.2020.04.016, NIHMSID: PMID: 32470392.
2019
Hsieh AL, Zheng X, Yue Z, Stine ZE, Mancuso A, Rhoades SD, Brooks R, Weljie AM, Eisenman RN, Sehgal A, Dang CV. (2019). Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism. Cell Reports 29, (2211-1247 (Electronic)):1778-88. doi: 10.1016/j.celrep.2019.10.022, NIHMSID: PMC6910219
Haritha Mathsyaraja, Brian Freie, Pei-Feng Cheng, Ekaterina Babaeva, Derek Janssens, Steven Henikoff, Robert N Eisenman (2019) Max deletion destabilizes MYC protein and abrogates Eµ-Myc lymphomagenesis. Genes Dev. published on-line: doi:10.1101/gad.325878.119
Neves, A., and Eisenman, R.N. (2019). Distinct gene-selective roles for a network of core promoter factors in Drosophila neural stem cell identity. Biol Open 8: bio042168 doi: 10.1242/bio.042168
2018
Carroll, P.A., Freie, B.W., Mathsyaraja, H. and Eisenman, R.N. (2018) The MYC: Transcription Factor Network: Balancing Metabolism, Proliferation and Oncogenesis. Frontiers of Medicine 12: 412-425.
Poudel KR, Roh-Johnson M, Su A, Ho T, Mathsyaraja H, Anderson S, Grady WM, Moens CB, Conacci-Sorrell M, Eisenman RN, Bai J. (2018) Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis. Developmental Cell 45(6):738-52.e6.
PMCID: PMC6095624 doi: 10.1016/j.devcel.2018.05.021.
Swygert, S.G., Kim, S., Wu, X., Fu, T., Hsieh, T.H., Rando, O.J., Eisenman, R.N., Shendure, J., McKnight, J.N., and Tsukiyama, T. (2018). Condensin-Dependent Chromatin Compaction Represses Transcription Globally during Quiescence. Molecular Cell. 73, 533-546.
PMCID: PMC6368455; doi: 10.1016/j.molcel.2018.11.020
Schaub FX, Dhankani V, Berger AC, Trivedi M, Richardson AB, Shaw R, Zhao W, Zhang X, Ventura A, Liu Y, Ayer DE, Hurlin PJ, Cherniack AD, Eisenman RN, Bernard B, and C. Grandori. (2018) Pan-Cancer Alterations of the MYC Oncogene and its Proximal Network Across the Cancer Genome Atlas. Cell Systems 6: 282-300.
2016
Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M. C., Altamura, S., Reyes, A., Prendergast, A. M., Baumgartner, D., Carnevalli, L. S., Atzberger, A., Haas, S., von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A (2016). Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell 164, 668-680. doi: 10.1016/j.cell.2015.12.033.
Kim, D.-W., Wu, N., Kim, Y.C., Cheng,P.F., Basom, R., Kim, D., Dunn, C.T., Lee, A.Y., Kim, K., Lee, C.S., Singh, A., Gazdar, A.F., Harris, C.R., Eisenman, R.N., Park, K.-S. and MacPherson, D. (2016) Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer. Genes Dev. 30, 1289-1299. doi: 10.1101/gad.279307.116
Anderson, S., Raj poudel, K., Roh-Johnson, M., Brabletz, T., Yu, M., Borenstein-Auerbach, N., Grady, W.M., Bai, J., Moens, C.B., *Eisenman, R.N., and *Conacci-Sorrell, M. (2016). MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation. PNAS 113(37):E5481-90. doi:10.1073/pnas.1610994113.
Kanatsu-Shinohara, M., Tanaka, T., Ogonuki, N., Ogura, Hiroko Morimoto, H., Cheng, P.F., Eisenman, R.N., Trumpp, A, and T. Shinohara (2016) Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal. Genes Dev. 30: 2637-2648; doi:10.1101/gad.287045.116.
