Accurate and faithful transfer of genetic information during cell duplication is critical for survival and the prevention of several diseases including cancers. This is particularly challenging because our cells are under constant assault from various stressors ranging from radiation exposure to viral infection. Our lab is interested in understanding the molecular mechanisms of genome maintenance; how cellular DNA integrity is maintained in response to different types of cellular insults, how these processes are dysregulated during genetic diseases, infections, aging and cancer, and how such knowledge can potentially be exploited towards novel therapies.
We employ cutting-edge genetic screening approaches to identify novel factors, followed by mechanistic molecular biology characterization to decipher how cellular DNA insults lead to genomic instability. Our interests also include the identification of therapeutic vulnerabilities of cancer cells as well as the delineation of host defense mechanisms against invading viral DNA.