Publications
Caniels, T. G., Prabhakaran, M., Ozorowski, G., MacPhee, K. J., Wu, W., van der Straten, K., Agrawal, S., Derking, R., Reiss, E. I. M. M., Millard, K., Turroja, M., Desrosiers, A., Bethony, J., Malkin, E., Liesdek, M. H., van der Veen, A., Klouwens, M., Snitselaar, J. L., Bouhuijs, J. H., Bronson, R., Jean-Baptiste, J., Gajjala, S., Rikhtegaran Tehrani, Z., Benner, A., Ramaswami, M., Duff, M. O., Liu, Y.-W., Sato, A. H., Kim, J. Y., Baken, I. J. L., Mendes Silva, C., Bijl, T. P. L., van Rijswijk, J., Burger, J. A., Cupo, A., Yasmeen, A., Phulera, S., Lee, W.-H., Randall, K. N. Jr., Zhang, S., Corcoran, M. M., Regadas, I., Sullivan, A. C., Brown, D. M., Bohl, J. A., Greene, K. M., Gao, H., Yates, N. L., Sawant, S., Prins, J. M., Kootstra, N. A., Kaminsky, S. M., Barin, B., Rahaman, F., Meller, M., Philiponis, V., Laufer, D. S., Lombardo, A., Mwoga, L., Shotorbani, S., Holman, D., Koup, R. A., Klasse, P. J., Karlsson Hedestam, G. B., Tomaras, G. D., van Gils, M. J., Montefiori, D. C., McDermott, A. B., Hyrien, O., Moore, J. P., Wilson, I. A., Ward, A. B., Diemert, D. J., de Bree, G. J., Andrews, S. F., Caskey, M., Sanders, R. W. (2025). Precise targeting of HIV broadly neutralizing antibody precursors in humans. Science. https://doi.org/10.1126/science.adv5572
Willis, J. R., Prabhakaran, M., Muthui, M., Naidoo, A., Sincomb, T., Wu, W., Cottrell, C. A., Landais, E., deCamp, A., Keshavarzi, N.R., Kalyuzhniy, O., Lee, J. H., Murungi, L., Ogondá, W. A., Yates, N. L., Corcoran, M. M., Phulera, S., Musando, J., Tsai, A., Lemire, G., Seín, Y., Muteti, M., Alamurti, P., Bohl, J. A., Holman, D., Himansuu, S., Leav, B., Reuter, C. J., Lin, L-A., Ding, B., He, C., Strauss, W. L., MacPhee, K. J., Regagado, I., Nyabundi, D. V., ChirChir, R., Anzala, O., Kimotho, J. N., Kibet, C., Greene, K., Gao, H., Beatman, E., Benson, K., Laddy, D., Brown, D. M., Bronson, R., Jean-Baptiste, J., Gajjala, S., Rikhtegaran-Tehrani, Z., Benner, A., Ramaswami, M., Lu, D., Alavi, N., Amirzehni, S., Kubitz, M., Tingle, R., Georgeson, E., Phelps, N., Adachi, Y., Liguori, A., Flynn, C., McKenney, K., Zhou, X., Owour, D. C., Owour, S. A., Kim, S. Y., Duff, M., Kim, J. Y., Gibson, G., Baboo, S., Diedrich, J., Schiffner, T., Shields, M., Matsoso, M., Santos, J., Syvertsen, K., Kennedy, A., Schroeter, M., Vekemans, J., Yates, J. R., Paulson, J. C., Hyrien, O., McDermott, A. B., Maenetje, P., Nyombayire, J., Karita, E., Ingabire, R., Edward, V., Muturi-Kioi, V., Maenza, J., Shapiro, A., McElrath, M. J., Edupuganti, S., Taylor, B.S., Diemert, D., Ozorowski, G., Koup, R. A., Montefiori, D., Ward, A. B., Karlsson Hedestam, G. B., Tomaras, G., Hunt, D. J., Muema, D., Sok, D., Laufer, D. S., Andrews, S. F., Nduati, E. W., Schief, W. R. (2025). Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans. Science. https://doi.org/10.1126/science.adr8382
Banjoko, A. W., Ng’uni, T., Naidoo, N., Ramsuran, V., Hyrien, O., and Ndhlovu, Z. M. (2025). High resolution class I HLA-A, -B, and -C diversity in Eastern and Southern African populations. Scientific Reports, accepted.
Slavtchova-Bojkova, M., Hyrien, O., Mitov, K., and Yanev, N. (2025). Multitype Markov branching processes with nonhomogeneous immigration. Lecture Notes in statistics, accepted.
