Publications
2023
Liao SY, Rudoy D, Frank SB, Phan LT, Klezovitch O, Kwan J, Coleman I, Haffner MC, Li D, Nelson PS, Emili A, Vasioukhin V. SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer. Nat Commun. 2023 Nov 16;14(1):7435. doi: 10.1038/s41467-023-43245-8. PMID: 37973913; PMCID: PMC10654515.
Eifert T, Hsu CJ, Becker AL, Graessle S, Horne A, Bemmann F, Zhang Q, Heuser M, Vasioukhin V, Scholl S, Hochhaus A, Siegerist F, Endlich N, Bullinger L, Lane SW, Haas S, Schnoeder TM, Heidel FH. Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia. Leukemia. 2023 Oct;37(10):2027-2035. doi: 10.1038/s41375-023-02005-9. Epub 2023 Aug 16. PMID: 37587260; PMCID: PMC10539176.
Bii VM, Rudoy D, Klezovitch O, Vasioukhin V. Lethal giant larvae gene family ( Llgl1 and Llgl2 ) functions as a tumor suppressor in mouse skin epidermis. bioRxiv [Preprint]. 2023 Mar 8:2023.03.06.531408. doi: 10.1101/2023.03.06.531408. PMID: 36945368; PMCID: PMC10028895.
2021
Belitškin D, Pant SM, Munne P, Suleymanova I, Belitškina K, Hongisto HA, Englund J, Raatikainen T, Klezovitch O, Vasioukhin V, Li S, Wu Q, Monni O, Kuure S, Laakkonen P, Pouwels J, Tervonen TA, Klefström J. Hepsin regulates TGFβ signaling via fibronectin proteolysis. EMBO Rep. 2021 Nov 4;22(11):e52532. doi: 10.15252/embr.202152532. Epub 2021 Sep 13.PMID: 34515392
Biswas R, Banerjee A, Lembo S, Zhao Z, Lakshmanan V, Lim R, Le S, Nakasaki M, Kutyavin V, Wright G, Palakodeti D, Ross RS, Jamora C, Vasioukhin V, Jie Y, Raghavan S. Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells. Dev Cell. 2021 Mar 22;56(6):761-780.e7. doi: 10.1016/j.devcel.2021.02.020. Epub 2021 Mar 15.PMID: 33725480
Szulzewsky F, Holland EC, Vasioukhin V. YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance. Dev Biol. 2021 Jul;475:205-221. doi: 10.1016/j.ydbio.2020.12.018. Epub 2021 Jan 8.PMID: 33428889
2020
Raghavan S, Vasioukhin V. Staying connected under tension. Science. 2020 Nov 27;370(6520):1036-1037. doi: 10.1126/science.abf2782.PMID: 33243876
Szulzewsky F, Arora S, Hoellerbauer P, King C, Nathan E, Chan M, Cimino PJ, Ozawa T, Kawauchi D, Pajtler KW, Gilbertson RJ, Paddison PJ, Vasioukhin V, Gujral TS, Holland EC. Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis. Genes Dev. 2020 Aug 1;34(15-16):1051-1064. doi: 10.1101/gad.338681.120. Epub 2020 Jul 16.PMID: 32675324
Kaczorowski A, Tolstov Y, Falkenstein M, Vasioukhin V, Prigge ES, Geisler C, Kippenberger M, Nientiedt C, Ratz L, Kuryshev V, Herpel E, Kristiansen G, Sültmann H, Stenzinger A, Doeberitz MVK, Hohenfellner M, Duensing A, Duensing S.Rearranged ERG confers robustness to prostate cancer cells by subverting the function of p53. Urol Oncol. 2020 Sep;38(9):736.e1-736.e10. doi: 10.1016/j.urolonc.2020.06.016. Epub 2020 Jul 13.PMID: 32674955 Free article.
2019
Scott J, Thakar S, Mao Y, Qin H, Hejran H, Lee SY, Yu T, Klezovitch O, Cheng H, Mu Y, Ghosh S, Vasioukhin V, Zou Y. "Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function." iScience. 2019 Oct 25;20:25-41. doi: 10.1016/j.isci.2019.09.005. Epub 2019 Sep 9. PMID: 31546104; PMCID: PMC6817635.
