Publications
2023
Coffey, D.G., Maura, F., Gonzalez-Kozlova, E., Diaz-Mejia, J., Luo, P., Zhang, Y., Xu, Y., Warren, EH., Dawson, T., Lee, H., Smith, E., Ciardiello, A., Cho, H., Rahman, A., Kim-Schulze, S., Diamond, B., Lesokhin, A., Kazandjian, D., Pugh, T., Green, D., Gnjatic, S., Landgren, O. Immunophenotypic correlates of sustained MRD negativity in patients with multiple myeloma. Nat Commun 14, 5335 (2023). https://doi.org/10.1038/s41467-023-40966-8 Full Text
Lynch RC, Poh C, Ujjani CS, Warren EH, Smith SD, Shadman M, Morris K, Lee S, Rasmussen H, Ottemiller S, Shelby M, Keo S, Verni K, Kurtz DM, Alizadeh AA, Chabon JJ, Hogan GJ, Schulz A, Gooley T, Voutsinas JM, Gopal AK. Polatuzumab vedotin with infusional chemotherapy for untreated aggressive B-cell non-Hodgkin lymphomas. Blood Adv. 2023 Jun 13;7(11):2449-2458. doi: 10.1182/bloodadvances.2022009145. PubMed PMID: 36521030; PubMed Central PMCID: PMC10241852. Full Text
Graf SA, Lynch RC, Ujjani CS, Gooley TA, Rasmussen H, Coffey DG, Cowan AJ, Smith SD, Shadman M, Warren EH, Libby EN, Greninger AL, Fromm JR, Gopal AK. Efficacy, safety, and molecular response predictors of oral ixazomib and short-course rituximab in untreated iNHL. Blood Adv. 2023 Mar 14;7(5):687-696. doi: 10.1182/bloodadvances.2022008628. PubMed PMID: 36385536; PubMed Central PMCID: PMC9984960. Full Text
Miller CP, Shokri F, Akilesh S, Xu Y, Warren EH, Tykodi SS, Tretiakova M. Immunohistochemical Detection of 5T4 in Renal Cell Carcinoma. Appl Immunohistochem Mol Morphol. 2023 Mar 1;31(3):135-144. doi: 10.1097/PAI.0000000000001101. Epub 2023 Feb 6. PubMed PMID: 36735485. Full Text
Phipps W, Adams SV, Mooka P, Kafeero J, Sekitene S, Mubiru D, Nankoma J, Namirembe C, Okoche L, Namubiru EB, Kayemba S, Baker KK, Redman MW, Casper C, Orem J, Warren EH. A prospective study of clinical outcomes of HIV-associated and HIV-negative Kaposi sarcoma in Uganda. AIDS. 2023 Jan 1;37(1):51-59. doi: 10.1097/QAD.0000000000003376. Epub 2022 Sep 2. PubMed PMID: 36083142; PubMed Central PMCID: PMC9742184. Full Text
2022
Xu Y, Morales AJ, Towlerton AMH, Akilesh S, Miller CP, Tykodi SS, Warren EH. Integrated TCR repertoire analysis and single-cell transcriptomic profiling of tumor-infiltrating T cells in renal cell carcinoma identifies shared and tumor-restricted expanded clones with unique phenotypes. Front Oncol. 2022;12:952252. doi: 10.3389/fonc.2022.952252. eCollection 2022. PubMed PMID: 36185254; PubMed Central PMCID: PMC9515957. Full Text
Coffey DG, Xu Y, Towlerton AMH, Kowanetz M, Hegde P, Darwish M, Yadav M, Blanchette C, Ruppert SM, Bertino S, Xu Q, Ferretti A, Weinheimer A, Hellmann M, Qin A, Thomas D, Warren EH, Ramnath N. Case report: A persistently expanded T cell response in an exceptional responder to radiation and atezolizumab for metastatic non-small cell lung cancer. Front Immunol. 2022;13:961105. doi: 10.3389/fimmu.2022.961105. eCollection 2022. PubMed PMID: 36159875; PubMed Central PMCID: PMC9500393. Full Text
Towlerton AMH, Ravishankar S, Coffey DG, Puronen CE, Warren EH. Serial Analysis of the T-Cell Receptor β-Chain Repertoire in People Living With HIV Reveals Incomplete Recovery After Long-Term Antiretroviral Therapy. Front Immunol. 2022;13:879190. doi: 10.3389/fimmu.2022.879190. eCollection 2022. PubMed PMID: 35585986; PubMed Central PMCID: PMC9108698. Full Text
Ujjani C, Shadman M, Lynch RC, Tu B, Stevenson PA, Grainger C, Zhu H, Hill JA, Huang ML, Nielsen L, Poh C, Sorensen T, Gopal AK, Warren EH, Till BG, Lee S, Gausman D, Smith SD, Gooley T, Greninger A. The impact of B-cell-directed therapy on SARS-CoV-2 vaccine efficacy in chronic lymphocytic leukaemia. Br J Haematol. 2022 May;197(3):306-309. doi: 10.1111/bjh.18088. Epub 2022 Feb 18. PubMed PMID: 35149986; PubMed Central PMCID: PMC9111753. Full Text
Ujjani C, Greninger AL, Shadman M, Hill JA, Lynch RC, Warren EH, Gopal AK. Heterologous SARS-CoV-2 vaccinations in patients with B-cell lymphoid malignancies. Am J Hematol. 2022 Feb 1;97(2):E67-E69. doi: 10.1002/ajh.26418. Epub 2021 Nov 30. PubMed PMID: 34807468; PubMed Central PMCID: PMC9011525. Full Text
