Researchers working in the J Lee Nelson lab

Selected Publications

20172016 | 20152014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2000 | 1999 | 1998 | 1997 | 1996 | 1994 | 1993


Nelson JL, Lambert NC.  Rheumatoid arthritis. Forward and reverse inheritance - the yin and the yang.  Nat Rev Rheumatol,13(7):396-7, 2017. PMID: 28592894

Kanaan SB, Gammill HS, Harrington WE, De Rosa SC, Stevenson PA, Forsyth AM, Allen J, Cousin E, van Besien K, Delaney CS, Nelson JL. Maternal microchimerism is prevalent in cord blood in memory T cells and other cell subsets, and persists post-transplantOncoimmunology 6(5):e1311436, 2017. PMCID: PMC5467984. PMID 28638735.

Harrington WE, Kanaan SB, Muehlenbachs A, Morrison R, Stevenson PA, Fried M, Duffy DENelson JL. Maternal microchimerism predicts increased infection but decreased disease due to P. falciparum during early childhood. J Infectious Dis 215(9):1445-51, 2017. PMID: 28329160.

Gentil CA, Gammill HS, Luu CT, Mayes MD, Furst DE, Nelson JL.  Characterization of HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis, Arthritis Res Therapy 19(1):46. doi: 10.1186/s13075-017-1253-9, 2017. PMCID: PMC5341397. PMID 28270189.

Milano F, Gammill HS, Oliver DC, Kanaan SB, Nelson JL, Delaney C.  Persistence of the losing cord blood unit following double cord blood transplantation: finding the unseen. Blood 130(12):1480-1482, 2017. doi: 10.1182/blood-2017-06-788513. PMC 5609336. PMID: 28765258.


Stevens AM, Kanaan SB, Torok KS, Medsger TA, Mayes MD, Reveille JD, Klein-Gitelman M, Reed AM, Lee T, Li SC, Henstorf G, Luu C, Aydelotte T, Lee Nelson J. Brief Report: HLA-DRB1, DQA1, and DQB1 in Juvenile-Onset Systemic Sclerosis. Arthritis Rheumatol. 2016 Nov;68(11):2772-2777. doi: 10.1002/art.39765. PubMed PMID: 27214100.


Mittal A, Pachter L, Nelson JL, Kjærgaard H, Smed MK, Gildengorin VL, Zoffmann V, Hetland ML, Jewell NP, Olsen J, Jawaheer D. Pregnancy-induced changes in systemic gene expression among healthy women and women with rheumatoid arthritis. PLoS One. 10(12):e0145204, 2015. PMCID: PMC4684291.


Gammill HS, Stephenson MD, Aydelotte TM, Nelson JL. Microchimerism in recurrent miscarriage. Cell Mol Immunol. 2014 Nov;11(6):589-94. doi: 10.1038/cmi.2014.82. PubMed PMID: 25242272; PubMed Central PMCID: PMC4220842.


Gammill HS, Aydelotte TM, Guthrie KA, Nkwopara EC, Nelson JL. Cellular fetal microchimerism in preeclampsia. Hypertension. 2013 Dec;62(6):1062-7. doi: 10.1161/HYPERTENSIONAHA.113.01486. PubMed PMID: 24101661; PubMed Central PMCID: PMC4395136.

Inamoto Y, Storer BE, Petersdorf EW, Nelson JL, Lee SJ, Carpenter PA, Sandmaier BM, Hansen JA, Martin PJ, Flowers ME. Incidence, risk factors, and outcomes of sclerosis in patients with chronic graft-versus-host disease. Blood. 2013 Jun 20;121(25):5098-103. doi: 10.1182/blood-2012-10-464198. PubMed PMID: 23547053; PubMed Central PMCID: PMC3689252.

Milano F, Nelson JL, Delaney C. Fetal maternal immunity and antileukemia activity in cord-blood transplant recipients. Bone Marrow Transplant. 2013 Mar;48(3):321-2. doi: 10.1038/bmt.2012.157. PubMed PMID: 23000655.

Mueller BA, Nelson JL, Newcomb PA. Intrauterine environment and multiple sclerosis: a population- based case-control study.Mult Scler. 2013 Jan;19(1):106-11. doi: 10.1177/1352458512447869. PubMed PMID: 22570360.


Nelson JL. The otherness of self: microchimerism in health and disease. Trends Immunol. 2012 Aug;33(8):421-7. doi: 10.1016/ Review. PubMed PMID: 22609148; PubMed Central PMCID: PMC3516290.

