Publications
2024
Hyrien, O.#, Yanev, N. M. (2024). A Branching stochastic evolutionary model of the B-cell repertoire. Journal of Mathematical Biology, in Press.
Hahn, W. O., Parks, K. R., Shen, M., Ozorowski, G., Janes, H., Ballweber-Fleming, L., Woodward Davis, A. S., Duplessis, C., Tomai, M., Dey, A. K., Sagawa, Z. K., De Rosa, S. C., Seese, A., Kallur Siddaramaiah, L., Stamatatos, L., Lee, W.-H., Sewall, L. M., Karlinsey, D., Turner, H. L., Rubin, V., Furth, S., MacPhee, K., Duff, M., Corey, L., Keefer, M. C., Edupuganti, s., Frank, I., Maenza, J., Baden, L. R., Hyrien, O., Sanders, R. W., Moore, J. P., Ward, A. P., Tomaras, G. D., Montefiori, D. C., Rouphael, N., McElrath, M. J. (2024). Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies (2024). Journal of Experimental Medicine, vol. 221, no. 10.
Lim, F. Y., Lea, H. G., Dostie, A. M., Kim, S.-Y., van Neel, T. L., Hassan, G. W., Takezawa, M. G., Starita, L. M., Adams, K. N., Boeckh, M., Schiffer, J. T., Hyrien, O., Waghmare, A., Berthier, E., Theberge, A. B. (2024). homeRNA self-blood collection enables high-frequency temporal profiling of presymptomatic host immune kinetics to respiratory viral infection: a prospective cohort study. eBioMedicine, accepted.
Carpp, L. N.#, Hyrien, O.#, Fong, Y.#, Benkeser, D., Roels, S., Stieh, D. J., Van Dromme, I., Van Roey, G. A., Kenny, A., Huang, Y., Carone, M., McDermott, A. B., Houchens, C. R., Martins, K., Jayashankar, L., Castellino, F., Amoa-Awua, O., Basappa, M., Flach, B., Lin, B. C., Moore, C. , Naisan, M., Naqvi, M., Narpala, S., O’Connell, S., Mueller, A., Serebryannyy, L., Castro, M., Wang, J., Petropoulos, C. J., Luedtke, A., Lu, Y., Yu, C., Juraska, M., Hejazi, N. S., Wolfe, D. N., Sadoff, J., Gray, G. E., Grinsztejn, B., Goepfert, P. A., Bekker, L.-G., Gaur, A. H., Veloso, V. G., Randhawa, A. K., Andrasik, M. P., Hendriks, J., Truyers, C., Vandebosch, A., Struyf, F., Schuitemaker, H., Douoguih, M., Kublin, J. G., Corey, L., Neuzil, K. M., Follmann, D., Koup, R. A., Donis, R. O., and Gilbert, P. B., on behalf of the Immune Assays Team, the Coronavirus Vaccine Prevention Network (CoVPN)/ENSEMBLE Team, and the United States Government (USG)/CoVPN Biostatistics Team. (2024). Neutralizing Antibody Correlate of Protection Against Severe-Critical COVID-19 in the ENSEMBLE Single-Dose Ad26.COV2.S Vaccine Efficacy Trial. Nature Communications, in Press.
Magaret, C.A., Li, L., deCamp, A. C., Rolland, M., Juraska, M., Williamson, B. D., Ludwig, J., Molitor, C., Benkeser, D., Luedtke, A., Simpkins, B., Heng, F., Sun, Y., Carpp, L. N., Bai, H., Dearlove, B. L., Giorgi, E. E., Jongeneelen, M., Brandenburg, B., McCallum, M., Bowen, J. E., Veesler, D., Sadoff, J., Gray, G. E., Roels, S., Vandebosch, A., Stieh, D. J., Le Gars, M., Vingerhoets, J., Grinsztejn, B., Goepfert, P. A., Paiva de Sousa, L., Secco Torres Silva, M., Casapia, M., Losso, M. H., Little, S. J., Gaur, A., Bekker, L.-G., Garrett, N., Truyers, C., Van Dromme, I., Swann, E., Marovich, M. A., Follmann, D., Neuzil, K. M., Corey, L., Greninger, A. L., Roychoudhury, P., Follmann, D., Neuzil, K. M., Corey, L., Greninger, A. L., Roychoudhury, P., Hyrien, O., and Gilbert, P. B. (2024). Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features. Nature Communications, in Press.
