Publications…     Preprints…       [and Journal Covers]



Davidson KA, Nakamura M, Verboon JM and Parkhurst SM.
The Centralspindlin proteins Pavarotti and Tumbleweed function in Nuclear Envelope budding.
J. Cell Biol. 222 (8): e202211074 [2023].
PMID: 37163553
[BioRxiv (preprint): doi: ]

Nakamura M, Hui J, Stjepić V, and Parkhurst SM.
Scar/WAVE has Rac GTPase-independent functions during cell wound repair.
Sci. Rep. 13(1):4763. doi: 10.1038/s41598-023-31973-2. [2023].
PMID: 36959278

Nakamura M, Hui J and Parkhurst SM.
Bending actin filaments: twists of fate.
Faculty Reviews [invited review] 12(7)  [2023].
PMID: 37081903

Hui J, Nakamura M, Dubrulle J and Parkhurst SM.
Coordinated efforts of different actin filament populations are needed for optimal cell wound repair
Mol. Biol. Cell 34(3):ar15. doi:  Epub 2023 Jan 4. [2023]
PMID: 36598808
[BioRxiv (preprint): doi:]
• Hutch Science Spotlight:

Hui J, Stjepić V, Nakamura M and Parkhurst SM.
Wrangling Actin Assemblies: Actin Ring Dynamics in Cell Wound Repair
Cells 11(18): 277.  [2022].
PMID:  36139352

Nakamura M, Verboon JM, Allen TE, Abreu-Blanco MT, Liu R, Dominguez AN, Delrow JJ and Parkhurst SM. 
Autocrine insulin pathway signaling regulates actin dynamics in cell wound repair
PLoS Genetics 16(12): e1009186. doi: 10.1371/journal.pgen.1009186  (2020).
PMID:  33306674
[BioRxiv (preprint):  doi:]
• Hutch Science

Nakamura M, Verboon JM, Prentiss CL and Parkhurst SM.
The kinesin-like protein Pavarotti functions non-canonically to regulate actin dynamics.
J. Cell Biol. 219(9): e201912117. doi: 10.1083/jcb.201912117  (2020).
PMID: 32673395
[BioRxiv (preprint):  doi: ]
• Hutch Science Spotlight:

Verboon JM, Nakamura M, Davidson KA, Decker JR, Nandakumar V and Parkhurst SM.
Drosophila Wash and the WASH Regulatory Complex function in Nuclear Envelope budding.
J. Cell Sci. 133(13): jcs243576.  doi: 10.1242/jcs.243576  (2020).
PMID: 32503943
[BioRxiv (preprint):  doi: ]
JCS “Research Highlights”: J. Cell Sci. 133(13): e1301.
• Hutch Science Spotlight: 

Beas AO, Gordon PB, Prentiss CL, Perez-Olsen C, Kukurugya MA, Bennett BD, Parkhurst SM and Gottschling DE.
Independent regulation of age associated fat accumulation and longevity.
Nat. Comm. 11(1): 2790.  (2020).
PMID: 32493904
• Hutch News Story:
• Hutch Science Spotlight:

Verboon JM, Mahmut D, Kim AR, Nakamura M, Abdulhay NJ, Nandakumar SK, Gupta N, Akie TE, Geddis AE, Manes B, Kapp ME, Hofmann I, Gabriel SB, Klein DE, Williams DA, Frangoul HA, Parkhurst SM, Crane GM, Cantor AB and Sankaran VG.
Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction.
J. Clin. Immunol. 40(4): 554-566.  (2020).
PMID: 32303876

Nakamura* M, Dominguez* AN, Decker* JR, Hull* AJ, Verboon* JM and Parkhurst SM.
Into the breach: How cells cope with wounds.
Open Biology (invited review) 8(10): 180135  (2018).
PMID: 30282661 |Abstract | Full Text

Verboon JM, Decker JR, Nakamura M and Parkhurst SM.
Wash exhibits context dependent phenotypes and, along with the WASH Regulatory Complex, regulates Drosophila oogenesis.
J. Cell Sci. 131(8): pii: jcs211573. doi: 10.1242/jcs.211573 (2018).  Erratum in: J. Cell Sci. 131(9): pii: jcs219212. doi: 10.1242/jcs.219212  (2018).
PMID: 29549166 | Abstract | Full Text

Nakamura M, Verboon JM and Parkhurst SM
Pre-patterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair.
J. Cell Biol. 216(12): 3959-3969  (2017).
PMID: 28923977 | Abstract | Full Text
• JCB Special Focus on Rho GTPases in Cell Migration:
• Hutch Science Spotlight:

