The Rongvaux Lab studies innate immunity in humans and in mice.
The innate immune response represents the very first step in the development of a protective response after exposure to a pathogen, stress or injury. But dysregulation of this response can contribute to the pathogenesis of inflammatory diseases or to the progression of cancer.
Our lab is studying how dying cells interact with the immune system and affect the outcome of the immune response, and how macrophages contribute to the tumor microenvironment and affect tumor development.
To address these questions, we are developing specific models of genetically-modified mice, including “humanized mouse” models that allow us to translate our findings to pre-clinical conditions.