Lab Members

Clinical Research Division, Program in Immunology
Endowed Chair: John C. and Karyl Kay Hughes Endowed Chair
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Area of Responsibility: Bo is working to develop target reporters to identify the targets of anti-tumor T cells residing in the tumors of cancer patients. She is also assisting in developing processes to support clinical products and IND generation to enable clinical trial initiation.

Area of Responsibility: Francesco Mazziotta's research focuses on the immunobiology of acute myeloid leukemia and the development of novel cancer immunotherapies. His work investigates the mechanisms of immune system dysfunction in cancer and aims to improve treatment outcomes by modulating immune responses. Previously, Francesco's research has elucidated the role of specific immune cell subsets in therapy resistance and survival, leading to potential new strategies for first-line treatments in acute myeloid leukemia. Francesco also worked as a clinician specializing in hematologic malignancies in Italy.

Area of Responsibility: Sinéad is focused on TCR discovery and metabolic regulation of antigen presentation across multiple tumor types. Previously, Sinéad’s research has centered on the molecular mechanisms of immune regeneration and enhancing immune function in response to cytoreductive therapies.

Area of Responsibility: Elise studies how different versions of the proteosome, a complex which breaks proteins down into peptides presented on the cell surface, affect immune recognition by T cells. The goal is to prevent cancer from evading treatment and to determine which T cell receptors recognize peptides made by all versions of the proteosome. Outside of the lab, she loves running, baking, and flying planes.

Area of Responsibility: Alex's project focuses on leveraging CD4 T cells and the tumor microenvironment to overcome tumor immune escape through HLA downregulation.

Area of Responsibility: Naina is working towards developing a cell based target reporter platform for T cell epitope discovery. She is also focused on exploring approaches to enhance TCR T cell therapy in patients with melanoma.