Verboon JM, Sugumar B and Parkhurst SM
Wiskott-Aldrich Syndrome proteins in the nucleus: aWASH with possibilities.
Nucleus 6(5): 349-359  (2015).
PMID: 26305109 | Abstract | Full Text

Verboon* JM, Rincon-Arano* H, Werwie TR, Delrow JJ, Scalzo D, Nandakumar V, Groudine M and Parkhurst SM
Wash Interacts with Lamin and Affects Global Nuclear Organization.
Curr Biol. 25(6): 804-810  (2015).
PMID: 25754639 | Abstract | Full Text
• Hutch News Story:
• Hutch Science Spotlight:

Verboon* JM, Rahe* TK, Rodriguez-Mesa E and Parkhurst SM
Wash functions downstream of Rho1 GTPase in a subset of Drosophila immune cell developmental migrations.
Mol. Biol. Cell  26(9): 1665-1674  (2015).
PMID: 25739458 |Abstract| Full Text

Verboon JM and Parkhurst SM
Rho family GTPase functions in Drosophila epithelial wound repair.
Small GTPases 6(1): 33-40  (2015).
PMID: 25862164 | Abstract | Full Text

Verboon JM and Parkhurst SM
Rho family GTPases bring a familiar ring to cell wound repair.
Small GTPases (extra view) 6(1): 1-7  (2015).
PMID: 25862160 | Abstract | Full Text

Abreu-Blanco MT, Verboon JM and Parkhurst SM
Coordination of Rho family GTPase activities to orchestrate cytoskeleton responses during cell wound repair.
Curr. Biol. 24(2): 144-155  (2014).
PMID: 24388847 | Abstract | Full Text
• Hutch Science Spotlight:

Ali* M, Rincón-Arano* H, Zhao W, Rothbart SB, Tong Q, Parkhurst SM, Strahl BD, Deng LW, Groudine M, and Kutateladze TG
Molecular basis for chromatin binding and regulation of MLL5.
PNAS 110(28): 11296-301  (2013).
PMID: 23798402 | Abstract | Full Text

• Hutch Science Spotlight:

Rincon-Arano H, Parkhurst SM and Groudine M
UpSET-ing the balance: Modulating open chromatin features in metazoan genomes.
Fly (extra view) 7(3): 153-160  (2013).
PMID: 23798402 | Abstract | Full Text

Abreu-Blanco* MT, Verboon* JM, Liu R, Watts JJ and Parkhurst SM
Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string.
J. Cell Sci. 125(24): 5984-5997  (2012).
PMID: 23038780 | Abstract | Full Text
• JCS “In this Issue”:
• Hutch News Story:
• Hutch Science Spotlight:

Rincon-Arano H, Halow J, Delrow JJ, Parkhurst SM and Groudine M
UpSET Recruits HDAC Complexes and Restricts Chromatin Accessibility and Acetylation at Promoter Regions.
Cell 151(6): 1214-1228  (2012).
PMID: 23177352 | Abstract | Full Text
• Hutch Science Spotlight:

Abreu-Blanco MT, Watts, JJ, Verboon JM and Parkhurst SM
Cytoskeleton Responses in Wound Repair. (Review).
Cell. Mol. Life Sci. 69(15): 2469-2483  (2012).
PMID: 22349211 | Abstract | Full Text

Rodriguez-Mesa E, Abreu-Blanco MT, Rosales-Nieves AE and Parkhurst SM
Developmental expression of Drosophila Wiskott Aldrich Syndrome family protein.
Dev. Dyn. 241(3): 608-626  (2012).
PMID: 22275148 | Abstract | Full Text

Abreu-Blanco MT, Verboon JM and Parkhurst SM
Single cell wound repair: Dealing with life’s little traumas. (perspective).
BioArchitecture 1(3): 114-121  (2011).
PMID: 21922041 | Abstract | Full Text

Abreu-Blanco MT, Verboon JM and Parkhurst SM
Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling.
J. Cell Biol. 193(3): 455-464  (2011).
PMID: 21518790 | Abstract | Full Text
Podcast: JCB Biosights: May 16, 2011

Barry* KC, Abed* M, Kenyagin D, Werwie TR, Boico O, Orian A and Parkhurst SM 
The Drosophila STUbL protein Degringolade limits HES function during embryogenesis.
Development 138: 1759-1769 (2011).
PMID: 21486924 | Abstract | Full Text