Mda, P., Mngadi, K. T., Zhang, B., Burnham, R., Juraska, M., Hyrien, O., Garrett, N., Dubula, T., Toni, S., Joseph, S., Kotze, P., Buchbinder, S., Takalani, A., Tomaka, F., Luedtke, A., Willems, W., Swann, E., Hutter, J., Gelderblom, H., McElrath, M. J., Lavreys, L., Stranix-Chibanda, L., Roxby, A. C., Bekker, L.-G., Gray, G. (2025). Pregnancy and contraceptive use among participants of childbearing potential in the HVTN 705 HIV vaccine trial in southern Africa. Frontiers in Reproductive Health, 7, 1565933. https://doi.org/10.3389/frph.2025.1565933
Mielke, D., Li, S. S., Schuster, D. J., Li, X., Hu, J., Karuna, S., Seaton, K. E., Brackett, C., Dunn, B., Keyes, T., Zalaquett, A., Stanfield-Oakley, S., Zhang, L., Wesley, M. S., Eisel, N., Yates, N. L., Shen, X., Premkumar, L., St. Germain, R., Sholukh, A. M., Cohen, K., de Rosa, S., Randhawa, A. K., Hural, J. A., Corey, L., McElrath, M. J., Tomaras, G. D., Hyrien, O.*, and Ferrari, G*. (2025). Distinct immune responses in people living with HIV following SARS-CoV-2 recovery. Communications Medicine; 5:132. https://doi.org/10.1038/s43856-025-00839-1
Lim, F. Y., Lea, H. G., Dostie, A., Kim, S. Y., van Neel, T., Hassan, G., Takezawa, M. G., Starita, L. M., Adams, K., Boeckh, M., Schiffer, J. T., Hyrien, O., Waghmare, A., Berthier, E., & Theberge, A. B. (2025). homeRNA self-blood collection enables high-frequency temporal profiling of presymptomatic host immune kinetics to respiratory viral infection: a prospective cohort study. eBioMedicine, Volume 112, 105531. https://doi.org/10.1016/j.ebiom.2024.105531
Chawana, T. D., Walsh, S. R., Stranix-Chibanda, L., Chirenje, Z. M., Yu, C., Zhang, L., Seaton, K. E., Heptinstall, J., Zhang, L., Paez, C. A., Gamble, T., Karuna, S. T., Andrew, P., Hanscom, B., Sobieszczyk, M. E., Edupuganti, S., Gay, C. L., Mannheimer, S. B., Hurt, C. B., Stephenson, K. E., Polakowski, L., Spiegel, H., Yacovone, M., Regenold, S., Yen, C., Baumblatt, J. A., Gama, L., Barouch, D. H., Piwowar-Manning, E., Koup, R. A., Tomaras, G. D., Hyrien, O., Roxby, A. C., Huang, Y. (2025). Pharmacokinetic interaction assessment of an HIV broadly neutralizing monoclonal antibody VRC07-523LS: a cross-protocol analysis of three phase 1 trials in people without HIV. BMC Immunology; 26(8). https://doi.org/10.1186/s12865-025-00687-7
Hyrien, O.#, Yanev, N. M. (2024). A Branching stochastic evolutionary model of the B-cell repertoire. Journal of Mathematical Biology, 89:10. https://doi.org/10.1007/s00285-024-02102-y
Hahn, W. O., Parks, K. R., Shen, M., Ozorowski, G., Janes, H., Ballweber-Fleming, L., Woodward Davis, A. S., Duplessis, C., Tomai, M., Dey, A. K., Sagawa, Z. K., De Rosa, S. C., Seese, A., Kallur Siddaramaiah, L., Stamatatos, L., Lee, W.-H., Sewall, L. M., Karlinsey, D., Turner, H. L., Rubin, V., Furth, S., MacPhee, K., Duff, M., Corey, L., Keefer, M. C., Edupuganti, s., Frank, I., Maenza, J., Baden, L. R., Hyrien, O., Sanders, R. W., Moore, J. P., Ward, A. P., Tomaras, G. D., Montefiori, D. C., Rouphael, N., McElrath, M. J. (2024). Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies. Journal of Experimental Medicine, 221 (10): e20240604. https://doi.org/10.1084/jem.20240604
Carpp, L. N.#, Hyrien, O.#, Fong, Y.#, Benkeser, D., Roels, S., Stieh, D. J., Van Dromme, I., Van Roey, G. A., Kenny, A., Huang, Y., Carone, M., McDermott, A. B., Houchens, C. R., Martins, K., Jayashankar, L., Castellino, F., Amoa-Awua, O., Basappa, M., Flach, B., Lin, B. C., Moore, C. , Naisan, M., Naqvi, M., Narpala, S., O’Connell, S., Mueller, A., Serebryannyy, L., Castro, M., Wang, J., Petropoulos, C. J., Luedtke, A., Lu, Y., Yu, C., Juraska, M., Hejazi, N. S., Wolfe, D. N., Sadoff, J., Gray, G. E., Grinsztejn, B., Goepfert, P. A., Bekker, L.-G., Gaur, A. H., Veloso, V. G., Randhawa, A. K., Andrasik, M. P., Hendriks, J., Truyers, C., Vandebosch, A., Struyf, F., Schuitemaker, H., Douoguih, M., Kublin, J. G., Corey, L., Neuzil, K. M., Follmann, D., Koup, R. A., Donis, R. O., and Gilbert, P. B., on behalf of the Immune Assays Team, the Coronavirus Vaccine Prevention Network (CoVPN)/ENSEMBLE Team, and the United States Government (USG)/CoVPN Biostatistics Team. (2024). Neutralizing antibody correlate of protection against severe-critical COVID-19 in the ENSEMBLE single-dose Ad26.COV2.S vaccine efficacy trial. Nature Communications, 15, 9785. https://doi.org/10.1038/s41467-024-53727-y