Radich JP, Briercheck E, Chiu DT, Menon MP, Sala Torra O, Yeung CCS, Warren EH. Precision Medicine in Low- and Middle-Income Countries. Annu Rev Pathol. 2022 Jan 24;17:387-402. doi: 10.1146/annurev-pathol-042320-034052. Review. PubMed PMID: 35073168; PubMed Central PMCID: PMC9275191. Full Text
James CA, Xu Y, Aguilar MS, Jing L, Layton ED, Gilleron M, Minnaard AJ, Scriba TJ, Day CL, Warren EH, Koelle DM, Seshadri C. CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells. Nat Commun. 2022 Jan 10;13(1):78. doi: 10.1038/s41467-021-27764-w. PubMed PMID: 35013257; PubMed Central PMCID: PMC8748927. Full Text
2021
Lynch RC, Cassaday RD, Smith SD, Fromm JR, Cowan AJ, Warren EH, Shadman MS, Shustov A, Till BG, Ujjani CS, Libby EN 3rd, Philip M, Coye H, Martino CN, Bhark SL, Morris K, Rasmussen H, Behnia S, Voutsinas J, Gopal AK. Dose-dense brentuximab vedotin plus ifosfamide, carboplatin, and etoposide for second-line treatment of relapsed or refractory classical Hodgkin lymphoma: a single centre, phase 1/2 study. Lancet Haematol. 2021 Aug;8(8):e562-e571. doi: 10.1016/S2352-3026(21)00170-8. PubMed PMID: 34329577; PubMed Central PMCID: PMC8457616. Full Text
Xu Y, Miller CP, Warren EH, Tykodi SS. Current status of antigen-specific T-cell immunotherapy for advanced renal-cell carcinoma. Hum Vaccin Immunother. 2021 Jul 3;17(7):1882-1896. doi: 10.1080/21645515.2020.1870846. Epub 2021 Mar 5. Review. PubMed PMID: 33667140; PubMed Central PMCID: PMC8189101. Full Text
Cargill MJ, Morales A, Ravishankar S, Warren EH. RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells. DNA Repair (Amst). 2021 Jul;103:103137. doi: 10.1016/j.dnarep.2021.103137. Epub 2021 May 18. PubMed PMID: 34083132; PubMed Central PMCID: PMC8544569. Full Text
Gulleen EA, Adams SV, Chang BH, Falk L, Hazard R, Kabukye J, Scala J, Liu C, Phipps W, Abrahams O, Moore CC. Factors and Outcomes Related to the Use of Guideline-Recommended Antibiotics in Patients With Neutropenic Fever at the Uganda Cancer Institute. Open Forum Infect Dis. 2021 Jul;8(7):ofab307. doi: 10.1093/ofid/ofab307. eCollection 2021 Jul. PubMed PMID: 34262989; PubMed Central PMCID: PMC8275883. Full Text
Coffey DG, Cowan AJ, DeGraaff B, Martins TJ, Curley N, Green DJ, Libby EN, Silbermann R, Chien S, Dai J, Morales A, Gooley TA, Warren EH, Becker PS. High-Throughput Drug Screening and Multi-Omic Analysis to Guide Individualized Treatment for Multiple Myeloma. JCO Precis Oncol. 2021;5. doi: 10.1200/PO.20.00442. eCollection 2021. PubMed PMID: 34250400; PubMed Central PMCID: PMC8232547. Full Text
Seremba E, Ocama P, Ssekitoleko R, Mayanja-Kizza H, Adams SV, Orem J, Katabira E, Reynolds SJ, Nabatanzi R, Casper C, Phipps W. Immune response to the hepatitis B vaccine among HIV-infected adults in Uganda. Vaccine. 2021 Feb 22;39(8):1265-1271. doi: 10.1016/j.vaccine.2021.01.043. Epub 2021 Jan 28. PubMed PMID: 33516601; PubMed Central PMCID: PMC7887054. Full Text
2020
Qin A, Rengan R, Lee S, Santana-Davila R, Goulart BHL, Martins R, Baik C, Kalemkerian GP, Hassan KA, Schneider BJ, Hayman JA, Jolly S, Hearn J, Lawrence TS, Towlerton AMH, Tewari M, Thomas D, Zhao L, Brown N, Frankel TL, Warren EH, Ramnath N. A Pilot Study of Atezolizumab Plus Hypofractionated Image Guided Radiation Therapy for the Treatment of Advanced Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2020 Sep 1;108(1):170-177. doi: 10.1016/j.ijrobp.2019.10.047. Epub 2019 Nov 19. PubMed PMID: 31756415. Full Text
Kim A, Stevenson P, Cassaday RD, Soma L, Fromm JR, Gopal AK, Smith SD, Till B, Lynch RC, Ujjani C, Shadman M, Warren EH, Menon M, Russell K, Tseng YD. Impact of Double- or Triple-Hit Pathology on Rates and Durability of Radiation Therapy Response Among Patients With Relapsed or Refractory Large B-Cell Lymphoma. Pract Radiat Oncol. 2020 Jan-Feb;10(1):44-52. doi: 10.1016/j.prro.2019.09.013. Epub 2019 Oct 1. PubMed PMID: 31585205. Full Text
2019
Xu Y, Morales AJ, Cargill MJ, Towlerton AMH, Coffey DG, Warren EH, Tykodi SS. Preclinical development of T-cell receptor-engineered T-cell therapy targeting the 5T4 tumor antigen on renal cell carcinoma. Cancer Immunol Immunother. 2019 Dec;68(12):1979-1993. doi: 10.1007/s00262-019-02419-4. Epub 2019 Nov 4. PubMed PMID: 31686124; PubMed Central PMCID: PMC6877496. Full Text