Abed* M, Barry* KC, Kenyagin D, Koltun B, Phippen TM, Delrow JJ, Parkhurst SM and Orian A
Degringolade, a SUMO Targeted Ubiquitin Ligase, inhibits Hairy/Groucho-mediated repression.
EMBO J. 30: 1289-1301 (2011).
PMID: 21343912 | Abstract | Full Text

Liu R, Linardopoulou EV, Osborn GE, and Parkhurst SM
Formins in Development: Orchestrating body plan origami. (review)
Biochim Biophys Acta 
1803, 207-225 (2010)
PMID: 18996154; NIHMS98776 | Abstract | Full Text  

Liu R, Abreu-Blanco MT, Barry KC, Linardopoulou EV, Osborn GE and Parkhurst SM
Wash functions downstream of Rho and links linear and branched action nucleation factors 
 136: 2849-2860 (2009).
PMID: 19633175 | Abstract  | Full Text

Liu R, Woolner S, Johndrow JE, Metzger D, Flores A and Parkhurst SM
Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos.
Development 135: 53-63 (2008)
PMCID: PMC | Abstract | Full Text  

Linardopoulou EV, Parghi SS, Friedman C, Osborn GE, Parkhurst SM and Trask BJ
Human subtelomeric WASH genes encode a new subclass of the WASP family.
PLoS Genetics 3, e237 (2007)
PMCID: PMC2151093 | Abstract | Full Text  

Orian A, Delrow JJ, Rosales-Nieves AE, Abed M, Metzger D, Paroush Z, Eisenman RN and Parkhurst SM
A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development.
Proc. Natl. Acad. Sci. USA 104: 15771-15776 (2007)
PMCID: PMC2000393 | Abstract | Full Text  

Rosales-Nieves* AE, Johndrow* JE, Keller* LC, Magie CR, Pinto-Santini D and Parkhurst SM
Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire, and Cappuccino.
Nature Cell Biol. 8: 367-376 (2006)
PMCID: PMC1997291 | Abstract | Full Text  

Verdier V, Johndrow JE, Chen G-C, Hughes DA, Parkhurst SM and Settleman J
Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis.
Dev. Biol. 297: 417-432 (2006)
PMCID: PMC2504748 | Abstract  | Full text

Tsukiyama T and Parkhurst S
Chromosomes and expression mechanisms. (editorial overview)
Curr. Opin. Genet. Dev. 16: 101-103 (2006)
Full Text  

Yu J, Starr DA, Wu X, Parkhurst SM, Zhuang Y, Xu T, Xu R and Han M
The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis.
Dev. Biol 289: 336-345 (2006) 
 | Full Text  

Magie CR and Parkhurst SM
Rho1 regulates signaling events required for proper Drosophila embryonic development.
Dev. Biol. 278: 144-154 (2005)
Abstract | Full Text 

Stramer B, Wood W, Galko MJ, Redd MJ, Jacinto A, Parkhurst SM and Martin P
Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration.
J. Cell Biol. 168: 567-573 (2005)
PMCID: PMC2171743 | Abstract | Full Text

Orian A, Grewal SS, Knoepfler PS, Edgar BA, Parkhurst SM and Eisenman RN
Genomic Binding and Transcriptional Regulation by the Drosophila Myc and Mnt Transcription Factors.
CSHSQB. (review) 70: 1-10 (2005)
PMID: 16869766| Abstract | Full Text  

Johndrow JE, Magie CR and Parkhurst SM
Rho GTPase function in flies: Insights from a developmental and organismal perspective.
Biochem. Cell Biol. 82, 643-657 (2004)
PMID: 15674432 | Abstract | Full Text 

Bianchi-Frias D, Orian A, Delrow JJ, Vazquez J, Rosales-Nieves AE and Parkhurst SM
Hairy Transcriptional Repression Targets and Cofactor Recruitment in Drosophila.
PLoS Biology 2, 0975-0990 (2004)
PMCID: PMC449821 | Abstract | Full Text  

Martin P and Parkhurst SM
Parallels between tissue repair and embryo morphogenesis. (review).
Development 131, 3021-3034 (2004)  

Secombe J and Parkhurst SM
Drosophila Topors is a RING finger-containing protein that functions as an E3 ubiquitin ligase for the Hairy bHLH repressor protein.
J. Biol. Chem. 279, 1726-17133 (2004)
PMID: 14871887| Abstract | Full Text  

Jafar-Nejad H, Acar M, Nolo R, Lacin H, Hacin H, Pan H, Parkhurst SM and Bellen HJ
Senseless acts a binary switch during sensory organ precursor selection.
Genes & Dev. 17, 2966-2978 (2003)
PMCID: PMC289154 | Abstract | Full Text  

