Current Projects
Evaluating Centralizing Interventions to Address Low Adherence to Lung Cancer Screening Follow-up in Decentralized Settings (ACCELL)
Principal Investigator: Matty Triplette, MD, MPH
Co-Investigator: Karen Wernli, PhD; Lorella Palazzo, PhD; Gloria Coronado, PhD
Funding Agency: NIH 1R01CA284032-01
ClinicalTrials.gov ID: NCT06324110
Study dates: August 1, 2023 - July 31, 2028
This 5-year study is grounded in the Consolidated Framework of Implementation Research (CFIR) and RE-AIM frameworks to support our scientific goals and integrated with the National Institute on Minority Health and Health Disparities (NIMHD) Research Framework to ensure intervention design and evaluation center equity. To achieve our objectives, we will utilize a type 2 hybrid effectiveness-implementation trial, whereby both key effectiveness measures (adherence) and implementation of the interventions are evaluated.
Lung Health Promotion for American Indian and Alaska Native People Through Human Center Design (Lung PATHs)
Principal Investigator: Matty Triplette, MD, MPH
Co-Investigator: Ann Rusk, MD; Myra Parker, JD, PhD, MPH
Funding Agency: Bristol Myers Squibb Foundation (BMSF)
Study Dates: June 1, 2024 - May 31, 2027
Among all racial and ethnic groups, AI/AN people have the highest prevalence commercial tobacco use in the US, and are twice as likely to be currently smoking compared to non-Hispanic Whites in the Pacific Northwest region. Despite the demonstrated need, well-conducted research or program creation and evaluation to address lung cancer prevention in the AI/AN community has been extremely limited. The goal of this study is to develop a holistic care model for lung cancer primary and secondary prevention in partnership with urban AI/AN community members using principles of human centered design.
Strengthening Awareness and Community Resources for Early Detection of Lung cancer through Navigation Guided Screening (SACRED LUNGS)
Principal Investigator: Matty Triplette, MD, MPH
Co-Investigator: Parth Shah, PharmaD, PhD; Ursula Tsosie, MS; Jamie Nikander
Funding Agency: NIMHD U19MD020533
ClinicalTrials.gov ID: NCT07176000
Study Dates: September 21, 2024 - May 31, 2029
SACRED LUNGS is part of an overall U19 grant called CANOE. In partnership with the Community Engagement core, administration core, and another project here at Fred Hutch, we are aiming to expand health care resources to AI/AN communities. This project will adapt and evaluate a Patient Navigation intervention to support lung cancer screening and commercial smoking cessation in collaboration with tribal clinics across rural-urban areas of Western Washington through a pragmatic hybrid effectiveness-implementation trial.
Expanding Lung Cancer Screening to Achieve Excellence (EXHALE)
Principal Investigator: Karen Wernli, PhD
Co-Investigators: Matty Triplette, MD, MPH; Anne Escaron, PhD; Andrea Cook, PhD; Prajakta Adsul, PhD; Allison Cole, MD; Gloria Coronado, PhD; Lorella Palazzo, PhD; Sanjeev Arora, MD; Jeffrey Arroyo, MD
Funding Agency: NIH UG3CA305707
Study Dates: September 1, 2024 - August 31, 2031
EXHALE is a UG3/UH3 mechanism funded by the NIH and partners with Kaiser Permanente Washington Research Institute, University of New Mexico, University of Arizona, and AltaMed. This project will test Project ECHO (developed by University of New Mexico) and practice facilitation in 7 federally qualified health centers (FQHCs) to increase uptake of lung cancer screening.