Chan WF, Gurnot C, Montine TJ, Sonnen JA, Guthrie KA, Nelson JL. Male microchimerism in the human female brain. PLoS One. 2012;7(9):e45592. doi: 10.1371/journal.pone.0045592. PubMed PMID: 23049819; PubMed Central PMCID: PMC3458919.

Burlingham WJ, Nelson JL.  Microchimerism in cord blood: mother as anti-cancer drug? Proc Natl Acad Sci USA 109(7):2190-1, 2012. PMCID: PMC3289348


Yan Z, Aydelotte T, Gadi VK, Guthrie KA, Nelson JL. Acquisition of the rheumatoid arthritis HLA shared epitope through microchimerism. Arthritis Rheum. 2011 Mar;63(3):640-4. doi: 10.1002/art.30160. PubMed PMID: 21360493; PubMed Central PMCID: PMC3188444.

Gammill HS, Adams Waldorf KM, Aydelotte TM, Lucas J, Leisenring WM, Lambert NC, Nelson JL. Pregnancy, microchimerism, and the maternal grandmother. PLoS One. 2011;6(8):e24101. doi: 10.1371/journal.pone.0024101. PubMed PMID: 21912617; PubMed Central PMCID: PMC3166068.


Gammill HS, Guthrie KA, Aydelotte TM, Adams Waldorf KM, Nelson JL. Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host? Blood. 2010 Oct 14;116(15):2706-12. doi: 10.1182/blood-2010-02-270942. PubMed PMID: 20628146; PubMed Central PMCID: PMC2974583.

Sunku CC, Gadi VK, de Laval de Lacoste B, Guthrie KA, Nelson JL. Maternal and fetal microchimerism in granulocytes. Chimerism. 2010 Jul-Sep;1(1):11-4. doi: 10.4161/chim.1.1.13098. PubMed PMID: 21327147; PubMed Central PMCID: PMC3035109.

Guthrie KA, Dugowson CE, Voigt LF, Koepsell TD, Nelson JL. Does pregnancy provide vaccine-like protection against rheumatoid arthritis? Arthritis Rheum. 2010 Jul;62(7):1842-8. doi: 10.1002/art.27459. PubMed PMID: 20309863; PubMed Central PMCID: PMC2910625.


Stevens AM, Hermes HM, Kiefer MM, Rutledge JC, Nelson JL. Chimeric maternal cells with tissue-specific antigen expression and morphology are common in infant tissues. Pediatr Dev Pathol. 2009 Sep-Oct;12(5):337-46. doi: 10.2350/08-07-0499.1. PubMed PMID: 18939886; PubMed Central PMCID: PMC2783488.

Guthrie KA, Tishkevich NR, Nelson JL. Non-inherited maternal human leukocyte antigen alleles in susceptibility to familial rheumatoid arthritis. Ann Rheum Dis. 2009 Jan;68(1):107-9. doi: 10.1136/ard.2008.092312. PubMed PMID: 18684745; PubMed Central PMCID: PMC2760537.

Nelson JL. Naturally acquired microchimerism: for better or for worse. Arthritis Rheum. 2009 Jan;60(1):5-7. doi: 10.1002/art.24217. PubMed PMID: 19116911; PubMed Central PMCID: PMC2693961.


Nelson JL. Your cells are my cells. Sci Am. 2008 Feb;298(2):64-71. PubMed PMID: 18376674.

Gadi VK, Malone KE, Guthrie KA, Porter PL, Nelson JL. Case-control study of fetal microchimerism and breast cancer. PLoS One. 2008 Mar 5;3(3):e1706. doi: 10.1371/journal.pone.0001706. PubMed PMID: 18320027; PubMed Central PMCID: PMC2248618.


Gadi VK, Nelson JL. Fetal microchimerism in women with breast cancer. Cancer Res. 2007 Oct 1;67(19):9035-8. PubMed PMID: 17909006.

Nash RA, McSweeney PA, Crofford LJ, Abidi M, Chen CS, Godwin JD, Gooley TA, Holmberg L, Henstorf G, LeMaistre CF, Mayes MD, McDonagh KT, McLaughlin B, Molitor JA, Nelson JL, Shulman H, Storb R, Viganego F, Wener MH, Seibold JR, Sullivan KM, Furst DE. High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study. Blood. 2007 Aug 15;110(4):1388-96. PubMed PMID: 17452515; PubMed Central PMCID: PMC1939909.

