Dr. Stamatatos’s Lab investigates B cell responses to infection and vaccination. We are particularly interested in monitoring the activation, survival, and maturation of B cell clonal lineages that produce protective antibodies against infectious agents, such as HIV-1, SARS-CoV-2, and Malaria. New immunogens and immunization regimens are developed to target these rare B cell lineages and are validated in vivo. To obtain the broadest and most detailed understanding of the immune responses elicited by our vaccine candidates, we employ diverse experimental approaches, including structure-based immunogen-design, X-ray crystallography and CryoEM, next generation deep sequencing, and immunological, molecular, and cellular techniques. The Lab’s work encompasses the entire space between pre-clinical and clinical evaluation of candidate vaccines.