Our Research

Our lab uses advanced mouse models to study human immune responses.

We use the MISTRG humanized mouse model to recapitulate in vivo the development and function of the human immune system in health and disease.

We combine this experimental approach to the analysis of high-dimensional profiling data from human samples. This combined approach allows us to address clinically relevant questions in human immunology, and to study them using in vivo models with high relevance to human biology.

We use this approach to study human tumor microenvironments, human macrophage biology, and the mechanism of innate sensing of human pathogens.