Martin P and Parkhurst SM
Development: May the Force Be With You. (perspective).
Science 300, 63-65 (2003)

Orian A, van Steensel B, Delrow J, Bussemaker HJ, Li L, Sawado T, Williams E, Loo LWM, Cowley SM, Yost C, Pierce S, Edgar BA, Parkhurst SM and Eisenman RN
Genomic Binding by the Drosophila Myc, Max, Mad/Mnt Transcription Factor Network.
Genes & Dev. 17, 1101-1114 (2003)
PMCID: PMC196053 | Abstract | Full Text  

Parkhurst SM and Delidakis C
Fly Development: An introspective. (review)
Bio Essays 25, 87-89 (2003)

Magie CR, Pinto-Santini D and Parkhurst SM
Rho1 interacts with p120ctn and a-catenin, and regulates cadherin-based adherens junction formation during Drosophila.
Development 129, 3771-3782 (2002)
PMID: 12135916| Abstract | Full Text

Rosenberg MI and Parkhurst SM
Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(spl) family of bHLH repressors in segmentation and sex determination.
Cell 109, 447-458 (2002)
PMID: 12086602: | Abstract | Full Text  

Phippen TM, Sweigart AL, Moniwa M, Krumm A, Davie JR and Parkhurst SM
Drosophila CtBP functions as a context-dependent transcriptional cofactor and interferes with both Mad and Groucho transcriptional repression.
J. Biol. Chem. 275, 37628-37637 (2000)
PMID: 10973955 | Abstract | Full Text  

Magie CR, Meyer M, Gorsuch M and Parkhurst SM
Mutations in the Rho1 small GTPase disrupt morphogenesis and segmentation during early Drosophila development.
Development 126, 5353-5364 (1999)
PMID: 10556060 | Abstract | Full Text  

Poortinga G, Watanabe M and Parkhurst SM
Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and Hairy-mediated transcriptional repression.
EMBO J. 17, 2067-2078 (1998)
PMCID: PMC1170551 | Abstract | Full Text  

Parkhurst SM
Groucho: making its Marx as a transcriptional corepressor
Trends Genet. 14, 130-132 (1998)
PMID: 9594657 | Abstract | Full Text

Alifragis* P, Poortinga* G, Parkhurst SM and Delidakis C
A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system.
Proc. Natl. Acad. Sci. U.S.A. 94, 13099-13104 (1997)
PMCID: PMC24269 | Abstract | Full Text  

Gallant P., Shiio Y, Cheng PF, Parkhurst SM and Eisenman RN
Myc and Max homologs in Drosophila.

Science 274, 1523-1527 (1996)
PMID: 8929412 | Abstract | Full Text  

Dawson SR, Turner DL, Weintraub H and Parkhurst SM
Specificity for the Hairy/ Enhancer of split basic-helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression.
Mol. Cell. Biol. 15, 6923-6931 (1995)
PMCID: PMC230947 | Abstract | Full Text  

Lepage T, Cohen SM, Diaz-Benjumea FJ and Parkhurst SM
Signal transduction by cAMP-dependent Protein Kinase A in Drosophila limb patterning.
Nature 373, 711-715 (1995)
PMID: 7854456 | Abstract | Full Text 

Parkhurst SM and Meneely PM
Sex determination and dosage compensation: Lessons from flies and worms. (review)
Science 264, 924-932 (1994)
PMID: 8178152 | Abstract | Full Text

Parkhurst SM, Lipshitz HD and Ish-Horowicz D
achaete-scute feminizing activities and Drosophila sex-determination.
Development 117, 737-749 (1993)
PMID: 8330537 | Abstract | Full Text

*authors contributed equally

Molecular biology journal cover

Molecular Biology of the Cell, Volume 34, Issue 3, March 2023

High-res version
Open biology journal cover
Open Biology, Volume 8, Issue 10, October 2018 High-res version
Fly journal cover
Fly, Volume 7, Issue 3, July/August/September 2013 High-res version
Developmental Dynamics journal Cover
Developmental Dynamics, Volume 241, Number 12, December 2012 High-res version
BioArchitecture cover
BioArchitecture, Volume 1, Issue 3, May/June 2011 High-res version
Development Journal Cover
Calendar image. Development, Company of Biologists (2009) High-res version
Nature Cell Biology cover
Nature Cell Biology, Volume 8, Number 4, April 2006 High-res version
Principles of Developmental Biology cover
Textbook cover. W.W. Norton & Co. (2003) High-res version
Development cover
Development, Volume 129, Number 16, August 2002 High-res version
Cell cover
Cell, Volume 42, Number 1, August 1985 High-res version

