Setty Lab

Setty Lab

Lake Union Steam Plant

Our Research

Welcome to the Setty Lab. We are a multi-disciplinary research group investigating the mechanisms of lineage decisions and cell-fate choices. We approach this fundamental problem by developing computational algorithms that model high-throughput single-cell genomics data using a broad array of machine learning techniques. We strongly believe in collaborative science and work in close conjunction with our collaborators in all aspects spanning experimental design of data collection, data analysis and modeling, and validation experiments.

Our lab is affiliated with the Basic Sciences Division, the Computational Biology Program, and the Translational Data Science Integrated Research Center. We will be physically located at the new Lake Union Steam Plant.

 

Featured Publications

The Emergent Landscape of the Mouse Gut Endoderm at Single-Cell Resolution
Nowotschin S, Setty M, Kuo YY, Liu V, Garg V, Sharma R, Simon CS, Saiz N, Gardner R, Boutet SC, Church DM, Hoodless PA, Hadjantonakis AK, Pe’er D. Nature 2019

Characterization of Cell Fate Probabilities in Single-Cell Data With Palantir
Setty M, Kiseliovas V, Levine J, Gayoso A, Mazutis L, Pe’er D. Nature Biotechnology 2019