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Post-doctoral Research Fellows

We are seeking highly motivated postdoctoral fellows interested in exploring how the dysregulation of chromatin modifying enzymes and developmental pathways contribute to pancreaticobiliary cancer pathogenesis and, further, whether these pathways present liabilities that can be exploited for cancer therapy.

The candidate is expected to have a PhD in the biological sciences and/or MD, a proven track record of productivity in science and a strong interest in cancer research. Applicants with specific expertise in RNA biology, biochemistry, cell biology, cancer genomics, animal models or computational biology are highly encouraged to apply. Proficiency in written and verbal English is required.

Fellows will be exposed to the rich and inclusive scientific environment at the Fred Hutch. They will learn to generate and exploit a series of cancer model systems including genetically engineered mouse models, patient-derived xenografts and novel human cancer cell lines to understand fundamental pathogenic mechanisms underlying pancreaticobiliary cancer. They will also get ample opportunity to present their work and be supported in their postdoctoral fellowship applications.

For more information, contact Dr. Kugel.


Research Technician I-II

We are accepting applications for a Research Technician position. The laboratory uses basic and translational research approaches to explore pathogenic mechanisms and novel targeted therapies in cholangiocarcinoma, a highly lethal malignancy of the liver bile ducts. Successful candidates will learn to generate and exploit a series of fundamental cancer model systems including genetically engineered murine models (GEMMs), patient-derived xenografts and novel human cancer cell lines.

In addition, the incumbent will have the opportunity to become involved with all the steps of research being completed by the group and contribute to publications, with the ultimate goal of translating their findings into novel clinical trials for cholangiocarcinoma patients. Scientific methodologies and areas of focus include animal models and murine genetics, molecular biology, cell biology and metabolism, proteomics, biochemistry, pharmacology, and genomics. The experience gained in the lab will useful for pursuing a career as a researcher or physician. 

Follow this link to apply.


Lab member Bryan Kynnap looking through a microscope.