ROR1 CAR-T cells (green) and endogenous CD8+ T cells (red) infiltrate a ROR1+ lung tumor in KP mice. Blue = DAPI, Green = CAR, Red = CD8.
Photo credit: Shivani Srivastava
The Srivastava lab is focused on applying principles of basic T cell biology towards the design for more effective adoptive T cell therapies for human cancers, with a particular emphasis on uncovering the factors within the tumor microenvironment that may limit the activity of tumor-specific T cells. We use clinically relevant mouse models to understand the mechanisms limiting the activity of engineered T cells in human cancers and develop strategies to overcome them that can be readily translated to the clinic.