Downing J, Niyonzima N, Guma S, Batuli M, Kiwanuka R, Atuhe I, Nalukwago Z, Mwesiga M, Phipps W, Ddungu H. Towards universal coverage-highlights from the 2nd Uganda Conference on Cancer and Palliative Care, 5-6 September 2019, Kampala, Uganda. Ecancermedicalscience. 2019;13:976. doi: 10.3332/ecancer.2019.976. eCollection 2019. PubMed PMID: 31921347; PubMed Central PMCID: PMC6946418. Full Text
Coffey DG, Wu QV, Towlerton AMH, Ornelas S, Morales AJ, Xu Y, Green DJ, Warren EH. Ultradeep, targeted sequencing reveals distinct mutations in blood compared to matched bone marrow among patients with multiple myeloma. Blood Cancer J. 2019 Sep 30;9(10):77. doi: 10.1038/s41408-019-0238-0. PubMed PMID: 31570697; PubMed Central PMCID: PMC6768874. Full Text
Chow VA, Gopal AK, Maloney DG, Turtle CJ, Smith SD, Ujjani CS, Shadman M, Cassaday RD, Till BG, Tseng YD, Warren EH, Shustov AR, Menon MP, Bhark S, Acharya UH, Mullane E, Hannan LM, Voutsinas JM, Gooley TA, Lynch RC. Outcomes of patients with large B-cell lymphomas and progressive disease following CD19-specific CAR T-cell therapy. Am J Hematol. 2019 Aug;94(8):E209-E213. doi: 10.1002/ajh.25505. Epub 2019 May 21. PubMed PMID: 31056762; PubMed Central PMCID: PMC6776079. Full Text
Lubwama M, Phipps W, Najjuka CF, Kajumbula H, Ddungu H, Kambugu JB, Bwanga F. Bacteremia in febrile cancer patients in Uganda. BMC Res Notes. 2019 Jul 30;12(1):464. doi: 10.1186/s13104-019-4520-9. PubMed PMID: 31362783; PubMed Central PMCID: PMC6668181. Full Text
Cooper JP, Khajaviyan S, Smith SD, Maloney DG, Shustov AR, Warren EH, Soma LA, Lynch RC, Ujjani C, Till B, Halpern AB, Gopal AK, Deeg HJ, Scott BL, Shadman M. Outcomes of Patients With Therapy-Related MDS After Chemoimmunotherapy for Chronic Lymphocytic Leukemia Compared With Patients With De Novo MDS: A Single-Institution Experience. Clin Lymphoma Myeloma Leuk. 2019 Jun;19(6):390-395. doi: 10.1016/j.clml.2019.03.003. Epub 2019 Mar 11. PubMed PMID: 30948330; NIHMSID:NIHMS1526183. Full Text
Mutyaba I, Wabinga HR, Orem J, Casper C, Phipps W. Presentation and Outcomes of Childhood Cancer Patients at Uganda Cancer Institute. Glob Pediatr Health. 2019;6:2333794X19849749. doi: 10.1177/2333794X19849749. eCollection 2019. PubMed PMID: 31205984; PubMed Central PMCID: PMC6537233. Full Text
Meier JA, Haque M, Fawaz M, Abdeen H, Coffey D, Towlerton A, Abdeen A, Toor A, Warren E, Reed J, Kanakry CG, Keating A, Luznik L, Toor AA. T Cell Repertoire Evolution after Allogeneic Bone Marrow Transplantation: An Organizational Perspective. Biol Blood Marrow Transplant. 2019 May;25(5):868-882. doi: 10.1016/j.bbmt.2019.01.021. Epub 2019 Jan 21. PubMed PMID: 30677510; PubMed Central PMCID: PMC6645918. Full Text
Smith SD, Reddy P, Sokolova A, Chow VA, Lynch RC, Shadman MA, Till BG, Shustov AR, Warren EH, Ujjani CS, Menon MP, Tseng YD, Gopal AK. Eligibility for CAR T-cell therapy: An analysis of selection criteria and survival outcomes in chemorefractory DLBCL. Am J Hematol. 2019 Apr;94(4):E117-E116. doi: 10.1002/ajh.25411. Epub 2019 Feb 4. PubMed PMID: 30663774. Full Text
Ddungu H, Krantz EM, Kajja I, Naluzze S, Nabbanja H, Nalubwama F, Phipps W, Orem J, Kiwanuka N, Wald A. How low can you go: What is the safe threshold for platelet transfusions in patients with hematologic malignancy in sub-Saharan Africa. PLoS One. 2019;14(2):e0211648. doi: 10.1371/journal.pone.0211648. eCollection 2019. PubMed PMID: 30726290; PubMed Central PMCID: PMC6364911. Full Text
Lindau P, Mukherjee R, Gutschow MV, Vignali M, Warren EH, Riddell SR, Makar KW, Turtle CJ, Robins HS. Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity. J Immunol. 2019 Jan 15;202(2):476-483. doi: 10.4049/jimmunol.1800217. Epub 2018 Dec 12. PubMed PMID: 30541882; PubMed Central PMCID: PMC6321841. Full Text
2018
Okello CD, Ddungu H, Omoding A, Towlerton AMH, Pitorak H, Maggard K, Ewart S, Phipps WT, Uldrick TS, Warren EH, Orem J. Capacity building for hematologic malignancies in Uganda: a comprehensive research, training, and care program through the Uganda Cancer Institute-Fred Hutchinson Cancer Research Center collaboration. Blood Adv. 2018 Nov 30;2(Suppl 1):8-10. doi: 10.1182/bloodadvances.2018GS111079. PMID: 30504187 Full text
