Intra-patient Tumor Heterogeneity

We meticulously investigate the variability within a single patient's tumor at both the temporal and anatomic levels. By analyzing how tumors evolve over time and differ across various locations within the body, we aim to uncover patterns and mechanisms that drive tumor progression and resistance to treatment. This knowledge is crucial for developing more effective, personalized treatment strategies that can adapt to the changing nature of a patient's cancer.

Tumor-microenvironmental Interactions

The relationship between a tumor and its surrounding environment is complex and dynamic. Our laboratory explores how tumors interact with the surrounding cells, tissues, and extracellular matrix, and how these interactions influence tumor growth, metastasis, and response to treatment. By dissecting these interactions, we aim to identify novel therapeutic targets within the tumor microenvironment that could be exploited to disrupt cancer progression and improve patient outcomes .

To achieve these goals, we employ a combination of sophisticated experimental models and techniques. Our toolkit includes genetically engineered mouse models that faithfully recapitulate human cancer, providing invaluable insights into tumor biology in a living organism. We also use a variety of cell lines that allow us to conduct detailed molecular and cellular studies under controlled conditions. Furthermore, our research is deeply integrated with clinical practice, as we utilize clinically derived samples to ensure that our findings are directly relevant to patient care.

Our comprehensive approach involves the interrogation of multiple genomic outputs, with a particular focus on genomic DNA and mRNA. By analyzing these genetic materials, we gain a deeper understanding of the genetic and transcriptomic landscapes of tumors. This enables us to identify key genetic alterations, gene expression patterns, and signaling pathways that drive cancer development and progression. Our research not only enhances our understanding of cancer biology but also paves the way for the development of innovative diagnostic tools and targeted therapies.

In addition to our scientific endeavors, our laboratory is committed to fostering a collaborative and inclusive research environment. We actively engage with other research groups, clinicians, and industry partners to accelerate the translation of our discoveries into clinical practice. By sharing our knowledge and resources, we aim to contribute to the global effort to combat cancer and improve the lives of patients worldwide.

Overall, our laboratory is dedicated to unraveling the complexities of cancer biology and translating our findings into tangible benefits for patients. Through our relentless pursuit of knowledge and innovation, we hope to make a lasting impact on the fight against cancer and move closer to the goal of eradicating these devastating diseases.

In addition to our scientific endeavors, our laboratory is committed to fostering a collaborative and inclusive research environment. We actively engage with other research groups, clinicians, and industry partners to accelerate the translation of our discoveries into clinical practice. By sharing our knowledge and resources, we aim to contribute to the global effort to combat cancer and improve the lives of patients worldwide.

Overall, our laboratory is dedicated to unraveling the complexities of cancer biology and translating our findings into tangible benefits for patients. Through our relentless pursuit of knowledge and innovation, we hope to make a lasting impact on the fight against cancer and move closer to the goal of eradicating these devastating diseases.