Grady Lab

Grady Lab

Group photo of the Grady Lab

Our Research

Welcome to the Grady Lab. Our research is focused on the role of genomic and epigenomic alterations in gastrointestinal carcinogenesis, specifically esophageal adenocarcinoma (EAC) and colorectal cancer (CRC). Projects involve the study of mechanisms which affect cancer risk, and the development of biomarkers, to aid in treatment and early diagnosis of gastrointestinal cancers and cancer precursors. A long-standing goal of the lab is development of a non-invasive strategy for colon cancer detection, encouraging more patients to seek preventative care. With this goal in mind, the Grady Lab is heavily invested in studying the molecular pathogenesis of gastrointestinal cancer and Barrett’s Esophagus (BE) for more informative diagnosis and development of active methods to decrease cancer risks.   

Current Studies

  • Epigenetic biomarker discovery and development in HGD/EAC and CRC progression.
  • Effects of dietary compounds on the molecular landscape of key genetic elements in colorectal cancer.
  • The roles of senescence and aging in CRC development.
  • Identification of molecular factors (e.g. methylation) associated with increased risk for pre-malignant and/or malignant gastrointestinal tissue.
  • Cutting edge organoid culture as a novel method to more accurately assess the intestinal microenvironment for in vitro experiments.