2018
Frank S, Nelson P, Vasioukhin V. "Recent advances in prostate cancer research: large-scale genomic analyses reveal novel driver mutations and DNA repair defects." F1000Res. 2018 Aug 2;7:F1000 Faculty Rev-1173. doi: 10.12688/f1000research.14499.1. PMID: 30135717; PMCID: PMC6073096.
2017
Sreenath TL, Macalindong SS, Mikhalkevich N, Sharad S, Mohamed A, Young D, Borbiev T, Xavier C, Gupta R, Jamal M, Babcock K, Tan SH, Nevalainen MT, Dobi A, Petrovics G, Sesterhenn IA, Rosner IL, Bieberich CJ, Nelson P, Vasioukhin V, Srivastava S. "Erratum: ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development." Sci Rep. 2017 Sep 6;7(1):10693. doi: 10.1038/s41598-017-09612-4. Erratum for: Sci Rep. 2017 Apr 24;7(1):1109. PMID: 28878398; PMCID: PMC5587674.
Winters B, Brown L, Coleman I, Nguyen H, Minas TZ, Kollath L, Vasioukhin V, Nelson P, Corey E, Üren A, Morrissey C. "Inhibition of ERG Activity in Patient-derived Prostate Cancer Xenografts by YK-4-279." Anticancer Res. 2017 Jul;37(7):3385-3396. Doi: 10.21873/anticanres.11705. PMID: 28668826.
Beattie R, Postiglione MP, Burnett LE, Laukoter S, Streicher C, Pauler FM, Xiao G, Klezovitch O, Vasioukhin V, Ghashghaei TH, Hippenmeyer S. "Mosaic Analysis with Double Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells." Neuron. 2017 May 3;94(3):517-533.e3. doi: 10.1016/j.neuron.2017.04.012.
Sreenath TL, Macalindong SS, Mikhalkevich N, Sharad S, Mohamed A, Young D, Borbiev T, Xavier C, Gupta R, Jamal M, Babcock K, Tan SH, Nevalainen MT, Dobi A, Petrovics G, Sesterhenn IA, Rosner IL, Bieberich CJ, Nelson P, Vasioukhin V, Srivastava S. "ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development." Sci Rep. 2017 Apr 24;7(1):1109. Doi: 10.1038/s41598-017-01187-4.
Jossin Y, Lee M, Klezovitch O, Kon E, Cossard A, Lien WH, Fernandez TE, Cooper JA, Vasioukhin V. "Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells." Dev Cell. 2017 May 25. Pii: S1534-5807(17)30384-2. Doi: 10.1016/j.devcel.2017.05.002. [Epub ahead of print]
2016
Kwan J, Sczaniecka A, Heidary Arash E, Nguyen L, Chen CC, Ratkovic S, Klezovitch O, Attisano L, McNeill H, Emili A, Vasioukhin V. "DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2." Genes Dev. 2016 Dec 15;30(24):2696-2709. doi: 10.1101/gad.284539.116. PubMed PMID: 28087714; PubMed Central PMCID: PMC5238729.
Li P, Silvis MR, Honaker Y, Lien WH, Arron ST, Vasioukhin V. "αE-catenin inhibits a Src-YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway." Genes Dev. 2016 Apr 1;30(7):798-811. doi: 10.1101/gad.274951.115. Epub 2016 Mar 24. PubMed PMID: 27013234; PubMed Central PMCID: PMC4826396.
2015
Nguyen LT, Tretiakova MS, Silvis MR, Lucas J, Klezovitch O, Coleman I, Bolouri H, Kutyavin VI, Morrissey C, True LD, Nelson PS, Vasioukhin V. "ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors." Cancer Cell. 2015 Jun 8;27(6):797-808. doi: 10.1016/j.ccell.2015.05.005. PubMed PMID: 26058078; PubMed Central PMCID: PMC4461839.
Klezovitch O, Vasioukhin V. "Cadherin signaling: keeping cells in touch." F1000Res. 2015 Aug 12;4(F1000 Faculty Rev):550. doi: 10.12688/f1000research.6445.1. eCollection 2015. Review. PubMed PMID: 26339481; PubMed Central PMCID: PMC4544379.
