Executive Director, HIV Vaccine Trials Network (HVTN)
Medical Director, Seattle Malaria Clinical Trials Center (Seattle MCTC)
Principal Staff Scientist, Vaccine and Infectious Disease Division (Fred Hutch)
Clinical Associate Professor, Global Health (UW)

Research Interests:

• HIV and tuberculosis (Tb) vaccine research and development
• Human challenge experiments
• Microbiome modulation of immunity
• Immune activation—polymicrobial infections
• Combination HIV prevention
• Malaria clinical trials/vaccines
• Molecular epidemiology

Research Interests: 

• Intestinal and systemic immune responses
• Host-microbe interactions
• Early life conditioning of the immune system
• Data science tools to integrate microbiome data with patient metadata to predict treatment efficacy

Research Interests: 

• Infectious diseases epidemiology
• Global health
• Health systems and policy
• Health access for marginalized communities

Research Interests: 

• Influence of gut microbiota on local and systemic immune cell populations
• Gut regulatory T cells, tolerance to luminal antigens and gut microbiota
• Impact of gut immune cell populations on systemic vaccine responses
• Infectious diseases affecting underrepresented or marginalized populations 

Research interests:

• Role of gut microbiome in population vaccine response heterogeneity
• Immune correlates of protection in vaccine efficacy trials
• T cell clonal diversity and cross-reactivity
• Innate predictors of vaccine immunogenicity
• Immunologically-informed sieve analysis
• Determinants of immunodominance
• Host-genetics and vaccine efficacy

Research interests: 

• Functional metagenomic analysis of the human microbiome
• Impact of the microbiome on chemotherapeutic efficacy and vaccine response
• Role of strain-level microbial diversity influencing common human diseases

Research Interests: 

• Microbial ecology and community structure and function of gut ecosystems
• The relationship between gut microbes and their host
• The influence of commensal gut bacteria on host health and vaccine response

Research Interests:

• Role of the microbiome in determining vaccine efficacy
• Host-microbe interactions at the mucosal surface and their influence on systemic immunity
• Effects of microbe-microbe interactions and metabolism on host physiology
• Understanding innate and innate-like subset interactions with commensal microbial communities

Research Interests: 

• Prediction of immune response to vaccines / infections based on composition of the microbiota
• How local host-microbe interactions (e.g. in the gut) affect the behavior of the immune system at large
• The influence of the microbiota on immune tolerance / activation

Research Interests:

• Vaccine development, especially in the context of using vaccines to combat the rising tide of antibiotic resistance.
• Mechanisms of bacterial pathogenesis
• Immune evasion strategies pathogens use to subvert host defenses

Research Interests: 

• The effect of microbiome on vaccine efficacy and metabolism of treatment
• How host-genetics and environmental factors modulates the microbiome and immune system
• Characterizing the crosstalk between immune system and gut microbes

Research interests:

• Microbial community ecology
  Understanding how microorganisms are affected by and in term shape their environment, such as the human host or marine environments
• Examining how microorganisms shape the human immune systems’ response to vaccines
• Using computational tools, statistics, and modeling to illuminate microbiome-environment interactions.