2015
Carroll, P. A., D. Diolaiti, L. McFerrin, H. Gu, D. Djukovic, J. Du, P. F. Cheng, S. Anderson, M. Ulrich, J. B. Hurley, D. Raftery, D. E. Ayer and R. N. Eisenman (2015). Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis. Cancer Cell 27:271-285. doi: 10.1016/j.ccell.2014.11.024
Gu, H., Du, J., Carnevale Neto, F., Carroll, P.A., Turner, S.J., Chiorean, E.G., Eisenman, R.N., and Raftery, D. (2015). Metabolomics method to comprehensively analyze amino acids in different domains. The Analyst 140, 2726-2734. doi: 10.1039/c4an02386b
Hiler, D., Chen, X., Hazen, J., Kupriyanov, S., Carroll, P. A., Qu, C., Xu, B., Johnson, D., Griffiths, L., Frase, S., Rodriguez, A. R., Martin, G., Zhang, J. ,Jeon, J., Fan, Y. , Finkelstein, D., Eisenman, R. N., Baldwin, K. and Dyer, M. A. (2015). Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors. Cell Stem Cell 17, 101-115. Epub 2015/07/04. doi: 10.1016/j.stem.2015.05.015.
Hunt, L.C., Xu, B., Finkelstein, D., Fan, Y., Carroll, P.A., Cheng, P.-F., Eisenman, R.N. and Demontis, F. The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling. (2015). Genes Dev. 29: 2479-2485. doi: 10.1101/gad.267419.115.
2014
Conacci-Sorrell M, McFerrin L, Eisenman RN. An overview of MYC and its interactome. Cold Spring Harb Perspect Med. 4(1):a014357. doi: 10.1101/cshperspect.a014357. PMID: 24384812. 2014.
Dang CV and Eisenman RN, editors. Myc and the Pathway to Cancer. Cold Spring Harbor, N.Y.: Cold Spring Harbor Press; 2014.
Conacci-Sorrell M, Ngouenet C, Anderson S, Brabletz T, Eisenman RN. Stress-induced cleavage of Myc promotes cancer cell survival. Genes Dev. 28(7):689-707. doi: 10.1101/gad.231894.113. PubMed PMID: 24696454; PMCID: in process. 2014
Diolaiti D, McFerrin L, Carroll PA, Eisenman RN. Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis. Biochim Biophys Acta. doi: 10.1016/j.bbagrm. PMCID: PMC4241192. 2014.
2010
Li, L., Greer, C., Eisenman, R.N., and Secombe. Essential functions of the histone demethylase Lid. PloS Genetics 6: e1001221 PMID: 21124823. 2010
Conacci-Sorrell, M., Ngouenet, C. and R.N. Eisenman. Myc-nick: A cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Cell, 142:480-493. PMID: 20691906. 2010
Mendrysa, S.M., Akagi, K., Roayaei, J., Lien, W.-H., Copeland, N.G., Jenkins, N.A., and R.N. Eisenman. An integrated genetic-genomic approach for the identification of novel cancer loci in mice sensitized to c-Myc-induced apoptosis. Genes & Cancer 1: 465-479. PMID: 20927200. 2010
Conerly, M. L., Teves, S. S., Diolaiti, D., Ulrich, M., Eisenman, R. N., and Henikoff, S. Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis. Genome Res. 20:1383-1390.PMID: 20709945. 2010
2009
Lin CH, Jackson AL, Guo J, Linsley PS, Eisenman RN Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J 28: 3157-3170. 2009.
2008
Freie, B.W. and Eisenman, R.N. Ratcheting Myc. Cancer Cell 22:2755-2766. 2008
Eilers, M., and Eisenman, R.N. Myc’s Broad Reach. Genes Dev. 22:2755-2766. 2008
Laurenti, E., Varnum-Finney, B., Wilson, A., Ferrero, I., Blanco-Rose, W., Ehninger, A., Knoepfler, P., Cheng, P.-F., MacDonald, R., Eisenman, R., Bernstein, I, and Trumpp, A. Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell 3:611-624. 2008
Martins, R.A., Zindy, F., Donovan, S., Zhang, J., Pounds, S., Wey, A., Knoepfler, P.S., Eisenman, R.N., Roussel, M.F., and Dyer, M.A. N-myc coordinates retinal growth with eye size during mouse development. Genes Dev 22(2): 179-193. 2008
2007
Pierce, S.B., Yost, C., Anderson, S.A., Flynn, E.M., Delrow, J., and Eisenman, R.N. Drosophila growth and development in the absence of dMyc and dMnt. Dev Biol 315(2): 303-316. 2007
Secombe, J. et al. The Trithorax group protein Lid is a trimethyl histone H3-K4 demethylase required for dMyc-induced cell growth., Genes & Development, 21, 537. 2007
2006
Knoepfler, P. S. et al. Myc influences global chromatin structure, EMBO Journal, 25, 2723. 2006
Hatton, BA; et al. N-myc Is an Essential Downstream Effector of Shh Signaling during both Normal and Neoplastic Cerebellar Growth, Cancer Research, 66, 8655. 2006
Zindy, F. et al. N-Myc and the cyclin-dependent kinase inhibitors, p18Ink4c and p27Kip1, coordinately regulate cerebellar development, PNAS, 103, 11579. 2006
Mendrysa, S.M., O’Leary, K.A., McElwee, M.K., Michalowski, J., Eisenman, R.N., Powell, D.A. and Perry, M.E. Tumor Suppression and Normal Aging in Mice with Constitutively High p53 Activity. Genes Dev. 20: 16-21 2006.
