The Markey lab was established in October 2021 at Fred Hutch in Seattle; we are a growing cross-disciplinary team that aims to draw together clinical knowledge, microbiology expertise, transplant immunology skills, molecular biology and sequencing techniques and computational biology. We aim to use both clinical samples and pre-clinical models to understand the relationships between the microbiome, the metabolites it produces and outcomes of cancer therapy, particularly for patients undergoing bone marrow transplantation and immunotherapy for hematological malignancies.
Sugar-rich foods exacerbate antibiotic-induced microbiome injury.
Dai A, Adintori PA, Funnell T, Jogia WP, Fei T, Waters NR, Rangesa M, Ballweg A, Gipson B, Raj S, Hayase E, Markey KA, Burgos da Silva M, Miltiadous O, Brambilla CZ, Buchan ML, Peets T, Gradissimo A, Smith N, Katsamakis Z, Warren A, Amoretti LA, Duan C, Zhang C, Matheis F, Sullivan AP, Slingerland JB, Clurman A, Brereton DG, Giardina PA, Gomes ALC, Johnson AJ, Knights D, Jenq RR, Perales MA, Giralt SA, Schluter J, van den Brink MRM, Peled J. bioRxiv. 2024 Oct 14;. doi: 10.1101/2024.10.14.617881. PubMed PMID: 39463943; PubMed Central PMCID: PMC11507691.
Smibert OC, Trubiano JA, Kwong JC, Markey KA, Slavin MA. BMJ Open. 2024 Sep 12;14(9):e085504. doi: 10.1136/bmjopen-2024-085504. PubMed PMID: 39266311; PubMed Central PMCID: PMC11440200.
Yeh AC, Koyama M, Waltner OG, Minnie SA, Boiko JR, Shabaneh TB, Takahashi S, Zhang P, Ensbey KS, Schmidt CR, Legg SRW, Sekiguchi T, Nelson E, Bhise SS, Stevens AR, Goodpaster T, Chakka S, Furlan SN, Markey KA, Bleakley ME, Elson CO, Bradley PH, Hill GR. Immunity. 2024 Jul 9;57(7):1648-1664.e9. doi: 10.1016/j.immuni.2024.05.018. Epub 2024 Jun 13. PubMed PMID: 38876098; PubMed Central PMCID: PMC11236519.
Lipocalin-2: a novel potential therapy for GVHD.
Markey KA. Trends Immunol. 2024 Apr;45(4):231-233. doi: 10.1016/j.it.2024.03.004. Epub 2024 Mar 27. PubMed PMID: 38548552.
Elkrief A, Waters NR, Smith N, Dai A, Slingerland J, Aleynick N, Febles B, Gogia P, Socci ND, Lumish M, Giardina PA, Chaft JE, Eng J, Motzer RJ, Mendelsohn RB, Markey KA, Zhuang M, Li Y, Yang Z, Hollmann TJ, Rudin CM, van den Brink MRM, Shia J, DeWolf S, Schoenfeld AJ, Hellmann MD, Babady NE, Faleck DM, Peled JU. Cancer Immunol Res. 2024 Mar 4;12(3):308-321. doi: 10.1158/2326-6066.CIR-23-0498. PubMed PMID: 38108398; PubMed Central PMCID: PMC10932930.
Lindner S, Miltiadous O, Ramos RJF, Paredes J, Kousa AI, Dai A, Fei T, Lauder E, Frame J, Waters NR, Sadeghi K, Armijo GK, Ghale R, Victor K, Gipson B, Monette S, Russo MV, Nguyen CL, Slingerland J, Taur Y, Markey KA, Andrlova H, Giralt S, Perales MA, Reddy P, Peled JU, Smith M, Cross JR, Burgos da Silva M, Campbell C, van den Brink MRM.. Nat Microbiol. 2024 Mar;9(3):614-630. doi: 10.1038/s41564-024-01617-w. Epub 2024 Mar 1. PubMed PMID: 38429422; PubMed Central PMCID: PMC11196888.
Blair LM, Akhund-Zade J, Katsamakis ZA, Smibert OC, Wolfe AE, Giardina P, Slingerland J, Bercovici S, Perales MA, Taur Y, van den Brink MRM, Peled JU, Markey KA. Blood Adv. 2023 Nov 14;7(21):6744-6750. doi: 10.1182/bloodadvances.2023010208. PubMed PMID: 37399491; PubMed Central PMCID: PMC10651422.
Microbes matter in pediatric allo-HSCT.
Smith M, Markey KA. Blood. 2023 Oct 19;142(16):1335-1337. doi: 10.1182/blood.2023021608. PubMed PMID: 37856093.