Magaret, C.A., Li, L., deCamp, A. C., Rolland, M., Juraska, M., Williamson, B. D., Ludwig, J., Molitor, C., Benkeser, D., Luedtke, A., Simpkins, B., Heng, F., Sun, Y., Carpp, L. N., Bai, H., Dearlove, B. L., Giorgi, E. E., Jongeneelen, M., Brandenburg, B., McCallum, M., Bowen, J. E., Veesler, D., Sadoff, J., Gray, G. E., Roels, S., Vandebosch, A., Stieh, D. J., Le Gars, M., Vingerhoets, J., Grinsztejn, B., Goepfert, P. A., Paiva de Sousa, L., Secco Torres Silva, M., Casapia, M., Losso, M. H., Little, S. J., Gaur, A., Bekker, L.-G., Garrett, N., Truyers, C., Van Dromme, I., Swann, E., Marovich, M. A., Follmann, D., Neuzil, K. M., Corey, L., Greninger, A. L., Roychoudhury, P., Follmann, D., Neuzil, K. M., Corey, L., Greninger, A. L., Roychoudhury, P., Hyrien, O., and Gilbert, P. B. (2024). Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features. Nature Communications, 15, 2175. https://doi.org/10.1038/s41467-024-46536-w
Walsh, S. R., Gay, C. L., Karuna, S. T., Hyrien, O., Skalland, T., Mayer, K. H., Sobieszczyk, M. E., Baden, L. R., Goepfert, P. A., del Rio, C., Pantaleo, G., Andrew, P., Karg, C., He, Z., Lu, H., Paez, C. A., Baumblatt, J. A. G., Polakowski, L. L., Chege, W., Janto, S., Han, S., Huang, Y. Dumond, J., Ackerman, M. E., McDermott, A. B., Flach, B. Piwowar-Manning, E., Seaton, K., Tomaras, G. D., Montefiori, D. C., Gama, L., Mascola, J. R. (2024). A randomised clinical trial of the safety and pharmacokinetics of VRC07-523LS administered via different routes and doses (HVTN 127/HPTN 087). PLoS Medicine, 21(6): e1004329. https://doi.org/10.1371/journal.pmed.1004329
Gray, G. E., Mngadi, K., Lavreys, L., Nijs, S., Gilbert, P. B., Hural, J., Hyrien, O., Juraska, M., Luedtke, A., Mann, P., McElrath, M. J., Odhiambo, J. A., Stieh, D. J., Takalani, A. N., Willems, W., Tapley, A., Tomaras, G. D., Van Hoof, J., Schuitemaker, H., Swann, E., Barouch, D. H., Kublin, J. G., Corey, L., Pau, M. J., Buchbinder, S., and Tomaka, F. (2023). Phase 2b study of a prophylactic adenoviral vector–based mosaic HIV-1 vaccine regimen in Southern African women. Lancet Infectious Diseases, 24(11), 1201-1212. https://doi.org/10.1016/S1473-3099(24)00358-X
Aubert, M., Haick, A. K., Strongin, D. E., Klouser, L. M., Loprieno, M. A., Stensland, L., Santo, T. K., Huang, M.-L., Hyrien, O., Stone, D., Jerome, K. R. (2024). AAV-delivered gene editing for latent genital or orofacial herpes simplex virus infection reduces ganglionic viral load and minimizes subsequent viral shedding in mice. Nature Communications, 15, 4018. https://doi.org/10.1038/s41467-024-47940-y
Kenny, A., van Duijn, J., Dintwe, O., Heptinstall, J., Burnham, R., Sawant, S., Zhang, L., Mielke, D.; Khuzwayo, S., Laher Omar, F., Stanfield-Oakley, S, Keyes, T, Dunn, B., Goodman, D., Fong, Y., Benkeser, D., Zou, R., Hural, J., Hyrien, O., Juraska, M., Luedtke, A., van der Laan, L., Giorgi, E. E., Magaret, C., Carpp, L. N., Pattacini, L., van de Kerkhof, T., Korber, B., Willems, W., Fisher, L. H., Schuitemaker, H., Swann, E., Kublin, J. K., Pau, M. G., Buchbinder, S., Tomaka, F., Nijs, S., Lavreys, L., Gelderblom, H. C., Corey, L., Mngadi, K., Gray, G. R., Borducchi, E., Hendriks, J., Seaton, K. E., Zolla-Pazner, S., Barouch, MD21,23; Guido Ferrari, MD5,6; Stephen C De Rosa, MD3; M Juliana McElrath, MD, D. H., Andersen-Nissen, E., Stieh, D. J., Tomaras, G. D., Gilbert, P. B., On behalf of the Imbokodo Study and Correlates Group (2024). Immune Correlates Analysis of the Imbokodo (HVTN 705/HPX2008) Efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study. eBioMedicine, 2024;108: 105320. https://doi.org/10.1016/j.ebiom.2024.105320