2014
Wang SH, Celic I, Choi SY, Riccomagno M, Wang Q, Sun LO, Mitchell SP, Vasioukhin V, Huganir RL, Kolodkin AL. "Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization." J Neurosci. 2014 Sep 17;34(38):12745-61. doi: 10.1523/JNEUROSCI.1280-14.2014. PubMed PMID: 25232112; PubMed Central PMCID: PMC4166160.
Tang X, Mahajan SS, Nguyen LT, Béliveau F, Leduc R, Simon JA, Vasioukhin V. "Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis." Oncotarget. 2014 Mar 15;5(5):1352-62. PubMed PMID: 24657880; PubMed Central PMCID: PMC4012739.
2013
Klezovitch O, Vasioukhin V. "Your gut is right to turn left." Dev Cell. 2013 Sep 30;26(6):553-4. doi: 10.1016/j.devcel.2013.08.018. PubMed PMID: 24091006; PubMed Central PMCID: PMC3888821.
Nechiporuk T, Klezovitch O, Nguyen L, Vasioukhin V. "Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis." Dev Biol. 2013 May 15;377(2):375-84. doi: 10.1016/j.ydbio.2013.02.019. Epub 2013 Mar 4. PubMed PMID: 23466739; PubMed Central PMCID: PMC3652546. .
Heidel FH, Bullinger L, Arreba-Tutusaus P, Wang Z, Gaebel J, Hirt C, Niederwieser D, Lane SW, Döhner K, Vasioukhin V, Fischer T, Armstrong SA. "The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML." J Exp Med. 2013 Jan 14;210(1):15-22. doi: 10.1084/jem.20120596. Epub 2012 Dec 31. PubMed PMID: 23277453; PubMed Central PMCID: PMC3549713.
2012
Vasioukhin V*. "Adherens junctions and cancer." Subcell Biochem. 2012; 60:379-414.
Clark BS, Cui S, Miesfeld JB, Klezovitch O, Vasioukhin V, Link BA. "Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis." Development. 2012 May;139(9):1599-610. doi: 10.1242/dev.078097. PubMed PMID: 22492354; PubMed Central PMCID: PMC3317966.
2011
Sripathy S, Lee M, Vasioukhin V. "Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development." Mol Cell Biol. 2011 Jul;31(14):2920-33. doi: 10.1128/MCB.05431-11. Epub 2011 May 23. PubMed PMID: 21606200; PubMed Central PMCID: PMC3133403.
Silvis MR, Kreger BT, Lien WH, Klezovitch O, Rudakova GM, Camargo FD, Lantz DM, Seykora JT, Vasioukhin V. "α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1." Sci Signal. 2011 May 24;4(174):ra33. doi: 10.1126/scisignal.2001823. PubMed PMID: 21610251; PubMed Central PMCID: PMC3366274.
Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD. "Yap1 acts downstream of α-catenin to control epidermal proliferation." Cell. 2011 Mar 4;144(5):782-95. doi: 10.1016/j.cell.2011.02.031. PubMed PMID: 21376238; PubMed Central PMCID: PMC3237196.
2010
Mohamed AA, Tan SH, Mikhalkevich N, Ponniah S, Vasioukhin V, Bieberich CJ, Sesterhenn IA, Dobi A, Srivastava S, Sreenath TL. "Ets family protein, erg expression in developing and adult mouse tissues by a highly specific monoclonal antibody." J Cancer. 2010 Oct 25;1:197-208. PubMed PMID: 21060730; PubMed Central PMCID: PMC2974237.
Chang Y, Klezovitch O, Walikonis RS, Vasioukhin V, LoTurco JJ. "Discs large 5 is required for polarization of citron kinase in mitotic neural precursors." Cell Cycle. 2010 May 15;9(10):1990-7. Epub 2010 May 15. PubMed PMID: 20436275; PubMed Central PMCID: PMC4766976.
