Publications

Selected Publications

JS Park, Y Kaygusuz, C Kenum, L He, MI Gatie, X Zhuang, R Sharma, R Chaligne, UK Bhanot, RP Koche, T Tammela, AK Hadjantonakis, CM Rudin, J Massague. Nature Comm. (2026), L1CAM signaling through planar cell polarity drives SOX2 expression and lung adenocarcinoma metastasis.
Z Zhang, Y-J Ho, X Fang, M Kim, M Li, W Luan, C Hinterleitner, S Haubner, F Kogel, EC Pratt, E Ozcelik, J Reyes, Q Jiang, VW Yang, Y-J Chen, T Wang, H Liu, H Hu, X Zhuang, J Park, SV Paffenholz, K Chen, Q Chang, A Kulick, J Zhang, E Chan, E Rosiek, N Fan, RA Williams, AC Wang, S Freeman, S Tian, G Gunset, A Garcia Angus, N Lecomte, SY Yildirim, E Ali, M Wu, IC Miranda, CR Antonescu, O Basturk, Z Tarcan, N Rekhtman, C Wilson, M Basar, JL Sauter, HA Al-Ahmadie, S Singer, C Iacobuzio-Donahue, C Rudin, E de Stanchina, K Ganesh, PB Romesser, B Weigelt, DD Huh, J Leibold, J Feucht, I Vázquez-García, MJ Bott, D Zamarin, SP Shah, JS Lewis, C Amor, D Pe'er, J Mansilla-Soto, A Filliol, M Sadelain, SW Lowe. Cell (2026). A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy.
X Zhuang, ES Wong, T Tammela, LW Jones. Nature Reviews Cancer (2026). Stem cells as an essential mediator of the exercise–tumorigenesis link.
JE Chan, C-H Pan, J Rub, G Guzman, K Krause, E Brown, Z Zhang, H Styers, G Hartmann, Z Li, X Zhuang, SW Lowe. Nature (2026). Critical role for a high-plasticity cell state in lung cancer.

X Zhuang, Q Wang, J Simon, A Ferrena, D Humphreys, Z Li, M Blum, K Krause, S Ding, Y Landais, Y Zhan, Y Zhao, R Chaligny, J-H Lee, SE Carrasco, UK Bhanot, RP Koche, MJ Bott, P Katajisto, YM Soto-Feliciano, T Pisanic, T Thomas, D Zheng, ES Wong, T Tammela. Nature (2025). Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis.

Z Li*, X Zhuang*, C-H Pan, Y Yan, R Thummalapalli, J Hallin, S Torborg, A Singhal, JC Chang, E Manchado, LE Dow, R Yaeger, JG Christensen, SW Lowe, CM Rudin, S Joost, T Tammela. Cancer Discovery (2024). Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma.

GJ Koelwyn, X Zhuang, T Tammela, A Schietinger, LW Jones. Nature Metabolism (2020). Exercise and immunometabolic regulation in cancer.
M Cong, Y Wang, Y Yang, C Lian, X Zhuang, X Li, P Zhang, Y Liu, J Tang, Q Yang, X Zhang, H Xiong, R Hu, G Hu. Nature Cancer (2020). MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination.

X Zhuang, H Zhang, G Hu. Trends in Pharmacological Sciences (2019). Cancer and Microenvironment Plasticity: Double-Edged Swords in Metastasis.

X Zhuang, G Hu. Bio-protocol (2018). In vitro Osteoclastogenesis Assays Using Primary Mouse Bone Marrow Cells.
X Zhuang, H Zhang, XY Li, XX Li, M Cong, F Peng, J Yu, X Zhang, Q Yang*, G Hu*. Nature Cell Biology (2017). Differential Effects on Lung and Bone Metastasis of Breast Cancer by Wnt Signalling Inhibitor DKK1.
J Hu, G Li, P Zhang, X Zhuang, G Hu. Cell Death & Disease (2017). A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity.
J Yu*, R Lei*, X Zhuang, X Li, G Li, S Lev, MF Segura, X Zhang, G Hu. Nature Communications (2016). MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells.
Y Liang, J Hu, J Li, Y Liu, J Yu, X Zhuang, L Mu, X Kong, D Hong, Q Yang, G Hu. Cancer Research (2015). Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer.
F Chen, X Zhuang, L Lin, P Yu, Y Wang, Y Shi, G Hu, Y Sun. BMC Medicine (2015). New horizons in tumor microenvironment biology: challenges and opportunities.
Y Wang, R Lei, X Zhuang, N Zhang, H Pan, G Li, J Hu, X Pan, Q Tao, D Fu, J Xiao, YE Chin, Y Kang, Q Yang, G Hu. Journal of Clinical Investigation (2014). DLC1-dependent parathyroid hormone–like hormone inhibition suppresses breast cancer bone metastasis.