Publications
Complete Bibliography
Visit PubMed to view Dr. William Grady's complete publication record.
Selected Publications
2022
Yu M, Moinova HR, Willbanks A, Cannon VK, Wang T, Carter K, Kaz A, Reddi D, Inadomi J, Luebeck G, Iyer PG, Canto MI, Wang JS, Shaheen NJ, Thota PN, Willis JE, LaFramboise T, Chak A, Markowitz SD, Grady WM. Novel DNA Methylation Biomarker Panel for Detection of Esophageal Adenocarcinoma and High-Grade Dysplasia. Clin Cancer Res. 2022 Sep 1;28(17):3761-3769. doi: 10.1158/1078-0432.CCR-22-0445.
2021
Matas J, Kohrn B, Fredrickson J, Carter K, Yu M, Wang T, Gui X, Soussi T, Moreno V, Grady WM, Peinado MA, Risques RA. Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon. Cancer Res. 2022 Apr 15;82(8):1492-1502. doi: 10.1158/0008-5472.CAN-21-3607.
2020
Wang T, Maden SK, Luebeck GE, Li CI, Newcomb PA, Ulrich CM, Joo JE, Buchanan DD, Milne RL, Southey MC, Carter KT, Willbanks AR, Luo Y, Yu M, and Grady WM. Dysfunctional epigenetic aging of the normal colon and colorectal cnacer risk. Clin Epigenetics. 2020; Jan 3. doi: 10.1186/s13148-019-0801-3.
2019
Yu M, Hazelton WD, Luebeck GE, Grady WM. Epigenetic Aging: More Than Just a Clock When It Comes to Cancer. Cancer Res. 2020 Feb 1;80(3):367-374. doi: 10.1158/0008-5472.CAN-19-0924. Epub 2019 Nov 6. Review.
Guo Y, Ayers JL, Carter KT, Wang T, Maden SK, Edmond D, Newcomb P P, Li C, Ulrich C, Yu M, Grady WM. Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15. Aging Cell. 2019 Dec;18(6):e13013. doi: 10.1111/acel.13013. Epub 2019 Aug 6.
2018
Yu M, Maden SK, Stachler M, Kaz AM, Ayers J, Guo Y, Carter KT, Willbanks A, Heinzerling TJ, O'Leary RM, Xu X, Bass A, Chandar AK, Chak A, Elliott R, Willis JE, Markowitz SD, Grady WM. Subtypes of Barrett's oesophagus and oesophageal adenocarcinoma based on genome-wide methylation analysis. Gut. 2019 Mar;68(3):389-399. doi: 10.1136/gutjnl-2017-314544. Epub 2018 Jun 8.
2017
E. Georg Luebeck, Kit Curtius, William D. Hazelton, Sean Maden, Ming Yu, Prashanthi N. Thota, Deepa T. Patil, Amitabh Chak, Joseph E. Willis, and William M. Grady Identification of a key role of widespread epigenetic drift in Barrett’s esophagus and esophageal adenocarcinoma. Clin Epigenetics. 2017; 9: 113. Published online 2017 Oct 16. doi: 10.1186/s13148-017-0409-4. PMCID: PMC5644061
Stacey A. Cohen, Ming Yu, Kelsey Baker, Mary Redman, Chen Wu, Tai J. Heinzerling, Ralph M. Wirtz, Elpida Charalambous,George Pentheroudakis, Vassiliki Kotoula, Konstantine T. Kalogeras, George Fountzilas, and William M. Grady The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases. Clin Epigenetics. 2017; 9: 46. Published online 2017 May 2. doi: 10.1186/s13148-017-0347-1 PMCID: PMC5414304
Barault L, Amatu A, Siravegna G, Ponzetti A, Moran S, Cassingena A, Mussolin B, Falcomatà C, Binder AM, Cristiano C, Oddo D, Guarrera S, Cancelliere C, Bustreo S, Bencardino K, Maden S, Vanzati A, Zavattari P, Matullo G, Truini M, Grady WM, Racca P, Michels KB, Siena S, Esteller M, Bardelli A, Sartore-Bianchi A, Di Nicolantonio F Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer. Gut. 2017 Oct 5. pii: gutjnl-2016-313372. doi: 10.1136/gutjnl-2016-313372. [Epub ahead of print]
2016
Curtius K, Wong CJ, Hazelton WD, Kaz AM, Chak A, Willis JE, Grady WM, Luebeck EG A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus. PLoS Comput Biol. 2016 May 11;12(5):e1004919. doi: 10.1371/journal.pcbi.1004919. eCollection 2016 May. PMID:27168458
2015
Yu M, Carter KT, Makar KW, Vickers K, Ulrich CM, Schoen RE, Brenner D, Markowitz SD, Grady WM. Methylight digital droplet PCR for detection and absolute quantification of infrequent methylated alleles. Epigenetics. 2015 Sep 2;10(9):803-9. Epub 2015 Jul 17. PMCID: PMC4623055 [Available on 2016-07-17].
