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Member & Head, Program of Immunology, Clinical Research Division, Fred Hutch
Professor of Immunology and Medicine, University of Washington
Endowed Chair: The Rona Jaffe Foundation Endowed Chair
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Dr. Tom Schmitt has made extensive contributions to the development of adoptive T cell therapy as an effective treatment against cancer. He and his team are applying novel high-throughput screening and genetic approaches to interrogate healthy immune repertoires, identify and characterize T cells specific for the most promising tumor antigens, and then isolate rare, highly effective T cell receptors (TCRs) for therapeutic use. Dr. Schmitt is also working to understand the molecular bases of effective antigen presentation by tumor cells and the complex structure/function relationships that govern tumor targeting by T cells, informing new strategies to improve the clinical efficacy of TCR-based T cell therapies.
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Natalie is an experienced and dedicated senior project manager in the Program in Immunology with more than 20 years of experience supporting clinical trials and leading effective, synergistic teams while ensuring that safety, regulatory and government standards are met. She is also Captain of Obliteride's Team T-cell promoting team spirit and and helping advance Fred Hutch's mission to cure cancer faster.