Complete Bibliography

Visit PubMed to view Dr. Holland's complete publications record

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1998 | 1984 - 1988

2024

Chung CI, Yang J, Yang X, Liu H, Ma Z, Szulzewsky F, Holland EC, Shen Y, Shu X. Phase separation of YAP-MAML2 differentially regulates the transcriptome. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2310430121. doi: 10.1073/pnas.2310430121. Epub 2024 Feb 5. PMID: 38315854

Schmid S, Russell ZR, Yamashita AS, West ME, Parrish AG, Walker J, Rudoy D, Yan JZ, Quist DC, Gessesse BN, Alvinez N, Cimino PJ, Kumasaka DK, Parchment RE, Holland EC, Szulzewsky F. ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models. bioRxiv [Preprint]. 2024 Mar 26:2024.03.13.584849. doi: 10.1101/2024.03.13.584849. PMID: 38558981

Henikoff S, Henikoff JG, Paranal RM, Greene JE, Zheng Y, Russell ZR, Szulzewsky F, Kugel S, Holland EC, Ahmad K. RNA Polymerase II hypertranscription in cancer FFPE samples. bioRxiv [Preprint]. 2024 May 21:2024.02.28.582647. doi: 10.1101/2024.02.28.582647. PMID: 38559075

Szulzewsky F, Thirimanne HN, Holland EC. Meningioma: current updates on genetics, classification, and mouse modeling. Ups J Med Sci. 2024 Mar 18;129. doi: 10.48101/ujms.v129.10579. eCollection 2024. PMID: 38571886

Nuechterlein N, Shelbourn A, Szulzewsky F, Arora S, Casad M, Pattwell S, Merino-Galan L, Sulman E, Arowa S, Alvinez N, Jung M, Brown D, Tang K, Jackson S, Stoica S, Chittaboina P, Banasavadi-Siddegowda YK, Wirsching HG, Stella N, Shapiro L, Paddison P, Patel AP, Gilbert MR, Abdullaev Z, Aldape K, Pratt D, Holland EC, Cimino PJ. Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype. Genes Dev. 2024 Apr 17;38(5-6):273-288. doi: 10.1101/gad.351350.123. PMID: 38589034

Rao A, Zhang X, Cillo AR, Sussman JH, Sandlesh P, Tarbay AC, Mallela AN, Cardello C, Krueger K, Xu J, Li A, Xu J, Patterson J, Akca E, Angione A, Jaman E, Kim WJ, Allen J, Venketeswaran A, Zinn PO, Parise R, Beumer J, Duensing A, Holland EC, Ferris R, Bagley SJ, Bruno TC, Vignali DAA, Agnihotri S, Amankulor NM. All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis. bioRxiv [Preprint]. 2024 Apr 13:2024.04.09.588752. doi: 10.1101/2024.04.09.588752. PMID: 38645178

Thirimanne HN, Almiron-Bonnin D, Nuechterlein N, Arora S, Jensen M, Parada CA, Qiu C, Szulzewsky F, English CW, Chen WC, Sievers P, Nassiri F, Wang JZ, Klisch TJ, Aldape KD, Patel AJ, Cimino PJ, Zadeh G, Sahm F, Raleigh DR, Shendure J, Ferreira M, Holland EC. Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome. Cell Genom. 2024 May 17:100566. doi: 10.1016/j.xgen.2024.100566. Online ahead of print. PMID: 38788713

Wang JZ, Patil V, Landry AP, Gui C, Ajisebutu A, Liu J, Saarela O, Pugh SL, Won M, Patel Z, Yakubov R, Kaloti R, Wilson C, Cohen-Gadol A, Zaazoue MA, Tabatabai G, Tatagiba M, Behling F, Almiron Bonnin DA, Holland EC, Kruser TJ, Barnholtz-Sloan JS, Sloan AE, Horbinski C, Chotai S, Chambless LB, Gao A, Rebchuk AD, Makarenko S, Yip S, Sahm F, Maas SLN, Tsang DS; Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma. International Consortium on Meningiomas (ICOM); Rogers CL, Aldape K, Nassiri F, Zadeh G. Nat Med. 2024 Aug 21. doi: 10.1038/s41591-024-03167-4. Online ahead of print. PMID: 39169220

Nuechterlein N, Cimino S, Shelbourn A, Ha V, Arora S, Rajan S, Shapiro LG, Holland EC, Aldape K, McGranahan T, Gilbert MR, Cimino PJ. HOXD12 defines an age-related aggressive subtype of oligodendroglioma. Acta Neuropathol. 2024 Sep 11;148(1):41. doi: 10.1007/s00401-024-02802-1. PMID: 39259414 Free

Schmid S, Russell ZR, Yamashita AS, West ME, Parrish AG, Walker J, Rudoy D, Yan JZ, Quist DC, Gessesse BN, Alvinez N, Hill KD, Anderson LW, Cimino PJ, Kumasaka DK, Parchment RE, Holland EC, Szulzewsky F. ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models. Cell Rep. 2024 Oct 22;43(10):114829. doi: 10.1016/j.celrep.2024.114829. Epub 2024 Oct 3. PMID: 39365700

Parrish AG, Arora S, Thirimanne HN, Rudoy D, Schmid S, Sievers P, Sahm F, Holland EC, Szulzewsky F. Aggressive high-grade NF2 mutant meningiomas downregulate oncogenic YAP signaling via the upregulation of VGLL4 and FAT3/4. Neurooncol Adv. 2024 Aug 24;6(1):vdae148. doi: 10.1093/noajnl/vdae148. eCollection 2024 Jan-Dec. PMID: 39380691

Arora S, Nuechterlein N, Jensen M, Glatzer G, Sievers P, Varadharajan S, Korshunov A, Sahm F, Mack SC, Taylor MD, Holland EC. Transcriptomic landscape identifies two unrecognized ependymoma subtypes and novel pathways in medulloblastoma. bioRxiv [Preprint]. 2024 Oct 22:2024.10.21.619495. doi: 10.1101/2024.10.21.619495. PMID: 39484476 

2023

Hoellerbauer P, Biery MC, Arora S, Rao Y, Girard EJ, Mitchell K, Dighe P, Kufeld M, Kuppers DA, Herman JA, Holland EC, Soroceanu L, Vitanza NA, Olson JM, Pritchard JR, Paddison PJ. Functional genomic analysis of adult and pediatric brain tumor isolates.  bioRxiv. 2023 Jan 6:2023.01.05.522885. doi: 10.1101/2023.01.05.522885. Preprint. PMID: 36711964

Arora S, Szulzewsky F, Jensen M, Nuechterlein N, Pattwell SS, Holland EC. An RNA seq-based reference landscape of human normal and neoplastic brain.  Res Sq. 2023 Jan 10:rs.3.rs-2448083. doi: 10.21203/rs.3.rs-2448083/v1. Preprint. PMID: 36711972

Mitchell K, Sprowls SA, Arora S, Shakya S, Silver DJ, Goins CM, Wallace L, Roversi G, Schafer RE, Kay K, Miller TE, Lauko A, Bassett J, Kashyap A, D'Amato Kass J, Mulkearns-Hubert EE, Johnson S, Alvarado J, Rich JN, Holland EC, Paddison PJ, Patel AP, Stauffer SR, Hubert CG, Lathia JD. WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma.  Genes Dev. 2023 Feb 1;37(3-4):86-102. doi: 10.1101/gad.349803.122. Epub 2023 Feb 2. PMID: 36732025

Hu X, Wu X, Berry K, Zhao C, Xin D, Ogurek S, Liu X, Zhang L, Luo Z, Sakabe M, Trubicka J, Łastowska M, Szulzewsky F, Holland EC, Lee L, Hu M, Xin M, Lu QR. Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis.  Nat Cell Biol. 2023 Feb;25(2):323-336. doi: 10.1038/s41556-022-01069-6. Epub 2023 Feb 2. PMID: 36732631

Rajendran S, Hu Y, Canella A, Peterson C, Gross A, Cam M, Nazzaro M, Haffey A, Serin-Harmanci A, Distefano R, Nigita G, Wang W, Kreatsoulas D, Li Z, Sepeda JA, Sas A, Hester ME, Miller KE, Elemento O, Roberts RD, Holland EC, Rao G, Mardis ER, Rajappa P. Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma.  Cell Rep. 2023 Mar 28;42(3):112197. doi: 10.1016/j.celrep.2023.112197. Epub 2023 Mar 3. PMID: 36871221

Arora S, Szulzewsky F, Jensen M, Nuechterlein N, Pattwell SS, Holland EC. Visualizing genomic characteristics across an RNA-Seq based reference landscape of normal and neoplastic brain. Sci Rep. 2023 Mar 14;13(1):4228. doi: 10.1038/s41598-023-31180-z. PMID: 36918656

Wirsching HG, Felsberg J, Prummer M, Moisoiu V, Lourman R, Hertler C, Antonios M, Cimino PJ, Roth P, Gorlia T, Prins RM, Cloughesy T, Wen PY, Holland EC, Reifenberger G, Weller M. Spatial immune profiling of glioblastoma identifies an inflammatory, perivascular phenotype associated with longer survival. Acta Neuropathol. 2023 Oct;146(4):647-649. doi: 10.1007/s00401-023-02617-6. Epub 2023 Aug 13. PMID: 37573572

Henikoff S, Henikoff JG, Ahmad K, Paranal RM, Janssens DH, Russell ZR, Szulzewsky F, Kugel S, Holland EC. Epigenomic analysis of formalin-fixed paraffin-embedded samples by CUT&Tag. Nat Commun. 2023 Sep 22;14(1):5930. doi: 10.1038/s41467-023-41666-z. PMID: 37739938

2022

Marshall JL, Peshkin BN, Yoshino T, Vowinckel J, Danielsen HE, Melino G, Tsamardinos I, Haudenschild C, Kerr DJ, Sampaio C, Rha SY, FitzGerald KT, Holland EC, Gallagher D, Garcia-Foncillas J, Juhl H. The Essentials of Multiomics. Oncologist. 2022 Apr 5;27(4):272-284. doi: 10.1093/oncolo/oyab048. PMID: 35380712

Yang H, Yuan L, Ibaragi S, Li S, Shapiro R, Vanli N, Goncalves KA, Yu W, Kishikawa H, Jiang Y, Hu AJ, Jay D, Cochran B, Holland EC, Hu GF. Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival. Br J Cancer. 2022 Aug;127(3):422-435. doi: 10.1038/s41416-022-01814-6. Epub 2022 Apr 13.

Chan M, Holland EC, Gujral TS. Olverembatinib inhibits SARS-CoV-2-Omicron variant-mediated cytokine release in human peripheral blood mononuclear cells. EMBO Mol Med. 2022 Jun 8;14(6):e15919. doi: 10.15252/emmm.202215919. Epub 2022 May 17.

Szulzewsky F, Arora S, Arakaki AKS, Sievers P, Almiron Bonnin DA, Paddison PJ, Sahm F, Cimino PJ, Gujral TS, Holland EC. Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice. Genes Dev. 2022 Aug 25. doi: 10.1101/gad.349876.122. Online ahead of print.

