The Neurochemical Symphony: A Song of Glia and Neurons

Neuron and Glia -inseparable sisters in the Labyrinth of Thought,
Fingers intertwined, singing in strange argot.
Yet, identical peas in a pod? Certainly not.

Neuron, full of action and potential; her electrifying intelligence a legend.
Glia, shy and soft-spoken; helping, cooking and ever running an errand.
Naturally then, Neuron often commanded the attention scend.

Still, Cajal found Glia more enigmatic than she showed; he was prescient!
When biologists realized that even Neuron heeded Glia’s counsel to be efficient,
They started forging tools to translate the sisters’ descant…

***

A. Singhvi, 2016

Publications

2020 | 2019 | 2016 | 2014 | 2011 | 2010 | 2009 | 2008 | 2004

Follow us on PubMed or Google Scholar.  Click on the titles below for articles.

2020

Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior 
Stephan Raiders, Erik Calvin Black, Andrea Bae, Stephen MacFarlane, Shai Shaham, Aakanksha Singhvi
2020, Biorxiv

Age-dependent changes in response property and morphology of a thermosensory neuron and thermotaxis behavior in Caenorhabditis elegans.
Huang TT, Matsuyama HJ, Tsukada Y, Singhvi A, Syu RT, Lu Y, Shaham S, Mori I, Pan CL.
Aging Cell. 2020 May;19(5):e13146. 

2019

Glia-Neuron Interactions in Caenorhabditis elegans.
Singhvi A and Shaham S
Annual Review of Neuroscience, 2019, 42:149-168.

Physical exertion exacerbates decline in the musculature of an animal model of Duchenne muscular dystrophy
K. J. Hughes, A. Rodriguez, K. M. Flatt, S. Ray, A. Schuler, B. Rodemoyer, V. Veerappan, K. Cuciarone, A. Kullman, C. Lim, N. Gutta, S. Vemuri, V. Andriulis, D. Niswonger, L. Barickman, W. Stein, A. Singhvi, N. E. Schroeder, A. G. Vidal-Gadea
Proceedings of the National Academy of Sciences (PNAS), 116 (9) 3508-3517.

2016

A Glial K/Cl Transporter Controls Neuronal Receptive-Ending Shape by Chloride Inhibition of an rGC.
Singhvi A, Liu B, Friedman CJ, Fong J, Lu Y, Huang XY, Shaham S.
Cell, 165, 936-48.

Preview by Sun, LO and Barres, B in Cell. “Glia Get Neurons in Shape”
Editor’s Choice by Wong, W in Science Signaling. “Glia dictate Neuronal Morphology”
Rockefeller NewsWire
F1000 Recommendation by Jenny, A

A PROS-1/Prospero Is a Major Regulator of the Glia-Specific Secretome Controlling Sensory Neuron Structure and Function in C. elegans.
Wallace SW, Singhvi A, Liang Y, Lu Y, Shaham S.
Cell Reports, 15(3):550-62. 

2014

Asymmetric Neuroblast Divisions Producing Apoptotic Cells Require the Cytohesin GRP-1 in Caenorhabditis elegans
Teuliere J, Cordes S, Singhvi A, Talavera K, Garriga G.
Genetics, 198 (1), 229-47.

2011

The ARF GAP protein, CNT-2 regulates asymmetric cell divisions in C. elegans.
Singhvi A, Teuliere J, Talavera K, Cordes S, Ou G, Vale RD, Prasad BC, Clark SG, Garriga G.
Current Biology, 21(11), 948-54.

2010

Building a sustainable career in science.
Singhvi A and Sachdev, P.
Nature Biotechnology, 28(4), 378-9 (2010).

What else can we do to enhance the scientific potential of India? 
Singhvi A and Singhvi AK.
Current Science, 99: 432-3 (2010).

2009

Asymmetric cell divisions, aggrosomes and apoptosis. (Review)
Singhvi A and Garriga G.
Trends in Cell Biology, 19(1), 1.

2008

The T-box gene tbx-2 and the homeobox gene egl-5 specify neural fate in the HSN/PHB lineage.
Singhvi A, Frank CA, Garriga G.
Genetics, 179(2), 887.

2004

Taste representations in the Drosophila brain. 
Wang Z, Singhvi A, Kong P, Scott K
Cell, 117 (7), 981-91.

F1000 Recommendation by Luo, L and Hildebrand, J