Yu M, O’Leary RM, Kaz AM, Morris SM, Carter KT, Chak A, Chandar A, Willis JE, Moinova HR, Markowitz SD, Brenner DE, Anandabapasathy S, Westerhoff M, Wong C-J, Shaheen NJ, Chen Y, Barnholtz-Sloan JS, Grady WM. Methylated B3GAT2 and ZNF793 are potential detection biomarkers for Barrett’s esophagus. Cancer, Epidemiology, Biomarkers and Prevention 2015, epub. NIHMSID 730238.
2014
Luo Y, Wong CJ, Kaz AM, Dzieciatkowski S, Carter KT, Morris SM, Wang J, Willis JE, Makar KW, Ulrich CM, Lutterbaugh JD, Shrubsole MJ, Zheng W, Markowitz SD, Grady WM. Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology 2014 Aug; 147(2):418-29.e8. Epub 2014 Apr 30. PMCID: PMC4107146.
Shiovitz S, Bertagnolli MM, Renfro LA, Nam E, Foster NR, Dzieciatkowski S, Luo YX, Valinluck Lao V, Monnat RJ, Emond MJ, Maizels N, Niedzwiecki N, Goldberg RM, Saltz LB, Venook A, Warren RS, Grady WM. CpG Island Methylator Phenotype Predicts Improved Response to Adjuvant Therapy with Irinotecan, Fluorouracil, and Leucovorin in Stage III Colon Cancer: Cancer and Leukemia Group B 89803 (Alliance). Gastroenterology 2014 Sep; 147(3):637-45; Epub 2014 May 21. PMCID: PMC4143495.
Yu M, Morris S, Trobridge P, Wang YX, Kanngurn S, Knoblaugh S, Grady WM. Inactivation of TGF-ß signaling and loss of PTEN cooperate to induce colon cancer in vivo. Oncogene, 2014 Mar 20;33(12):1538-47. PMCID: PMC3883899 [Available on 2015-03-20].
2013
Luo Y, Kaz AM, Kanngurn S, Welsch P, Moris SM, Wang JP, Lutterbaugh JD, Markowitz SD, Grady WM. NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer. PLoS Genetics 2013. Jul; 9(7):epub. PMCID: PMC3708790.
2012
Kaz AM, Luo Y, Dzieciatkowski S, Chak A, Willis JE, Upton MP, Leidner RS, Grady WM. Aberrantly methylated PKP1 in the progression of Barrett’s esophagus to esophageal adenocarcinoma. Genes, Chromosomes, and Cancer, 2012 Apr;51(4):384-393; PMCID: PMC3292431.
2011
Kaz AM, Wong C-J, Luo Y, Virgin JB, Washington MK, Willis JE, Leidner RS, Chak A, Grady WM. DNA Methylation Profiling in Barrett’s Esophagus and Esophageal Adenocarcinoma Reveals Unique Methylation Signatures and Molecular Subclasses. Epigenetics. 2011;6:1403-1412. PMCID: PMC3256330.
2009
Ausch C, Kim YH, Tsuchiya KD, Dzieciatkowski S, Washington MK, Paraskeva C, Radich J, Grady WM. Comparative Analysis of PCR-Based Biomarker Assay Methods for Colorectal Polyp Detection from Fecal DNA. Clinical Chemistry 2009 Aug;55(8):1559-63. Epub 2009 Jun 18. PMID: 19541867.
Trobridge P, Knoblaugh S, Washington MK, Munoz NM, Tsuchiya KD, Rojas A, Ulrich C, Sasazuki T, Shiraswa S, Grady WM. TGF-â receptor inactivation cooperates with mutant Kras in vivo to induce intestinal neoplasms through a ß-catenin independent pathway. Gastroenterology. 2009; 136:1680-88. PMCID: PMC2782436.
2008
Grady WM, Parkin RK, Mitchell PS, Lee JH, Kim Y-H, Tsuchiya KD, Washington MK, Paraskeva C, Willson JKV, Kaz AM, Kroh EM, Allen A, Fritz BR, Markowitz SD, Tewari M. Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. Oncogene 2008: Feb 11.
2006
Muñoz NM, Upton MP, Rojas A, Washington MK, Lin L, Chytil A, Sozmen EG, Madison BB, Pozzi A, Moon RT, Moses HL, Grady WM. Transforming growth factor â receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Research 2006; 66: 9837-44.
2005
Petko Z, Ghiassi M, Shuber A, Gorham J, Smalley W, Washington MK, Schultenover S, Gautam S, Markowitz SD, Grady WM. Aberrantly methylated CDKN2A, MGMT and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin Cancer Res 2005 Feb 1; 11(3):1203-9.
2001
Grady WM, Rajput A, Lutterbaugh JD, Markowitz SD. Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer. Cancer Research 2001; 61:900-902.
2000
Grady WM, Willis J, Guilford PJ, Dunbier AK, Toro, TT, Lynch H, Weisner G, Ferguson K, Markowitz S. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genetics 2000; 26:16-17.
1999
Grady WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S, Lutterbaugh JD, Neumann A, Brattain MG, Chang J, Kim S-J, Kinzler KW, Vogelstein B, Willson JKV, Markowitz S. Mutational inactivation of transforming growth factor ß receptor type II in microsatellite stable colon cancers. Cancer Research 1999; 59:320-324.
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