Dai J, Cimino PJ, Gouin KH 3rd, Grzelak CA, Barrett A, Lim AR, Long A, Weaver S, Saldin LT, Uzamere A, Schulte V, Clegg N, Pisarsky L, Lyden D, Bissell MJ, Knott S, Welm AL, Bielas JH, Hansen KC, Winkler F, Holland EC, Ghajar CM. Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain.  Nat Cancer. 2022 Jan;3(1):25-42. doi: 10.1038/s43018-021-00297-3. Epub 2021 Dec 24. PMID: 35121993

Marshall JL, Peshkin BN, Yoshino T, Vowinckel J, Danielsen HE, Melino G, Tsamardinos I, Haudenschild C, Kerr DJ, Sampaio C, Rha SY, FitzGerald KT, Holland EC, Gallagher D, Garcia-Foncillas J, Juhl H. The Essentials of Multiomics.  Oncologist. 2022 Apr 5;27(4):272-284. doi: 10.1093/oncolo/oyab048. PMID: 35380712

Pattwell SS, Arora S, Nuechterlein N, Zager M, Loeb KR, Cimino PJ, Holland NC, Reche-Ley N, Bolouri H, Almiron Bonnin DA, Szulzewsky F, Phadnis VV, Ozawa T, Wagner MJ, Haffner MC, Cao J, Shendure J, Holland EC. Oncogenic role of a developmentally regulated NTRK2 splice variant.  Sci Adv. 2022 Oct 7;8(40):eabo6789. doi: 10.1126/sciadv.abo6789. Epub 2022 Oct 7. PMID: 36206341

2021 

Szulzewsky F, Holland EC, Vasioukhin V. YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance.  Dev Biol. 2021 Jan 8:S0012-1606(21)00004-X. doi: 10.1016/j.ydbio.2020.12.018. Online ahead of print. PMID: 33428889

Horne EA, Diaz P, Cimino PJ, Jung E, Xu C, Hamel E, Wagenbach M, Kumasaka D, Wageling NB, Azorín DD, Winkler F, Wordeman LG, Holland EC, Stella N. A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis. Neurooncol Adv. 2020 Dec 3;3(1):vdaa165. doi: 10.1093/noajnl/vdaa165. eCollection 2021 Jan-Dec. PMID: 33506204

Nuechterlein N, Li B, Feroze A, Holland EC, Shapiro L, Haynor D, Fink J, Cimino PJ. Radiogenomic modeling predicts survival-associated prognostic groups in glioblastoma. Neurooncol Adv. 2021 Feb 15;3(1):vdab004. doi: 10.1093/noajnl/vdab004. eCollection 2021 Jan-Dec. PMID: 33615222

Kanvinde PP, Malla AP, Connolly NP, Szulzewsky F, Anastasiadis P, Ames HM, Kim AJ, Winkles JA, Holland EC, Woodworth GF. Leveraging the replication-competent avian-like sarcoma virus/tumor virus receptor-A system for modeling human gliomas. Glia. 2021 Feb 27. doi: 10.1002/glia.23984. Online ahead of print. PMID: 33638562

Ozawa T, Kaneko S, Szulzewsky F, Qiao Z, Takadera M, Narita Y, Kondo T, Holland EC, Hamamoto R, Ichimura K. C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.  Acta Neuropathol Commun. 2021 Mar 8;9(1):36. doi: 10.1186/s40478-021-01135-4. PMID: 33685520

Randles A, Wirsching HG, Dean JA, Cheng YK, Emerson S, Pattwell SS, Holland EC, Michor F. Computational modelling of perivascular-niche dynamics for the optimization of treatment schedules for glioblastoma.  Nat Biomed Eng. 2021 Apr;5(4):346-359. doi: 10.1038/s41551-021-00710-3. Epub 2021 Apr 16. PMID: 33864039

Wagner MJ, Lyons YA, Siedel JH, Dood R, Nagaraja AS, Haemmerle M, Mangala LS, Chanana P, Lazar AJ, Wang WL, Ravi V, Holland EC, Sood AK.  Combined VEGFR and MAPK pathway inhibition in angiosarcoma.  Sci Rep. 2021 Apr 30;11(1):9362. doi: 10.1038/s41598-021-88703-9. PMID: 33931674

Chan M, Vijay S, McNevin J, McElrath MJ, Holland EC, Gujral TS. Machine learning identifies molecular regulators and therapeutics for targeting SARS-CoV2-induced cytokine release.  Mol Syst Biol. 2021 Sep;17(9):e10426. doi: 10.15252/msb.202110426. PMID: 34486798

Arakaki AKS, Szulzewsky F, Gilbert MR, Gujral TS, Holland EC. Utilizing preclinical models to develop targeted therapies for rare central nervous system cancers.  Neuro Oncol. 2021 Nov 2;23(23 Suppl 5):S4-S15. doi: 10.1093/neuonc/noab183.

Nuechterlein N, Shapiro LG, Holland EC, Cimino PJ. Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma.  Acta Neuropathol Commun. 2021 Dec 4;9(1):191. doi: 10.1186/s40478-021-01295-3.

Dai J, Cimino PJ, Gouin KH 3rd, Grzelak CA, Barrett A, Lim AR, Long A, Weaver S, Saldin LT, Uzamere A, Schulte V, Clegg N, Pisarsky L, Lyden D, Bissell MJ, Knott S, Welm AL, Bielas JH, Hansen KC, Winkler F, Holland EC, Ghajar CM. Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain. Nat Cancer. 2022 Jan;3(1):25-42. doi: 10.1038/s43018-021-00297-3. Epub 2021 Dec 24. PMID: 35121993 

2020

Ma Z, Niu B, Phan TA, Stensjøen AL, Ene C, Woodiwiss T, Wang T, Maini PK, Holland EC, Tian JP. Stochastic growth pattern of untreated human glioblastomas predicts the survival time for patients. Sci Rep. 2020 Apr 20;10(1):6642. doi: 10.1038/s41598-020-63394-w. PMID: 32313150

Wang Y, Wild AT, Turcan S, Wu WH, Sigel C, Klimstra DS, Ma X, Gong Y, Holland EC, Huse JT, Chan TA. Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas. Sci Adv. 2020 Apr 22;6(17):eaaz3221. doi: 10.1126/sciadv.aaz3221. eCollection 2020 Apr. PMID: 32494639

Pattwell SS, Arora S, Cimino PJ, Ozawa T, Szulzewsky F, Hoellerbauer P, Bonifert T, Hoffstrom BG, Boiani NE, Bolouri H, Correnti CE, Oldrini B, Silber JR, Squatrito M, Paddison PJ, Holland EC. A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways. Nat Commun. 2020 Jun 12;11(1):2977. doi: 10.1038/s41467-020-16786-5. PMID: 32532995

Niu B, Zeng X, Phan TA, Szulzewsky F, Holte S, Holland EC, Tian JP. Mathematical modeling of PDGF-driven glioma reveals the dynamics of immune cells infiltrating into tumors. Neoplasia. 2020 Jun 22;22(9):323-332. doi: 10.1016/j.neo.2020.05.005. Online ahead of print. PMID: 32585427

Alexander J, LaPlant QC, Pattwell SS, Szulzewsky F, Cimino PJ, Caruso FP, Pugliese P, Chen Z, Chardon F, Hill AJ, Spurrell C, Ahrendsen D, Pietras A, Starita LM, Hambardzumyan D, Iavarone A, Shendure J, Holland EC. Multimodal single-cell analysis reveals distinct radioresistant stem-like and progenitor cell populations in murine glioma. Glia. 2020 Jul 4. doi: 10.1002/glia.23866. Online ahead of print. PMID: 32621641

Szulzewsky F, Arora S, Hoellerbauer P, King C, Nathan E, Chan M, Cimino PJ, Ozawa T, Kawauchi D, Pajtler KW, Gilbertson RJ, Paddison PJ, Vasioukhin V, Gujral TS, Holland EC. Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis. Genes Dev. 2020 Aug 1;34(15-16):1051-1064. doi: 10.1101/gad.338681.120. Epub 2020 Jul 16. PMID: 32675324

Glorioso JC, Cohen JB, Goins WF, Hall B, Jackson JW, Kohanbash G, Amankulor N, Kaur B, Caligiuri MA, Chiocca EA, Holland EC, Quéva C. Oncolytic HSV Vectors and Anti-Tumor Immunity. Curr Issues Mol Biol. 2020 Sep 17;41:381-468. doi: 10.21775/cimb.041.381. Online ahead of print. PMID: 32938804

Ene CI, Cimino PJ, Fine HA, Holland EC.  Incorporating genomic signatures into surgical and medical decision-making for elderly glioblastoma patients. Neurosurg Focus. 2020 Oct;49(4):E11. doi: 10.3171/2020.7.FOCUS20418. PMID: 33002863

De Boeck A, Ahn BY, D'Mello C, Lun X, Menon SV, Alshehri MM, Szulzewsky F, Shen Y, Khan L, Dang NH, Reichardt E, Goring KA, King J, Grisdale CJ, Grinshtein N, Hambardzumyan D, Reilly KM, Blough MD, Cairncross JG, Yong VW, Marra MA, Jones SJM, Kaplan DR, McCoy KD, Holland EC, Bose P, Chan JA, Robbins SM, Senger DL. Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression.  Nat Commun. 2020 Oct 5;11(1):4997. doi: 10.1038/s41467-020-18569-4. PMID: 33020472

Brempelis KJ, Cowan CM, Kreuser SA, Labadie KP, Prieskorn BM, Lieberman NAP, Ene CI, Moyes KW, Chinn H, DeGolier KR, Matsumoto LR, Daniel SK, Yokoyama JK, Davis AD, Hoglund VJ, Smythe KS, Balcaitis SD, Jensen MC, Ellenbogen RG, Campbell JS, Pierce RH, Holland EC, Pillarisetty VG, Crane CA. J Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responses.  Immunother Cancer. 2020 Oct;8(2):e001356. doi: 10.1136/jitc-2020-001356. PMID: 33115946

Takadera M, Satomi K, Szulzewsky F, Cimino PJ, Holland EC, Yamamoto T, Ichimura K, Ozawa T. Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes. Acta Neuropathol Commun. 2020 Nov 23;8(1):203. doi: 10.1186/s40478-020-01080-8. PMID: 33228790 

Georganaki M, Ramachandran M, Tuit S, Núñez NG, Karampatzakis A, Fotaki G, van Hooren L, Huang H, Lugano R, Ulas T, Kaunisto A, Holland EC, Ellmark P, Mangsbo SM, Schultze J, Essand M, Tugues S, Dimberg A. Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy. Oncoimmunology. 2020 Mar 9;9(1):1730538. doi: 10.1080/2162402X.2020.1730538. eCollection 2020. PMID: 32231867

Kaley TJ, Panageas KS, Pentsova EI, Mellinghoff IK, Nolan C, Gavrilovic I, DeAngelis LM, Abrey LE, Holland EC, Omuro A, Lacouture ME, Ludwig E, Lassman AB. Phase I clinical trial of temsirolimus and perifosine for recurrent glioblastoma. Ann Clin Transl Neurol. 2020 Apr;7(4):429-436. doi: 10.1002/acn3.51009. Epub 2020 Apr 15. PMID: 32293798

Bohm AK, DePetro JA, Binding CE, Gerber A, Chahley N, Berger ND, Ware MA, Thomas KA, Senapathi U, Bukhari S, Chen C, Chahley E, Grisdale CJ, Lawn S, Yu Y, Wong R, Shen Y, Omairi H, Mirzaei R, Alshatti N, Pederson H, Yong VW, Weiss S, Chan JA, Cimino PJ, Kelly JJ, Jones SJM, Holland EC, Blough MD, Cairncross JG. In Vitro Modeling of GBM Initiation using PDGF-AA and P53-Null Neural Progenitors.  Neuro Oncol. 2020 Apr 16:noaa093. doi: 10.1093/neuonc/noaa093. Online ahead of print. PMID: 32296841 

Arora S, Pattwell SS, Holland EC, Bolouri H. "Variability in estimated gene expression among commonly used RNA-seq pipelines." Sci Rep. 2020 Feb 17;10(1):2734. doi: 10.1038/s41598-020-59516-z. PubMed PMID: 32066774; PubMed Central PMCID: PMC7026138.

Dirks PB, Gilbert MR, Holland EC, Maher EA, Weiss WA. "Translating basic science discoveries into improved outcomes for glioblastoma." Clin Cancer Res. 2020 Feb 14. pii: clincanres.3924.2019. doi: 10.1158/1078-0432.CCR-19-3924. [Epub ahead of print] PubMed PMID: 32060102.

