For a complete list of publications, see Dr. David MacPherson's NCBI bibliography.

Selected Publications

2020 | 2019 | 2018 | 2017 | 2014  | 2012 | 2011  | 2008 | 2007 | 2004 | 2003 | 2002 | 2001 | 2000 | 1998

2021

Norton JP, Augert A, Eastwood E, Basom R, Rudin CM, MacPherson D. "Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas." Genes Dev. 2021 June:35(11-12):870-887.   PMID: 34016692

2020

Augert A, Mathsyaraja H, Ibrahim AH, Freie B, Geuenich MJ, Cheng PF, Alibeckoff SP, Wu N, Hiatt JB, Basom R, Gazdar A, Sullivan LB, Eisenman RN, MacPherson D. "MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer." Cancer Cell. 2020 May 13:S1535-6108(20)30215-4.   PMID: 32470392

Poirier JT, George J, Owonikoko TK, Berns A, Brambilla E, Byers LA, Carbone D, Chen HJ, Christensen CL, Dive C, Farago AF, Govindan R, Hann C, Hellmann MD, Horn L, Johnson JE, Ju YS, Kang S, Krasnow M, Lee J, Lee SH, Lehman J, Lok B, Lovly C, MacPherson D, McFadden D, Minna J, Oser M, Park K, Park KS, Pommier Y, Quaranta V, Ready N, Sage J, Scagliotti G, Sos ML, Sutherland KD, Travis WD, Vakoc CR, Wait SJ, Wistuba I, Wong KK, Zhang H, Daigneault J, Wiens J, Rudin CM, Oliver TG. "New Approaches to SCLC Therapy: From the Laboratory to the Clinic." J Thorac Oncol. 2020 Apr;15(4):520-540. doi: 10.1016/j.jtho.2020.01.016. Epub 2020 Feb 1. Review. PubMed PMID: 32018053; NIHMSID:NIHMS1555428.

Corella AN, Cabiliza Ordonio MVA, Coleman I, Lucas JM, Kaipainen A, Nguyen HM, Sondheim D, Brown LG, True LD, Lee JK, MacPherson D, Nghiem P, Gulati R, Morrissey C, Corey E, Nelson PS. "Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer. " Clin Cancer Res. 2020 Apr 1;26(7):1667-1677. doi: 10.1158/1078-0432.CCR-19-0775. Epub 2019 Dec 5. PubMed PMID: 31806643; PubMed Central PMCID: PMC7124974.

2019

Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF. "Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data." Nat Rev Cancer. 2019 May;19(5):289-297. doi: 10.1038/s41568-019-0133-9. Review. PubMed PMID: 30926931; PubMed Central PMCID: PMC6538259.

Hiatt JB, MacPherson D. "Delivering a STINGing Blow to Small Cell Lung Cancer via Synergistic Inhibition of DNA-Damage Response and Immune-Checkpoint Pathways." Cancer Discov. 2019 May;9(5):584-586. doi: 10.1158/2159-8290.CD-19-0234. PubMed PMID: 31043412.

Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton KD, Martins R, Poirier JT, Rudin CM, Milletti F, Cheng WY, Mack F, MacPherson D. "Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition." Sci Signal. 2019 Feb 5;12(567). doi: 10.1126/scisignal.aau2922. PubMed PMID: 30723171; PubMed Central PMCID: PMC6530478.

2018

Jia D, Augert A, Kim DW, Eastwood E, Wu N, Ibrahim AH, Kim KB, Dunn CT, Pillai SPS, Gazdar AF, Bolouri H, Park KS, MacPherson D. "Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition." Cancer Discov. 2018 Nov;8(11):1422-1437. doi: 10.1158/2159-8290.CD-18-0385. Epub 2018 Sep 4. PubMed PMID: 30181244; PubMed Central PMCID: PMC6294438.

2017

Augert A, Zhang Q, Bates B, Cui M, Wang X, Wildey G, Dowlati A, MacPherson D.  "Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance)." J Thorac Oncol. 2017 Apr;12(4):704-713. doi: 10.1016/j.jtho.2016.12.011. Epub 2016 Dec 19. PubMed PMID: 28007623; PubMed Central PMCID: PMC5669801.