Fisher, L. H., Kee, J. J., Liu, A., Espinosa, C. M., Randhawa, A. K., Ludwig, J., Magaret, C. A., Robinson, S. T., Gilbert, P. B., Hyrien, O., Kublin, J., Rouphael, N., Falsey, A. R., Sobieszczyk, M. E., El Sahly, H., Grinsztein, B., Gray, G. E., Kotloff, K. L., Gay, C. L., Leav, B., Hirsch, I. Struyf, F. Dunkle, L. M., Neuzil, K. M., Corey, L., Huang, Y., Goepfert, P. A., Walsh, S. R., Baden, L. R., Janes, H., for the COVID-19 Prevention Network (2024). SARS-CoV-2 viral load among placebo recipients diagnosed with COVID-19 in four phase 3 COVID-19 prevention trials. JAMA Network Open; 7(5): e2412835. https://doi:10.1001/jamanetworkopen.2024.12835
Mayer, B.T., Zhang, L., DeCamp A.C., Yu C.., Sato A, Angier H., Seaton K.E., Yates N., Ledgerwood J.E., Mayer K., Caskey M., Nussenzweig M., Stephenson K., Julg B., Barouch D.H., Sobieszczyk M.E., Edupuganti S., Kelley C., McElrath M.J., Gelderblom H.C., Pensiero M., McDermott A., Gama L., Koup R.A., Gilbert P.B., Cohen M.S., Corey L., Hyrien O., Tomaras G.D., Huang Y. (2024). Impact of LS mutation on pharmacokinetics of HIV broadly neutralizing monoclonal antibodies: a cross-protocol analysis of 16 clinical trials in people without HIV. Pharmaceutics, 16(5), 594. https://doi.org/10.3390/pharmaceutics16050594
DeCamp, A. C., Corcoran, M. C., Fulp, W. J., Willis, J. R., Leggat, D. J., Cohen, K. W., Hyrien, O., Menis, S., Finak, G., Ballweber-Fleming, L., Srikanth, A., Plyler, J. R., Rahaman, F., Lombardo, A., Philiponis, V., Whaley, R. E., Seese, A., Brand, J., Ruppel, A. M., Hoyland, W., Mahoney, C. R., Cagigi, A., Taylor, A., Brown, D. M., Ambrozak, D. R., Sincomb, T., Mullen, T.-M., Maenza, J., Kolokythas, O., Khati, N., Bethony, J., Roederer, M., Diemert, D., Koup, R. A., Laufer, D. S., McElrath, J. M., McDermott, A. B., Karlsson Hedestam G. B., Schief, W. R. (2024). Allelic variation in immunoglobulin heavy chain variable gene influences the efficiency of germline-targeting vaccine priming. npj Vaccines, 9, 58. https://doi.org/10.1038/s41541-024-00811-5
Lim, F. Y., Kim, S. Y., Kulkarni, K. N., Blazevic, R. L., Kimball, L. E., Lea, H. G., Haack, A. J., Gower, M. S., Stevens-Ayers, T., Starita, L. M., Boeckh, M., Hyrien, O., Schiffer, J. T., Theberge, A. B., Waghmare, A. (2023). Longitudinal home self-collection of capillary blood using homeRNA correlates interferon and innate viral defense pathways with SARS-CoV-2 viral clearance. Journal of Clinical Investigation, 133(23), e173715. https://doi.org/10.1172/JCI173715
Fong, Y., McDermott, A. B., Benkeser, D., Roels, S., Stieh, D. J., Vandebosch, A., Le Gars, M., Van Roey, G. A., Houchens, C. R., Martins, K., Jayashankar, L., Castellino, F., Amoa-Awua, O., Basappa, M., Flach, B., Lin, B. C., Moore, C., Naisan, M., Naqvi, M., Narpala, S., O’Connell, S., Mueller, A., Serebryannyy, L., Castro, M., Wang, J., Petropoulos, C. J., Luedtke, A., Hyrien, O., Lu, Y., Yu, C., Borate, B., van der Laan, L. W. P., Hejazi, N. S., Kenny, A., Carone, M., Wolfe, D. N., Sadoff, J., Gray, G. E., Grinsztejn, B., Goepfert, P. A., Little, S. J., de Sousa, L. P., Maboa, R., Randhawa, A. K., Andrasik, M. P., Hendriks, J., Truyers, C., Struyf, F., Schuitemaker, H., Douoguih, M., Kublin, J. G., Corey, L., Neuzil, K. M., Carpp, L. N., Follmann, D., Gilbert, P. B., Koup, R. A., & Donis, R. O. (2022). Immune correlates analysis of the ENSEMBLE single Ad26.COV2.S dose vaccine efficacy clinical trial. Nature Microbiology, 7, 1996–2010.
Cohen, K. W., De Rosa, S. C., Fulp, W. J., deCamp, A. C., Fiore-Gartland, A., Mahoney, C. R., Furth, S., Donahue, J., Whaley, R. E., Ballweber-Fleming, L., Seese, A., Schwedhelm, K., Geraghty, D., Finak, G., Menis, S., Leggat, D. J., Rahaman, F., Lombardo, A., Borate, B. R., Philiponis, V., Maenza, J., Diemert, D., Kolokythas, O., Khati, N., Bethony, J., Hyrien, O., Laufer, D. S., Koup, R. A., McDermott, A. B., Schief, W. R., & McElrath, M. J. (2023). A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses. Science Translational Medicine, 15, eadf3309
Slavtchova-Bojkova, M., Hyrien, O., Yanev, N. M. (2023). Limiting distributions for subcritical multitype Markov branching processes with immigration generated by Poisson random measures. Communications in Statistics - Theory and Methods, 53(14), 5076–5091. https://doi.org/10.1080/03610926.2023.2205972
Slavtchova-Bojkova, M., Hyrien, O., Yanev, N. M. (2023). Poisson random measures and supercritical multitype Markov branching processes. Stochastic Models, 39(1), 141–160.