Brat DJ, Aldape K, Colman H, Figrarella-Branger D, Fuller GN, Giannini C, Holland EC, Jenkins RB, Kleinschmidt-DeMasters B, Komori T, Kros JM, Louis DN, McLean C, Perry A, Reifenberger G, Sarkar C, Stupp R, van den Bent MJ, von Deimling A, Weller M. "cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas." Acta Neuropathol. 2020 Mar;139(3):603-608. doi: 10.1007/s00401-020-02127-9. Epub 2020 Jan 29. PubMed PMID: 31996992.

2019

Ene CI, Kreuser SA, Jung M, Zhang H, Arora S, White Moyes K, Szulzewsky F, Barber J, Cimino PJ, Wirsching HG, Patel A, Kong P, Woodiwiss TR, Durfy SJ, Houghton AM, Pierce RH, Parney IF, Crane CA, Holland EC. "Anti-PD-L1 antibody direct activation of macrophages contributes to a radiation-induced abscopal response in glioblastoma." Neuro Oncol. 2019 Dec 3. pii: noz226. doi: 10.1093/neuonc/noz226. [Epub ahead of print] PubMed PMID: 31793634.

Kaffes I, Szulzewsky F, Chen Z, Herting CJ, Gabanic B, Velázquez Vega JE, Shelton J, Switchenko JM, Ross JL, McSwain LF, Huse JT, Westermark B, Nelander S, Forsberg-Nilsson K, Uhrbom L, Maturi NP, Cimino PJ, Holland EC, Kettenmann H, Brennan CW, Brat DJ, Hambardzumyan D. "Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors." Oncoimmunology. 2019 Aug 22;8(11):e1655360. doi: 10.1080/2162402X.2019.1655360. eCollection 2019. PubMed PMID: 31646100; PubMed Central PMCID: PMC6791439.

Yoda RA, Marxen T, Longo L, Ene C, Wirsching HG, Keene CD, Holland EC, Cimino PJ. "Mitotic Index Thresholds Do Not Predict Clinical Outcome for IDH-Mutant Astrocytoma." J Neuropathol Exp Neurol. 2019 Nov 1;78(11):1002-1010. doi: 10.1093/jnen/nlz082. PubMed PMID: 31529048.

Zhang F, Parayath NN, Ene CI, Stephan SB, Koehne AL, Coon ME, Holland EC, Stephan MT. "Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers." Nat Commun. 2019 Sep 3;10(1):3974. doi: 10.1038/s41467-019-11911-5. PubMed PMID: 31481662; PubMed Central PMCID: PMC6722139.

Wirsching HG, Arora S, Zhang H, Szulzewsky F, Cimino PJ, Quéva C, Houghton AM, Glorioso JC, Weller M, Holland EC. "Cooperation of oncolytic virotherapy with VEGF-neutralizing antibody treatment in IDH wildtype glioblastoma depends on MMP9." Neuro Oncol. 2019 Dec 17;21(12):1607-1609. doi: 10.1093/neuonc/noz145. PubMed PMID: 31412117; PubMed Central PMCID: PMC6917394.

Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, Flanary VL, Ramkissoon A, Chow LML, Kiyokawa J, Mashimo T, Lucey G, Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT. "IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma." Nat Cell Biol. 2019 Aug;21(8):1003-1014. doi: 10.1038/s41556-019-0363-9. Epub 2019 Aug 1. PubMed PMID: 31371825; PubMed Central PMCID: PMC6686884.

Kaley TJ, Panageas KS, Mellinghoff IK, Nolan C, Gavrilovic IT, DeAngelis LM, Abrey LE, Holland EC, Lassman AB. "Phase II trial of an AKT inhibitor (perifosine) for recurrent glioblastoma." J Neurooncol. 2019 Sep;144(2):403-407. doi: 10.1007/s11060-019-03243-7. Epub 2019 Jul 19. PubMed PMID: 31325145.

Wirsching HG, Zhang H, Szulzewsky F, Arora S, Grandi P, Cimino PJ, Amankulor N, Campbell JS, McFerrin L, Pattwell SS, Ene C, Hicks A, Ball M, Yan J, Zhang J, Kumasaka D, Pierce RH, Weller M, Finer M, Quéva C, Glorioso JC, Houghton AM, Holland EC. "Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma." JCI Insight. 2019 Jul 11;4(13). pii: 128217. doi: 10.1172/jci.insight.128217. eCollection 2019 Jul 11. PubMed PMID: 31292299; PubMed Central PMCID: PMC6629248.

Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ. "Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'." Nat Rev Clin Oncol. 2019 Aug;16(8):522-523. doi: 10.1038/s41571-019-0236-y. PubMed PMID: 31150022.

Cimino PJ, Holland EC. "The molecular landscape of adult diffuse gliomas and relevance to clinical trials." Oncotarget. 2019 Mar 5;10(19):1758-1759. doi: 10.18632/oncotarget.26750. eCollection 2019 Mar 5. PubMed PMID: 30956755; PubMed Central PMCID: PMC6443000.

Cimino PJ, Holland EC. "Targeted copy number analysis outperforms histologic grading in predicting patient survival for WHO grades II/III IDH-mutant astrocytomas." Neuro Oncol. 2019 Jun 10;21(6):819-821. doi: 10.1093/neuonc/noz052. PubMed PMID: 30918961; PubMed Central PMCID: PMC6556841.

Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ. "Challenges to curing primary brain tumours." Nat Rev Clin Oncol. 2019 Aug;16(8):509-520. doi: 10.1038/s41571-019-0177-5. Review. PubMed PMID: 30733593; PubMed Central PMCID: PMC6650350.

Ene CI, Macomber MW, Barber JK, Ferreira MJ, Ellenbogen RG, Holland EC, Rockhill JK, Silbergeld DL, Halasz LM. "Patterns of Failure After Stereotactic Radiosurgery for Recurrent High-Grade Glioma: A Single Institution Experience of 10 Years." Neurosurgery. 2019 Aug 1;85(2):E322-E331. doi: 10.1093/neuros/nyy520. PubMed PMID: 30576476.

2018

Wallmann T, Zhang XM, Wallerius M, Bolin S, Joly AL, Sobocki C, Leiss L, Jiang Y, Bergh J, Holland EC, Enger PØ, Andersson J, Swartling FJ, Miletic H, Uhrbom L, Harris RA, Rolny C. "Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity." iScience. 2018 Nov 30;9:71-83. doi: 10.1016/j.isci.2018.10.011. Epub 2018 Oct 16. PubMed PMID: 30384135; PubMed Central PMCID: PMC6214839.

Brat DJ, Aldape K, Colman H, Holland EC, Louis DN, Jenkins RB, Kleinschmidt-DeMasters BK, Perry A, Reifenberger G, Stupp R, von Deimling A, Weller M. "cIMPACT-NOW update 3: recommended diagnostic criteria for Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV." Acta Neuropathol. 2018 Nov;136(5):805-810. doi: 10.1007/s00401-018-1913-0. Epub 2018 Sep 26. PubMed PMID: 30259105; PubMed Central PMCID: PMC6204285.

McFerrin LG, Zager M, Zhang J, Krenn G, McDermott R, Horse-Grant D, Silgard E, Colevas K, Shannon P, Bolouri H, Holland EC. "Analysis and visualization of linked molecular and clinical cancer data by using Oncoscape." Nat Genet. 2018 Sep;50(9):1203-1204. doi: 10.1038/s41588-018-0208-7. PubMed PMID: 30158685.

Wang AC, Jones DTW, Abecassis IJ, Cole BL, Leary SES, Lockwood CM, Chavez L, Capper D, Korshunov A, Fallah A, Wang S, Ene C, Olson JM, Geyer JR, Holland EC, Lee A, Ellenbogen RG, Ojemann JG. "Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations." Mol Cancer Res. 2018 Oct;16(10):1491-1498. doi: 10.1158/1541-7786.MCR-17-0507. Epub 2018 Jul 13. PubMed PMID: 30006355.

Cimino PJ, McFerrin L, Wirsching HG, Arora S, Bolouri H, Rabadan R, Weller M, Holland EC. "Copy number profiling across glioblastoma populations has implications for clinical trial design." Neuro Oncol. 2018 Sep 3;20(10):1368-1373. doi: 10.1093/neuonc/noy108. PubMed PMID: 29982740; PubMed Central PMCID: PMC6120353.

Ozawa T, Arora S, Szulzewsky F, Juric-Sekhar G, Miyajima Y, Bolouri H, Yasui Y, Barber J, Kupp R, Dalton J, Jones TS, Nakada M, Kumabe T, Ellison DW, Gilbertson RJ, Holland EC. "A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB." Cell Rep. 2018 Jun 26;23(13):3787-3797. doi: 10.1016/j.celrep.2018.04.099. PubMed PMID: 29949764; PubMed Central PMCID: PMC6411037.

Zhang F, Stephan SB, Ene CI, Smith TT, Holland EC, Stephan MT. "Nanoparticles That Reshape the Tumor Milieu Create a Therapeutic Window for Effective T-cell Therapy in Solid Malignancies." Cancer Res. 2018 Jul 1;78(13):3718-3730. doi: 10.1158/0008-5472.CAN-18-0306. Epub 2018 May 14. PubMed PMID: 29760047; PubMed Central PMCID: PMC6030470.

Cimino PJ, Kim Y, Wu HJ, Alexander J, Wirsching HG, Szulzewsky F, Pitter K, Ozawa T, Wang J, Vazquez J, Arora S, Rabadan R, Levine R, Michor F, Holland EC. "Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma." Genes Dev. 2018 Apr 1;32(7-8):512-523. doi: 10.1101/gad.312157.118. Epub 2018 Apr 9. PubMed PMID: 29632085; PubMed Central PMCID: PMC5959235.

Connolly NP, Shetty AC, Stokum JA, Hoeschele I, Siegel MB, Miller CR, Kim AJ, Ho CY, Davila E, Simard JM, Devine SE, Rossmeisl JH, Holland EC, Winkles JA, Woodworth GF. "Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma." Sci Rep. 2018 Jan 19;8(1):1180. doi: 10.1038/s41598-018-19451-6. PubMed PMID: 29352201; PubMed Central PMCID: PMC5775420.

Szulzewsky F, Schwendinger N, Güneykaya D, Cimino PJ, Hambardzumyan D, Synowitz M, Holland EC, Kettenmann H. "Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment." Neuro Oncol. 2018 Feb 19;20(3):355-366. doi: 10.1093/neuonc/nox165. PubMed PMID: 29016864; PubMed Central PMCID: PMC5817947.

2017

Pattwell SS, Holland EC. "Putting Glioblastoma in Its Place: IRF3 Inhibits Invasion." Trends Mol Med. 2017 Sep;23(9):773-776. doi: 10.1016/j.molmed.2017.07.008. Epub 2017 Jul 31. PubMed PMID: 28774478; PubMed Central PMCID: PMC5843370.

Kievit FM, Wang K, Ozawa T, Tarudji AW, Silber JR, Holland EC, Ellenbogen RG, Zhang M. "Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma." Nanomedicine. 2017 Oct;13(7):2131-2139. doi: 10.1016/j.nano.2017.06.004. Epub 2017 Jun 11. PubMed PMID: 28614736; PubMed Central PMCID: PMC6002851.

Cimino PJ, Zager M, McFerrin L, Wirsching HG, Bolouri H, Hentschel B, von Deimling A, Jones D, Reifenberger G, Weller M, Holland EC. "Multidimensional scaling of diffuse gliomas: application to the 2016 World Health Organization classification system with prognostically relevant molecular subtype discovery." Acta Neuropathol Commun. 2017 May 22;5(1):39. doi: 10.1186/s40478-017-0443-7. PubMed PMID: 28532485; PubMed Central PMCID: PMC5439117.

Amankulor NM, Kim Y, Arora S, Kargl J, Szulzewsky F, Hanke M, Margineantu DH, Rao A, Bolouri H, Delrow J, Hockenbery D, Houghton AM, Holland EC. "Mutant IDH1 regulates the tumor-associated immune system in gliomas." Genes Dev. 2017 Apr 15;31(8):774-786. doi: 10.1101/gad.294991.116. Epub 2017 May 2. PubMed PMID: 28465358; PubMed Central PMCID: PMC5435890.

