It is recognized that genetic variants play an important role in colorectal cancer risk. To comprehensively study the millions of genetic variations across the genome, large-scale studies are key for elucidating inherited risk factors and their interaction with environmental factors.
The Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) is a collaborative effort of researchers across the world. The GECCO Coordinating Center, based at the Fred Hutch (Principal investigator: Ulrike Peters; lead statistician: Li Hsu), also manages data from the Colorectal Transdisciplinary Study (CORECT) consortium.
We have discovered close to 200 novel colorectal cancer risk loci through large-scale genome-wide association scans using genotype and sequencing data from a growing resource of over 60 studies and roughly 150,000 colorectal cancer patients and control participants.
To ensure that data can be used to its full potential, we are harmonizing clinical and epidemiologic data across all studies. The availability of detailed individual-level phenotype data in over 100,000 participants with genome-wide genotype data allows us to conduct comprehensive investigations into gene-environment interactions, risk prediction, and integrative tumor analyses.
We welcome new studies and collaborators to join our research efforts.
GECCO collaborators and consortium members can access the GECCO portal here: