Viruses are important human pathogens that impose a global burden of morbidity and mortality each year. However, viruses and their hosts have been engaged in a constant battle for survival for millions of years. The evolutionary interplay between virus and host has resulted in a myriad of overlapping, complex and interconnected cellular pathways that are activated upon infection. Our lab aims to decipher the properties of viral infections across time scales to understand how these agents have shaped human evolution and influenced human history.