Connolly NP, Stokum JA, Schneider CS, Ozawa T, Xu S, Galisteo R, Castellani RJ, Kim AJ, Simard JM, Winkles JA, Holland EC, Woodworth GF. "Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer." PLoS One. 2017 Mar 30;12(3):e0174557. doi: 10.1371/journal.pone.0174557. eCollection 2017. PubMed PMID: 28358926; PubMed Central PMCID: PMC5373526.

Weller M, Holland EC, Hambardzumyan D. "Reply: Corticosteroids compromise survival in glioblastoma in part through their elevation of blood glucose levels." Brain. 2017 Mar 1;140(3):e17. doi: 10.1093/brain/aww325. PubMed PMID: 28007996.

Pajtler KW, Mack SC, Ramaswamy V, Smith CA, Witt H, Smith A, Hansford JR, von Hoff K, Wright KD, Hwang E, Frappaz D, Kanemura Y, Massimino M, Faure-Conter C, Modena P, Tabori U, Warren KE, Holland EC, Ichimura K, Giangaspero F, Castel D, von Deimling A, Kool M, Dirks PB, Grundy RG, Foreman NK, Gajjar A, Korshunov A, Finlay J, Gilbertson RJ, Ellison DW, Aldape KD, Merchant TE, Bouffet E, Pfister SM, Taylor MD. "The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants." Acta Neuropathol. 2017 Jan;133(1):5-12. doi: 10.1007/s00401-016-1643-0. Epub 2016 Nov 17. PubMed PMID: 27858204; PubMed Central PMCID: PMC5209402.

2016

Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM. "Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression." Nat Cell Biol. 2016 Dec;18(12):1336-1345. doi: 10.1038/ncb3429. Epub 2016 Nov 7. PubMed PMID: 27820599; PubMed Central PMCID: PMC5361403.

Wee B, Pietras A, Ozawa T, Bazzoli E, Podlaha O, Antczak C, Westermark B, Nelander S, Uhrbom L, Forsberg-Nilsson K, Djaballah H, Michor F, Holland EC. "ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells." Sci Rep. 2016 Jul 26;6:25956. doi: 10.1038/srep25956. PubMed PMID: 27456282; PubMed Central PMCID: PMC4960591.

Szulzewsky F, Arora S, de Witte L, Ulas T, Markovic D, Schultze JL, Holland EC, Synowitz M, Wolf SA, Kettenmann H. "Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples." Glia. 2016 Aug;64(8):1416-36. doi: 10.1002/glia.23014. PubMed PMID: 27312099.

Huang R, Harmsen S, Samii JM, Karabeber H, Pitter KL, Holland EC, Kircher MF. "High Precision Imaging of Microscopic Spread of Glioblastoma with a Targeted Ultrasensitive SERRS Molecular Imaging Probe." Theranostics. 2016 May 7;6(8):1075-84. doi: 10.7150/thno.13842. eCollection 2016. PubMed PMID: 27279902; PubMed Central PMCID: PMC4893636.

Quail DF, Bowman RL, Akkari L, Quick ML, Schuhmacher AJ, Huse JT, Holland EC, Sutton JC, Joyce JA. "The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas." Science. 2016 May 20;352(6288):aad3018. doi: 10.1126/science.aad3018. PubMed PMID: 27199435; PubMed Central PMCID: PMC5450629.

Lu F, Chen Y, Zhao C, Wang H, He D, Xu L, Wang J, He X, Deng Y, Lu EE, Liu X, Verma R, Bu H, Drissi R, Fouladi M, Stemmer-Rachamimov AO, Burns D, Xin M, Rubin JB, Bahassi EM, Canoll P, Holland EC, Lu QR. "Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma." Cancer Cell. 2016 May 9;29(5):669-683. doi: 10.1016/j.ccell.2016.03.027. PubMed PMID: 27165742; PubMed Central PMCID: PMC4946168.

Bolouri H, Zhao LP, Holland EC. "Big data visualization identifies the multidimensional molecular landscape of human gliomas." Proc Natl Acad Sci U S A. 2016 May 10;113(19):5394-9. doi: 10.1073/pnas.1601591113. Epub 2016 Apr 26. PubMed PMID: 27118839; PubMed Central PMCID: PMC4868421.

Pitter KL, Tamagno I, Alikhanyan K, Hosni-Ahmed A, Pattwell SS, Donnola S, Dai C, Ozawa T, Chang M, Chan TA, Beal K, Bishop AJ, Barker CA, Jones TS, Hentschel B, Gorlia T, Schlegel U, Stupp R, Weller M, Holland EC, Hambardzumyan D. "Corticosteroids compromise survival in glioblastoma." Brain. 2016 May;139(Pt 5):1458-71. doi: 10.1093/brain/aww046. Epub 2016 Mar 28. PubMed PMID: 27020328; PubMed Central PMCID: PMC5006251.

Lemasson B, Wang H, Galbán S, Li Y, Zhu Y, Heist KA, Tsein C, Chenevert TL, Rehemtulla A, Galbán CJ, Holland EC, Ross BD. "Evaluation of Concurrent Radiation, Temozolomide and ABT-888 Treatment Followed by Maintenance Therapy with Temozolomide and ABT-888 in a Genetically Engineered Glioblastoma Mouse Model." Neoplasia. 2016 Feb;18(2):82-9. doi: 10.1016/j.neo.2015.11.014. PubMed PMID: 26936394; PubMed Central PMCID: PMC5005260.

2015

Becher OJ, Holland EC. "Glioma Stem-like Cells Keep Their H3.3 Variant Levels at Bay." Cancer Cell. 2015 Dec 14;28(6):679-680. doi: 10.1016/j.ccell.2015.12.001. PubMed PMID: 26678332.

Xie Y, Bergström T, Jiang Y, Johansson P, Marinescu VD, Lindberg N, Segerman A, Wicher G, Niklasson M, Baskaran S, Sreedharan S, Everlien I, Kastemar M, Hermansson A, Elfineh L, Libard S, Holland EC, Hesselager G, Alafuzoff I, Westermark B, Nelander S, Forsberg-Nilsson K, Uhrbom L. "The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes." EBioMedicine. 2015 Aug 15;2(10):1351-63. doi: 10.1016/j.ebiom.2015.08.026. eCollection 2015 Oct. PubMed PMID: 26629530; PubMed Central PMCID: PMC4634360.

Badri H, Pitter K, Holland EC, Michor F, Leder K. "Optimization of radiation dosing schedules for proneural glioblastoma." J Math Biol. 2016 Apr;72(5):1301-36. doi: 10.1007/s00285-015-0908-x. Epub 2015 Jun 21. PubMed PMID: 26094055.

Parrish-Novak J, Holland EC, Olson JM. "Image-Guided Tumor Resection." Cancer J. 2015 May-Jun;21(3):206-12. doi: 10.1097/PPO.0000000000000113. Review. PubMed PMID: 26049700; PubMed Central PMCID: PMC4459523.

Ene CI, Holland EC. "Personalized medicine for gliomas." Surg Neurol Int. 2015 Feb 13;6(Suppl 1):S89-95. doi: 10.4103/2152-7806.151351. eCollection 2015. PubMed PMID: 25722938; PubMed Central PMCID: PMC4338492.

Venneti S, Dunphy MP, Zhang H, Pitter KL, Zanzonico P, Campos C, Carlin SD, La Rocca G, Lyashchenko S, Ploessl K, Rohle D, Omuro AM, Cross JR, Brennan CW, Weber WA, Holland EC, Mellinghoff IK, Kung HF, Lewis JS, Thompson CB. "Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo." Sci Transl Med. 2015 Feb 11;7(274):274ra17. doi: 10.1126/scitranslmed.aaa1009. PubMed PMID: 25673762; PubMed Central PMCID: PMC4431550.

Harmsen S, Huang R, Wall MA, Karabeber H, Samii JM, Spaliviero M, White JR, Monette S, O'Connor R, Pitter KL, Sastra SA, Saborowski M, Holland EC, Singer S, Olive KP, Lowe SW, Blasberg RG, Kircher MF. "Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging." Sci Transl Med. 2015 Jan 21;7(271):271ra7. doi: 10.1126/scitranslmed.3010633. PubMed PMID: 25609167; PubMed Central PMCID: PMC4414254.

2014

50: Ozawa T, Holland EC. "Rethinking glioma treatment strategy." Oncotarget. 2014 Oct 30;5(20):9532-3. PubMed PMID: 25393981; PubMed Central PMCID: PMC4259417.

51: Lindberg N, Jiang Y, Xie Y, Bolouri H, Kastemar M, Olofsson T, Holland EC, Uhrbom L. "Oncogenic signaling is dominant to cell of origin and dictates astrocytic or oligodendroglial tumor development from oligodendrocyte precursor cells." J Neurosci. 2014 Oct 29;34(44):14644-51. doi: 10.1523/JNEUROSCI.2977-14.2014. PubMed PMID: 25355217; PubMed Central PMCID: PMC6608431.

52: Ozawa T, Riester M, Cheng YK, Huse JT, Squatrito M, Helmy K, Charles N, Michor F, Holland EC. "Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma." Cancer Cell. 2014 Aug 11;26(2):288-300. doi: 10.1016/j.ccr.2014.06.005. PubMed PMID: 25117714; PubMed Central PMCID: PMC4143139.

53: Karabeber H, Huang R, Iacono P, Samii JM, Pitter K, Holland EC, Kircher MF. "Guiding brain tumor resection using surface-enhanced Raman scattering nanoparticles and a hand-held Raman scanner." ACS Nano. 2014 Oct 28;8(10):9755-66. doi: 10.1021/nn503948b. Epub 2014 Aug 22. PubMed PMID: 25093240; PubMed Central PMCID: PMC4212801.

54: Becher OJ, Holland EC. "Sox2, a marker for stem-like tumor cells in skin squamous cell carcinoma and hedgehog subgroup medulloblastoma." EMBO J. 2014 Sep 17;33(18):1984-6. doi: 10.15252/embj.201489479. Epub 2014 Jul 24. PubMed PMID: 25061226; PubMed Central PMCID: PMC4195767.

55: Pitter KL, Tamagno I, Feng X, Ghosal K, Amankulor N, Holland EC, Hambardzumyan D. "The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions." Glia. 2014 Oct;62(10):1595-607. doi: 10.1002/glia.22702. Epub 2014 Jun 4. PubMed PMID: 24895267; PubMed Central PMCID: PMC4489138.

56: Ortiz B, Fabius AW, Wu WH, Pedraza A, Brennan CW, Schultz N, Pitter KL, Bromberg JF, Huse JT, Holland EC, Chan TA. "Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis." Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8149-54. doi: 10.1073/pnas.1401952111. Epub 2014 May 19. PubMed PMID: 24843164; PubMed Central PMCID: PMC4050622.

57: Halliday J, Helmy K, Pattwell SS, Pitter KL, LaPlant Q, Ozawa T, Holland EC. "In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift." Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5248-53. doi: 10.1073/pnas.1321014111. Epub 2014 Mar 24. PubMed PMID: 24706837; PubMed Central PMCID: PMC3986190.

58: Pietras A, Katz AM, Ekström EJ, Wee B, Halliday JJ, Pitter KL, Werbeck JL, Amankulor NM, Huse JT, Holland EC. "Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth." Cell Stem Cell. 2014 Mar 6;14(3):357-69. doi: 10.1016/j.stem.2014.01.005. PubMed PMID: 24607407; PubMed Central PMCID: PMC3999042.

59: Leder K, Pitter K, LaPlant Q, Hambardzumyan D, Ross BD, Chan TA, Holland EC, Michor F. "Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules." Cell. 2014 Jan 30;156(3):603-616. doi: 10.1016/j.cell.2013.12.029. PubMed PMID: 24485463; PubMed Central PMCID: PMC3923371.

