The Strong Lab's research focus is translational biophysics, structural molecular immunology and vaccinology. We are applying biophysical approaches to understand the recognition mechanisms of innate and adaptive immunoreceptors from a molecular perspective, ultimately to further vaccine development and engineer targeted immunotheranostics. These efforts are fostered and enabled by the highly-collaborative environment at the Hutch, providing an interface to clinical investigators and global health initiatives.
We use the tools of structural molecular biology (including biophysical methods such as x-ray crystallography and surface plasmon resonance (Biacore) biomolecular interaction analysis), combined with our recently developed Daedalus protein expression platform, to study receptor/ligand and antibody/antigen interactions. Results are exploited to engineer proteins with desirable specificities, activities and pharmacokinetic properties, but research projects are always conducted with the dual propose of advancing basic science.