Statistical Methodology

* indicates corresponding authors

Dong, X., Zheng, Y., Zhao, Y. Q.∗(2023) ‘Constructing stabilized dynamic surveillance rules for optimal monitoring schedule’, Accepted, Biometrics.
[⋆⋆ An earlier version won an ENAR Distinguished Student Paper Award ⋆⋆] 

Liang, M, Choi, Y-G, Ning, Y., Smith, M. A., Zhao, Y. Q.* (2022) “Estimation and inference on high dimensional individualized treatment rule in observational data using split-and-pooled de-correlated score”, Journal of Machine Learning Research, 23 (262), pp. 1-65. LinkSoftware

Pan, Y. , Laber, E. B., Smith, M. A., Zhao, YQ.* Reinforced risk prediction with budget constraint using irregularly measured data from electronic health records. Journal of the American Statistical Association 2022 doi: 10.1080/01621459.2021.1978467. Link, Software

Zhang, S. , LeBlanc, M. L., Zhao, YQ.* (2022) Restricted survival benefit with right-censored data. Biometrical Journal 64(4), pp. 696-713.LinkSoftware

Choi, Y-G, Hanrahan, LP, Norton, D, Zhao, YQ.* (2022) Simultaneous spatial smoothing and outlier using penalized regression, with application to childhood obesity surveillance from electronic health records. Biometrics 78(1), pp. 324-336. DOI: 10.1111/biom.13404 LinkSoftware 
[⋆⋆ Results featured as cover image of Biometrics March 2022 issue. ⋆⋆] 

Pan Y, Zhao YQ.* Improved Doubly Robust Estimation in Learning Optimal Individualized Treatment Rules. Journal of the American Statistical Association 2021 116(533), pp. 283-294 DOI: 10.1080/01621459.2020.1725522. LinkSoftware

Meng H, Zhao,YQ, Fu H, Qiao X. (2020) Near-optimal Individualized Treatment Recommendations. Journal of Machine Learning Research 2020 20(48), 1-28. Link

Wang Y, Zhao YQ, Zheng Y. Learning-based Biomarker-assisted Rules for Optimized Clinical Benefit under a Risk-constraint. Biometrics 2020 76(3), pp. 853-862. LinkSoftware

Zhao YQ*, Zhu R, Chen G, Zheng Y. Constructing dynamic treatment regimes with shared parameters for censored data. Statistics in Medicine 2020 39(9), 1250-1263. LinkSoftware

Zhao YQ*, LeBlanc ML. Designing precision medicine trials to yield greater population impact. Biometrics 2020 76(2):643-653. LinkSoftware

Zhao YQ*, Redman MW, LeBlanc ML. Quantifying treatment effects using the personalized chance of longer survival. Statistics in Medicine 2019 38:5317-5331. Link

Zhao YQ*, Laber EB, Ning Y, Saha S, Sands B. Efficient augmentation and relaxation learning for treatment regimes using observational data. Journal of Machine Learning Research 2019 20(48)1-23. LinkSoftwareSupplementary

Zhao YQ*, Zeng D,Tangen CM, LeBlanc ML. Robustifying Trial-Derived Treatment Rules to a Target Population. Electronic Journal of Statistics 2019 13(1):1717-1743. Link, Software

Zhu R, Zhao YQ, Chen G, Ma S, Zhao H. Greedy outcome weighted tree learning of optimal personalized treatment rules. Biometrics 2017 Jun;73(2):391-400. PMCID: PMC5378692. Link

Chen J, Liu Y, Zeng D, Song R, Zhao YQ, Kosorok MR. Comment on Bayesian nonparametric estimation for dynamic treatment regimes with sequential transition times. Journal of the American Statistical Association 2016;111(515):942-947. PMC5167482. Link

Minsker S, Zhao YQ*, Cheng G. Active Clinical Trials for Personalized Medicine. Journal of the American Statistical Association 2016;111(514):875-887. PMCID: PMC5179145. LinkSoftware

Laber EB, Zhao YQ, Regh T, Davidian M, Tsiatis A, Stanford JB, Zeng D, Song R, Kosorok MR. Using pilot data to size a two-arm randomized trial to find a nearly optimal personalized treatment strategy. Statistics in Medicine 2016 15;35(8):1245-56. PMCID: PMC4777666. Link

Xu Y, Yu M, Zhao YQ, Li Q, Wang S, Shao J. Regularized outcome weighted subgroup identification for differential treatment effects. Biometrics 2015 Sep;71(3):645-53. PMCID: PMC5395466. [An earlier version won an ENAR John Van Ryzin Award] Link

Laber EB, Zhao YQ. Tree-based methods for individualized treatment regimes. Biometrika 2015;102(3):501-514. PMCID: PMC4755313. Link

Zhao YQ, Zeng D, Laber EB, Kosorok MR. New Statistical Learning Methods for Estimating Optimal Dynamic Treatment Regimes. Journal of the American Statistical Association 2015;110(510):583-598. PMCID: PMC4517946. LinkSoftware

Song R, Kosorok M, Zeng D, Zhao YQ, Laber E, Yuan M. On Sparse representation for Optimal Individualized Treatment Selection with Penalized Outcome Weighted Learning. Stat 2015;4(1):59-68. PMCID: PMC4394905. Link