2013

60: Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, Olson OC, Quick ML, Huse JT, Teijeiro V, Setty M, Leslie CS, Oei Y, Pedraza A, Zhang J, Brennan CW, Sutton JC, Holland EC, Daniel D, Joyce JA. "CSF-1R inhibition alters macrophage polarization and blocks glioma progression." Nat Med. 2013 Oct;19(10):1264-72. doi: 10.1038/nm.3337. Epub 2013 Sep 22. PubMed PMID: 24056773; PubMed Central PMCID: PMC3840724.

61: Antczak C, Wee B, Radu C, Bhinder B, Holland EC, Djaballah H. "A high-content assay strategy for the identification and profiling of ABCG2 modulators in live cells." Assay Drug Dev Technol. 2014 Jan-Feb;12(1):28-42. doi: 10.1089/adt.2013.521. Epub 2013 Aug 30. PubMed PMID: 23992118; PubMed Central PMCID: PMC3934439.

62: Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. "A physical sciences network characterization of non-tumorigenic and metastatic cells." Sci Rep. 2013;3:1449. doi: 10.1038/srep01449. PubMed PMID: 23618955; PubMed Central PMCID: PMC3636513.

63: Williams TM, Galbán S, Li F, Heist KA, Galbán CJ, Lawrence TS, Holland EC, Thomae TL, Chenevert TL, Rehemtulla A, Ross BD. "DW-MRI as a Predictive Biomarker of Radiosensitization of GBM through Targeted Inhibition of Checkpoint Kinases." Transl Oncol. 2013 Apr;6(2):133-42. Epub 2013 Apr 1. PubMed PMID: 23544166; PubMed Central PMCID: PMC3610547.

64: Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, Avşar T, Li J, Murray PB, Henegariu O, Yilmaz S, Günel JM, Carrión-Grant G, Yilmaz B, Grady C, Tanrikulu B, Bakircioğlu M, Kaymakçalan H, Caglayan AO, Sencar L, Ceyhun E, Atik AF, Bayri Y, Bai H, Kolb LE, Hebert RM, Omay SB, Mishra-Gorur K, Choi M, Overton JD, Holland EC, Mane S, State MW, Bilgüvar K, Baehring JM, Gutin PH, Piepmeier JM, Vortmeyer A, Brennan CW, Pamir MN, Kiliç T, Lifton RP, Noonan JP, Yasuno K, Günel M. "Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO." Science. 2013 Mar 1;339(6123):1077-80. doi: 10.1126/science.1233009. Epub 2013 Jan 24. PubMed PMID: 23348505; PubMed Central PMCID: PMC4808587.

65: Liu Y, Raheja R, Yeh N, Ciznadija D, Pedraza AM, Ozawa T, Hukkelhoven E, Erdjument-Bromage H, Tempst P, Gauthier NP, Brennan C, Holland EC, Koff A. "TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.)." Oncogene. 2014 Jan 16;33(3):308-15. doi: 10.1038/onc.2012.596. Epub 2013 Jan 14. PubMed PMID: 23318451; PubMed Central PMCID: PMC3928554.

2012

Benezra M, Hambardzumyan D, Penate-Medina O, Veach DR, Pillarsetty N, Smith-Jones P, Phillips E, Ozawa T, Zanzonico PB, Longo V, Holland EC, Larson SM, Bradbury MS. "Fluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-driven murine glioblastoma model." Neoplasia. 2012 Dec;14(12):1132-43. PubMed PMID: 23308046; PubMed Central PMCID: PMC3540940.

Bazzoli E, Pulvirenti T, Oberstadt MC, Perna F, Wee B, Schultz N, Huse JT, Fomchenko EI, Voza F, Tabar V, Brennan CW, DeAngelis LM, Nimer SD, Holland EC, Squatrito M. "MEF promotes stemness in the pathogenesis of gliomas." Cell Stem Cell. 2012 Dec 7;11(6):836-44. doi: 10.1016/j.stem.2012.09.012. PubMed PMID: 23217424; PubMed Central PMCID: PMC3812924.

Helmy K, Halliday J, Fomchenko E, Setty M, Pitter K, Hafemeister C, Holland EC. "Identification of global alteration of translational regulation in glioma in vivo." PLoS One. 2012;7(10):e46965. doi: 10.1371/journal.pone.0046965. Epub 2012 Oct 3. PubMed PMID: 23056544; PubMed Central PMCID: PMC3463531.

Setty M, Helmy K, Khan AA, Silber J, Arvey A, Neezen F, Agius P, Huse JT, Holland EC, Leslie CS. "Inferring transcriptional and microRNA-mediated regulatory programs in glioblastoma." Mol Syst Biol. 2012;8:605. doi: 10.1038/msb.2012.37. PubMed PMID: 22929615; PubMed Central PMCID: PMC3435504.

Komotar RJ, Iorgulescu JB, Raper DM, Holland EC, Beal K, Bilsky MH, Brennan CW, Tabar V, Sherman JH, Yamada Y, Gutin PH. "The role of radiotherapy following gross-total resection of atypical meningiomas." J Neurosurg. 2012 Oct;117(4):679-86. doi: 10.3171/2012.7.JNS112113. Epub 2012 Aug 24. PubMed PMID: 22920955.

Squatrito M, Vanoli F, Schultz N, Jasin M, Holland EC. "53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma." Cancer Res. 2012 Oct 15;72(20):5250-60. doi: 10.1158/0008-5472.CAN-12-0045. Epub 2012 Aug 21. PubMed PMID: 22915756; PubMed Central PMCID: PMC3771704.

Dougherty JD, Fomchenko EI, Akuffo AA, Schmidt E, Helmy KY, Bazzoli E, Brennan CW, Holland EC, Milosevic A. "Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma." Cancer Res. 2012 Sep 15;72(18):4856-68. doi: 10.1158/0008-5472.CAN-11-2632. Epub 2012 Aug 3. PubMed PMID: 22865458; PubMed Central PMCID: PMC3543775.

Jones TS, Holland EC. "Animal models for glioma drug discovery." Expert Opin Drug Discov. 2011 Dec;6(12):1271-83. doi: 10.1517/17460441.2011.632628. Epub 2011 Oct 28. PubMed PMID: 22647066.

Able RA Jr, Ngnabeuye C, Beck C, Holland EC, Vazquez M. "Low Concentration Microenvironments Enhance the Migration of Neonatal Cells of Glial Lineage." Cell Mol Bioeng. 2012 Jun;5(2). doi: 10.1007/s12195-012-0226-y. PubMed PMID: 24285985; PubMed Central PMCID: PMC3839109.

Galbán S, Lemasson B, Williams TM, Li F, Heist KA, Johnson TD, Leopold JS, Chenevert TL, Lawrence TS, Rehemtulla A, Mikkelsen T, Holland EC, Galbán CJ, Ross BD. "DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma." PLoS One. 2012;7(4):e35857. doi: 10.1371/journal.pone.0035857. Epub 2012 Apr 20. PubMed PMID: 22536446; PubMed Central PMCID: PMC3334987.

Kircher MF, de la Zerda A, Jokerst JV, Zavaleta CL, Kempen PJ, Mittra E, Pitter K, Huang R, Campos C, Habte F, Sinclair R, Brennan CW, Mellinghoff IK, Holland EC, Gambhir SS. "A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle." Nat Med. 2012 Apr 15;18(5):829-34. doi: 10.1038/nm.2721. PubMed PMID: 22504484; PubMed Central PMCID: PMC3422133.

Silber J, Jacobsen A, Ozawa T, Harinath G, Pedraza A, Sander C, Holland EC, Huse JT. "miR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis." PLoS One. 2012;7(3):e33844. doi: 10.1371/journal.pone.0033844. Epub 2012 Mar 27. PubMed PMID: 22479456; PubMed Central PMCID: PMC3313940.

Katz AM, Amankulor NM, Pitter K, Helmy K, Squatrito M, Holland EC. "Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment." PLoS One. 2012;7(2):e32453. doi: 10.1371/journal.pone.0032453. Epub 2012 Feb 29. PubMed PMID: 22393407; PubMed Central PMCID: PMC3290579.

Charles NA, Holland EC, Gilbertson R, Glass R, Kettenmann H. "The brain tumor microenvironment." Glia. 2012 Mar;60(3):502-14. Review. PubMed PMID: 22379614.

Lindberg N, Holland EC. "PDGF in gliomas: more than just a growth factor?" Ups J Med Sci. 2012 May;117(2):92-8. doi: 10.3109/03009734.2012.654860. Epub 2012 Feb 29. PubMed PMID: 22376240; PubMed Central PMCID: PMC3339541.

Szerlip NJ, Pedraza A, Chakravarty D, Azim M, McGuire J, Fang Y, Ozawa T, Holland EC, Huse JT, Jhanwar S, Leversha MA, Mikkelsen T, Brennan CW. "Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response." Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3041-6. doi: 10.1073/pnas.1114033109. Epub 2012 Feb 8. PubMed PMID: 22323597; PubMed Central PMCID: PMC3286976.

Barrett LE, Granot Z, Coker C, Iavarone A, Hambardzumyan D, Holland EC, Nam HS, Benezra R. "Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma." Cancer Cell. 2012 Jan 17;21(1):11-24. doi: 10.1016/j.ccr.2011.11.025. PubMed PMID: 22264785.

Hofstetter CP, Burkhardt JK, Shin BJ, Gürsel DB, Mubita L, Gorrepati R, Brennan C, Holland EC, Boockvar JA. "Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia." PLoS One. 2012;7(1):e30059. doi: 10.1371/journal.pone.0030059. Epub 2012 Jan 11. PubMed PMID: 22253878; PubMed Central PMCID: PMC3256196.

Cheng YK, Beroukhim R, Levine RL, Mellinghoff IK, Holland EC, Michor F. "A mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesis." PLoS Comput Biol. 2012 Jan;8(1):e1002337. doi: 10.1371/journal.pcbi.1002337. Epub 2012 Jan 5. PubMed PMID: 22241976; PubMed Central PMCID: PMC3252265.

2011

Hambardzumyan D, Cheng YK, Haeno H, Holland EC, Michor F. "The probable cell of origin of NF1- and PDGF-driven glioblastomas." PLoS One. 2011;6(9):e24454. doi: 10.1371/journal.pone.0024454. Epub 2011 Sep 9. PubMed PMID: 21931722; PubMed Central PMCID: PMC3170338.

Squatrito M, Holland EC. "DNA damage response and growth factor signaling pathways in gliomagenesis and therapeutic resistance." Cancer Res. 2011 Sep 15;71(18):5945-9. doi: 10.1158/0008-5472.CAN-11-1245. Epub 2011 Sep 13. Review. PubMed PMID: 21917735.

Lefave CV, Squatrito M, Vorlova S, Rocco GL, Brennan CW, Holland EC, Pan YX, Cartegni L. "Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas." EMBO J. 2011 Sep 13;30(19):4084-97. doi: 10.1038/emboj.2011.259. PubMed PMID: 21915099; PubMed Central PMCID: PMC3209773.

Jones TS, Holland EC. "Standard of care therapy for malignant glioma and its effect on tumor and stromal cells." Oncogene. 2012 Apr 19;31(16):1995-2006. doi: 10.1038/onc.2011.398. Epub 2011 Sep 12. Review. PubMed PMID: 21909136.

Fernandez-L A, Squatrito M, Northcott P, Awan A, Holland EC, Taylor MD, Nahlé Z, Kenney AM. "Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation." Oncogene. 2012 Apr 12;31(15):1923-37. doi: 10.1038/onc.2011.379. Epub 2011 Aug 29. PubMed PMID: 21874045; PubMed Central PMCID: PMC3583298.

Huang R, Cheung NK, Vider J, Cheung IY, Gerald WL, Tickoo SK, Holland EC, Blasberg RG. "MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas." FASEB J. 2011 Dec;25(12):4138-49. doi: 10.1096/fj.11-185033. Epub 2011 Aug 19. PubMed PMID: 21856782; PubMed Central PMCID: PMC3236625.

