2023 | 2022 | 2021 | 2020 | 2018 | 2017 | 2016 | 2015 and earlier

2023

Davidsen K & Sullivan LB. A robust method for measuring aminoacylation through tRNA-Seq. bioRxiv 2023, Aug 1. 

Uo T, Ojo KK, Spenger CC, Epilepsia KS, Perera GK, Damodarasamy M, Sun S, Kim S, Hogan HH, Hulverson MA, Choi R, Whitman GR, Barret LK, Micheals SA, Xu LH, Pang HJ, Nguyen MM, Vigil ABG, Kamat V, Sullivan LB, Sweet IR, Vadala R, Maly DJ, Van Voorhis WC, Plymate SR. A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer. bioRxiv 2023, July 3.

Davidsen K^‡, Marvin JS^‡*, Aggarwal A, Brown TA, Sullivan LB*. An engineered biosensor enables dynamic aspartate measurements in living cells. bioRxiv 2023, June 27. (^‡Co-first author, *Co-corresponding author)

Jaeger-Ruckstuhl CA, Lo Y, Fulton E, Waltner O, Shabaneh TB, Correnti CE, Newsom O, Engstrom I, Kanaan SB, Bhise S, Peralta JM, Ruff R, Price J, Stull S, Stevens A, Voillet V, Muhunthan V, Morrish F, Gottardo R, Sarthy JF, Henikoff S, Sullivan LB, Furlan SN, Riddell SR. CD27 Costimulation Modulates Naïve T Cell Activation Through TRAF2/SHP-1 and Induces Memory-Associated Gene Regulatory Networks. Cell Press Sneak Peek 2023, March 29. 

Nguyen TH, Tang E, Webster ALH, Whiteaker JR, Chandler CM, Errazquin R, Roohollahi K, Fritzke M, Hoskins EE, Jonlin E, Wakefield L, Sullivan LB, Chen EY, Dorsman J, Brakenhoff R, Paulovich AG, Grompe M, Garcia-Escudero R, Wells SI, Smogorzewska A, Monnat RJ Jr. Fanconi anemia-isogenic head and neck cancer cell line pairs - a basic and translational science resource. Int J Cancer. 2023 Mar 13. (bioRxiv. 2022. Sept 13)

Hart ML, Quon E, Vigil ABG, Engstrom IA, Newsom OJ, Davidsen K, Hollerbauer P, Carlisle SM, Sullivan LB. Mitochondrial Redox Adaptations Enable Alternative Aspartate Synthesis in SDH-impaired Cells. eLife.. 2023. Mar 8;12:e78654 (bioRxiv. 2022, Mar 14)

Kinsella S, Evandy CA, Cooper K, Cardinale A, Iovino L, deRoos P, Hopwo KS, Smith CW, Grandier D, Sullivan LB, Velardi E, Dudakov JA. Damage-induced pyroptosis drives endogenous thymic regeneration via induction of Foxn1 by purinergic receptor activation. (bioRxiv. 2023, Jan 21)

2022

Newsom OJ, Sullivan LB. Targeting PDAC metabolism: environment determines what has GOT2 give. Cell Metab. 2022 Nov 1;34(11):1617-1619.

Li Z, Ji BW, Dixit PD, Tchourine K, Lien EC, Hosios AM, Abbott KL, Rutter JC, Westermark AM, Gorodetsky EF, Sullivan LB, Vander Heiden MG, Vitkup D. Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited. Nat Metab. 2022 Jun;4(6):711-723. (bioRxiv. 2020).

Crist SB, Nemkov T, Dumpit RF, Dai J, Tapscott S, True LD, Swarbrick A, Sullivan LB, Nelson PS, Hansen KC, Ghajar CM. Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells. Nat Cell Biol. 2022 Apr 11.

Arnold PK, Jackson BT, Paras KI, Brunner JS, Hart ML, Newsom OJ, Alibeckoff SP, Endress J, Drill E, Sullivan LB, Finley LWS. A non-canonical tricarboxylic acid cycle underlies cellular identity. Nature. 2022. Mar;603(7901):477-481.

2021

Engstrom IA, Davidsen K, Sullivan LB. Packed cell volume is an overestimate in common cancer cell lines. Bio-101. 2021 e4216.

Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI. Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science. 2021 May 14;372(6543):716-721.

Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, Vander Heiden MG, Stephanopoulos G. Differential Substrate Use in EGF- and Oncogenic KRAS-Stimulated Human Mammary Epithelial Cells. FEBS J. 2021 Apr 3.

Luengo A, Li Z, Gui DY, Sullivan LB, Zagorulya M, Do BT, Ferriera R, Naamati A, Ali A, Lewis CA, Thomas CJ, Spranger S, Matheson NJ, Vander Heiden MG. Increased demand for NAD+ relative to ATP drives aerobic glycolysis. Mol Cell. 2021 Feb 18;81(4):691-707. (bioRxiv, 2020).

