Select Publications
O'Connor SA, Garcia L, Hoover R, Patel AP, Bartelle BB, Hugnot JP, Paddison PJ, Plaisier CL. Classifying cell cycle states and a quiescent-like G0 state using single-cell transcriptomics. bioRxiv [Preprint]. 2025 Jan 15:2024.04.16.589816. doi: 10.1101/2024.04.16.589816. PMID: 38659838; PMCID: PMC11042294. See article in PubMed
Olson JM, Paddison PJ. FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation and lethality in glioblastoma and other cancers. NAR Cancer. 2024 May 20;6(2):zcae021. doi: 10.1093/narcan/zcae021. PMID: 38774470; PMCID: PMC11106029. See article in PubMed
Mihalas AB, Arora S, O'Connor SA, Feldman HM, Arora, S, Bassett J, Mitchell K, Jin K, Hoellerbauer P, Delegard J, Ling M, Jenkins W, Kufeld M, Corrin P, Carter L, Holland E, Aronow B, Plaisier C, Patel AP, and Paddison PJ. KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma. bioRxiv doi.org/10.1101/2022.03.17.484768, 2023. See article in bioRxiv
Hoellerbauer P, Biery MC, Arora S, Rao Y, Girard EJ, Mitchell K, Dighe P, Kufeld M, Kuppers DA, Herman JA, Holland EC, Soroceanu L, Vitanza NA, Olson JM, Pritchard JR, Paddison PJ. Functional genomic analysis of adult and pediatric brain tumor isolates. bioRxiv [Preprint]. 2023 Jan 6:2023.01.05.522885. doi: 10.1101/2023.01.05.522885. PMID: 36711964; PMCID: PMC9881972. See article in bioRxiv
Anca B. Mihalas, Sonali Arora, Samantha A. O’Connor, Heather M. Feldman, Christine E. Cucinotta, Kelly Mitchell, John Bassett, Dayoung Kim, Kang Jin, Pia Hoellerbauer, Jennifer Delegard, Melissa Ling, Wesley Jenkins, Megan Kufeld, Philip Corrin, Lucas Carter, Toshio Tsukiyama, Bruce Aronow, Christopher L. Plaisier, Anoop P. Patel, Patrick J. Paddison. KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma. bioRxiv 2022.03.17.484768; doi: 10.1101/2022.03.17.484768. See article in bioRxiv
Herman JA, Arora S, Carter L, Zhu J, Biggins S, Paddison PJ. Functional dissection of human mitotic genes using CRISPR-Cas9 tiling screens. Genes Dev. 2022 Apr 1;36(7-8):495-510. doi: 10.1101/gad.349319.121. Epub 2022 Apr 28. PMID: 35483740; PMCID: PMC9067404. See article in PubMed
O'Connor SA, Feldman HM, Arora S, Hoellerbauer P, Toledo CM, Corrin P, Carter L, Kufeld M, Bolouri H, Basom R, Delrow J, McFaline-Figueroa JL, Trapnell C, Pollard SM, Patel A, Paddison PJ*, Plaisier CL*. Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma. Mol Syst Biol. 2021 Jun;17(6):e9522. doi: 10.15252/msb.20209522. PMID: 34101353; PMCID: PMC8186478. in PubMed
*Co-corresponding authors
Hoellerbauer P, Kufeld M, Paddison PJ. Efficient Multi-Allelic Genome Editing of Primary Cell Cultures via CRISPR-Cas9 Ribonucleoprotein Nucleofection. Curr Protoc Stem Cell Biol. 2020 Sep;54(1):e126. doi: 10.1002/cpsc.126. PMID: 32833346. See article in PubMed
Pattwell SS, Arora S, Cimino PJ, Ozawa T, Szulzewsky F, Hoellerbauer P, Bonifert T, Hoffstrom BG, Boiani NE, Bolouri H, Correnti CE, Oldrini B, Silber JR, Squatrito M, Paddison PJ, Holland EC. A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways. Nat Commun. 2020 Jun 12;11(1):2977. doi: 10.1038/s41467-020-16786-5. PMID: 32532995; PMCID: PMC7293284. See article in PubMed
Kuppers DA, Arora S, Lim Y, Lim AR, Carter LM, Corrin PD, Plaisier CL, Basom R, Delrow JJ, Wang S, Hansen He H, Torok-Storb B, Hsieh AC, Paddison PJ. N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis. Nat Commun. 2019 Oct 10;10(1):4596. doi: 10.1038/s41467-019-12518-6. PMID: 31601799; PMCID: PMC6787028. See article in PubMed
Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, Levy S, Robitaille AM, Ferreccio A, Bottorff T, McAlister A, Somasundaram L, Artoni F, Battle S, Hawkins RD, Moon RT, Ware CB, Paddison PJ, Ruohola-Baker H. Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency. Nat Commun. 2019 Feb 7;10(1):632. doi: 10.1038/s41467-018-08020-0. PMID: 30733432; PMCID: PMC6367455. See article in PubMed
Pollak J, Rai KG, Funk CC, Arora S, Lee E, Zhu J, Price ND, Paddison PJ, Ramirez JM, Rostomily RC. Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy. PLoS One 2017;12(3):e0172884. PMID: 28264064 PMC5338779.