Ciznadija D, Liu Y, Pyonteck SM, Holland EC, Koff A. "Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma." Cancer Res. 2011 Oct 1;71(19):6174-83. doi: 10.1158/0008-5472.CAN-11-1031. Epub 2011 Aug 15. PubMed PMID: 21844184; PubMed Central PMCID: PMC3185142.

Iwamoto FM, Hottinger AF, Karimi S, Riedel E, Dantis J, Jahdi M, Panageas KS, Lassman AB, Abrey LE, Fleisher M, DeAngelis LM, Holland EC, Hormigo A. "Serum YKL-40 is a marker of prognosis and disease status in high-grade gliomas." Neuro Oncol. 2011 Nov;13(11):1244-51. doi: 10.1093/neuonc/nor117. Epub 2011 Aug 10. PubMed PMID: 21831900; PubMed Central PMCID: PMC3199155.

Halliday JJ, Holland EC. "Connective tissue growth factor and the parallels between brain injury and brain tumors." J Natl Cancer Inst. 2011 Aug 3;103(15):1141-3. doi: 10.1093/jnci/djr261. Epub 2011 Jul 19. PubMed PMID: 21771731.

Fomchenko EI, Dougherty JD, Helmy KY, Katz AM, Pietras A, Brennan C, Huse JT, Milosevic A, Holland EC. "Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression." PLoS One. 2011;6(7):e20605. doi: 10.1371/journal.pone.0020605. Epub 2011 Jul 6. PubMed PMID: 21754979; PubMed Central PMCID: PMC3130733.

Iwamoto FM, Hottinger AF, Karimi S, Riedel E, Dantis J, Jahdi M, Panageas KS, Lassman AB, Abrey LE, Fleisher M, Deangelis LM, Holland EC, Hormigo A. "Longitudinal prospective study of matrix metalloproteinase-9 as a serum marker in gliomas." J Neurooncol. 2011 Dec;105(3):607-12. doi: 10.1007/s11060-011-0628-z. Epub 2011 Jun 28. PubMed PMID: 21710351.

Wee B, Charles N, Holland EC. "Animal models to study cancer-initiating cells from glioblastoma." Front Biosci (Landmark Ed). 2011 Jun 1;16:2243-58. Review. PubMed PMID: 21622174.

Charles NA, Holland EC, Gilbertson R, Glass R, Kettenmann H. "The brain tumor microenvironment." Glia. 2011 Aug;59(8):1169-80. doi: 10.1002/glia.21136. Epub 2011 Mar 28. Review. Corrected and republished in: Glia. 2012 Mar;60(3):502-14. PubMed PMID: 21446047.

Gronych J, Korshunov A, Bageritz J, Milde T, Jugold M, Hambardzumyan D, Remke M, Hartmann C, Witt H, Jones DT, Witt O, Heiland S, Bendszus M, Holland EC, Pfister S, Lichter P. "An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice." J Clin Invest. 2011 Apr;121(4):1344-8. doi: 10.1172/JCI44656. Epub 2011 Mar 14. PubMed PMID: 21403401; PubMed Central PMCID: PMC3069779.

Hottinger AF, Iwamoto FM, Karimi S, Riedel E, Dantis J, Park J, Panageas KS, Lassman AB, Abrey LE, Fleisher M, Holland EC, DeAngelis LM, Hormigo A. "YKL-40 and MMP-9 as serum markers for patients with primary central nervous system lymphoma." Ann Neurol. 2011 Jul;70(1):163-9. doi: 10.1002/ana.22360. Epub 2011 Mar 9. PubMed PMID: 21391238.

Hambardzumyan D, Parada LF, Holland EC, Charest A. "Genetic modeling of gliomas in mice: new tools to tackle old problems." Glia. 2011 Aug;59(8):1155-68. doi: 10.1002/glia.21142. Epub 2011 Feb 8. Review. PubMed PMID: 21305617; PubMed Central PMCID: PMC3619979.

Pitter KL, Galbán CJ, Galbán S, Tehrani OS, Li F, Charles N, Bradbury MS, Becher OJ, Chenevert TL, Rehemtulla A, Ross BD, Holland EC, Hambardzumyan D. "Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma." PLoS One. 2011 Jan 18;6(1):e14545. doi: 10.1371/journal.pone.0014545. Erratum in: PLoS One. 2011;6(1). doi: 10.1371/annotation/66641ad6-afb9-4d3c-ade6-73fcd5aab061. Saeed-Tehrani, Omid [corrected to Tehrani, Omid Saeed]. PubMed PMID: 21267448; PubMed Central PMCID: PMC3022633.

Ramirez CN, Ozawa T, Takagi T, Antczak C, Shum D, Graves R, Holland EC, Djaballah H. "Validation of a high-content screening assay using whole-well imaging of transformed phenotypes." Assay Drug Dev Technol. 2011 Jun;9(3):247-61. doi: 10.1089/adt.2010.0342. Epub 2010 Dec 23. PubMed PMID: 21182456; PubMed Central PMCID: PMC3123874.

2010

Leder K, Holland EC, Michor F. "The therapeutic implications of plasticity of the cancer stem cell phenotype." PLoS One. 2010 Dec 17;5(12):e14366. doi: 10.1371/journal.pone.0014366. PubMed PMID: 21179426; PubMed Central PMCID: PMC3003707.

Squatrito M, Brennan CW, Helmy K, Huse JT, Petrini JH, Holland EC. "Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas." Cancer Cell. 2010 Dec 14;18(6):619-29. doi: 10.1016/j.ccr.2010.10.034. PubMed PMID: 21156285; PubMed Central PMCID: PMC3818087.

Jones TS, Holland EC. "Molecular pathogenesis of malignant glial tumors." Toxicol Pathol. 2011 Jan;39(1):158-66. doi: 10.1177/0192623310387617. Epub 2010 Nov 15. PubMed PMID: 21078918.

Becher OJ, Holland EC. "Evidence for and against regional differences in neural stem and progenitor cells of the CNS." Genes Dev. 2010 Oct 15;24(20):2233-8. doi: 10.1101/gad.1988010. PubMed PMID: 20952533; PubMed Central PMCID: PMC2956202.

Ozawa T, Brennan CW, Wang L, Squatrito M, Sasayama T, Nakada M, Huse JT, Pedraza A, Utsuki S, Yasui Y, Tandon A, Fomchenko EI, Oka H, Levine RL, Fujii K, Ladanyi M, Holland EC. "PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas." Genes Dev. 2010 Oct 1;24(19):2205-18. doi: 10.1101/gad.1972310. PubMed PMID: 20889717; PubMed Central PMCID: PMC2947772.

Howard BM, Gursel DB, Bleau AM, Beyene RT, Holland EC, Boockvar JA. "EGFR signaling is differentially activated in patient-derived glioblastoma stem cells." J Exp Ther Oncol. 2010;8(3):247-60. PubMed PMID: 20734923.

Charles N, Holland EC. "The perivascular niche microenvironment in brain tumor progression." Cell Cycle. 2010 Aug 1;9(15):3012-21. doi: 10.4161/cc.9.15.12710. Review. PubMed PMID: 20714216; PubMed Central PMCID: PMC3040926.

Huse JT, Holland EC. "Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma." Nat Rev Cancer. 2010 May;10(5):319-31. doi: 10.1038/nrc2818. Review. PubMed PMID: 20414201.

See WL, Heinberg AR, Holland EC, Resh MD. "p27 deficiency is associated with migration defects in PDGF-expressing gliomas in vivo." Cell Cycle. 2010 Apr 15;9(8):1562-7. Epub 2010 Apr 15. PubMed PMID: 20404478.

Becher OJ, Hambardzumyan D, Walker TR, Helmy K, Nazarian J, Albrecht S, Hiner RL, Gall S, Huse JT, Jabado N, MacDonald TJ, Holland EC. "Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma." Cancer Res. 2010 Mar 15;70(6):2548-57. doi: 10.1158/0008-5472.CAN-09-2503. Epub 2010 Mar 2. PubMed PMID: 20197468; PubMed Central PMCID: PMC3831613.

Charles N, Ozawa T, Squatrito M, Bleau AM, Brennan CW, Hambardzumyan D, Holland EC. "Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells." Cell Stem Cell. 2010 Feb 5;6(2):141-52. doi: 10.1016/j.stem.2010.01.001. PubMed PMID: 20144787; PubMed Central PMCID: PMC3818090.

Claus EB, Abdel-Wahab M, Burger PC, Engelhard HH, Ellison DW, Gaiano N, Gutmann DH, Heck DA, Holland EC, Jallo GI, Kruchko C, Kun LE, Maria BL, Rumboldt Z, Seminara D, Spinella GM, Stophel L, Wechsler-Reya R, Wrensch M, Gilbertson RJ. "Defining future directions in spinal cord tumor research: proceedings from the National Institutes of Health workshop." J Neurosurg Spine. 2010 Feb;12(2):117-21. doi: 10.3171/2009.7.SPINE09137. PubMed PMID: 20121344; PubMed Central PMCID: PMC3193276.

Charles NA, Holland EC. "TRRAP and the maintenance of stemness in gliomas." Cell Stem Cell. 2010 Jan 8;6(1):6-7. doi: 10.1016/j.stem.2009.12.005. PubMed PMID: 20085736.

Veeriah S, Taylor BS, Meng S, Fang F, Yilmaz E, Vivanco I, Janakiraman M, Schultz N, Hanrahan AJ, Pao W, Ladanyi M, Sander C, Heguy A, Holland EC, Paty PB, Mischel PS, Liau L, Cloughesy TF, Mellinghoff IK, Solit DB, Chan TA. "Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies." Nat Genet. 2010 Jan;42(1):77-82. doi: 10.1038/ng.491. Epub 2009 Nov 29. PubMed PMID: 19946270; PubMed Central PMCID: PMC4002225.

2009

Momota H, Holland EC. "Mouse models of CNS embryonal tumors." Brain Tumor Pathol. 2009;26(2):43-50. doi: 10.1007/s10014-009-0253-0. Epub 2009 Oct 27. Review. PubMed PMID: 19856214.

Ayuso-Sacido A, Moliterno JA, Kratovac S, Kapoor GS, O'Rourke DM, Holland EC, García-Verdugo JM, Roy NS, Boockvar JA. "Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells." J Neurooncol. 2010 May;97(3):323-37. doi: 10.1007/s11060-009-0035-x. Epub 2009 Oct 24. PubMed PMID: 19855928.

Huse JT, Holland EC. "Yin and yang: cancer-implicated miRNAs that have it both ways." Cell Cycle. 2009 Nov 15;8(22):3611-2. PubMed PMID: 19855181.

Bleau AM, Holland EC. "Chemotherapeutic treatment of gliomas increases the amount of cancer stem-like cells." Med Sci (Paris). 2009 Oct;25(10):775-7. doi: 10.1051/medsci/20092510775. French. PubMed PMID: 19849969.

Charles N, Holland EC. "Brain tumor treatment increases the number of cancer stem-like cells." Expert Rev Neurother. 2009 Oct;9(10):1447-9. doi: 10.1586/ern.09.91. PubMed PMID: 19831832.

Bhatia B, Northcott PA, Hambardzumyan D, Govindarajan B, Brat DJ, Arbiser JL, Holland EC, Taylor MD, Kenney AM. "Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization." Cancer Res. 2009 Sep 15;69(18):7224-34. doi: 10.1158/0008-5472.CAN-09-1299. Epub 2009 Sep 8. PubMed PMID: 19738049; PubMed Central PMCID: PMC2745891.

Bleau AM, Huse JT, Holland EC. "The ABCG2 resistance network of glioblastoma." Cell Cycle. 2009 Sep 15;8(18):2936-44. Epub 2009 Sep 13. Review. PubMed PMID: 19713741.

Amankulor NM, Hambardzumyan D, Pyonteck SM, Becher OJ, Joyce JA, Holland EC. "Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation." J Neurosci. 2009 Aug 19;29(33):10299-308. doi: 10.1523/JNEUROSCI.2500-09.2009. PubMed PMID: 19692604; PubMed Central PMCID: PMC3849831.