Walsh, S. R., Gay, C. L., Karuna, S. T., Hyrien, O., Skalland, T., Mayer, K. H., Sobieszczyk, M. E., Baden, L. R., Goepfert, P. A., del Rio, C., Pantaleo, G., Andrew, P., Karg, C., He, Z., Lu, H., Paez, C. A., Baumblatt, J. A. G., Polakowski, L. L., Chege, W., Janto, S., Han, S., Huang, Y. Dumond, J., Ackerman, M. E., McDermott, A. B., Flach, B. Piwowar-Manning, E., Seaton, K., Tomaras, G. D., Montefiori, D. C., Gama, L., Mascola, J. R. (2024). A randomised clinical trial of the safety and pharmacokinetics of VRC07-523LS administered via different routes and doses (HVTN 127/HPTN 087). PLoS Medicine, 21(6): e1004329.
Aubert, M., Haick, A. K., Strongin, D. E., Klouser, L. M., Loprieno, M. A., Stensland, L., Santo, T. K., Huang, M.-L., Hyrien, O., Stone, D., Jerome, K. R. (2024). AAV-delivered gene editing for latent genital or orofacial herpes simplex virus infection reduces ganglionic viral load and minimizes subsequent viral shedding in mice. Nature Communications, in Press.
Kenny, A., van Duijn, J., Dintwe, O., Heptinstall, J., Burnham, R., Sawant, S., Zhang, L., Mielke, D.; Khuzwayo, S., Laher Omar, F., Stanfield-Oakley, S, Keyes, T, Dunn, B., Goodman, D., Fong, Y., Benkeser, D., Zou, R., Hural, J., Hyrien, O., Juraska, M., Luedtke, A., van der Laan, L., Giorgi, E. E., Magaret, C., Carpp, L. N., Pattacini, L., van de Kerkhof, T., Korber, B., Willems, W., Fisher, L. H., Schuitemaker, H., Swann, E., Kublin, J. K., Pau, M. G., Buchbinder, S., Tomaka, F., Nijs, S., Lavreys, L., Gelderblom, H. C., Corey, L., Mngadi, K., Gray, G. R., Borducchi, E., Hendriks, J., Seaton, K. E., Zolla-Pazner, S., Barouch, MD21,23; Guido Ferrari, MD5,6; Stephen C De Rosa, MD3; M Juliana McElrath, MD, D. H., Andersen-Nissen, E., Stieh, D. J., Tomaras, G. D., Gilbert, P. B., On behalf of the Imbokodo Study and Correlates Group (2024). Immune Correlates Analysis of the Imbokodo (HVTN 705/HPX2008) Efficacy Trial of a Mosaic HIV-1 Vaccine Regimen Evaluated in Southern African People Assigned Female Sex at Birth: A Two-Phase Case-Control Study. eBioMedicine, 2024;108: 105320.
Fisher, L. H., Kee, J. J., Liu, A., Espinosa, C. M., Randhawa, A. K., Ludwig, J., Magaret, C. A., Robinson, S. T., Gilbert, P. B., Hyrien, O., Kublin, J., Rouphael, N., Falsey, A. R., Sobieszczyk, M. E., El Sahly, H., Grinsztein, B., Gray, G. E., Kotloff, K. L., Gay, C. L., Leav, B., Hirsch, I. Struyf, F. Dunkle, L. M., Neuzil, K. M., Corey, L., Huang, Y., Goepfert, P. A., Walsh, S. R., Baden, L. R., Janes, H., for the COVID-19 Prevention Network (2024). SARS-CoV-2 viral load among placebo recipients diagnosed with COVID-19 in four phase 3 COVID-19 prevention trials. JAMA Network Open, in Press.
Mayer, B.T., Zhang, L., DeCamp A.C., Yu C.., Sato A, Angier H., Seaton K.E., Yates N., Ledgerwood J.E., Mayer K., Caskey M., Nussenzweig M., Stephenson K., Julg B., Barouch D.H., Sobieszczyk M.E., Edupuganti S., Kelley C., McElrath M.J., Gelderblom H.C., Pensiero M., McDermott A., Gama L., Koup R.A., Gilbert P.B., Cohen M.S., Corey L., Hyrien O., Tomaras G.D., Huang Y. (2024). Impact of LS mutation on pharmacokinetics of HIV broadly neutralizing monoclonal antibodies: a cross-protocol analysis of 16 clinical trials in people without HIV. Pharmaceutics, 16(5), 594. doi.org/10.3390/pharmaceutics16050594.
