Galloway Lab

Galloway Lab

Galloway lab group photo

Our Research

The Galloway Lab studies how human papillomaviruses (HPVs) and human polyomaviruses (HPyV), specifically Merkel Cell polyomavirus (MCPyV) contribute to the development of cancers, and how that information can be used to better prevent, diagnose or treat malignancies. We have taken a broad-based approach to studying these viruses employing state of the art molecular and immunologic tools, and collaborating with clinicians, epidemiologists and biostatisticians. Current work is focused in the following areas:

  1. The immune response to HPV infection and vaccination
  2. The mechanisms by which HPV generates genetic instability
  3. The mechanisms by which MCPyV contributes to carcinogenicity
  4. The antibody response to MCPyV T antigens

Select Publications

Scherer, E.M., Smith, R.A., Carter, J.J., Wipf, G.C., Gallego, D.F., Stern, M., Wald, A., Galloway, D.A. Analysis of memory B cell responses reveals suboptimal dosing schedule of a licensed vaccine. J. Infec. Dis.  Jan 30;217(4):572-580. 2018.

Dye, K.N., Welcker, M., Clurman, B.E., Roman, A., Galloway, D.A. Merkel Cell polyomavirus tumor antigens expressed in Merkel Cell carcinoma function independently of the ubiquitin ligases Fbw7 and b-TrCP.  PLoS Pathogens, Jan 28;15(1):e10075. 2019