Huse JT, Brennan C, Hambardzumyan D, Wee B, Pena J, Rouhanifard SH, Sohn-Lee C, le Sage C, Agami R, Tuschl T, Holland EC. "The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo." Genes Dev. 2009 Jun 1;23(11):1327-37. doi: 10.1101/gad.1777409. PubMed PMID: 19487573; PubMed Central PMCID: PMC2701585.

Sabharwal N, Holland EC, Vazquez M. "Live cell labeling of glial progenitor cells using targeted quantum dots." Ann Biomed Eng. 2009 Oct;37(10):1967-73. doi: 10.1007/s10439-009-9703-4. Epub 2009 May 5. PubMed PMID: 19415494.

Hambardzumyan D, Amankulor NM, Helmy KY, Becher OJ, Holland EC. "Modeling Adult Gliomas Using RCAS/t-va Technology." Transl Oncol. 2009 May;2(2):89-95. PubMed PMID: 19412424; PubMed Central PMCID: PMC2670576.

Bleau AM, Hambardzumyan D, Ozawa T, Fomchenko EI, Huse JT, Brennan CW, Holland EC. "PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells." Cell Stem Cell. 2009 Mar 6;4(3):226-35. doi: 10.1016/j.stem.2009.01.007. PubMed PMID: 19265662; PubMed Central PMCID: PMC3688060.

Ventikos Y, Holland EC, Bowker TJ, Watton PN, Kakalis NM, Megahed M, Zhu F, Summers PE, Byrne JV. "Computational modelling for cerebral aneurysms: risk evaluation and interventional planning." Br J Radiol. 2009 Jan;82 Spec No 1:S62-71. doi: 10.1259/bjr/14303482. Review. PubMed PMID: 20348538.

Huse JT, Holland EC. "Genetically engineered mouse models of brain cancer and the promise of preclinical testing." Brain Pathol. 2009 Jan;19(1):132-43. doi: 10.1111/j.1750-3639.2008.00234.x. Review. PubMed PMID: 19076778; PubMed Central PMCID: PMC2659383.

Brenet F, Socci ND, Sonenberg N, Holland EC. "Akt phosphorylation of La regulates specific mRNA translation in glial progenitors." Oncogene. 2009 Jan 8;28(1):128-39. doi: 10.1038/onc.2008.376. Epub 2008 Oct 6. PubMed PMID: 18836485.

2008

Hambardzumyan D, Squatrito M, Carbajal E, Holland EC. "Glioma formation, cancer stem cells, and akt signaling." Stem Cell Rev. 2008 Sep;4(3):203-10. doi: 10.1007/s12015-008-9021-5. Review. PubMed PMID: 18595010.

Dudu V, Ramcharan M, Gilchrist ML, Holland EC, Vazquez M. "Liposome delivery of quantum dots to the cytosol of live cells." J Nanosci Nanotechnol. 2008 May;8(5):2293-300. PubMed PMID: 18572640.

Lyustikman Y, Momota H, Pao W, Holland EC. "Constitutive activation of Raf-1 induces glioma formation in mice." Neoplasia. 2008 May;10(5):501-10. PubMed PMID: 18472967; PubMed Central PMCID: PMC2373912.

Perry A, Miller CR, Gujrati M, Scheithauer BW, Zambrano SC, Jost SC, Raghavan R, Qian J, Cochran EJ, Huse JT, Holland EC, Burger PC, Rosenblum MK. "Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases." Brain Pathol. 2009 Jan;19(1):81-90. doi: 10.1111/j.1750-3639.2008.00167.x. Epub 2008 Apr 29. PubMed PMID: 18452568.

Hambardzumyan D, Becher OJ, Holland EC. "Cancer stem cells and survival pathways." Cell Cycle. 2008 May 15;7(10):1371-8. Epub 2008 Mar 19. Review. PubMed PMID: 18421251.

Becher OJ, Hambardzumyan D, Fomchenko EI, Momota H, Mainwaring L, Bleau AM, Katz AM, Edgar M, Kenney AM, Cordon-Cardo C, Blasberg RG, Holland EC. "Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas." Cancer Res. 2008 Apr 1;68(7):2241-9. doi: 10.1158/0008-5472.CAN-07-6350. PubMed PMID: 18381430.

Momota H, Shih AH, Edgar MA, Holland EC. "c-Myc and beta-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice." Oncogene. 2008 Jul 24;27(32):4392-401. doi: 10.1038/onc.2008.81. Epub 2008 Mar 31. PubMed PMID: 18372915.

Bleau AM, Howard BM, Taylor LA, Gursel D, Greenfield JP, Lim Tung HY, Holland EC, Boockvar JA. "New strategy for the analysis of phenotypic marker antigens in brain tumor-derived neurospheres in mice and humans." Neurosurg Focus. 2008;24(3-4):E28. doi: 10.3171/FOC/2008/24/3-4/E27. PubMed PMID: 18341405.

Bradbury MS, Hambardzumyan D, Zanzonico PB, Schwartz J, Cai S, Burnazi EM, Longo V, Larson SM, Holland EC. "Dynamic small-animal PET imaging of tumor proliferation with 3'-deoxy-3'-18F-fluorothymidine in a genetically engineered mouse model of high-grade gliomas." J Nucl Med. 2008 Mar;49(3):422-9. doi: 10.2967/jnumed.107.047092. Epub 2008 Feb 20. PubMed PMID: 18287265; PubMed Central PMCID: PMC2888473.

Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova-Todorova K, Holland EC. "PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo." Genes Dev. 2008 Feb 15;22(4):436-48. doi: 10.1101/gad.1627008. PubMed PMID: 18281460; PubMed Central PMCID: PMC2238666.

2007

Lassman AB, Holland EC. "Incorporating molecular tools into clinical trials and treatment for gliomas?" Curr Opin Neurol. 2007 Dec;20(6):708-11. Review. PubMed PMID: 17992094.

Hambardzumyan D, Lyustikman Y, Holland EC. "An update on mouse brain tumor models in cancer drug discovery." Expert Opin Drug Discov. 2007 Nov;2(11):1435-51. doi: 10.1517/17460441.2.11.1435. PubMed PMID: 23484596.

Zhang L, Lee KC, Bhojani MS, Khan AP, Shilman A, Holland EC, Ross BD, Rehemtulla A. "Molecular imaging of Akt kinase activity." Nat Med. 2007 Sep;13(9):1114-9. Epub 2007 Aug 12. PubMed PMID: 17694068.

Dunlap SM, Celestino J, Wang H, Jiang R, Holland EC, Fuller GN, Zhang W. "Insulin-like growth factor binding protein 2 promotes glioma development and progression." Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11736-41. Epub 2007 Jul 2. PubMed PMID: 17606927; PubMed Central PMCID: PMC1913900.

McConville P, Hambardzumyan D, Moody JB, Leopold WR, Kreger AR, Woolliscroft MJ, Rehemtulla A, Ross BD, Holland EC. "Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of glioma." Clin Cancer Res. 2007 May 15;13(10):2897-904. PubMed PMID: 17504989.

Bleau AM, Holland EC. "Trapping the mouse genome to hunt human alterations." Proc Natl Acad Sci U S A. 2007 May 8;104(19):7737-8. Epub 2007 May 3. PubMed PMID: 17483476; PubMed Central PMCID: PMC1876515.

Bradley SV, Holland EC, Liu GY, Thomas D, Hyun TS, Ross TS. "Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor." Cancer Res. 2007 Apr 15;67(8):3609-15. PubMed PMID: 17440072.

Tchougounova E, Kastemar M, Bråsäter D, Holland EC, Westermark B, Uhrbom L. "Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma." Oncogene. 2007 Sep 20;26(43):6289-96. Epub 2007 Apr 16. PubMed PMID: 17438529.

Fomchenko EI, Holland EC. "Platelet-derived growth factor-mediated gliomagenesis and brain tumor recruitment." Neurosurg Clin N Am. 2007 Jan;18(1):39-58, viii. Review. PubMed PMID: 17244553.

2006

151: Shih AH, Holland EC. "Notch signaling enhances nestin expression in gliomas." Neoplasia. 2006 Dec;8(12):1072-82. PubMed PMID: 17217625; PubMed Central PMCID: PMC1790729.

Hambardzumyan D, Squatrito M, Holland EC. "Radiation resistance and stem-like cells in brain tumors." Cancer Cell. 2006 Dec;10(6):454-6. Erratum in: Cancer Cell. 2007 Jan;11(1):97. Squartro, Massimo [corrected to Squatrito, Massimo]. PubMed PMID: 17157785.

Lassman AB, Dai C, Fuller GN, Vickers AJ, Holland EC. "Overexpression of c-MYC promotes an undifferentiated phenotype in cultured astrocytes and allows elevated Ras and Akt signaling to induce gliomas from GFAP-expressing cells in mice." Neuron Glia Biol. 2004 May;1(2):157-63. PubMed PMID: 17047730; PubMed Central PMCID: PMC1615889.

Hormigo A, Gu B, Karimi S, Riedel E, Panageas KS, Edgar MA, Tanwar MK, Rao JS, Fleisher M, DeAngelis LM, Holland EC. "YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas." Clin Cancer Res. 2006 Oct 1;12(19):5698-704. PubMed PMID: 17020973.

Fomchenko EI, Holland EC. "Mouse models of brain tumors and their applications in preclinical trials." Clin Cancer Res. 2006 Sep 15;12(18):5288-97. Review. PubMed PMID: 17000661.

Fomchenko EI, Holland EC. "Origins of brain tumors--a disease of stem cells?" Nat Clin Pract Neurol. 2006 Jun;2(6):288-9. Review. PubMed PMID: 16932567.

Salpietro M, Holland EC. "Modeling and preclinical trials for gliomas." Clin Neurosurg. 2005;52:104-11. PubMed PMID: 16626060.

Becher OJ, Holland EC. "Genetically engineered models have advantages over xenografts for preclinical studies." Cancer Res. 2006 Apr 1;66(7):3355-8, discussion 3358-9. Erratum in: Cancer Res. 2006 May 15;66(10):5526. PubMed PMID: 16585152.

Villanueva J, Shaffer DR, Philip J, Chaparro CA, Erdjument-Bromage H, Olshen AB, Fleisher M, Lilja H, Brogi E, Boyd J, Sanchez-Carbayo M, Holland EC, Cordon-Cardo C, Scher HI, Tempst P. "Differential exoprotease activities confer tumor-specific serum peptidome patterns." J Clin Invest. 2006 Jan;116(1):271-84. PubMed PMID: 16395409; PubMed Central PMCID: PMC1323259.

Lassman AB, Rossi MR, Raizer JJ, Abrey LE, Lieberman FS, Grefe CN, Lamborn K, Pao W, Shih AH, Kuhn JG, Wilson R, Nowak NJ, Cowell JK, DeAngelis LM, Wen P, Gilbert MR, Chang S, Yung WA, Prados M, Holland EC. "Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01." Clin Cancer Res. 2005 Nov 1;11(21):7841-50. Erratum in: Clin Cancer Res. 2006 Jan 1;12(1):322. Razier, Jeffrey R [corrected to Raizer, Jeffrey J]. PubMed PMID: 16278407.

2005

Momota H, Holland EC. "Bioluminescence technology for imaging cell proliferation." Curr Opin Biotechnol. 2005 Dec;16(6):681-6. Epub 2005 Nov 2. PubMed PMID: 16263256.

Shih AH, Holland EC. "Platelet-derived growth factor (PDGF) and glial tumorigenesis." Cancer Lett. 2006 Feb 8;232(2):139-47. Epub 2005 Aug 31. Review. PubMed PMID: 16139423.

Momota H, Nerio E, Holland EC. "Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo." Cancer Res. 2005 Aug 15;65(16):7429-35. PubMed PMID: 16103096.

Hu X, Holland EC. "Applications of mouse glioma models in preclinical trials." Mutat Res. 2005 Aug 25;576(1-2):54-65. Review. PubMed PMID: 16011838.

