The Neurochemical Symphony: A Song of Glia and Neurons
Neuron and Glia -inseparable sisters in the Labyrinth of Thought,
Fingers intertwined, singing in strange argot.
Yet, identical peas in a pod? Certainly not.
Neuron, full of action and potential; her electrifying intelligence a legend.
Glia, shy and soft-spoken; helping, cooking and ever running an errand.
Naturally then, Neuron often commanded the attention scend.
Still, Cajal found Glia more enigmatic than she showed; he was prescient!
When biologists realized that even Neuron heeded Glia’s counsel to be efficient,
They started forging tools to translate the sisters’ descant…
***
A. Singhvi, 2016
Publications
Follow us on PubMed or Google Scholar. Click on the titles below for articles.
2021
Engulfed by Glia: Glial Pruning in Development, Function, and Injury across Species
Raiders S, Han T, Scott-Hewitt N, Kucenas S, Lew D, Logan MA, Singhvi A.
Journal of Neuroscience 3 February 2021, 41 (5) 823-833
2020
Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior
Raiders S, Black EC, Bae A, MacFarlane S, Shaham S, Singhvi A.
2020, Biorxiv
Age-dependent changes in response property and morphology of a thermosensory neuron and thermotaxis behavior in Caenorhabditis elegans.
Huang TT, Matsuyama HJ, Tsukada Y, Singhvi A, Syu RT, Lu Y, Shaham S, Mori I, Pan CL.
Aging Cell. 2020 May;19(5):e13146.
2019
Glia-Neuron Interactions in Caenorhabditis elegans.
Singhvi A and Shaham S
Annual Review of Neuroscience, 2019, 42:149-168.
Physical exertion exacerbates decline in the musculature of an animal model of Duchenne muscular dystrophy
Hughes KJ, Rodriguez A, Flatt KM, Ray S, Schuler A, Rodemoyer B, Veerappan V, Cuciarone K, Kullman A, Lim C, Gutta N, Vemuri S, Andriulis V, Niswonger D, Barickman L, Stein W, Singhvi A, Schroeder NE, Vidal-Gadea AG.
Proceedings of the National Academy of Sciences (PNAS), 116 (9) 3508-3517.
2016
A Glial K/Cl Transporter Controls Neuronal Receptive-Ending Shape by Chloride Inhibition of an rGC.
Singhvi A, Liu B, Friedman CJ, Fong J, Lu Y, Huang XY, Shaham S.
Cell, 165, 936-48.
Preview by Sun, LO and Barres, B in Cell. “Glia Get Neurons in Shape”
Editor’s Choice by Wong, W in Science Signaling. “Glia dictate Neuronal Morphology”
Rockefeller NewsWire
F1000 Recommendation by Jenny, A
A PROS-1/Prospero Is a Major Regulator of the Glia-Specific Secretome Controlling Sensory Neuron Structure and Function in C. elegans.
Wallace SW, Singhvi A, Liang Y, Lu Y, Shaham S.
Cell Reports, 15(3):550-62.
2014
Asymmetric Neuroblast Divisions Producing Apoptotic Cells Require the Cytohesin GRP-1 in Caenorhabditis elegans
Teuliere J, Cordes S, Singhvi A, Talavera K, Garriga G.
Genetics, 198 (1), 229-47.
2011
The ARF GAP protein, CNT-2 regulates asymmetric cell divisions in C. elegans.
Singhvi A, Teuliere J, Talavera K, Cordes S, Ou G, Vale RD, Prasad BC, Clark SG, Garriga G.
Current Biology, 21(11), 948-54.
2010
Building a sustainable career in science.
Singhvi A and Sachdev P.
Nature Biotechnology, 28(4), 378-9 (2010).
What else can we do to enhance the scientific potential of India?
Singhvi A and Singhvi AK.
Current Science, 99: 432-3 (2010).
2009
Asymmetric cell divisions, aggrosomes and apoptosis. (Review)
Singhvi A and Garriga G.
Trends in Cell Biology, 19(1), 1.
2008
The T-box gene tbx-2 and the homeobox gene egl-5 specify neural fate in the HSN/PHB lineage.
Singhvi A, Frank CA, Garriga G.
Genetics, 179(2), 887.
2004
Taste representations in the Drosophila brain.
Wang Z, Singhvi A, Kong P, Scott K
Cell, 117 (7), 981-91.
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