Lab Members

Aude Chapuis, MD

Aude Chapuis, MD

Title: Principal Investigator
Phone: 206.667.4369

Clinical Research Division, Program in Immunology
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Frank Schmitz

Frank Schmitz

Title: Affiliate Investigator
Sinéad Kinsella, PhD

Sinéad Kinsella, PhD

Title: Staff Scientist
Area of Responsibility: Sinéad is focused on TCR discovery and metabolic regulation of antigen presentation across multiple tumor types. Previously, Sinéad’s research has centered on the molecular mechanisms of immune regeneration and enhancing immune function in response to cytoreductive therapies.
Shihong Zhang, PhD

Shihong Zhang, PhD

Title: Staff Scientist
Area of Responsibility: Shihong's work focuses on improving the efficacy of TCR T cell therapy by adding a costimulatory receptor to the T cells. She now has multiple costimulatory receptor candidates that can increase the binding of TCR T cells to tumor cells and/or give the T cells additional stimulation signals to help with the fitness and functionality of the T cells. She will find the winning receptor by next generation sequencing after in vitro and in vivo stimulation of mixed T cells, and eventually take it to the clinics.
Yuta Asano

Yuta Asano

Title: Post Doctoral Research Fellow
Area of Responsibility: Yuta is working on development of T-cell immunotherapy for Merkel cell carcinoma. Outside the lab, he enjoys bouldering and chilling with his cat.
Denise Buenrostro, PhD

Denise Buenrostro, PhD

Title: Post-Doctoral Research Fellow
Area of Responsibility: Denise is working on common DNA viruses that cause serious complications and even death for post-transplant patients. The goal is to engineer and transfer virus-specific T cells that will enhance their virus-specific T cell immunity. If we can control viral reactivation and infection, we can save more lives.
Tianzi Zhang

Tianzi Zhang

Title: Post Doctoral Research Fellow
Area of Responsibility: Tianzi is working on developing a high-throughput screening system that enables rapid patient-specific CD8+ TCR-antigen pair discovery. By using single-cell transcriptomic sequencing and TCR sequencing, the TCRs with high antigen specificity and anti-tumor reactivity will be engineered in lab and translated into the clinic.
Elise Wilcox, PhD

Elise Wilcox, PhD

Title: Post Doctoral Research Fellow
Area of Responsibility: Elise studies how different versions of the proteosome, a complex which breaks proteins down into peptides presented on the cell surface, affect immune recognition by T cells. The goal is to prevent cancer from evading treatment and to determine which T cell receptors recognize peptides made by all versions of the proteosome. Outside of the lab, she loves running, baking, and flying planes.
Francesco Mazziotta

Francesco Mazziotta

Title: Post Doctoral Research Fellow
Miranda Lahman

Miranda Lahman

Title: Graduate Student
Area of Responsibility: Miranda is a M3D graduate student. Her research advances cell therapies by uncovering how cancer resists these treatments. Her PhD thesis has two main foci. The first is understanding how cancer can modify antigen processing (primarily done be the proteasome) to confer resistance to our T cell receptor (TCR) based therapy. The second is a collaboration with the Strong Lab using their innovative peptide discovery platform, Artemis. She is particularly interested in using Artemis to understand contributions from individual proteasome isoforms and reveal new TCR therapy targets.
Steph Lee-Diaz

Steph Lee-Diaz

Title: Research Lab Manager
Bo Lee

Bo Lee

Title: Research Technician
Area of Responsibility: Bo is working to develop target reporters to identify the targets of anti-tumor T cells residing in the tumors of cancer patients. She is also assisting in developing processes to support clinical products and IND generation to enable clinical trial initiation.
Lauren Martin

Lauren Martin

Title: Research Technician
Colton Smith

Colton Smith

Title: Research Technician
Phone: 206-667-4475
Alex Tang

Alex Tang

Title: Research Technician