Andeen NK, Qu X, Antic T, Tykodi SS, Fang M, Tretiakova MS. Clinical Utility of Chromosome Genomic Array Testing for Unclassified and Advanced-Stage Renal Cell Carcinomas. Arch Pathol Lab Med. 2018 Nov 1. doi: 10.5858/arpa.2018-0104-OA. [Epub ahead of print]. PMID: 30383394 Full text
Tykodi SS, Schadendorf D, Cella D, Reck M, Harrington K, Wagner S, Shaw JW. Patient-reported outcomes with nivolumab in advanced solid cancers. Cancer Treat Rev. 2018 Nov;70:75-87. doi: 10.1016/j.ctrv.2018.08.001. Epub 2018 Aug 2. PMID: 30125799 Full text
Zeidan AM, Knaus HA, Robinson TM, Towlerton AMH, Warren EH, Zeidner JF, Blackford AL, Duffield AS, Rizzieri D, Frattini MG, Levy YM, Schroeder MA, Ferguson A, Sheldon KE, DeZern AE, Gojo I, Gore SD, Streicher H, Luznik L, Smith BD. A Multi-center Phase I Trial of Ipilimumab in Patients with Myelodysplastic Syndromes following Hypomethylating Agent Failure. Clin Cancer Res. 2018 Aug 1;24(15):3519-3527. doi: 10.1158/1078-0432.CCR-17-3763. Epub 2018 May 1. PMID: 29716921 Full text
Macleod LC, Odisho AY, Tykodi SS, Holt SK, Harper JD, Gore JL. Comparative Effectiveness of Initial Surgery vs Initial Systemic Therapy for Metastatic Kidney Cancer in the Targeted Therapy Era: Analysis of a Population-based Cohort. Urology. 2018 Mar;113:146-152. doi: 10.1016/j.urology.2017.11.014. Epub 2017 Nov 23. PMID: 29174942 Full text
Escudier B, Sharma P, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, Castellano D, Gurney H, Donskov F, Peltola K, Wagstaff J, Gauler TC, Ueda T, Zhao H, Waxman IM, Motzer RJ; CheckMate 025 investigators. Erratum to "CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma" [Eur Urol 2017;72:962-71]. Eur Urol. 2018 Apr;73(4):e116-e118. doi: 10.1016/j.eururo.2017.12.016. Epub 2018 Jan 3. PMID: 29306512 Full text
2017
Katharine A. Lombardo, David G. Coffey, Alicia J. Morales, Christopher S. Carlson, Andrea M. H. Towlerton, Sarah E. Gerdts, Francis K. Nkrumah, Janet Neequaye, Robert J. Biggar, Jackson Orem, Corey Casper, Sam M. Mbulaiteye, Kishor G. Bhatia and Edus H. Warren. High-throughput sequencing reveals novel features of immunoglobulin gene rearrangements in Burkitt lymphoma. Blood Adv. 2017 Jul 3;1(16):1261-1262. doi: 10.1182/bloodadvances.2017008060. eCollection 2017 Jul 11. PMID:29296767 Full Text
Christopher G. Kanakry, Giorgos Bakoyannis, Susan M. Perkins, Shannon R. McCurdy, Ante Vulic, Edus H. Warren, Etienne Daguindau, Taylor Olmsted, Christen Mumaw, Andrea M.H. Towlerton, Kenneth R. Cooke, Paul V. O’Donnell, Heather J. Symons, Sophie Paczesny, Leo Luznik. Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide. Haematologica May 2017 102: 932-940; doi:10.3324/haematol.2016.152322 PMID: 28126963 Full Text
Katharine A. Lombardo, David G. Coffey, Alicia J. Morales, Christopher S. Carlson, Andrea M. H. Towlerton, Sarah E. Gerdts, Francis K. Nkrumah, Janet Neequaye, Robert J. Biggar, Jackson Orem, Corey Casper, Sam M. Mbulaiteye, Kishor G. Bhatia and Edus H. Warren. High-throughput sequencing of the B-cell receptor in African Burkitt lymphoma reveals clues to pathogenesis. Blood Adv. 2017 Mar 21;1(9):535-544. doi: 10.1182/bloodadvances.2016000794. eCollection 2017 Mar 28. PMID: 29296973 Full Text
Angel Qin, Lindsay Street, Kemp Cease, Benjamin L. Viglianti, Edus H. Warren, Lili Zhao, Nithya Ramnath. Clinical Determinants of Durable Clinical Benefit of Pembrolizumab in Veterans With Advanced Non-Small-Cell Lung Cancer. Clin Lung Cancer. 2017 Sep;18(5):559-564. doi: 10.1016/j.cllc.2017.01.012. Epub 2017 Feb 9. PMID: 28366756
Chapuis AG, Desmarais C, Emerson R, Schmitt TM, Shibuya K, Lai I, Wagener F, Chou J, Roberts JM, Coffey DG, Warren E., Robbins H, Greenberg PD., Yee C. Tracking the Fate and Origin of Clinically Relevant Adoptively Transferred CD8+ T Cells In Vivo. Sci Immunol. 2017 Feb;2(8). pii: eaal2568. doi: 10.1126/sciimmunol.aal2568. Epub 2017 Feb 24. PMID: 28367538 Full Text
2016
Kanakry CG, Coffey DG, Towlerton AM, Vulic A, Storer BE, Chou J, Yeung CC, Gocke CD, Robins HS, O'Donnell PV, Luznik L, Warren EH. Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide. JCI insight. 2016;1(5). Epub 2016/05/24. doi: 10.1172/jci.insight.86252. PubMed PMID: 27213183.