Toledo CM, DY, Hoellerbauer P, Davis RJ, Basom R, Girard EJ, Lee E, Corrin P, Hart T, Bolouri H, Davison J, Zhang Q, Hardcastle J, Aronow BJ, Plaisier CL, Baliga NS, Moffat J, Lin Q, Li X-N, Nam D-H, Lee J, Pollard SM, Zhu J, Delrow JJ, Clurman BE, Olson JM, and Paddison PJ. Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells, Cell Reports. 2015. PMID 26673326 PMC 4691575. See Science Spotlight article.
Toledo CM*, Herman JA*, Olsen JB, Ding Y, Corrin P, Girard EJ, Olson JM, Emili A, DeLuca JG, and Paddison PJ. BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment. Dev Cell 28(3): 282-94, 2014. PMID 24462187, PMC 3995079
(*These authors contributed equally to this work).
Hubert CG, Bradley RK, Ding Y, Toledo CM, Herman J, Skutt-Kakaria K, Girard EJ, Davison J, Berndt J, Corrin P, Hardcastle J, Basom R, Delrow JJ, Webb T, Pollard SM, Lee J, Olson JM, and Paddison PJ. Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A. Genes Dev. 27:1032-45, 2013. PMID 23651857, PMC3656321 comment in Cancer Discovery
Betschinger J, Nichols J, Dietmann S, Corrin P, Paddison PJ, Smith A. Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell 153: 335-47, 2013. PMID: 23582324, PMC3661979
Ding Y, Hubert CG, Herman J, Corrin P, Toledo CM, Skutt-Kakaria K, Vazquez J, Basom R, Zhang B, Risler JK, Pollard SM, Nam DH, Delrow JJ, Zhu J, Lee J, DeLuca J, Olson JM, Paddison PJ. Cancer-Specific requirement for BUB1B/BUBR1 in human brain tumor isolates and genetically transformed cells. Cancer Discov. 3:198-211, 2013. PMID: 23154965, PMC3632446 comment in Cancer Discovery
Chen X, Skutt-Kakaria K, Davison J, Ou YL, Choi E, Malik P, Loeb K, Wood B, Georges G, Torok-Storb B, Paddison PJ. G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment. Genes Dev. 26:2499-511, 2012. PMID: 23105005, PMC3505820. See Science Spotlight article.
Paddison PJ. RNA interference in mammalian cell systems. In: RNA interference. Current Topics in Microbiology and Immunology. Paddison PJ, Vogt PK (eds.). Springer Press, 2008. PMID: 18268837
Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Gnoj L, Balija V, O’Shaughnessy A, Scobie K, Aruleba S, Chang K, Westbrook T, Sachidanandam R, McCombie WR, Elledge SJ, Hannon GJ. A resource for large-scale RNAi based screens in mammals. Nature 428: 427-431, 2004. PMID:15042091
Paddison PJ, Hannon GJ. RNA interference: The New Somatic Cell Genetics? Cancer Cell 2:17-23, 2002. PMID: 12150821
Chen X, Skutt-Kakaria K, Davison J, Ou YL, Choi E, Malik P, Loeb K, Wood B, Georges G, Torok-Storb B, Paddison PJ. G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment. Genes Dev. 26:2499-511, 2012. PMID: 23105005, PMC3505820. See Science Spotlight article.
Paddison PJ. RNA interference in mammalian cell systems. In: RNA interference. Current Topics in Microbiology and Immunology. Paddison PJ, Vogt PK (eds.). Springer Press, 2008. PMID: 18268837
Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Gnoj L, Balija V, O’Shaughnessy A, Scobie K, Aruleba S, Chang K, Westbrook T, Sachidanandam R, McCombie WR, Elledge SJ, Hannon GJ. A resource for large-scale RNAi based screens in mammals. Nature 428: 427-431, 2004. PMID:15042091
Paddison PJ, Hannon GJ. RNA interference: The New Somatic Cell Genetics? Cancer Cell 2:17-23, 2002. PMID: 12150821
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