Wu N, Jia D, Bates B, Basom R, Eberhart CG, MacPherson D.  "A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence." J Clin Invest. 2017 Mar 1;127(3):888-898. doi: 10.1172/JCI88508. Epub 2017 Feb 6. PubMed PMID: 28165337; PubMed Central PMCID: PMC5330763.

Kooi IE, van Mil SE, MacPherson D, Mol BM, Moll AC, Meijers-Heijboer H, Kaspers GJ, Cloos J, Te Riele H, Dorsman JC. "Genomic landscape of retinoblastoma in Rb-/- p130-/- mice resembles human retinoblastoma " Genes Chromosomes Cancer. 2017 Mar;56(3):231-242. doi: 10.1002/gcc.22429. Epub 2016 Nov 21. PubMed PMID: 27750399.

2016

Busch SE, Hanke ML, Kargl J, Metz HE, MacPherson D, Houghton AM.  "Lung Cancer Subtypes Generate Unique Immune Responses." J Immunol. 2016 Dec 1;197(11):4493-4503. doi: 10.4049/jimmunol.1600576. Epub 2016 Oct 31. PubMed PMID: 27799309; PubMed Central PMCID: PMC5116260.

Wu N, Jia D, Ibrahim AH, Bachurski CJ, Gronostajski RM, MacPherson D. "NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer. " Oncotarget. 2016 Sep 6;7(36):57514-57524. doi: 10.18632/oncotarget.11583. PubMed PMID: 27613844; PubMed Central PMCID: PMC5295369.

Kim DW, Wu N, Kim YC, Cheng PF, Basom R, Kim D, Dunn CT, Lee AY, Kim K, Lee CS, Singh A, Gazdar AF, Harris CR, Eisenman RN, Park KS, MacPherson D. "Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer." Genes Dev. 2016 Jun 1;30(11):1289-99. doi: 10.1101/gad.279307.116. PubMed PMID: 27298335; PubMed Central PMCID: PMC4911928.

Bunn PA Jr, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR.  "Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?" J Thorac Oncol. 2016 Apr;11(4):453-74. doi: 10.1016/j.jtho.2016.01.012. Epub 2016 Jan 30. Review. PubMed PMID: 26829312; PubMed Central PMCID: PMC4836290.

2015

Gazdar AF, Savage TK, Johnson JE, Berns A, Sage J, Linnoila RI, MacPherson D, McFadden DG, Farago A, Jacks T, Travis WD, Brambilla E. "The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung." J Thorac Oncol. 2015 Apr;10(4):553-64. doi: 10.1097/JTO.0000000000000459. PubMed PMID: 25675280; PubMed Central PMCID: PMC4523224.

2014

Augert A, MacPherson D. "Treating transcriptional addiction in small cell lung cancer." Cancer Cell. 2014 Dec 8;26(6):783-784. doi: 10.1016/j.ccell.2014.11.012. PubMed PMID: 25490443.

Dabir S, Babakoohi S, Kluge A, Morrow JJ, Kresak A, Yang M, MacPherson D, Wildey G, Dowlati A.  "RET mutation and expression in small-cell lung cancer. " J Thorac Oncol. 2014 Sep;9(9):1316-23. doi: 10.1097/JTO.0000000000000234. PubMed PMID: 25122427.

Cui M, Augert A, Rongione M, Conkrite K, Parazzoli S, Nikitin AY, Ingolia N, MacPherson D.  "PTEN is a potent suppressor of small cell lung cancer. " Mol Cancer Res. 2014 May;12(5):654-9. doi: 10.1158/1541-7786.MCR-13-0554. Epub 2014 Jan 30. PubMed PMID: 24482365; PubMed Central PMCID: PMC4020961.

2012

Conkrite K, Sundby M, Mu D, Mukai S, MacPherson D. "Cooperation between Rb and Arf in suppressing mouse retinoblastoma." J Clin Invest. 2012 May;122(5):1726-33. doi: 10.1172/JCI61403. Epub 2012 Apr 9. PubMed PMID: 22484813; PubMed Central PMCID: PMC3336990.

MacPherson D. "Small cell lung cancer: new insights into origins." Cell Cycle. 2011 Oct 15;10(20):3432. doi: 10.4161/cc.10.20.17664. Epub 2011 Oct 15. PubMed PMID: 22030465.