2015
Nakasone H, Tian L, Sahaf B, Kawase T, Schoenrock K, Perloff S, Ryan CE, Paul J, Popli R, Wu F et al.. 2015. Allogeneic HY antibodies detected 3 months after female-to-male HCT predict chronic GVHD and nonrelapse mortality in humans. Blood. 125(20):3193-201.
DeWitt WS, Emerson RO, Lindau P, Vignali M, Snyder TM, Desmarais C, Sanders C, Utsugi H, Warren EH, McElrath J et al.. 2015. Dynamics of the cytotoxic T cell response to a model of acute viral infection. Journal of virology. 89(8):4517-26.
2014
Klippel, Z.K., Chou, J., Towlerton, A.M., Voong, L.N., Robbins, P., Bensinger, W.I., and Warren, E.H., Immune escape from NY-ESO-1-specific T-cell therapy via loss of heterozygosity in the MHC. Gene Ther., 21:337-342, 2014. PMCID: PMC4040020 Full Text
Pollack, S.M., Jones, R.L., Farrar, E.A., Lai, I.P., Lee, S.M., Cao, J., Pillarisetty, V.G., Hoch, B.L., Gullet, A., Bleakley, M., Conrad, E.U., Eary, J.F., Shibuya, K.C., Warren, E.H., Carstens, J.N., Heimfeld, S., Riddell, S.R., and Yee, C., Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8+ T cells. J. Immunother. Can., 2(1):36.
2013
Warren, E.H., Matsen, F.A., and Chou, J., High-throughput sequencing of B- and T-lymphocyte antigen receptors in hematology. Blood, 122:19-22, 2013. PMCID: PMC3701903
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Torikai, H., Reik, A., Soldner, F., Warren, E.H., Yuen, C., Zhou, Y., Crossland, D.L., Huls, H., Littman, N., Zhang, Z., Tykodi, S.S., Kebriaei, P., Lee, D.A., Miller, J.C., Rebar, E.J., Holmes, M.C., Jaenisch, R., Champlin, R.E., Gregory, P.D., and Cooper, L.J.N., Towards eliminating HLA class I expression to generate universal cells from allogeneic donors. Blood, 122:1341-1349, 2013. PMCID: PMC3750336 Full Text
Goodridge, J.P., Lee, N., Burian, A., Pyo, C.-W., Tykodi, S.S., Warren, E.H., Yee, C., Riddell, S.R., and Geraghty, D.E., HLA-F and MHC-I open conformers cooperate in a MHC-I antigen cross-presentation pathway. J. Immunol., 191:1567-1577, 2013. PMCID: PMC3732835 Full Text
Chou, J., Fitzgibbon, M.P., Mortales, C.-L., Towlerton, A.M.H., Upton, M.P., Yeung, R.S., McIntosh, M.W., and Warren, E.H., Phenotypic and transcriptional fidelity of patient-derived colorectal cancer xenografts in immune-deficient mice. PLoS ONE, 8:e79874, 2013. PMCID: PMC3835935 Full Text
2012
Ochsenreither S, Majeti R, Schmitt T, Stirewalt D, Keilholz U, Loeb KR, Wood B, Choi YE, Bleakley M, Warren EH, Hudecek M, Akatsuka Y, Weissman IL, Greenberg P. Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen. Blood. 2012 Apr 23. [Epub ahead of print] PubMed PMID: 22529286. Full Text
Chou J, Voong LN, Mortales CL, Towlerton AM, Pollack SM, Chen X, Yee C, Robbins PF, Warren EH. Epigenetic Modulation to Enable Antigen-specific T-cell Therapy of Colorectal Cancer. J Immunother. 2012 Feb;35(2):131-41. PubMed PMID: 22306901.
