Our Research

Dr Aude Chapuis is an oncologist who sees patients in the Bone Marrow Transplant and Immunotherapy services. She leads a laboratory employing a translational pipeline to improve T cell receptor (TCR) gene-engineered immunotherapy. Their work spans target identification, generation of high-affinity TCR constructs and standard operating methods to translate these constructs into effective cell products for patients, clinical trial development and initiation, and sophisticated high dimensional immune-monitoring to maximize the information that can be derived from each treated patient. Current projects include T cell therapies against virally-driven tumors (targeting Merkel-cell polyoma virus antigens in Merkel cell carcinoma), solid tumors (targeting the MAGE-A1 cancer-testis antigen in non-small cell lung cancer, triple negative breast cancer, and bladder cancers; and targeting WT1 antigen in thoracic and gynecological cancers), and leukemias (targeting two WT1 epitopes in acute myeloid leukemia). The lab benefits from a highly collaborative network at the Fred Hutch, including expert investigators in basic science, cancer immunology and immunotherapy, as well as disease-specific clinical oncologists.