Mills, M., Bruce, E., Huang, M.-L., Crothers, J., Hyrien, O. et al (2022). An international, interlaboratory ring trial confirms the feasibility of an extraction-less “direct” RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples. PLOS One 17(1): e0261853. https://doi.org/10.1371/journal.pone.0261853
Schuster, D. J., Karuna, S., Brackett, C., Wesley, M., Li, S. S., Eisel, N., Tenney, D., Hilliard, S., Yates, N. L., Heptinstall, J. R., Williams, L. D., Shen, X., Rolfe, R., Cabello, R., Zhang, L., Sawant, S., Hu, J., Randhawa, A. K., Hyrien, O., Hural, J. A., Corey, L., Frank, I., Tomaras, G. D., Seaton, K. E. (2022). Lower SARS-CoV-2-specific humoral immunity in people living with HIV-1 recovered from symptomatic non-hospitalized COVID-19. JCI Insight; 7(21):e158402.
Fong, Y., McDermott, A. B., Benkeser, D., Roels, S., Stieh, D. J., Vandebosch, A., Le Gars, M., Van Roey, G. A., Houchens, C. R., Martins, K., Jayashankar, L., Castellino, F., Amoa-Awua, O., Basappa, M., Flach, B., Lin, B. C., Moore, C., Naisan, M., Naqvi, M., Narpala, S., O’Connell, S., Mueller, A., Serebryannyy, L., Castro, M., Wang, J., Petropoulos, C. J., Luedtke, A., Hyrien, O., Lu, Y., Yu, C., Borate, B., van der Laan, L. W. P., Hejazi, N. S., Kenny, A., Carone, M., Wolfe, D. N., Sadoff, J., Gray, G. E., Grinsztejn, B., Goepfert, P. A., Little, S. J., de Sousa, L. P., Maboa, R., Randhawa, A. K., Andrasik, M. P., Hendriks, J., Truyers, C., Struyf, F., Schuitemaker, H., Douoguih, M., Kublin, J. G., Corey, L., Neuzil, K. M., Carpp, L. N., Follmann, D., Gilbert, P. B., Koup, R. A., and Donis, R. O. (2022). Immune correlates analysis of the ENSEMBLE single Ad26.COV2.S dose vaccine efficacy clinical trial. Nature Microbiology, 7, 1996–2010.
Nemes, E, Fiore-Gartland, A, Boggiano C, Coccia M, D'Souza P, Gilbert P, Ginsberg A, Hyrien O, Laddy D, Makar K, McElrath MJ, Ramachandra L, Schmidt AC, Shotorbani S, Sunshine J, Tomaras G, Yu WH, Scriba TJ, Frahm N; BCG Correlates PIs Study Team, M72 Correlates PIs Study Team (2022). The quest for vaccine-induced immune correlates of protection against tuberculosis. Vaccine Insights; 1(3):165-181.
Mehrotra D.V., Janes H.E., Fleming T.R., et al (2021). Clinical endpoints for evaluating efficacy in COVID-19 vaccine trials. Annals of Internal Medicin; 174, 221-228. https://doi.org/10.7326/M20-6169
Follmann, D., Fintzi, J., Fay, M. P., Janes, H. E., Baden, L. R., El Sahly, H. M., Fleming, T. R., Mehrotra, D. V., Carpp, L. N., Juraska, M., Benkeser, D., Donnell, D., Fong, Y., Han, S., Hirsch, I., Huang, Y., Huang, Y., Hyrien, O., Luedtke, A., Carone, M., Nason, M., Vandebosch, A., Zhou, H., Cho, I., Gabriel, E., Kublin, J. G., Cohen, M. S., Corey, L., Gilbert, P. B., and Neuzil, K. M. (2021). A deferred-vaccination design to assess durability of COVID-19 vaccine effect after the placebo group is vaccinated (2021). Annals of Internal Medicine; 174, 1118-1125.
Karuna, S., Li, S. S., Grant S., Walsh, S. R., Frank, I., Casapia, M., Trahey, M., Hyrien, O., Fisher, L., Miner, M. D., Randhawa, A. K., Polakowski, L., Kublin, J. G., Corey, L., Montefiori, D., for the HVTN 405/HPTN 1901 Study Team (2021). Neutralizing antibody responses over time in demographically and clinically diverse individuals recovered from SARS-CoV-2 infection in the United States and Peru: A cohort study. PLOS Medicine 18(12): e1003868.
Hyrien, O, and Yanev, N (2020). Age-dependent branching processes with non-homogeneous Poisson immigration as models of cell kinetics. Statistical Modeling for Biological Systems: In Memory of Andrei Yakovlev, Anthony Almudevar, David Oakes and Jack Hall, Editors, Springer, New York.
Mitchell, C. M., Watson, L., Mitchell, A. J., Hyrien, O., Bergerat, A., Valint, D. J., Pascale, A. Hoffman, N., Srinivasan, S., and Fredricks, D. N. (2020). Vaginal microbiota and mucosal immune markers in women with vulvovaginal discomfort. Sexually Transmitted Diseases, 47, 269-274.