Chien JW, Zhang XC, Fan W, Wang H, Zhao LP, Martin PJ, Storer BE, Boeckh M, Warren EH, Hansen JA. Evaluation of published single nucleotide polymorphisms associated with acute graft versus host disease. Blood. 2012 Jan 26. [Epub ahead of print] PubMed PMID: 22282500. Full Text
Chapman M, Warren EH 3rd, Wu CJ. Applications of next-generation sequencing to blood and marrow transplantation. Biol Blood Marrow Transplant. 2012 Jan;18(1 Suppl):S151-60. PubMed PMID: 22226099 Full Text
2011
Inamoto Y, Flowers ME, Lee SJ, Carpenter PA, Warren EH, Deeg HJ, Storb RF, Appelbaum FR, Storer BE, Martin PJ. Influence of immunosuppressive treatment on risk of recurrent malignancy after allogeneic hematopoietic cell transplantation. Blood. 2011 Jul 14;118(2):456-63. Epub 2011 Jun 1. PubMed PMID: 21633087. Full Text
Warren EH. Blazing a trail in T-cell recognition. Blood. 2011 May 5;117(18):4681-2. PubMed PMID: 21546465. Full Text
Grogan BM, Tabellini L, Storer B, Bumgarner TE, Astigarraga CC, Flowers ME, Lee SJ, Martin PJ, Warren EH, Hansen JA. Activation and Expansion of CD8(+) T Effector Cells in Patients with Chronic Graft-Versus-Host Disease. Biol Blood Marrow Transplant. 2011 Mar 23. [Epub ahead of print] PubMed PMID: 21440078. Full Text
Tykodi SS, Sandmaier BM, Warren EH, Thompson JA. Allogeneic hematopoietic cell transplantation for renal cell carcinoma: ten years after. Expert Opin Biol Ther. 2011 Mar 21. [Epub ahead of print] PubMed PMID: 21417772. Full Text
Flowers ME, Inamoto Y, Carpenter PA, Lee SJ, Kiem HP, Petersdorf EW, Pereira SE, Nash RA, Mielcarek M, Fero ML, Warren EH, Sanders JE, Storb RF, Appelbaum FR, Storer BE, Martin PJ. Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria. Blood. 2011 Mar 17;117(11):3214-9. Epub 2011 Jan 24. PubMed PMID: 21263156. Full Text
Inamoto Y, Fefer A, Sandmaier BM, Gooley TA, Warren EH, Petersdorf SH, Sanders JE, Storb RF, Appelbaum FR, Martin PJ, Flowers ME. A Phase I/II Study of Chemotherapy Followed by Donor Lymphocyte Infusion plus Interleukin-2 for Relapsed Acute Leukemia after Allogeneic Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2011 Jan 11. [Epub ahead of print] PubMed PMID: 21232624. Full Text
Falkenburg JH, Warren EH. Graft versus leukemia reactivity after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2011 Jan;17(1 Suppl):S33-8. PubMed PMID: 21195308. Full Text
2010
Hansen JA, Chien JW, Warren EH, Zhao LP, Martin PJ. Defining genetic risk for graft-versus-host disease and mortality following allogeneic hematopoietic stem cell transplantation. Curr Opin Hematol. 2010 Nov;17(6):483-92. PubMed PMID: 20827186.
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Robins HS, Srivastava SK, Campregher PV, Turtle CJ, Andriesen J, Riddell SR, Carlson CS, Warren EH. Overlap and effective size of the human CD8+ T cell receptor repertoire. Sci Transl Med. 2010 Sep 1;2(47):47ra64. PubMed PMID: 20811043.
Full Text (Supplementary Material)
Warren EH, Fujii N, Akatsuka Y, Chaney CN, Mito JK, Loeb KR, Gooley TA, BrownML, Koo KK, Rosinski KV, Ogawa S, Matsubara A, Appelbaum FR, Riddell SR. Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens. Blood. 2010 May 13;115(19):3869-78. Epub 2010 Jan 13. PubMed PMID: 20071660; PubMed Central PMCID: PMC2869557 Full Text
Miller JS, Warren EH, van den Brink MR, Ritz J, Shlomchik WD, Murphy WJ, Barrett AJ, Kolb HJ, Giralt S, Bishop MR, Blazar BR, Falkenburg JH. NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction. Biol Blood Marrow Transplant. 2010 May;16(5):565-86. Epub 2010 Feb 10. PubMed PMID: 20152921; PubMed Central PMCID: PMC2858433. Full Text
Bleakley M, Otterud BE, Richardt JL, Mollerup AD, Hudecek M, Nishida T, Chaney CN, Warren EH, Leppert MF, Riddell SR. Leukemia-associated minor histocompatibility antigen discovery using T-cell clones isolated by in vitro stimulation of naive CD8+ T cells. Blood. 2010 Jun 10;115(23):4923-33. Epub 2010 Mar 4. PubMed PMID: 20203263; PubMed Central PMCID: PMC2890170. Full Text
Campregher PV, Srivastava SK, Deeg HJ, Robins HS, Warren EH. Abnormalities of the alphabeta T-cell receptor repertoire in advanced myelodysplastic syndrome. Exp Hematol. 2010 Mar;38(3):202-12. Epub 2009 Dec 24. PubMed PMID: 20035823; PubMed Central PMCID: PMC2826587. Full Text
Tykodi SS, Voong LN, Warren EH. Combining allogeneic immunotherapy with an mTOR inhibitor for advanced renal cell carcinoma. Bone Marrow Transplant. 2010 Aug;45(8):1360-2. Epub 2009 Dec 7. PubMed PMID: 19966847; PubMed Central PMCID:PMC2922048. Full Text
2009
McCarroll SA, Bradner JE, Turpeinen H, Volin L, Martin PJ, Chilewski SD, Antin JH, Lee SJ, Ruutu T, Storer B, Warren EH, Zhang B, Zhao LP, Ginsburg D, Soiffer RJ, Partanen J, Hansen JA, Ritz J, Palotie A, Altshuler D. Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease. Nat Genet. 2009 Dec;41(12):1341-4. PubMed PMID: 19935662; PubMed Central PMCID:PMC2804745. Full Text
Robins HS, Campregher PV, Srivastava SK, Wacher A, Turtle CJ, Kahsai O, Riddell SR, Warren EH, Carlson CS. Comprehensive assessment of T-cell receptorbeta-chain diversity in alphabeta T cells. Blood. 2009 Nov 5;114(19):4099-107. Epub 2009 Aug 25. PubMed PMID: 19706884; PubMed Central PMCID: PMC2774550. Full Text (Supplementary Material)
Warren EH. Genetic risk for colitis-associated colorectal cancer. Gut. 2009 Sep;58(9):1177-9. PubMed PMID: 19671548.
