Our Research

Welcome to the Hadland lab. We study the development of the blood and immune systems in both healthy and diseased states.  Our research examines the emergence of hematopoietic stem cells (HSCs), the mechanisms that endow them with lifelong self-renewal and multilineage potential, and how these developmental processes are hijacked during leukemogenesis. We aim to recreate HSC development ex vivo to model disease, develop cellular therapies, and advance early detection and prevention strategies for childhood leukemias.