Hyrien, O, and Yanev, N (2020). Age-dependent branching processes with non-homogeneous Poisson immigration as models of cell kinetics. Statistical Modeling for Biological Systems: In Memory of Andrei Yakovlev, Anthony Almudevar, David Oakes and Jack Hall, Editors, Springer, New York.
Pattacini, L, Woodward Davis, A, Czartoski, J, Mair, F, Presnell, S, Hughes, SM, Hyrien, O, Lentz, GM, Kirby, AC, Fialkow, MF, Hladik, F, Prlic, M, and Lund JM. (2019). A pro-inflammatory CD8+ T-cell subset patrols the cervicovaginal tract. Mucosal Immunology, 12, 1118–1129.
Wang, J, Hilchey, SP, DeDiego, M, Perry, S, Hyrien, O, et al (2018). Broad cross-reactive IgG responses elicited by adjuvanted vaccination with recombinant influenza hemagglutinin (rHA) in ferrets and mice. PloS One, 13(4): e0193680.
Mitov, K, Yanev, N, and Hyrien, O (2018). Multitype branching processes with non-homogeneous Poisson immigration. Advances in Applied Probability, 50A, 211-228.
Oh JK, Messing S, Hyrien O, Hammert WC. (2017) Corticosteroid injections in deQuervains tenosynovitis: an effective treatment. Hand; 4:357-361.
*Hyrien O, Mitov K, Yanev NM. (2017). Subcritical Sevastyanov branching processes with non-homogeneous Poisson immigration. Journal of Applied Probability. 2017;54: 569-587.
*Hyrien O, Baran A. Fast nonparametric density-based clustering of large data sets using a stochastic approximation mean-shift algorithm. Journal of Computational and Graphical Statistics. 2016;25:899-916.
Nedelkovska H, Rosenberg AF, Hilchey SP, Hyrien O, Burack WR, Quataert SA, Azadniv M, Welle SL, Ansell SM, Kim M, Bernstein SH. Follicular lymphoma regulatory T cells (Treg) have a distinct transcriptional profile impacting Treg migration and retention in the malignant lymph node. PLoS One. 2016;11(5): e0155347.
Hyrien O, Mitov K, Yanev NM. (2016). Supercritical Sevastyanov branching processes with non-homogeneous Poisson immigration. Lecture Notes in Statistics, Branching Processes and their Applications (del Puerto et al. Editors), Springer, Berlin; 219.
Wang J, Hilchey SP, Hyrien O, Huertas N, Perry S, Ramanunninair M, Bucher D, Zand, MS. Multi-dimensional measurement of antibody-mediated heterosubtypic immunity to influenza. PLoS One. 2015;10(6): e0129858.
Xiao G-Q, Li F, Findeis-Hosey J, Hyrien O, Unger PD, Kim E, Dunne R, Xiao L, Yang Q, McMahon L, Burstein DE. Down-regulation of cytoplasmic PLZF correlates with high tumor grade and tumor aggression in non-small cell lung carcinoma. Human Pathology, 2015;46:1607-1615.
Hyrien O, Peslak S, Yanev NM, Palis J. A stochastic model of stress erythropoiesis using a two-type age-dependent branching process with immigration, Journal of Mathematical Biology. 2015;70:1485-1521.
Hyrien O, Jordan C, Yanev NM. A test of homogeneity for age-dependent branching processes with non-homogeneous immigration. Electronic Journal of Statistics. 2015;9:898-925.
Petraglia AL, Plog BA, Dayawansa S, Chen M, Dashnaw ML, Czerniecka K, Walker CT, Viterise T, Hyrien O, Iliff JF, Deane R, Nedergaard M, Huang JH. The Spectrum of neuro-behavioral sequelae following repetitive mild traumatic brain injury: A novel mouse model of chronic traumatic encephalopathy (CTE). Journal of Neurotrauma. 2014;31:1211-1224.
Brady MT, Hilchey SP, Hyrien O, Spence SA, Bernstein SH. Mesenchymal stromal cells support the viability and differentiation of follicular lymphoma-infiltrating follicular helper T-cells. PLoS One. 2014;9(5): e97597.
Petraglia, AL, Plog BA, Dayawansa S, Chen M, Dashnaw ML, Czerniecka K, Walker CT, Viterise T, Hyrien O, Iliff JF, Deane R, Huang JH, Nedergaard M. The pathophysiology underlying repeti- tive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy. Surgical Neurology International. 2014;5:184.
Hezel AF, Noel MS, Allen JN, Abrams TA, Yurgelun M, Faris JE, Goyal L, Clark JW, Blaszkowsky LS, Murphy JE, Zheng H, Khorana AA, Connolly GC, Hyrien O, Baran A, Herr M, Ng K, Sheehan S, Harris DJ, Regan E, Borger DR, Lafrate AJ, Fuchs C, Ryan DP, Zhu AX. Phase II study of gemcitabine, oxaliplatin in combination with panitumumab in KRAS wild-type unresectable or metastatic biliary tract and gallbladder cancer. British Journal of Cancer. 2014:111:430-436.
Chen R, and Hyrien O. On equivalence classes and identifiability for age-dependent branching processes. Advances in Applied Probability. 2014;46:704-718.
