The Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)

GECCO logo

It is recognized that genetic variants play an important role in colorectal cancer risk. To comprehensively study the millions of genetic variations across the genome, large-scale studies are key for elucidating inherited risk factors and their interaction with environmental factors.

The Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) is a collaborative effort of researchers across the world. The GECCO Coordinating Center, based at the Fred Hutch (Principal investigator: Ulrike Peters; lead statistician: Li Hsu), also manages data from the Colorectal Transdisciplinary Study (CORECT) consortium.

We have discovered close to 200 novel colorectal cancer risk loci through large-scale genome-wide association scans using genotype and sequencing data from a growing resource of over 60 studies and roughly 150,000 colorectal cancer patients and control participants.

To ensure that data can be used to its full potential, we are harmonizing clinical and epidemiologic data across all studies. The availability of detailed individual-level phenotype data in over 100,000 participants with genome-wide genotype data allows us to conduct comprehensive investigations into gene-environment interactions, risk prediction, and integrative tumor analyses.

We welcome new studies and collaborators to join our research efforts. 

GECCO Portal Access

GECCO collaborators and consortium members can access the GECCO portal here:

GECCO annual meeting

GECCO Annual Meeting

Studies working in this consortium

  • Advanced Colorectal Cancer of Serrated Subtype (ACCESS)
  • ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED)
  • Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC)
  • French Association Study Evaluating RISK for sporadic colorectal cancer (ASTERISK)
  • Basque-colon-cohort
  • Black Women's Health Study (BWHS)
  • Colon cancer clinical trial C08
  • Cancer Risk Assessment study (CRA)
  • USC Norris Comprehensive Cancer Center Genetics Registry (CGN)
  • Campaign against Cancer and Heart Disease II (CLUEII)
  • Cancer Prevention Study II (CPSII)
  • Hawaii Colorectal Cancer Studies 2 & 3 (Colo2&3)
  • ColoCare Consortium (ColoCare)
  • Colorectal cancer: Longitudinal Observational study on Nutritional and lifestyle factors that influence colorectal tumour recurrence, survival and quality of life (COLON)
  • Colorectal Cancer Study of Austria (CORSA)
  • Colorectal cancer study on Oahu, Hawaii (CR2&3)
  • Colorectal Cancer Genetics & Genomics (CRCGEN)
  • Czech Republic CCS (CzechCCS)
  • Darmkrebs: Chancen der Verhütung durch Screening (DACHS)
  • Diet, Activity, and Lifestyle Study (DALS)
  • Early Detection Research Network (EDRN)
  • European Prospective Investigation into Cancer (EPIC)
  • EPICOLON Consortium (EPICOLON)
  • Epidemiologische Studie zu Chancen der Verhutung, Fruherkennung und optimierten THerapie chronischer ERkrankungen in der alteren Bevolkerung (ESTHER_VERDI)
  • 5-FU, Folinic Acid and Irinotecan (FOLFIRI) Plus Cetuximab Versus FOLFIRI Plus Bevacizumab in First Line Treatment Colorectal Cancer (FIRE3)
  • Fukuoka Colorectal Cancer Study (FukuokaCCS)
  • GALicia Estudio Oncológico de coloN (GALEON)
  • Hawaii Adenoma Study (HawaiiCCS)
  • Health Professionals Follow-up Study (HPFS)
  • Hispanic Colorectal Cancer Study (HCCS)
  • Hwasun Cancer Epidemiology Study-Colon and Rectum Cancer (HCES-CRC)
  • Indonesia Colorectal Cancer Study (ICROSC)
  • Iowa Women’s Health Study (IWHS)
  • Japan Public Health Center-based prospective Study (JPHC)
  • Kentucky Case-Control Study (Kentucky)
  • Leeds Colorectal Cancer Study (LCCS)
  • Study of Bevacizumab/mFOLFOX6 Versus Bevacizumab/Folfiri With Biomarker Stratification in Patients With Previously Untreated Metastatic Colorectal Cancer (MAVERICC)
  • Colorectal cancer case-controls study at MD Anderson
  • Melbourne Collaborative Cohort Study (MCCS)
  • Multiethnic Cohort (MEC)
  • Molecular Epidemiology of Colorectal Cancer study (MECC)
  • Colorectal Cancer Outcomes Prognosis and Epidemiology (COPE) Study and Total Cancer Care (TCC) (MOFFITT)
  • Memorial Sloan Kettering cohort (MSKCC)
  • Nagano Colorectal Cancer Study (NaganoCCS)
  • North Carolina Colon Cancer Studies I & II (NCCCS I & II)
  • Newfoundland Case-Control Study (NFCCR)
  • North German Case Control Study (NGCCS)
  • Nurses' Health Study (NHS) 
  • Nurses’ Health Study II (NHSII)
  • Nanjing ColoRectal Cancer cohort (NJCRC)
  • Northern Sweden Health and Disease Study (NSHDS)
  • Colon cancer clinical trial N0147
  • Metastatic colorectal cancer clinical trial N9741
  • Ontario Colorectal Cancer Family Registry (OFCCR) 
  • Columbus-area HNPCC Study, OCCPI study, Ohio Colorectal Cancer Prevention Initiative (OSUMC)
  • Physicians' Health Study (PHS)
  • Prostate, Lung, Colorectal, and Ovarian (PLCO)
  • Postmenopausal Hormones Supplementary Study to the Colon cancer family registries (PMH)
  • Aspirin/Folate Polyp Prevention Study (PPS3)
  • Vitamin D/Calcium Polyp Prevention Study (PPS4)
  • Puerto Rico Familial Colorectal Cancer Registry (PURIFICAR)
  • Colon Cancer Pathways: Hyperplastic Polyps and Adenomas (REACH)
  • Research Program on Genes, Environment and Health (RPGEH)
  • Seattle Colon Cancer Family Registry (SCCFR)
  • Southern Community Cohort Study (SCCS)
  • Studies of Epidemiology and Risk Factors in Cancer Heredity (SEARCH)
  • Selenium and VItamin E Prevention Trial (SELECT)
  • Swedish Low-Risk Colorectal Cancer Study (SLRCCS)
  • Swedish Mammography Cohort (SMC) and Swedish Men Cohort (SMC_COSM)
  • Shanghai Men’s Health Study and Shanghai Women’s Health Study (SMHS/SWHS)
  • Screening Markers for Colorectal Disease Study and Colonoscopy and Health Study (SMS)
  • Taiwan Colorectal Cancer Study (Taiwan)
  • The Cancer Genome Atlas (TCGA)
  • Combination Chemotherapy and Bevacizumab as First-Line Therapy in Treating Patients with Metastatic Colorectal Cancer (TRIBE)
  • UK Biobank (UKB)
  • University of North Carolina CanCORS study (UNC-CanCORS)
  • North Carolina Rectal Cancer Study (UNC-Rectal)
  • University of Southern California Hormone Replacement Therapy Study for Colorectal Cancer (USC-HRT-CRC)
  • VITamins And Lifestyle (VITAL)
  • Women's Health Initiative (WHI)

Additionally, the Colon Cancer Family Registry (CCFR) is collaborating with GECCO on many analyses.