Nandana S, Ellwood-Yen K, Sawyers C, Wills M, Weidow B, Case T, Vasioukhin V, Matusik R. "Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model." Prostate. 2010 May 1;70(6):591-600. doi: 10.1002/pros.21093. PubMed PMID: 19938013; PubMed Central PMCID: PMC2925264.
Knudsen BS, Vasioukhin V. "Mechanisms of prostate cancer initiation and progression." Adv Cancer Res. 2010;109:1-50. doi: 10.1016/B978-0-12-380890-5.00001-6. Review. PubMed PMID: 21070913.
2009
Stepniak E, Radice GL, Vasioukhin V. "Adhesive and signaling functions of cadherins and catenins in vertebrate development." Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a002949. doi: 10.1101/cshperspect.a002949. Review. PubMed PMID: 20066120; PubMed Central PMCID: PMC2773643.
2008
Lien WH, Gelfand VI, Vasioukhin V. "Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic." J Cell Biol. 2008 Dec 15;183(6):989-97. doi: 10.1083/jcb.200805041. PubMed PMID: 19075109; PubMed Central PMCID: PMC2600751.
Lien WH, Stepniak E, Vasioukhin V. "Dissecting the role of cadherin-catenin proteins in mammalian epidermis." Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15225-6. doi: 10.1073/pnas.0808458105. Epub 2008 Oct 1. PubMed PMID: 18832145; PubMed Central PMCID: PMC2563091.
Lien W-H, Vasioukhin V*. "Cadherin-catenin complexes in tumor progression." Chapter in the monograph titled "Cancer Genome and Tumor Microenvironment". (2009) (Thomas-Tikhonenko, ed.) Springer.
Klezovitch O, Risk M, Coleman I, Lucas JM, Null M, True LD, Nelson PS, Vasioukhin V. "A causal role for ERG in neoplastic transformation of prostate epithelium." Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2105-10. doi: 10.1073/pnas.0711711105. Epub 2008 Feb 1. PubMed PMID: 18245377; PubMed Central PMCID: PMC2538886.
2007
Nechiporuk T, Fernandez TE, Vasioukhin V. "Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice." Dev Cell. 2007 Sep;13(3):338-50. PubMed PMID: 17765678; PubMed Central PMCID: PMC2023971.
2006
Lien WH, Klezovitch O, Vasioukhin V. "Cadherin-catenin proteins in vertebrate development." Curr Opin Cell Biol. 2006 Oct;18(5):499-506. Epub 2006 Jul 21. Review. PubMed PMID: 16859905.
Haegebarth A, Bie W, Yang R, Crawford SE, Vasioukhin V, Fuchs E, Tyner AL. "Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine." Mol Cell Biol. 2006 Jul;26(13):4949-57. PubMed PMID: 16782882; PubMed Central PMCID: PMC1489160.
Lien WH, Klezovitch O, Fernandez TE, Delrow J, Vasioukhin V. "alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway." Science. 2006 Mar 17;311(5767):1609-12. PubMed PMID: 16543460; PubMed Central PMCID: PMC2556178.
Nechiporuk T, Vasioukhin V. "Planar cell polarity planes the inconveniences of cell division into a smooth morphogenetic process." Dev Cell. 2006 Feb;10(2):153-4. PubMed PMID: 16459292.
Vasioukhin V. "Lethal giant puzzle of Lgl." Dev Neurosci. 2006;28(1-2):13-24. Review. PubMed PMID: 16508300.
2004
Vasioukhin V. "Hepsin paradox reveals unexpected complexity of metastatic process." Cell Cycle. 2004 Nov;3(11):1394-7. Epub 2004 Nov 28. PubMed PMID: 15539945.
Klezovitch O, Chevillet J, Mirosevich J, Roberts RL, Matusik RJ, Vasioukhin V. "Hepsin promotes prostate cancer progression and metastasis." Cancer Cell. 2004 Aug;6(2):185-95. PubMed PMID: 15324701.
Klezovitch O, Fernandez TE, Tapscott SJ, Vasioukhin V. "Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice." Genes Dev. 2004 Mar 1;18(5):559-71. PubMed PMID: 15037549; PubMed Central PMCID: PMC374237.