Tong J, Liu W, Wang X, Han X, Hyrien O, Samadani U, Smith D, Giger R, Huang J. Inhibition of Nogo-66 receptor 1 enhances recovery of cognitive function after traumatic brain injury in mice. Journal of Neurotrauma. 2013;30:247-258.
Liesveld J, Pawlowski J, Chen R, Hyrien O, Debolt J, Becker M, Phillips G, Chen Y. Clinical factors affecting engraftment and transfusion needs in stem cell transplantation; a single center retrospective analysis. Bone Marrow Transplantation. 2013;48:691-697.
Liesveld JL, Phillips GL, Becker MW, Constine LS, Friedberg JW, Andolina JR, Milner LA, Debolt J, Smudzin T, Hyrien O, Erickson-Miller C, Johnson B, Dawson K, Chen Y. (2013). A Phase 1 trial of eltrombopag in patients undergoing stem cell transplantation after total body irradiation. Biology of Blood and Marrow Transplantation. 19:1745-1752.
Zhang H, Messing EM, Travis LB, Hyrien O, Chen R, Milano MT, Brasacchio RA, Chen Y. PSA-detected prostate cancer in the U.S.: a population-based study of 70,345 men with AJCC stage T1cN0M0 disease. Frontiers in Oncology. 2013;3:312.
Zhang H, Travis LB, Chen R, Hyrien O, Milano MT, Newlands SD, and Chen Y. Impact of radiotherapy on laryngeal cancer survival: a population-based study of 13,808 U.S. patients. Cancer. 2012;118:1276-1287.
Hyrien O, Yanev NM. Asymptotic behavior of cell populations described by a class of two-type reducible age-dependent branching processes with nonhomogeneous immigration. Mathematical Population Studies. 2012;19:164-176.
Chen Y, Pandya K, Hyrien O, Keng P, Smudzin T, Anderson J, Qazi R, Smith B, Watson T, Feins R, Johnstone D. Preclinical and pilot clinical study of docetaxel chemoradiation for stage III non-small cell lung cancer. International Journal of Radiation Oncology, Biology, Physics. 2011;80:1358-1364.
Hilchey SP, Rosenberg A, Hyrien O, Secor-Socha S, Cochran MR, Wang JCE, Sanz I, Burack WR, Quataert SA, and Bernstein SH. Follicular lymphoma tumor infiltrating T-helper (TH) cells have the same in- trinsic polyfunctional potential upon stimulation as do reactive and normal nodal TH cells despite having skewed differentiation. Blood. 2011;118:3591-3602.
Chen R, Hyrien O. Quasi- and pseudo-likelihood estimation for discretely observed Markov branching processes. Journal of Statistical Planning and Inference. 2011;141:2209-2227.
Kaspler P, Hyrien O, Hill RP. Dynamics of micronuclei in mice skin fibroblasts after gamma irradiation. Health Physics Journal. 2010;98:228-233.
Bhogal N, Kaspler P, Jalali F, Hyrien O, Chen R, Hill RP, Bristow RG. Late residual H2AX FOCI in murine skin are dose-responsive and predict radiosensitivity in vivo. Radiation Research. 2010;173:1-9.
Phonethepswath S, Franklin D, Torous DK, Bryce SM, Bemis JC, Raja S, Avlasevich S, Weller P, Hyrien O, Palis J, MacGregor JT, and Dertinger SD Pig-A mutation: kinetics of appearance and disappearance of mutant phenotype erythrocytes in rat blood following exposure to five prototypical mutagens. Toxicological Sciences. 2010;114;59-70.
Biswas T, Dhakal S, Chen R, Hyrien O, Bernstein S, Friedberg J, Fisher R, Liesveld J, Phillips G, Constine L. Involved field radiation after autologous stem cell transplant for large B-cell lymphoma in the rituximab era. International Journal of Radiation Oncology, Biology, Physics. 2010;77:79-85.
Chen Y, Tsai Y, Nowak I, Wang N, Hyrien O, Wilkins R, Ferrarotto C, Sun H and Dertinger SD. Validating high throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model. Health Physics Journal. 2010;98:218-227.
Dertinger SD, Phonethepswath S, Franklin D, Weller P, Torous DK, Bryce SM, Avlasevich S, Bemis JC, Hyrien O, Palis J, MacGregor JT. Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies, Toxicological Sciences. 2010;634:119-125.
Kaspler P, Jelveha S, Chen R, Hyrien O, Bristow RG, Hill RP. Biodosimetry using radiation-induced micronuclei in skin fibroblasts. International Journal of Radiation Biology. 2010;87:824-838.
Hyrien O, Chen R, Zand MS. An age-dependent branching process model for the analysis of CFSE-labeling experiments. Biology Direct, Mathematical Biology Section. 2010;5:41.
*Hyrien O, Dietrich J, Noble M. Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors. Cancer Research. 2010;70:10051-10059.
Chen R, Hyrien O, Mayer-Proschel M, Noble M. A composite likelihood approach to the analysis of longitudinal clonal data under an age-dependent branching process, Biostatistics. 2010;12:173-191.
Hyrien O, Chen R, Mayer-Proschel M, Noble M. Saddlepoint approximations to the moments of age-dependent branching processes, with applications. Biometrics. 2010;66:567-577.
Hilchey SP, Hyrien O, Gold D, Mossman T, Livingstone A, Friedberg J, Young J, Fisher RI, Kelleher Jr R, Bankert RB, Bernstein SH. Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma; support for a ”vaccinal effect” of rituximab. Blood. 2009;113:3809-3812.