Zhao YQ, Zeng D, Laber EB, Song R, Yuan M, Kosorok MR. Doubly Robust Learning for Estimating Individualized Treatment with Censored Data. Biometrika 2015 Mar 1;102(1):151-168. PMCID: PMC4414056. Link

Chakraborty B, Laber EB, Zhao YQ. Inference about the expected performance of a data-driven dynamic treatment regime. Clinical Trials 2014 Aug;11(4):408-417. PMCID: PMC4265005. LinkSoftware

Chakraborty, B., Laber, E., Zhao, YQ. Inference for optimal dynamic treatment regimes using an adaptive m-out-of-n bootstrap scheme. Biometrics 2013; 69;714-723. PMCID: PMC3864701 Link

Esserman D, Zhao YQ, Tang Y, Cai J. Sample size estimation in educational intervention trials with subgroup heterogeneity in only one arm. Statistics in Medicine 2013 May 30;32(12):2140-54. PMCID: PMC3615113. Link

Zhao YQ, Zeng D, Rush AJ, Kosorok MR. Estimating Individualized Treatment Rules Using Outcome Weighted Learning. Journal of the American Statistical Association  2012 Sep 1;107(449):1106-1118. PMCID: PMC3636816.  LinkSoftware,

Zhao YQ, Zeng D, Herring AH, Ising A, Waller A, Richardson D, Kosorok MR. Detecting disease outbreaks using local spatiotemporal methods. Biometrics 2011 Dec;67(4):1508-17. PMCID: PMC3698245. Link

Nadkarni NV, Zhao YQ, Kosorok MR. Inverse regression estimation for censored data. Journal of the American Statistical Association  2011 Mar 1;106(493):178-190. PMCID: PMC3110674. Link


Chari ST, Maitra A, Matrisian LM, Shrader EE, Wu BU, Kambadakone A, Zhao YQ, Kenner B, Rinaudo JAS, Srivastava S, Huang Y, Feng Z; Early Detection Initiative Consortium. Early Detection Initiative: A randomized controlled trial of algorithm-based screening in patients with new onset hyperglycemia and diabetes for early detection of pancreatic ductal adenocarcinoma. Contemp Clin Trials. 2021 Dec 23;113:106659. doi: 10.1016/j.cct.2021.106659. Link 

Zhao YQ*, Norton D, Hanrahan L. Small area estimation and childhood obesity surveillance using electronic health records. PLOS One. 2021; 16(2):e0247476. doi: 10.1371/journal.pone.0247476.  PMCID: PMC7895416. Link

Bartels CM, Johnson H, Voelker KV, Ogdie A, McBride P, Jacobs EA, Zhao YQ, Smith M. Frequency and predictors of communication about high blood pressure in rheumatoid arthritis visits. Journal of Clinical Rheumatology 2018 24(4):210–217. Link

Smith J, Jacobs E, Li Z, Vogelman B, Zhao YQ, Feldstein D. Successful Implementation of a Direct Observation Program in an Ambulatory Block Rotation. J Grad Med Educ. 2017 Feb;9(1):113-117. doi: 10.4300/JGME-D-16-00167.1. PubMed PMID: 28261405; PMCID: PMC5319609. Link

Caldera F, Saha S, Wald A, Cooley DM, Zhao YQ, Li Z, Bartels CM. Comparing guideline-based care quality for inflammatory bowel disease and rheumatoid arthritis patients within a medical home. Expert Rev Gastroenterol Hepatol. 2016 Jun;10(6):759-66. PMCID: PMC4970643. Link

Golden SK, Harringa JB, Pickhardt PJ, Ebinger A, Svenson JE, Zhao YQ, Li Z, Westergaard RP, Ehlenbach WJ, Repplinger MD. Prospective evaluation of the ability of clinical scoring systems and physician-determined likelihood of appendicitis to obviate the need for CT. Emerg Med J. 2016 Jul;33(7):458-64.  PMCID: PMC5443621. Link

Patterson BW, Pang PS, AlKhawam L, Hamedani AG, Mendonca EA, Zhao YQ, Venkatesh AK. The Association Between Use of Brain CT for Atraumatic Headache and 30-Day Emergency Department Revisitation. AJR Am J Roentgenol. 2016 Dec;207(6):W117-W124.  PMID: 27575483. Link

Flood TL, Zhao YQ, Tomayko EJ, Tandias A, Carrel AL, Hanrahan LP. Electronic health records and community health surveillance of childhood obesity. Am J Prev Med. 2015 Feb;48(2):234-240. PMCID: PMC4435797. Link

Saha S, Zhao YQ, Shah SA, Esposti SD, Lidofsky S, Shapiro J, Leleiko N, Bright R, Law M, Moniz H, Samad Z, Merrick M, Sands BE. Body image dissatisfaction in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2015 Feb;21(2):345-52.  PMCID: PMC4373552. Link

Zhao YQ, Zeng D. Recent development on statistical methods for personalized medicine discovery. Front Med. 2013 Mar;7(1):102-10.  PMID: 23377890. Link