Nemade RV, Bierie B, Nozawa M, Bry C, Smith GH, Vasioukhin V, Fuchs E, Hennighausen L. "Biogenesis and function of mouse mammary epithelium depends on the presence of functional alpha-catenin." Mech Dev. 2004 Jan;121(1):91-9. PubMed PMID: 14706703; PubMed Central PMCID: PMC2405923.
2002
Vaezi A, Bauer C, Vasioukhin V, Fuchs E. "Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium." Dev Cell. 2002 Sep;3(3):367-81. PubMed PMID: 12361600.
2001
Vasioukhin V, Bauer C, Degenstein L, Wise B, Fuchs E. "Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin." Cell. 2001 Feb 23;104(4):605-17. PubMed PMID: 11239416.
Vasioukhin V, Fuchs E. "Actin dynamics and cell-cell adhesion in epithelia." Curr Opin Cell Biol. 2001 Feb;13(1):76-84. Review. PubMed PMID: 11163137.
2000
Derry JJ, Richard S, Valderrama Carvajal H, Ye X, Vasioukhin V, Cochrane AW, Chen T, Tyner AL. "Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability." Mol Cell Biol. 2000 Aug;20(16):6114-26. PubMed PMID: 10913193; PubMed Central PMCID: PMC86087.
Mulcahy HE, Lyautey J, Lederrey C, Chen XQ, Lefort F, Vasioukhin V, Anker P, Alstead EM, Farthing MJ, Stroun M. "Plasma DNA K-ras mutations in patients with gastrointestinal malignancies." Ann N Y Acad Sci. 2000 Apr;906:25-8. PubMed PMID: 10818591.
Stroun M, Maurice P, Vasioukhin V, Lyautey J, Lederrey C, Lefort F, Rossier A, Chen XQ, Anker P. "The origin and mechanism of circulating DNA." Ann N Y Acad Sci. 2000 Apr;906:161-8. PubMed PMID: 10818614.
Vasioukhin V, Bauer C, Yin M, Fuchs E. "Directed actin polymerization is the driving force for epithelial cell-cell adhesion." Cell. 2000 Jan 21;100(2):209-19. PubMed PMID: 10660044.
1999
Vasioukhin V, Degenstein L, Wise B, Fuchs E. "The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin." Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8551-6. PubMed PMID: 10411913; PubMed Central PMCID: PMC17554.
Llor X, Serfas MS, Bie W, Vasioukhin V, Polonskaia M, Derry J, Abbott CM, Tyner AL. "BRK/Sik expression in the gastrointestinal tract and in colon tumors." Clin Cancer Res. 1999 Jul;5(7):1767-77. PubMed PMID: 10430081.
1998
Gallicano GI, Kouklis P, Bauer C, Yin M, Vasioukhin V, Degenstein L, Fuchs E. "Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage." J Cell Biol. 1998 Dec 28;143(7):2009-22. PubMed PMID: 9864371; PubMed Central PMCID: PMC2175222.
1997
Vasioukhin V, Tyner AL. "A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation." Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14477-82. PubMed PMID: 9405638; PubMed Central PMCID: PMC25027.
Anker P, Lefort F, Vasioukhin V, Lyautey J, Lederrey C, Chen XQ, Stroun M, Mulcahy HE, Farthing MJ. "K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer." Gastroenterology. 1997 Apr;112(4):1114-20. PubMed PMID: 9097993.
1995
Vasioukhin V, Serfas MS, Siyanova EY, Polonskaia M, Costigan VJ, Liu B, Thomason A, Tyner AL. "A novel intracellular epithelial cell tyrosine kinase is expressed in the skin and gastrointestinal tract." Oncogene. 1995 Jan 19;10(2):349-57. PubMed PMID: 7838533.
1994
Vasioukhin V, Stroun M, Maurice P, Lyautey J, Lederrey C, Anker P*. "K-ras point mutations in the blood plasma DNA of patients with colorectal tumors." Challenges of Modern Medicine: Biotechnology Today." 1994 May; 5:141-150
Vasioukhin V, Anker P, Maurice P, Lyautey J, Lederrey C, Stroun M. "Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia." Br J Haematol. 1994 Apr;86(4):774-9. PubMed PMID: 7918071.
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