Henn A.D, Rebhahn J, Brown MA, Murphy A, Coca MN, Hyrien O, Pellegrin T, Mosmann T, Zand M.S.). Cell division affects the fre- quency of antibody secreting cells but not the distribution of single-cell IgG secretion rates in CpG activated human memory B cells. Journal of Immunology.2009;183:3177-3187.
Sun H, Dertinger SD, Hyrien O, Wu D, Chen Y. Gamma radiation induces micronucleated reticulocytes in ex-vivo 3-D bone marrow bioreactors. Mutation Research, 2009;680:49-55.
Hilchey SP, Kobie JJ, Cochran MR, Secor-Socha S, Wang E, Hyrien O, Mosmann TR, Quataert SA, Bernstein SH. Human follicular lymphoma CD39+ -infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness. Journal of Immunology. 2009;183;6157-6166.
Hocde SA, Hyrien O, Waugh RE. Cell adhesion molecule distribution relative to neutrophil surface topography assessed by TIRFM. Biophysical Journal. 2009;97: 379-387.
Hocde SA, Hyrien O, Waugh RE. Molecular accessibility in relation to cell surface topography and compression against a flat substrate. Biophysical Journal. 2009;97:369-378.
Connolly GC, Chen R, Hyrien O, Mantry P, Abt P, Khorana AA. Portal vein and systemic thromboses in hepatocellular carcinoma. Thrombosis Research. 2008;122:299-306.
Couderc JP, McNitt S, Hyrien O, Vaglio M, Xia X, Polonsky S, Moss AJ, Zareba W.. Electrocardiographic abnormalities of repolarization induced by moxifloxacin: improving the detection of subtle IKr-inhibition. Drug Safety. 2008;31(3):249-260.
Zhang H, Hyrien O, Pandya K, Keng P, Chen Y. Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization. Journal of Thoracic Oncology. 2008;3:563-568.
Khorana A A, Francis CW, Menzies KE, Wang JG, Hyrien O, Hathcock J, Mackman N, Taubman MB. Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer. Journal of Thrombosis and Haemostasis. 2008;11:1983-1985.
Dertinger SD, Bemis JC, Phonethepswath S, Tsai Y, Nowak I, Hyrien O, Palis J, Chen Y. Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age. Mutation Research. 2008;67:77-80.
*Hyrien O, Zand MS. A mixture model with dependent observations for the analysis of CFSE-labeling experiments. Journal of the American Statistical Association. 2008;103:222-239.
Dertinger SD, Tsai Y, Nowak I, Hyrien O, Sun H, Bemis JC, Torous DK, Keng P, Palis J, Chen Y. Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry. Mutation Research. 2007;634(1-2):119-125.
Hyrien O. A pseudo maximum likelihood estimator for discretely observed multitype Bellman-Harris branching processes. Journal of Statistical Planning and Inference. 2007;137:1375-1388.
Couderc JP, Vaglio M, Xia X, McNitt S, Hyrien O. Electrocardiographic method for identifying drug-induced repolarization abnormalities associated with a reduction of the rapidly activating delayed rectifier potassium current. IEEE Engineering in Medicine and Biology Society. 2006;4010-4015.
Hanin L, Hyrien O, Bedford J, Yakovlev A. A comprehensive stochastic model of irradiated cell population in cell culture. Journal of Theoretical Biology. 2006;239:401-416.
*Hyrien O, Ambeskovic I, Mayer-Proschel M, Noble M, Yakovlev A. Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data. Theoretical Biology and Medical Modelling. 2006;3:21.
Chen Y, Hyrien, O, Williams J, Okunieff P, Smudzin T, Rubin P. IL-1a and IL-6: application to the predictive diagnostic testing of radiation pneumonitis. International Journal of Radiation Oncology, Biology, Physics. 2005;62(1):260-266.
*Hyrien O, Mayer-Proschel M, Noble M, Yakovlev A. Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture. Mathematical Biosciences. 2005;193:255-274.
*Hyrien O, Mayer-Proschel M, Noble M, Yakovlev A. A stochastic model to analyze clonal data on multi type cell populations. Biometrics. 2005;61:199-207.
Baker L, Hyrien O, Ratka A. Contributions of morphine-3-glucuronide and morphine-6-glucuronide to differences in morphine analgesia in humans. American Journal of Pain Management. 2003;13(1):16-28.
Kles V, Hyrien O, Poul JM, Sanders P). Application of pharmacokinetic/pharmaco-dynamic and stochastic modeling to 6-mercaptopurine micronucleus induction in mouse bone marrow erythrocytes. Journal of Applied Toxicology.2003;23:59-70.
*Hyrien O, Kles V, Concordet D, Bonneu M, Laurentie M, and Sanders P. Stochastic modeling in toxicokinetics. Application to the in vivo micronucleus assay. Mathematical Biosciences. 2001;169:27-51.
Godard T, Fessard V, Huet S, Mourot A, Deslandes E, Pottier D, Hyrien O, Sichel F, Gauduchon P, and Poul JM. Comparative in vitro and in vivo assessment of genotoxic effects of etoposide and chlorotalonil by the comet assay. Mutation Research. 1999;444:103-116.
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