A hallmark of many diseases and cancers is a dysfunctional cytoskeleton. A properly functioning cytoskeleton is needed for a wide variety of cellular events ranging from cell shape to cell signaling and migration/metastasis. We use multidisciplinary approaches to study these dynamic structural elements in various processes including wound repair and nuclear architecture/organization. The goal of the Parkhurst Lab is to understand the role of these elements in regulating normal developmental events and how this regulation goes awry in diseases/cancers, thereby providing new avenues for possible therapeutic targets or to enhance the effectiveness of existing treatment modalities.
Molecular and cellular mechanisms of single cell and epithelial (multi-cellular) wound repair.
Mechanisms governing nuclear organization and the role of the WASH gene in these events.
Actin and microtuble dynamics mediated by Rho family GTPases and their downstream effectors.