Since 2001, the Fredricks lab has pursued research involving the diagnosis and treatment of fungal infections in cancer patients, understanding how bacteria function and change their environment, linking genital tract microbial communities to adverse health outcomes, describing changes in the microbiota of patients undergoing hematopoietic cell transplantation (HCT), and the connection between gut bacterial species and graft versus host disease (GVHD). We use tools in molecular biology such as broad range 16S rRNA gene PCR to describe microbial diversity in human body sites.
Key Vaginal Bacteria Associated with Increased Risk of HIV Acquisition in African Women: A Nested Case-Control Study. McClelland RS, Lingappa JR, Srinivasan S, Kinuthia J, John-Stewart GC, Jaoko W, Richardson BA, Yuhas K, Fiedler TL, Mandaliya KN, Munch MM, Mugo NR, Cohen CR, Baeten JM, Celum C, Overbaugh J, Fredricks DN.
The Stool Microbiota at Neutrophil Recovery is Predictive for Severe Acute Graft versus Host Disease after Hematopoietic Cell Transplantation. Golob JL, Pergam SA, Srinivasan S, Fiedler TL, Liu C, Garcia K, Mielcarek M, Ko D, Aker S, Marquis S, Loeffelholz T, Plantinga A, Wu MC, Celustka K, Morrison A, Woodfield M, Fredricks DN.
Metabolic Signatures of Bacterial Vaginosis. Srinivasan S, Morgan MT, Fiedler TL, Djukovic D, Hoffman NG, Raftery D, Marrazzo J, Fredricks DN.