Blanco-Melo Lab

Blanco-Melo Lab

Digitally-colorized TEM images from CDC-PHIL.

Digitally-colorized TEM images from CDC-PHIL. Credits: Frederick Murphy, Cynthia Goldsmith, A. Harrison, P. Feorino, A. Balsh, Charles Humphrey & NIAID

Our Research

The Blanco-Melo Lab at Fred Hutch studies the strategies that animal hosts have deployed throughout evolution to combat viral infections. Through the combination of molecular biology, genomics and bioinformatics, we seek to characterize modern and ancient viral infections, understand the evolution of our antiviral immune response, and enable the design of broadly acting therapeutics against current and emerging viral threats.
 

Lab News

ancient viral genome graphic

Modulation of IAV NS1 expression reveals prioritization of host response antagonism. Now published in Frontiers Microbiology

join our team

Sophie Kogut wins the Advisory Board Favorite Fast Pitch at the 2024 TDS-IRC retreat. Contratulations Sophie!

Fred Hutch steam plant building

Daniel was named one of this year's SN10: Scientists to Watch by Science News Magazine. Check the full SN10 list here.


 

Viruses are important human pathogens that impose a global burden of morbidity and mortality each year. However, viruses and their hosts have been engaged in a constant battle for survival for millions of years. The evolutionary interplay between virus and host has resulted in a myriad of overlapping, complex and interconnected cellular pathways that are activated upon infection. Our lab aims to decipher the properties of viral infections across time scales to understand how these agents have shaped human evolution and influenced human history.

PaleoTimeline

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