2020

Davidsen K, Sullivan LB. Free asparagine or die: Cancer cells require proteasomal protein breakdown to survive asparagine depletion. Cancer Discov. 2020 Nov;10(11):1632-1634.

Li Y, Ivica NA, Dong T, Kleyman M, Hu G, Papageorgiou DP, He Y, Chen W, Sullivan LB, Del Rosario AM, Hammond PT, Vander Heiden MG, Chen J. MFSD7C Switches Mitochondrial ATP Synthesis to Thermogenesis in Response to Heme. Nat Commun. 2020 Sept 24;11(1):4837.

Augert A, Mathsyaraja H, Ibrahim AH, Freie B, Geuenich MJ, Cheng P, Alibeckoff SP, Wu N, Hiatt JB, Basom R, Gazdar A, Sullivan LB, Eisenman RN, MacPherson D. MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer. Cancer Cell. 2020 Jul 13;38:1-18.

Quon E, Hart ML, Sullivan LB. Redox debt leads to metabolic bankruptcy in tumors. Trends Cancer. 2020 May 1; 6(5):359-61.

2018

Sullivan LB. Metabolic frugality marks cancer cells for immune targeting. Cell. 2018 Sep 6; 275(6):1344-1346.

Sullivan LB*, Luengo A, Danai LV, Bush LB, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG*. Aspartate is an Endogenous Metabolic Limitation for Tumour Growth. Nat Cell Biol. 2018 Jul;20(7):782-788. (*Co-Corresponding Author)

McLellan CA, Vincent BM, Solos NV, Lancaster AK, Sullivan LB, Hartland CL, Youngsaye W, Filler SG, Whitesell L, Lindquist S. Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy. Nat Chem Biol. 2018 Feb;14(2):135-141.

2017

Sullivan LB. Extracellular Vesicles: Taking Metabolism on the Road. Nat Chem Biol. 2017 Aug 18;13(9):924-925.

2016

Sullivan LB, Gui DY, Vander Heiden MG. Altered metabolite levels in cancer: implications for tumor biology and cancer therapy. Nat Rev Cancer. 2016 Nov;16(11):680-693.

Gui DY*, Sullivan LB*, Luengo A, Davidson SM, Hosios AM, Bush LB, Gitego N, Thomas CJ, Vander Heiden MG. Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin. Cell Metab. 2016 Nov 8;24(5):716-727. (*Co-First Author)

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM. A PHGDH inhibitor reveals coordination between serine synthesis and 1-carbon unit utilization. Nat Chem Biol. 2016 Jun; 12(6): 452-8.

Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O’Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander Heiden MG. Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. Cell Metab. 2016 Mar 8;23(3):517-28.

Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams JL, Gibson WJ, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG, Jr. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell. 2016 Feb 25; 164(5):884-95.

Hecht VC*, Sullivan LB*, Kimmerling RJ, Kim DH, Hosios AM, Stockslager MA, Stevens MM, Kang JH, Wirtz D, Vander Heiden MG, Manalis SR. Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. J Cell Biol. 2016 Feb 15;212(4):439-47. (*Co-First Author)

2015 and earlier

2015

Sullivan LB*, Gui DY*, Hosios AM, Bush LN, Freinkman E, Vander Heiden MG. Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells. Cell. 2015 Jul 30; 162(3):552-63. (*Co-First Author)

2014

Sullivan LB, Chandel NS. Mitochondrial reactive oxygen species and cancer. Cancer Metab. 2014 Nov 28, 2:17.

Luengo A, Sullivan LB, Vander Heiden MG. Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy. BMC Biol. 2014 Oct 24;12:82.

Mullen AR, Hu Z, Shi X, Jiang L, Buroughs LK, Kovacs Z, Boriak R, Rakheja D, Sullivan LB, Linehan WM, Chandel NS, DeBerardinis RJ. Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. Cell Rep. 2014 Jun 12;7(5):1679-90.

Wheaton WW, Weinberg S, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budinger GRS, Chandel, NS. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. eLife. 2014 May 13;3

Sullivan LB, Chandel NS. Mitochondrial metabolism in TCA cycle mutant cancer cells. Cell cycle. 2014 Feb 1;13(3):347-8.

2013

Sullivan LB, Garcia-Martinez E, Mullen AR, Nguyen H, Dufour E, Sudarshan S, Yang Y, Linehan WM, Licht JD, Deberardinis RJ, Chandel NS The proto-oncometabolite fumarate binds glutathione to amplify ROS dependent signaling. Mol Cell. 2013 Jul 25;51(2):236-48.

2012

Sullivan LB, Santos JH, Chandel NS. Mitochondria and Telomeres: The promiscuous role of TIN2. Mol Cell. 2012 Sep 28;47(6):823-4.

2011

Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 2011 Nov 20;481(7381):385-8.