DeCamp, A. C., Corcoran, M. C., Fulp, W. J., Willis, J. R., Leggat, D. J., Cohen, K. W., Hyrien, O., Menis, S., Finak, G., Ballweber-Fleming, L., Srikanth, A., Plyler, J. R., Rahaman, F., Lombardo, A., Philiponis, V., Whaley, R. E., Seese, A., Brand, J., Ruppel, A. M., Hoyland, W., Mahoney, C. R., Cagigi, A., Taylor, A., Brown, D. M., Ambrozak, D. R., Sincomb, T., Mullen, T.-M., Maenza, J., Kolokythas, O., Khati, N., Bethony, J., Roederer, M., Diemert, D., Koup, R. A., Laufer, D. S., McElrath, J. M., McDermott, A. B., Karlsson Hedestam G. B., Schief, W. R. (2024). Allelic variation in immunoglobulin heavy chain variable gene influences the efficiency of germline-targeting vaccine priming. npj Vaccines, in Press.
2023
Gray, G. E., Mngadi, K., Lavreys, L., Nijs, S., Gilbert, P. B., Hural, J., Hyrien, O., Juraska, M., Luedtke, A., Mann, P., McElrath, M. J., Odhiambo, J. A., Stieh, D. J., Takalani, A. N., Willems, W., Tapley, A., Tomaras, G. D., Van Hoof, J., Schuitemaker, H., Swann, E., Barouch, D. H., Kublin, J. G., Corey, L., Pau, M. J., Buchbinder, S., and Tomaka, F. (2023). Phase 2b Study of a Prophylactic Adenoviral Vector–Based Mosaic HIV-1 Vaccine Regimen in Southern African Women. Lancet Infectious Diseases, in Press.
Lim, F. Y., Kim, S. Y., Kulkarni, K. N., Blazevic, R. L., Kimball, L. E., Lea, H. G., Haack, A. J., Gower, M. S., Stevens-Ayers, T., Starita, L. M., Boeckh, M., Hyrien, O., Schiffer, J. T., Theberge, A. B., Waghmare, A. (2023). Longitudinal home self-collection of capillary blood using homeRNA correlates interferon and innate viral defense pathways with SARS-CoV-2 viral clearance. Journal of Clinical Investigation, in Press.
Slavtchova-Bojkova, M., Hyrien, O., Yanev, N. M. (2023). Poisson random measures and supercritical multitype Markov branching processes. Stochastic Models, In Press.
Cohen, K., de Rosa, S., … Hyrien, O., et al (2023). A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses. Science Translational Medicine, 15, eadf3309
Slavtchova-Bojkova, M., Hyrien, O., Yanev, N. M. (2023). Limiting distributions for subcritical multitype Markov branching processes with immigration generated by Poisson random measures. In Press.
2022
Fong, Y., McDermott, A. B., Benkeser, D., Roels, S., Stieh, D. J., Vandebosch, A., Le Gars, M., Van Roey, G. A., Houchens, C. R., Martins, K., Jayashankar, L., Castellino, F., Amoa-Awua, O., Basappa, M., Flach, B., Lin, B. C., Moore, C., Naisan, M., Naqvi, M., Narpala, S., O’Connell, S., Mueller, A., Serebryannyy, L., Castro, M., Wang, J., Petropoulos, C. J., Luedtke, A., Hyrien, O., Lu, Y., Yu, C., Borate, B., van der Laan, L. W. P., Hejazi, N. S., Kenny, A., Carone, M., Wolfe, D. N., Sadoff, J., Gray, G. E., Grinsztejn, B., Goepfert, P. A., Little, S. J., de Sousa, L. P., Maboa, R., Randhawa, A. K., Andrasik, M. P., Hendriks, J., Truyers, C., Struyf, F., Schuitemaker, H., Douoguih, M., Kublin, J. G., Corey, L., Neuzil, K. M., Carpp, L. N., Follmann, D., Gilbert, P. B., Koup, R. A., & Donis, R. O. (2022). Immune correlates analysis of the ENSEMBLE single Ad26.COV2.S dose vaccine efficacy clinical trial. Nature Microbiology, 7, 1996–2010.
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