Previous Publications (Susan Parkhurst)

Ding, D., Parkhurst, S.M., Halsell, S.R. and Lipshitz, H.D.
Dynamic hsp83 localization during Drosophila oogenesis and embryogenesis.
Mol. Cell. Biol. 13, 3773-3781 (1993)
PMCID: PMC359859   

Ding, D., Parkhurst, S.M. and Lipshitz, H.D.
Different genetic requirements for anterior RNA localization revealed by the distribution of Adducin-like transcripts during Drosophila oogenesis.
Proc. Natl. Acad. Sci. 90, 2512-2516 (1993)
PMCID: PMC46118   

Parkhurst, S.M. and Ish-Horowicz, D.
Common denominators for sex. (review)
Current Biology 2, 629-631 (1992)  

Parkhurst, S.M. and Ish-Horowicz, D.
wimp, a dominant maternal-effect mutation, reduces transcription of a specific subset of segmentation genes in Drosophila.
Genes & Dev5, 341-357 (1991)  

Parkhurst, S.M. and Ish-Horowicz, D.
Mis-regulating segmentation gene expression in Drosophila. 
 111, 1121-1135 (1991) 

Parkhurst, S.M., Bopp, D. and Ish-Horowicz, D.
X:A ratio, the primary sex-determining signal in Drosophila, is transduced by helix-loop-helix proteins.
Cell 63, 1179-1191 (1990)

Hooper, K.L., Parkhurst, S.M. and Ish-Horowicz, D.
Spatial control of hairy protein expression during embryogenesis.
Development 107, 489-504 (1989)  

Parkhurst, S.M., Harrison, D.A., Remington, M.P., Spana, C., Kelley, R.L., Coyne, R.S. and Corces, V.G.
The Drosophila su(Hw) gene, which controls the phenotypic effect of the gypsy transposable element, encodes a putative DNA-binding protein.
Genes & Dev. 2, 1205-1215 (1988)  

Parkhurst, S.M. and Corces, V.G.
Developmental expression of Drosophila melanogaster retrovirus-like transposable elements.
EMBO J6, 419-424 (1987)
PMCID: PMC553412   

Parkhurst, S.M. and Corces, V.G.
Retroviral elements and suppressor genes in Drosophila. (review)
BioEssays 5, 52-57 (1986)  

Parkhurst, S.M. and Corces, V.G.
Mutations at the suppressor of forked locus increase the accumulation of gypsy-encoded transcripts in Drosophila melanogaster.
Mol. Cell. Biol. 6, 2271-2274 (1986)
PMCID: PMC367771   

Marlor, R.L., Parkhurst, S.M. and Corces, V.G.
The Drosophila melanogaster gypsy transposable element encodes putative gene products homologous to retroviral proteins.
Mol. Cell. Biol. 6, 1129-1134 (1986)
PMCID: PMC367623   

Parkhurst, S.M. and Corces, V.G.
Interactions among the gypsy transposable element and the yellow and suppressor of Hairy-wing loci in Drosophila melanogaster.
Mol. Cell. Biol. 6, 47-53 (1986)
PMCID: PMC367482   

Parkhurst, S.M. and Corces, V.G.
forked, gypsys, and suppressors in Drosophila.
Cell 41, 429-437 (1985)  

Mozer, B.A., Marlor, R.L., Parkhurst, S.M. and Corces, V.G.
Characterization and developmental expression of a Drosophila ras oncogene.
Mol. Cell. Biol. 5, 885-889 (1985)  

Hardy, M.R., Townsend, R.R., Parkhurst, S.M., and Lee, Y.C.
Different modes of ligand binding to the hepatic galactose/N-acetylgalactosamine lectin on the surface of rabbit hepatocytes.
Biochemistry 24, 22-28 (1985) 

Parkhurst, S.M., Blaser, M.J., Laxson, L.B., and Wang, W-L.
Surveillance for the detection of nosocomial infections and the potential for nosocomial outbreaks. II. Development of a laboratory-based system.
Am. J. Infect. Control 13, 7-15 (1985)  

Laxson, L.B., Blaser, M.J., and Parkhurst, S.M.
Surveillance for the detection of nosocomial infections and the potential for nosocomial outbreaks. I. Microbiology culture surveillance is an effective method of detecting nosocomial infections.
Am. J. Infect. Control 12, 318-324 (1984)