Lab Members
Aude Chapuis, MD
Title:
Principal Investigator
Phone:
206.667.4369
Email:
achapuis@fredhutch.org
Clinical Research Division, Program in Immunology
Endowed Chair: John C. and Karyl Kay Hughes Endowed Chair
View faculty profile
Bo Lee
Title:
Lab Manager/Staff Scientist
Email:
blee2@fredhutch.org
Area of Responsibility:
Bo is working to develop target reporters to identify the targets of anti-tumor T cells residing in the tumors of cancer patients. She is also assisting in developing processes to support clinical products and IND generation to enable clinical trial initiation.
Francesco Mazziotta
Title:
Immunotherapy Physician Scientist
Email:
fmazziot@fredhutch.org
Area of Responsibility:
Francesco Mazziotta's research focuses on the immunobiology of acute myeloid leukemia and the development of novel cancer immunotherapies. His work investigates the mechanisms of immune system dysfunction in cancer and aims to improve treatment outcomes by modulating immune responses. Previously, Francesco's research has elucidated the role of specific immune cell subsets in therapy resistance and survival, leading to potential new strategies for first-line treatments in acute myeloid leukemia. Francesco also worked as a clinician specializing in hematologic malignancies in Italy.
Sinéad Kinsella, PhD
Title:
Staff Scientist
Email:
skinsell@fredhutch.org
Area of Responsibility:
Sinéad is focused on TCR discovery and metabolic regulation of antigen presentation across multiple tumor types.
Previously, Sinéad’s research has centered on the molecular mechanisms of immune regeneration and enhancing immune function in response to cytoreductive therapies.
Tianzi Zhang
Title:
Post Doctoral Research Fellow
Email:
tzhang2@fredhutch.org
Area of Responsibility:
Tianzi is working on the immune monitoring study of a personalized tumor vaccines clinical trial to treat patients with PD-1 inhibitor refractory metastatic melanoma. Neoantigen peptides were synthesized and administered to the patients every 4 weeks in combination with the adjuvant Poly-ICLC and nivolumab. Biospecimens were longitudinally collected to characterize the antigen specificity of T cell receptors (TCRs) among tumor-infiltrating lymphocytes (TILs) and to evaluate the vaccine-induced, tumor-specific T cell responses.
Elise Wilcox, PhD
Title:
Post Doctoral Research Fellow
Email:
ewilcox@fredhutch.org
Area of Responsibility:
Elise studies how different versions of the proteosome, a complex which breaks proteins down into peptides presented on the cell surface, affect immune recognition by T cells. The goal is to prevent cancer from evading treatment and to determine which T cell receptors recognize peptides made by all versions of the proteosome. Outside of the lab, she loves running, baking, and flying planes.
Alex Chen
Title:
Graduate Student
Email:
hchen@fredhutch.org
Area of Responsibility:
Alex's project focuses on leveraging CD4 T cells and the tumor microenvironment to overcome tumor immune escape through HLA downregulation.
Naina Singhi
Title:
Graduate Student
Email:
nsinghi@fredhutch.org
Area of Responsibility:
Naina is working towards developing a cell based target reporter platform for T cell epitope discovery. She is also focused on exploring approaches to enhance TCR T cell therapy in patients with melanoma.
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© 2025 Fred Hutchinson Cancer Center, a 501(c)(3) nonprofit organization.