Welcome to the Singhvi Lab. We investigate the molecular mechanisms of glia-neuron interactions. Our nervous system has two major cell types, neurons and glia, in about equal numbers. These two cell types communicate extensively with each other, which is critical for proper nervous system function. Disrupted interactions between these two cell types underlie many neurological disorders of development (e.g. Autism), function (sensory or cognitive impairments) and aging (e.g. Alzheimer’s).
Our lab is interested in understanding how glia and neurons communicate with each other to regulate sensory perception, neuronal physiology, neural circuit activity, memory formation and animal behavior. We aim to map glia-neuron interactions at a molecular and mechanistic level, in health and disease.