Dai C, Lyustikman Y, Shih A, Hu X, Fuller GN, Rosenblum M, Holland EC. "The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats." Neoplasia. 2005 Apr;7(4):397-406. PubMed PMID: 15967117; PubMed Central PMCID: PMC1501153.

Hu X, Pandolfi PP, Li Y, Koutcher JA, Rosenblum M, Holland EC. "mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma." Neoplasia. 2005 Apr;7(4):356-68. PubMed PMID: 15967113; PubMed Central PMCID: PMC1501155.

Fomchenko EI, Holland EC. "Stem cells and brain cancer." Exp Cell Res. 2005 Jun 10;306(2):323-9. Epub 2005 Apr 14. Review. PubMed PMID: 15925587.

Uhrbom L, Kastemar M, Johansson FK, Westermark B, Holland EC. "Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis." Cancer Res. 2005 Mar 15;65(6):2065-9. PubMed PMID: 15781613.

Barbashina V, Salazar P, Holland EC, Rosenblum MK, Ladanyi M. "Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene." Clin Cancer Res. 2005 Feb 1;11(3):1119-28. PubMed PMID: 15709179.

2004

Shih AH, Holland EC. "Developmental neurobiology and the origin of brain tumors." J Neurooncol. 2004 Nov;70(2):125-36. Review. PubMed PMID: 15674474.

Parsa AT, Holland EC. "Cooperative translational control of gene expression by Ras and Akt in cancer." Trends Mol Med. 2004 Dec;10(12):607-13. Review. PubMed PMID: 15567331.

Uhrbom L, Nerio E, Holland EC. "Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model." Nat Med. 2004 Nov;10(11):1257-60. Epub 2004 Oct 24. PubMed PMID: 15502845.

Holland EC. "Mouse models of human cancer as tools in drug development." Cancer Cell. 2004 Sep;6(3):197-8. PubMed PMID: 15380508.

Dupont J, Tanwar MK, Thaler HT, Fleisher M, Kauff N, Hensley ML, Sabbatini P, Anderson S, Aghajanian C, Holland EC, Spriggs DR. "Early detection and prognosis of ovarian cancer using serum YKL-40." J Clin Oncol. 2004 Aug 15;22(16):3330-9. PubMed PMID: 15310777.

Shih AH, Dai C, Hu X, Rosenblum MK, Koutcher JA, Holland EC. "Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis." Cancer Res. 2004 Jul 15;64(14):4783-9. PubMed PMID: 15256447.

Rao G, Pedone CA, Del Valle L, Reiss K, Holland EC, Fults DW. "Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice." Oncogene. 2004 Aug 12;23(36):6156-62. PubMed PMID: 15195141.

Rajasekhar VK, Holland EC. "Postgenomic global analysis of translational control induced by oncogenic signaling." Oncogene. 2004 Apr 19;23(18):3248-64. Review. PubMed PMID: 15094774.

Holland EC, Sonenberg N, Pandolfi PP, Thomas G. "Signaling control of mRNA translation in cancer pathogenesis." Oncogene. 2004 Apr 19;23(18):3138-44. Review. PubMed PMID: 15094763.

Villanueva J, Philip J, Entenberg D, Chaparro CA, Tanwar MK, Holland EC, Tempst P. "Serum peptide profiling by magnetic particle-assisted, automated sample processing and MALDI-TOF mass spectrometry." Anal Chem. 2004 Mar 15;76(6):1560-70. PubMed PMID: 15018552.

Holland EC. "Regulation of translation and cancer." Cell Cycle. 2004 Apr;3(4):452-5. Epub 2004 Apr 1. Review. PubMed PMID: 14976427.

Collignon FP, Holland EC, Feng S. "Organ donors with malignant gliomas: an update." Am J Transplant. 2004 Jan;4(1):15-21. Review. PubMed PMID: 14678030. 

2003

Rajasekhar VK, Viale A, Socci ND, Wiedmann M, Hu X, Holland EC. "Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes." Mol Cell. 2003 Oct;12(4):889-901. PubMed PMID: 14580340.

Hesselager G, Holland EC. "Using mice to decipher the molecular genetics of brain tumors." Neurosurgery. 2003 Sep;53(3):685-94; discussion 695. Review. PubMed PMID: 12943584.

Rao G, Pedone CA, Coffin CM, Holland EC, Fults DW. "c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice." Neoplasia. 2003 May-Jun;5(3):198-204. doi: 10.1016/S1476-5586(03)80052-0. PubMed PMID: 12869303; PubMed Central PMCID: PMC1502413.

Dai C, Holland EC. "Astrocyte differentiation states and glioma formation." Cancer J. 2003 Mar-Apr;9(2):72-81. Review. PubMed PMID: 12784872.

Wolf RM, Draghi N, Liang X, Dai C, Uhrbom L, Eklöf C, Westermark B, Holland EC, Resh MD. "p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3." Genes Dev. 2003 Feb 15;17(4):476-87. PubMed PMID: 12600941; PubMed Central PMCID: PMC196001.

Xu S, Gade TP, Matei C, Zakian K, Alfieri AA, Hu X, Holland EC, Soghomonian S, Tjuvajev J, Ballon D, Koutcher JA. "In vivo multiple-mouse imaging at 1.5 T." Magn Reson Med. 2003 Mar;49(3):551-7. PubMed PMID: 12594759.

2002

Koutcher JA, Hu X, Xu S, Gade TP, Leeds N, Zhou XJ, Zagzag D, Holland EC. "MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials." Neoplasia. 2002 Nov-Dec;4(6):480-5. PubMed PMID: 12407441; PubMed Central PMCID: PMC1503661.

Uhrbom L, Dai C, Celestino JC, Rosenblum MK, Fuller GN, Holland EC. "Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt." Cancer Res. 2002 Oct 1;62(19):5551-8. PubMed PMID: 12359767.

Tanwar MK, Gilbert MR, Holland EC. "Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma." Cancer Res. 2002 Aug 1;62(15):4364-8. PubMed PMID: 12154041.

De Miguel MP, Cheng L, Holland EC, Federspiel MJ, Donovan PJ. "Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer." Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10458-63. Epub 2002 Jul 24. PubMed PMID: 12140361; PubMed Central PMCID: PMC124938.

Fults D, Pedone C, Dai C, Holland EC. "MYC expression promotes the proliferation of neural progenitor cells in culture and in vivo." Neoplasia. 2002 Jan-Feb;4(1):32-9. PubMed PMID: 11922389; PubMed Central PMCID: PMC1503312.

Begemann M, Fuller GN, Holland EC. "Genetic modeling of glioma formation in mice." Brain Pathol. 2002 Jan;12(1):117-32. Review. PubMed PMID: 11770894.

2001

Holland EC. "Progenitor cells and glioma formation." Curr Opin Neurol. 2001 Dec;14(6):683-8. Review. PubMed PMID: 11723374.

Uhrbom L, Holland EC. "Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors." J Neurooncol. 2001 Jul;53(3):297-305. Review. PubMed PMID: 11718262.

Lang FF, Olansen NE, DeMonte F, Gokaslan ZL, Holland EC, Kalhorn C, Sawaya R. "Surgical resection of intrinsic insular tumors: complication avoidance." J Neurosurg. 2001 Oct;95(4):638-50. PubMed PMID: 11596959.

Dai C, Holland EC. "Glioma models." Biochim Biophys Acta. 2001 Aug 31;1551(1):M19-27. Review. PubMed PMID: 11553418.

Louis DN, Holland EC, Cairncross JG. "Glioma classification: a molecular reappraisal." Am J Pathol. 2001 Sep;159(3):779-86. Review. PubMed PMID: 11549567; PubMed Central PMCID: PMC1850454.

Dai C, Celestino JC, Okada Y, Louis DN, Fuller GN, Holland EC. "PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo." Genes Dev. 2001 Aug 1;15(15):1913-25. PubMed PMID: 11485986; PubMed Central PMCID: PMC312748.

Holland EC. "Animal models of cell cycle dysregulation and the pathogenesis of gliomas." J Neurooncol. 2001 Feb;51(3):265-76. Review. PubMed PMID: 11407597.

Holland EC. "Brain tumor animal models: importance and progress." Curr Opin Oncol. 2001 May;13(3):143-7. Review. PubMed PMID: 11307055.

Holland EC. "Gliomagenesis: genetic alterations and mouse models." Nat Rev Genet. 2001 Feb;2(2):120-9. Review. PubMed PMID: 11253051.

2000

Holland EC. "A dream awakened." Rehabil Nurs. 2000 Jan-Feb;25(1):4-5. PubMed PMID: 10754920. 204: Laywell ED, Rakic P, Kukekov VG, Holland EC, Steindler DA. Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13883-8. PubMed PMID: 11095732; PubMed Central PMCID: PMC17670.

Holland EC, Li Y, Celestino J, Dai C, Schaefer L, Sawaya RA, Fuller GN. "Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo." Am J Pathol. 2000 Sep;157(3):1031-7. PubMed PMID: 10980141; PubMed Central PMCID: PMC1885688.

Caskey LS, Fuller GN, Bruner JM, Yung WK, Sawaya RE, Holland EC, Zhang W. "Toward a molecular classification of the gliomas: histopathology, molecular genetics, and gene expression profiling." Histol Histopathol. 2000 Jul;15(3):971-81. doi: 10.14670/HH-15.971. Review. PubMed PMID: 10963139.

Holland EC. "Glioblastoma multiforme: the terminator." Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6242-4. PubMed PMID: 10841526; PubMed Central PMCID:PMC33993.

Holland EC, Celestino J, Dai C, Schaefer L, Sawaya RE, Fuller GN. "Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice." Nat Genet. 2000 May;25(1):55-7. PubMed PMID: 10802656.

Holland EC. "A mouse model for glioma: biology, pathology, and therapeutic opportunities." Toxicol Pathol. 2000 Jan-Feb;28(1):171-7. PubMed PMID: 10669005.

1998

Holland EC, Hively WP, DePinho RA, Varmus HE. "A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice." Genes Dev. 1998 Dec 1;12(23):3675-85. PubMed PMID: 9851974; PubMed Central PMCID: PMC317252.

Holland EC, Hively WP, Gallo V, Varmus HE. "Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes." Genes Dev. 1998 Dec 1;12(23):3644-9. PubMed PMID: 9851971; PubMed Central PMCID: PMC317261.

Holland EC, Varmus HE. "Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice." Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1218-23. PubMed PMID: 9448312; PubMed Central PMCID: PMC18724.

1984-1988

Feng S, Holland EC. "HIV-1 tat trans-activation requires the loop sequence within tar." Nature. 1988 Jul 14;334(6178):165-7. PubMed PMID: 3386755.

Halberg DF, Wager RE, Farrell DC, Hildreth J 4th, Quesenberry MS, Loeb JA, Holland EC, Drickamer K. "Major and minor forms of the rat liver asialoglycoprotein receptor are independent galactose-binding proteins. Primary structure and glycosylation heterogeneity of minor receptor forms." J Biol Chem. 1987 Jul 15;262(20):9828-38. PubMed PMID: 3597443.

Hsueh EC, Holland EC, Carrera GM Jr, Drickamer K. "The rat liver asialoglycoprotein receptor polypeptide must be inserted into a microsome to achieve its active conformation." J Biol Chem. 1986 Apr 15;261(11):4940-7. PubMed PMID: 3082873.

Holland EC, Drickamer K. "Signal recognition particle mediates the insertion of a transmembrane protein which has a cytoplasmic NH2 terminus." J Biol Chem. 1986 Jan 25;261(3):1286-92. PubMed PMID: 3003063.

Leung JO, Holland EC, Drickamer K. "Characterization of the gene encoding the major rat liver asialoglycoprotein receptor." J Biol Chem. 1985 Oct 15;260(23):12523-7. PubMed PMID: 2995379.

Holland EC, Leung JO, Drickamer K. "Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence." Proc Natl Acad Sci U S A. 1984 Dec;81(23):7338-42. PubMed PMID: 6095287; PubMed Central PMCID: PMC392141.