Lab Members

Clinical Research Division, Program in Immunology
Endowed Chair: John C. and Karyl Kay Hughes Endowed Chair
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Area of Responsibility: Bo is working to develop target reporters to identify the targets of anti-tumor T cells residing in the tumors of cancer patients. She is also assisting in developing processes to support clinical products and IND generation to enable clinical trial initiation.

Area of Responsibility: Francesco Mazziotta's research focuses on the immunobiology of acute myeloid leukemia and the development of novel cancer immunotherapies. His work investigates the mechanisms of immune system dysfunction in cancer and aims to improve treatment outcomes by modulating immune responses. Previously, Francesco's research has elucidated the role of specific immune cell subsets in therapy resistance and survival, leading to potential new strategies for first-line treatments in acute myeloid leukemia. Francesco also worked as a clinician specializing in hematologic malignancies in Italy.

Area of Responsibility: Erica is a postdoctoral fellow with the Invent at Seattle Children’s program focused on the development of cellular immunotherapies for the treatment of cancer. In the Chapuis lab, she is developing novel ways to integrate “signal 2” into TCR-T cell therapeutics, independent of ligands in the tumor microenvironment (TME), to improve the potency and longevity of these cell therapies. Prior to joining the Chapuis lab, Erica researched mechanisms of T cell dysfunction in the ovarian cancer TME at the University of Pennsylvania. 

Area of Responsibility: Alex's project focuses on leveraging CD4 T cells and the tumor microenvironment to overcome tumor immune escape through HLA downregulation.

Area of Responsibility: Naina is working towards developing a cell based target reporter platform for T cell epitope discovery. She is also focused on exploring approaches to enhance TCR T cell therapy in patients with melanoma.