Vigorito AC, Campregher PV, Storer BE, Carpenter PA, Moravec CK, Kiem HP, Fero ML, Warren EH, Lee SJ, Appelbaum FR, Martin PJ, Flowers ME; National Institutes of Health. Evaluation of NIH consensus criteria for classification of late acute and chronic GVHD. Blood. 2009 Jul 16;114(3):702-8. Epub 2009 May 21. PubMed PMID: 19470693; PubMed Central PMCID: PMC2713471. Full Text
Nishida T, Hudecek M, Kostic A, Bleakley M, Warren EH, Maloney D, Storb R, Riddell SR. Development of tumor-reactive T cells after nonmyeloablative allogeneic hematopoietic stem cell transplant for chronic lymphocytic leukemia. Clin Cancer Res. 2009 Jul 15;15(14):4759-68. Epub 2009 Jun 30. PubMed PMID: 19567591; PubMed Central PMCID: PMC2785487. Full Text
Spellman S, Warden MB, Haagenson M, Pietz BC, Goulmy E, Warren EH, Wang T, Ellis TM. Effects of mismatching for minor histocompatibility antigens on clinical outcomes in HLA-matched, unrelated hematopoietic stem cell transplants. Biol Blood Marrow Transplant. 2009 Jul;15(7):856-63. PubMed PMID: 19539218; PubMed Central PMCID: PMC2721718. Full Text
Chien JW, Zhao LP, Storer B, Martin PJ, Boeckh M, Warren EH, Hansen JA. Improving hematopoietic cell transplant outcomes in a new era of genomic research. Biol Blood Marrow Transplant. 2009 Jan;15(1 Suppl):42-5. Review. PubMed PMID: 19147077; PubMed Central PMCID: PMC2946198. Full Text
2008
Flowers ME, Storer B, Carpenter P, Rezvani AR, Vigorito AC, Campregher PV, Moravec C, Kiem HP, Fero M, Georges G, Warren E, Lee S, Sanders JE, Appelbaum F, Martin PJ. Treatment change as a predictor of outcome among patients with classic chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2008 Dec;14(12):1380-4. PubMed PMID: 19041060; PubMed Central PMCID: PMC2810860. Full Text
Tykodi SS, Fujii N, Vigneron N, Lu SM, Mito JK, Miranda MX, Chou J, Voong LN, Thompson JA, Sandmaier BM, Cresswell P, Van den Eynde B, Riddell SR, Warren EH. C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxicT cells from renal cell carcinoma patients. Clin Cancer Res. 2008 Aug 15;14(16):5260-9. PubMed PMID: 18698046; PubMed Central PMCID: PMC2693478. Full Text
Rosinski KV, Fujii N, Mito JK, Koo KK, Xuereb SM, Sala-Torra O, Gibbs JS, Radich JP, Akatsuka Y, Van den Eynde BJ, Riddell SR, Warren EH. DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells. Blood. 2008 May 1;111(9):4817-26. Epub 2008 Feb 25. PubMed PMID: 18299450; PubMed Central PMCID: PMC2343610. Full Text
2007
Campregher PV, Gooley T, Scott BL, Moravec C, Sandmaier B, Martin PJ, Deeg HJ, Warren EH, Flowers ME. Results of donor lymphocyte infusions for relapsed myelodysplastic syndrome after hematopoietic cell transplantation. Bone Marrow Transplant. 2007 Nov;40(10):965-71. Epub 2007 Sep 10. PubMed PMID: 17846603. Full Text
Terakura S, Murata M, Warren EH, Sette A, Sidney J, Naoe T, Riddell SR. A single minor histocompatibility antigen encoded by UGT2B17 and presented by human leukocyte antigen-A*2902 and -B*4403. Transplantation. 2007 May 15;83(9):1242-8. PubMed PMID: 17496542. Full Text
2006
Deeg HJ, Maris MB, Scott BL, Warren EH. Optimization of allogeneic transplant conditioning: not the time for dogma. Leukemia. 2006 Oct;20(10):1701-5. Epub 2006 Aug 3. Review. PubMed PMID: 16888618. Full Text
Warren EH, Vigneron NJ, Gavin MA, Coulie PG, Stroobant V, Dalet A, Tykodi SS, Xuereb SM, Mito JK, Riddell SR, Van den Eynde BJ. An antigen produced by splicing of noncontiguous peptides in the reverse order. Science. 2006 Sep 8;313(5792):1444-7. PubMed PMID: 16960008 Full Text
Deeg HJ, Storer BE, Boeckh M, Martin PJ, McCune JS, Myerson D, Heimfeld S, Flowers ME, Anasetti C, Doney KC, Hansen JA, Kiem HP, Nash RA, O'Donnell PV, Radich JP, Sandmaier BM, Scott BL, Sorror ML, Warren EH, Witherspoon RP, Woolfrey A, Appelbaum FR, Storb R. Reduced incidence of acute and chronic graft-versus-host disease with the addition of thymoglobulin to a targeted busulfan/cyclophosphamide regimen. Biol Blood Marrow Transplant. 2006 May;12(5):573-84. PubMed PMID: 16635793. Full Text
Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE, Foon KA, Hunt DF, Shabanowitz J, Engelhard VH, Riddell SR, Warren EH. The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL. Blood. 2006 May 1;107(9):3779-86. Epub 2006 Jan 3. PubMed PMID: 16391015; PubMed Central PMCID: PMC1895781. Full Text