Shiio Y., Rose D. W., Donohoe S., Aebersold R., and Eisenman R. N. Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex. Mol. Cell Biol. 26: 1386-1397. 2006.
2005
Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ, C-Myc Binds to Human Ribosomal DNA and Stimulates Transcription of RRNA Genes By RNA Polymerase I., Nature Cell Biology, 7(3):311-8, Mar 2005
Orian, A., Grewal, S.S., Knoepfler, P.S., Edgar, B.A., Parkhurst, S.M. and Eisenman, R.N. Genomic Binding and Transcriptional Regulation by the Drosophila Myc and Mnt Transcription Factors. Cold Spring Harbor Symp. Quant. Biol.70. 2005
Grewal SS, Li L, Orian A, Eisenman RN, Edgar BA, Myc-dependent Regulation of Ribosomal RNA Synthesis During Drosophila Development., Nature Cell Biology, 7(3):295-302, Mar 2005
Okubo T, Knoepfler PS, Eisenman RN, Hogan BL, Nmyc Plays An Essential Role During Lung Development As a Dosage-sensitive Regulator of Progenitor Cell Proliferation and Differentiation., Development (cambridge, England), 132(6):1363-74, Mar 2005
2004
Welcker M, Orian A, Grim JA, Eisenman RN, Clurman BE, A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates C-Myc and Cell Size., Current Biology : Cb, 14(20):1852-7, Oct 2004
Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I, HBP1 and Mad1 Repressors Bind the Sin3 Corepressor PAH2 Domain With Opposite Helical Orientations., Nat Struct Mol Biol, 11(8):738-46, Aug 2004
Welcker M, Orian A, Jin J, Grim JA, Harper JW, Eisenman RN, Clurman BE, The Fbw7 Tumor Suppressor Regulates Glycogen Synthase Kinase 3 Phosphorylation-dependent C-Myc Protein Degradation., Proceedings of the National Academy of Sciences of the United States of America., 101(24):9085-90, Jun 2004
Pierce SB, Yost C, Britton JS, Loo LW, Flynn EM, Edgar BA, Eisenman RN, DMyc Is Required for Larval Growth and Endoreplication in Drosophila., Development (cambridge, England), 131(10):2317-27, May 2004
Cowley SM, Kang RS, Frangioni JV, Yada JJ, DeGrand AM, Radhakrishnan I, Eisenman RN, Functional Analysis of the Mad1-mSin3A Repressor-corepressor Interaction Reveals Determinants of Specificity, Affinity, and Transcriptional Response., Molecular and Cellular Biology, 24(7):2698-709, Apr 2004
Secombe J, Pierce SB, Eisenman RN, Myc: a Weapon of Mass Destruction., Cell, 117(2):153-6, Apr 2004
2002
Shiio Y, Donohoe S, Yi EC, Goodlett DR, Aebersold R, Eisenman RN, Quantitative proteomic analysis of Myc oncoprotein function, The Embo Journal, 21(19):5088-96, October 2002
Iritani BM, Delrow J, Grandori C, Gomez I, Klacking M, Carlos LS, Eisenman RN, Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1, The Embo Journal, 21(18):4820-30, September 2002
McArthur GA, Foley KP, Fero ML, Walkley CR, Deans AJ, Roberts JM, Eisenman RN, MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity, Molecular and Cellular Biology, 22(9):3014-23, May 2002
1999
Hurlin PJ, Steingrimsson E, Copeland NG, Jenkins NA, Eisenman RN, Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif, Embo Journal, 18(24):7019-28, December 1999
Johnston LA, Prober DA, Edgar BA, Eisenman RN, Gallant P, Drosophila myc regulates cellular growth during development, Cell, 98(6):779-90, September 1999
1998
Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN, SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors, Molecular Cell, 2(1):33-42, July 1998
Foley KP, McArthur GA, Queva C, Hurlin PJ, Soriano P, Eisenman RN, Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation, Embo Journal, 17(3):774-85, February 1998
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