2011

Conkrite K, Sundby M, Mukai S, Thomson JM, Mu D, Hammond SM, MacPherson D.  "miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma." Genes Dev. 2011 Aug 15;25(16):1734-45. doi: 10.1101/gad.17027411. Epub 2011 Aug 4. PubMed PMID: 21816922; PubMed Central PMCID: PMC3165937.

2008

MacPherson D.  "Insights from mouse models into human retinoblastoma." Cell Div. 2008 May 19;3:9. doi: 10.1186/1747-1028-3-9. PubMed PMID: 18489754; PubMed Central PMCID: PMC2430952.

2007

MacPherson D, Dyer MA. "Retinoblastoma: from the two-hit hypothesis to targeted chemotherapy." Cancer Res. 2007 Aug 15;67(16):7547-50. doi: 10.1158/0008-5472.CAN-07-0276. Review. PubMed PMID: 17699756.

MacPherson D, Conkrite K, Tam M, Mukai S, Mu D, Jacks T.  "Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification." EMBO J. 2007 Feb 7;26(3):784-94. doi: 10.1038/sj.emboj.7601515. Epub 2007 Jan 18. PubMed PMID: 17235288; PubMed Central PMCID: PMC1794380.

2004

MacPherson D, Kim J, Kim T, Rhee BK, Van Oostrom CT, DiTullio RA, Venere M, Halazonetis TD, Bronson R, De Vries A, Fleming M, Jacks T.  "Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23." EMBO J. 2004 Sep 15;23(18):3689-99. doi: 10.1038/sj.emboj.7600363. Epub 2004 Sep 2. PubMed PMID: 15343266; PubMed Central PMCID: PMC517606.

MacPherson D, Sage J, Kim T, Ho D, McLaughlin ME, Jacks T. "Cell type-specific effects of Rb deletion in the murine retina." Genes Dev. 2004 Jul 15;18(14):1681-94. doi: 10.1101/gad.1203304. Epub 2004 Jul 1. PubMed PMID: 15231717; PubMed Central PMCID: PMC478190.

2003

MacPherson D, Sage J, Crowley D, Trumpp A, Bronson RT, Jacks T. "Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. " Mol Cell Biol. 2003 Feb;23(3):1044-53. doi: 10.1128/mcb.23.3.1044-1053.2003. PubMed PMID: 12529408; PubMed Central PMCID: PMC140709.

2002

Tsai KY, MacPherson D, Rubinson DA, Nikitin AY, Bronson R, Mercer KL, Crowley D, Jacks T. "ARF mutation accelerates pituitary tumor development in Rb+/- mice." Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16865-70. doi: 10.1073/pnas.262499599. Epub 2002 Dec 16. PubMed PMID: 12486224; PubMed Central PMCID: PMC139235.

Tsai KY, MacPherson D, Rubinson DA, Crowley D, Jacks T. "ARF is not required for apoptosis in Rb mutant mouse embryos." Curr Biol. 2002 Jan 22;12(2):159-63. doi: 10.1016/s0960-9822(01)00659-5. PubMed PMID: 11818069.

2001

Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, Benchimol S, Mak TW. "Regulation of PTEN transcription by p53. " Mol Cell. 2001 Aug;8(2):317-25. doi: 10.1016/s1097-2765(01)00323-9. PubMed PMID: 11545734.

Ruland J, Sirard C, Elia A, MacPherson D, Wakeham A, Li L, de la Pompa JL, Cohen SN, Mak TW. "p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101." Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1859-64. doi: 10.1073/pnas.98.4.1859. PubMed PMID: 11172041; PubMed Central PMCID: PMC29347.

2000

Stambolic V, Tsao MS, MacPherson D, Suzuki A, Chapman WB, Mak TW. "High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. " Cancer Res. 2000 Jul 1;60(13):3605-11. PubMed PMID: 10910075.

1998

Rasper DM, Vaillancourt JP, Hadano S, Houtzager VM, Seiden I, Keen SL, Tawa P, Xanthoudakis S, Nasir J, Martindale D, Koop BF, Peterson EP, Thornberry NA, Huang J, MacPherson DP, Black SC, Hornung F, Lenardo MJ, Hayden MR, Roy S, Nicholson DW. "Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. " Cell Death Differ. 1998 Apr;5(4):271-88. doi: 10.1038/sj.cdd.4400370. PubMed PMID: 10200473.