Riddell SR, Bleakley M, Nishida T, Berger C, Warren EH. Adoptive transfer of allogeneic antigen-specific T cells. Biol Blood Marrow Transplant. 2006 Jan;12(1 Suppl 1):9-12. Review. PubMed PMID: 16399578. Full Text
Warren EH (2006) Minor histocompatibility antigens in allogeneic hematopoietic cell transplantation, Current Opinion in Organ Transplantation, 11, 31-36
Berger C, Flowers ME, Warren EH, Riddell SR. Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation. Blood. 2006 Mar 15;107(6):2294-302. Epub 2005 Nov 10. PubMed PMID: 16282341; PubMed Central PMCID: PMC1895724. Full Text
2004
Tykodi SS, Warren EH, Thompson JA, Riddell SR, Childs RW, Otterud BE, LeppertMF, Storb R, Sandmaier BM. Allogeneic hematopoietic cell transplantation for metastatic renal cell carcinoma after nonmyeloablative conditioning: toxicity, clinical response, and immunological response to minor histocompatibility antigens. Clin Cancer Res. 2004 Dec 1;10(23):7799-811. PubMed PMID: 15585611. Full Text
Torikai H, Akatsuka Y, Miyazaki M, Warren EH 3rd, Oba T, Tsujimura K, Motoyoshi K, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene. J Immunol. 2004 Dec 1;173(11):7046-54. PubMed PMID: 15557202. Full Text
Randolph SS, Gooley TA, Warren EH, Appelbaum FR, Riddell SR. Female donors contribute to a selective graft-versus-leukemia effect in male recipients of HLA-matched, related hematopoietic stem cell transplants. Blood. 2004 Jan 1;103(1):347-52. Epub 2003 Sep 11. PubMed PMID: 12969970. Full Text
2003
Deeg HJ, Gooley TA, Flowers ME, Sale GE, Slattery JT, Anasetti C, Chauncey TR, Doney K, Georges GE, Kiem HP, Martin PJ, Petersdorf EW, Radich J, Sanders JE, Sandmaier BM, Warren EH, Witherspoon RP, Storb R, Appelbaum FR. Allogeneic hematopoietic stem cell transplantation for myelofibrosis. Blood. 2003 Dec 1;102(12):3912-8. Epub 2003 Aug 14. PubMed PMID: 12920019. Full Text
Akatsuka Y, Warren EH, Gooley TA, Brickner AG, Lin MT, Hansen JA, Martin PJ, Madtes DK, Engelhard VH, Takahashi T, Riddell SR. Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling. Br J Haematol. 2003 Nov;123(4):671-5. PubMed PMID: 14616971. Full Text
Riddell SR, Berger C, Murata M, Randolph S, Warren EH. The graft versus leukemia response after allogeneic hematopoietic stem cell transplantation. Blood Rev. 2003 Sep;17(3):153-62. Review. PubMed PMID: 12818225. Full Text
Murata M, Warren EH, Riddell SR. A human minor histocompatibility antigen resulting from differential expression due to a gene deletion. J Exp Med. 2003 May 19;197(10):1279-89. Epub 2003 May 12. PubMed PMID: 12743171; PubMed Central PMCID: PMC2193779. Full Text
2002
Warren EH, Otterud BE, Linterman RW, Brickner AG, Engelhard VH, Leppert MF, Martin PJ, Riddell SR. Feasibility of using genetic linkage analysis to identify the genes encoding T cell-defined minor histocompatibility antigens. Tissue Antigens. 2002 Apr;59(4):293-303. PubMed PMID: 12135428. Full Text
Riddell SR, Murata M, Bryant S, Warren EH. T-cell therapy of leukemia. CancerControl. 2002 Mar-Apr;9(2):114-22. Review. PubMed PMID: 11965232.
2001
Brickner AG, Warren EH, Caldwell JA, Akatsuka Y, Golovina TN, Zarling AL, Shabanowitz J, Eisenlohr LC, Hunt DF, Engelhard VH, Riddell SR. The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing. J Exp Med. 2001 Jan 15;193(2):195-206. PubMed PMID: 11148223; PubMed Central PMCID: PMC2193344. Full Text
2000
Warren EH, Gavin MA, Simpson E, Chandler P, Page DC, Disteche C, Stankey KA, Greenberg PD, Riddell SR. The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen. J Immunol. 2000 Mar 1;164(5):2807-14. PubMed PMID: 10679124. Full Text
1999
Bonnet D, Warren EH, Greenberg PD, Dick JE, Riddell SR. CD8(+) minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8639-44. PubMed PMID: 10411928; PubMed Central PMCID: PMC17569. Full Text
1998
Warren EH, Gavin M, Greenberg PD, Riddell SR. Minor histocompatibility antigens as targets for T-cell therapy after bone marrow transplantation. Curr Opin Hematol. 1998 Nov;5(6):429-33. Review. PubMed PMID: 9814651.
Warren EH, Greenberg PD, Riddell SR. Cytotoxic T-lymphocyte-defined human minor histocompatibility antigens with a restricted tissue distribution. Blood.1998 Mar 15;91(6):2197-207. PubMed PMID: 9490709. Full Text
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