Adams KM, Yan Z, Stevens AM, Nelson JL. The changing maternal "self" hypothesis: a mechanism for maternal tolerance of the fetus. Placenta. 2007 May-Jun;28(5-6):378-82. PubMed PMID: 16934327.

Nelson JL, Gillespie KM, Lambert NC, Stevens AM, Loubiere LS, Rutledge JC, Leisenring WM, Erickson TD, Yan Z, Mullarkey ME, Boespflug ND, Bingley PJ, Gale EA. Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerism. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1637-42. PubMed PMID: 17244711; PubMed Central PMCID: PMC1785262.


Loubière LS, Lambert NC, Flinn LJ, Erickson TD, Yan Z, Guthrie KA, Vickers KT, Nelson JL. Maternal microchimerism in healthy adults in lymphocytes, monocyte/macrophages and NK cells. Lab Invest. 2006 Nov;86(11):1185-92. PubMed PMID: 16969370.

Yan Z, Lambert NC, Ostensen M, Adams KM, Guthrie KA, Nelson JL. Prospective study of fetal DNA in serum and disease activity during pregnancy in women with inflammatory arthritis. Arthritis Rheum. 2006 Jul;54(7):2069-73. PubMed PMID: 16804866.

Nash RA, McSweeney PA, Nelson JL, Wener M, Georges GE, Langston AA, Shulman H, Sullivan KM, Lee J, Henstorf G, Storb R, Furst DE. Allogeneic marrow transplantation in patients with severe systemic sclerosis: resolution of dermal fibrosis. Arthritis Rheum. 2006 Jun;54(6):1982-6. PubMed PMID: 16732546; PubMed Central PMCID: PMC2956579.

Gadi VK, Nelson JL, Boespflug ND, Guthrie KA, Kuhr CS. Soluble donor DNA concentrations in recipient serum correlate with pancreas-kidney rejection. Clin Chem. 2006 Mar;52(3):379-82. PubMed PMID: 16397013.


Yan Z, Lambert NC, Guthrie KA, Porter AJ, Loubiere LS, Madeleine MM, Stevens AM, Hermes HM, Nelson JL. Male microchimerism in women without sons: quantitative assessment and correlation with pregnancy history. Am J Med. 2005 Aug;118(8):899-906. PubMed PMID: 16084184.

Lambert NC, Pang JM, Yan Z, Erickson TD, Stevens AM, Furst DE, Nelson JL. Male microchimerism in women with systemic sclerosis and healthy women who have never given birth to a son. Ann Rheum Dis. 2005 Jun;64(6):845-8. PubMed PMID: 15550532; PubMed Central PMCID: PMC1755528.

Lucas KG, Nelson JL, Erickson TD, Sun Q. Microchimerism detection by human leucocyte antigen-specific quantitative-polymerase chain reaction analysis in recipients of allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes. Br J Haematol. 2005 May;129(3):443-4. PubMed PMID: 15842671.

Loubière LS, Lambert NC, Madeleine MM, Porter AJ, Mullarkey ME, Pang JM, Galloway DA, Furst DE, Nelson JL. HLA allelic variants encoding DR11 in diffuse and limited systemic sclerosis in Caucasian women. Rheumatology (Oxford). 2005 Mar;44(3):318-22. Erratum in: Rheumatology (Oxford). 2005 Apr;44(4):569. PubMed PMID: 15572392.

Mullarkey ME, Stevens AM, McDonnell WM, Loubière LS, Brackensick JA, Pang JM, Porter AJ, Galloway DA, Nelson JL. Human leukocyte antigen class II alleles in Caucasian women with primary biliary cirrhosis. Tissue Antigens. 2005 Feb;65(2):199-205. PubMed PMID: 15713222.


Stevens AM, McDonnell WM, Mullarkey ME, Pang JM, Leisenring W, Nelson JL. Liver biopsies from human females contain male hepatocytes in the absence of transplantation. Lab Invest. 2004 Dec;84(12):1603-9. PubMed PMID: 15502859.

Adams KM, Holmberg LA, Leisenring W, Fefer A, Guthrie KA, Tylee TS, McDonald GB, Bensinger WI, Nelson JL. Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation. Blood. 2004 Sep 15;104(6):1894-7. PubMed PMID: 15117763.

Adams KM, Nelson JL. Microchimerism: an investigative frontier in autoimmunity and transplantation. JAMA. 2004 Mar 3;291(9):1127-31. Review. PubMed PMID: 14996783.

Lambert NC, Erickson TD, Yan Z, Pang JM, Guthrie KA, Furst DE, Nelson JL. Quantification of maternal microchimerism by HLA-specific real-time polymerase chain reaction: studies of healthy women and women with scleroderma. Arthritis Rheum. 2004 Mar;50(3):906-14. PubMed PMID: 15022334.


Stevens AM, Hermes HM, Rutledge JC, Buyon JP, Nelson JL. Myocardial-tissue-specific phenotype of maternal microchimerism in neonatal lupus congenital heart block. Lancet. 2003 Nov 15;362(9396):1617-23. PubMed PMID: 14630442.

Adams KM, Lambert NC, Heimfeld S, Tylee TS, Pang JM, Erickson TD, Nelson JL. Male DNA in female donor apheresis and CD34-enriched products. Blood. 2003 Nov 15;102(10):3845-7. PubMed PMID: 12869496.


Lambert NC, Lo YM, Erickson TD, Tylee TS, Guthrie KA, Furst DE, Nelson JL. Male microchimerism in healthy women and women with scleroderma: cells or circulating DNA? A quantitative answer. Blood. 2002 Oct 15;100(8):2845-51. PubMed PMID: 12351394.

McSweeney PA, Nash RA, Sullivan KM, Storek J, Crofford LJ, Dansey R, Mayes MD, McDonagh KT, Nelson JL, Gooley TA, Holmberg LA, Chen CS, Wener MH, Ryan K, Sunderhaus J, Russell K, Rambharose J, Storb R, Furst DE. High-dose immunosuppressive therapy for severe systemic sclerosis: initial outcomes. Blood. 2002 Sep 1;100(5):1602-10. PubMed PMID: 12176878; PubMed Central PMCID: PMC2956742.


Lambert NC, Distler O, Müller-Ladner U, Tylee TS, Furst DE, Nelson JL. HLA-DQA1*0501 is associated with diffuse systemic sclerosis in Caucasian men. Arthritis Rheum. 2000 Sep;43(9):2005-10. PubMed PMID: 11014350.

Lambert NC, Evans PC, Hashizumi TL, Maloney S, Gooley T, Furst DE, Nelson JL. Cutting edge: persistent fetal microchimerism in T lymphocytes is associated with HLA-DQA1*0501: implications in autoimmunity. J Immunol. 2000 Jun 1;164(11):5545-8. PubMed PMID: 10820227.


Maloney S, Smith A, Furst DE, Myerson D, Rupert K, Evans PC, Nelson JL. Microchimerism of maternal origin persists into adult life. J Clin Invest. 1999 Jul;104(1):41-7. PubMed PMID: 10393697; PubMed Central PMCID: PMC408407.

Evans PC, Lambert N, Maloney S, Furst DE, Moore JM, Nelson JL. Long-term fetal microchimerism in peripheral blood mononuclear cell subsets in healthy women and women with scleroderma. Blood. 1999 Mar 15;93(6):2033-7. PubMed PMID: 10068676.


Nelson JL, Furst DE, Maloney S, Gooley T, Evans PC, Smith A, Bean MA, Ober C, Bianchi DW. Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. Lancet. 1998 Feb 21;351(9102):559-62. PubMed PMID: 9492775.


Nash RA, McSweeney PA, Storb R, Nelson JL, Gauthier J, Furst DE, Sullivan KM. Development of a protocol for allogeneic marrow transplantation for severe systemic sclerosis: paradigm for autoimmune disease. J Rheumatol Suppl. 1997 May;48:72-8. Review. PubMed PMID: 9150123.


Nelson JL. Maternal-fetal immunology and autoimmune disease: is some autoimmune disease auto-alloimmune or allo-autoimmune? Arthritis Rheum. 1996 Feb;39(2):191-4. PubMed PMID: 8849367.


Nelson JL, Dugowson CE, Koepsell TD, Voigt LF, Branchaud AM, Barrington RA, Wener MH, Hansen JA. Rheumatoid factor, HLA-DR4, and allelic variants of DRB1 in women with recent-onset rheumatoid arthritis. Arthritis Rheum. 1994 May;37(5):673-80. PubMed PMID: 8185694.


Nelson JL, Hughes KA, Smith AG, Nisperos BB, Branchaud AM, Hansen JA. Maternal-fetal disparity in HLA class II alloantigens and the pregnancy-induced amelioration of rheumatoid arthritis. N Engl J Med. 1993 Aug 12;329(7):466-71. PubMed PMID: 8332151.