Structures and Publications
Lim SYT, Huo J, Laszlo GS, Cole FM, Kehret AR, Li J, Lunn-Halbert MC, Persicke JL, Rupert PB, Strong RK, Walter RB.
Optimizing Siglec-8-Directed Immunotherapy for Eosinophilic and Mast Cell Disorders.
Cancers (Basel). 2024 Oct 14;16(20):3476. doi: 10.3390/cancers16203476. PMID: 39456570; PMCID: PMC11506601.
The MUC16/MSLN binding interface features a “yin-yang” (☯) proline.
Rupert PB, Buerger M, Friend DJ, Strong RK.
Structural elucidation of the mesothelin-mucin-16/CA125 interaction.
Structure. 2024 Aug 8;32(8):1049-1054.e2. doi: 10.1016/j.str.2024.04.011. Epub 2024 May 3. PMID: 38703776; PMCID: PMC11316652.
Wacker JN, Woods JJ, Rupert PB, Peterson A, Allaire M, Lukens WW, Gaiser AN, Minasian SG, Strong RK, Abergel RJ.
Actinium chelation and crystallization in a macromolecular scaffold.
Nat Commun. 2024 Jul 15;15(1):5741. doi: 10.1038/s41467-024-50017-5. PMID: 39009580; PMCID: PMC11251196.
Rupert PB, Buerger M, Girard EJ, Frutoso M, Parrilla D, Ng K, Gooley T, Groh V, Strong RK.
Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys.
Heliyon. 2024 Mar 27;10(7):e28583. doi: 10.1016/j.heliyon.2024.e28583. PMID: 38586421; PMCID: PMC10998067.
Berckmueller K, Thomas J, Taha EA, Choo S, Madhu R, Kanestrom G, Rupert PB, Strong R, Kiem HP, Radtke S.
CD90-targeted lentiviral vectors for HSC gene therapy.
Mol Ther. 2023 Oct 4;31(10):2901-2913. doi: 10.1016/j.ymthe.2023.08.003. Epub 2023 Aug 7. PMID: 37550965; PMCID: PMC10556220.
Lin* I, Rupert* PB, Pilat K, Ruff RO, Friend DJ, Chan MK, Clarke M, Hoffstrom BG, Carter J, Meshinchi S, Bandaranayake AD, Mehlin C, Olson JM, Strong RK & Correnti CE.
“Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodomain and Engineering of Potent, T cell-engaging Bispecific Therapeutics”
Frontiers in Drug Discovery. 2023 Aug 2; 3. doi:10.3389/fddsv.2023.1216516.
Petersdorf EW, McKallor C, Malkki M, He M, Spellman SR, Hsu KC, Strong RK, Gooley T, Stevenson P.
Role of NKG2D ligands and receptor in haploidentical related donor hematopoietic cell transplantation.
Blood Adv. 2023 Jun 27;7(12):2888-2896. doi: 10.1182/bloodadvances.2022008922. PMID: 36763517; PMCID: PMC10300293.
Cosby AG, Arino T, Bailey TA, Buerger M, Woods JJ, Aguirre Quintana LM, Alvarenga Vasquez JV, Wacker JN, Gaiser AN, Strong RK, Abergel RJ.
Siderocalin fusion proteins enable a new 86Y/90Y theranostic approach.
RSC Chem Biol. 2023 Jun 15;4(8):587-591. doi: 10.1039/d3cb00050h. PMID: 37547455; PMCID: PMC10398355.
Chour W, Choi J, Xie J, Chaffee ME, Schmitt TM, Finton K, DeLucia DC, Xu AM, Su Y, Chen DG, Zhang R, Yuan D, Hong S, Ng AHC, Butler JZ, Edmark RA, Jones LC, Murray KM, Peng S, Li G, Strong RK, Lee JK, Goldman JD, Greenberg PD, Heath JR.
Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis.
Commun Biol. 2023 May 16;6(1):528. doi: 10.1038/s42003-023-04899-8. PMID: 37193826; PMCID: PMC10186326.
Finton KAK, Rupert PB, Friend DJ, Dinca A, Lovelace ES, Buerger M, Rusnac DV, Foote-McNabb U, Chour W, Heath JR, Campbell JS, Pierce RH, Strong RK.
Effects of HLA single chain trimer design on peptide presentation and stability.
Front Immunol. 2023 May 3;14:1170462. doi: 10.3389/fimmu.2023.1170462. PMID: 37207206; PMCID: PMC10189100.
Rodarte JV, Baehr C, Hicks D, Liban TL, Weidle C, Rupert PB, Jahan R, Wall A, McGuire AT, Strong RK, Runyon S, Pravetoni M, Pancera M.
Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding.
Structure. 2023 Jan 5;31(1):20-32.e5. doi: 10.1016/j.str.2022.11.008. Epub 2022 Dec 12. PMID: 36513069.
Mao Z, Nesterenko PA, McLaughlin J, Deng W, Burton Sojo G, Cheng D, Noguchi M, Chour W, DeLucia DC, Finton KA, Qin Y, Obusan MB, Tran W, Wang L, Bangayan NJ, Ta L, Chen CC, Seet CS, Crooks GM, Phillips JW, Heath JR, Strong RK, Lee JK, Wohlschlegel JA, Witte ON.
Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation.
Proc Natl Acad Sci. 2022 Aug 2;119(31):e2203410119. doi: 10.1073/pnas.2203410119. Epub 2022 Jul 25. PMID: 35878026; PMCID: PMC9351518.
Crook ZR, Girard EJ, Sevilla GP, Brusniak MY, Rupert PB, Friend DJ, Gewe MM, Clarke M, Lin I, Ruff R, Pakiam F, Phi TD, Bandaranayake A, Correnti CE, Mhyre AJ, Nairn NW, Strong RK, Olson JM.
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager.
Sci Transl Med. 2022 May 18;14(645):eabn0402. doi: 10.1126/scitranslmed.abn0402. Epub 2022 May 18. PMID: 35584229; PMCID: PMC10118748.
Sholukh.JClinMicrobiol.2021
Sholukh, A.M., Fiore-Gartland, A., Ford, E.S., Miner, M.D., Hou, Y.J., Tse, L.V., Kaiser, H., Zhu, H., Lu, J., Madarampalli, B., Park, A., Lempp, F.A., St Germain, R., Bossard, E.L., Kee, J.J., Diem, K., Stuart, A.B., Rupert, P.B., Brock, C., Buerger, M., Doll, M.K., Randhawa, A.K., Stamatatos, L., Strong, R.K., McLaughlin, C., Huang, M.L., Jerome, K.R., Baric, R.S., Montefiori, D., Corey, L.
Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays
Journal of Clinical Microbiology (2021) 59(10):e0052721 2021 09 20
Finton.FrontImmunol.2021
Finton, K.A.K., Brusniak, M.Y., Jones, L.A., Lin, C., Fiore-Gartland, A.J., Brock, C., Gafken, P.R., Strong, R.K.
ARTEMIS: A novel mass-spec platform for HLA-restricted self and disease-associated peptide discovery
Frontiers in immunology (2021) 12:658372
CookSanger.SciTranslMed.2020
Cook Sangar, M.L., Girard, E.J., Hopping, G., Yin, C., Pakiam, F., Brusniak, M.Y., Nguyen, E., Ruff, R., Gewe, M.M., Byrnes-Blake, K., Nairn, N.W., Miller, D.M., Mehlin, C., Strand, A.D., Mhyre, A.J., Correnti, C.E., Strong, R.K., Simon, J.A., Olson, J.M
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure
Science Translational Medicine (2020) 12(533), eaay1041
Crook.JMolBiol.2020
Crook, Z.R., Girard, E., Sevilla, G.P., Merrill, M., Friend, D., Rupert, P.B., Pakiam, F., Nguyen, E., Yin, C., Ruff, R.O., Hopping, G., Strand, A.D., Finton, K.A., Coxon, M., Mhyre, A.J., Strong, R.K., Olson, J.M.
A TfR-binding cystine-dense peptide promotes blood-brain barrier penetration of bioactive molecules
Journal of Molecular Biology (2020) 432(14), pp. 3989-4009
Lopez-Yglesias, A.H., Lu, C.C., Zhao, X., Chou, T., Vanden Bos, T., Strong, R.K., Smith, K.D.
FliC's Hypervariable D3 Domain Is Required for Robust Anti-Flagellin Primary Antibody Responses
ImmunoHorizons (2019) 3(9), pp. 422-432
Bancroft, T., DeBuysscher, B.L., Weidle, C., Schwartz, A., Wall, A., Gray, M.D., Feng, J., Steach, H.R., Fitzpatrick, K.S., Gewe, M.M., Skog, P.D., Doyle-Cooper, C., Ota, T., Strong, R.K., Nemazee, D., Pancera, M., Stamatatos, L., McGuire, A.T., Taylor, J.J.
Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes
Journal of Experimental Medicine (2019) 216(10), pp. 2331-2347
- iglb12 scFv in complex with anti-idiotype ib2 Fab 6OL6.pdb
- iglb12 Fab in complex with anti-idiotype ib3 Fab 6OL5.pdb
Clifton, M.C., Rupert, P.B., Hoette, T.M., Raymond, K.N., Abergel, R.J., Strong, R.K.
Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands
Journal of Structural Biology: X (2019) 2 100008
Siderocalin-Ligand Complexes:
Petersdorf, E.W., Stevenson, P., Malkki, M., Strong, R.K., Spellman, S.R., Haagenson, M.D., Horowitz, M.M., Gooley, T., Wang, T.
Patient HLA Germline Variation and Transplant Survivorship
Journal of Clinical Oncology (2018) 36(24), pp. 2524-2531
Correnti, C.E., Gewe, M.M., Mehlin, C., Bandaranayake, A.D., Johnsen, W.A., Rupert, P.B., Brusniak, M.Y., Clarke, M., Burke, S.E., De Van Der Schueren, W., Pilat, K., Turnbaugh, S.M., May, D., Watson, A., Chan, M.K., Bahl, C.D., Olson, J.M., Strong, R.K.
Screening, large-scale production and structure-based classification of cystine-dense peptides
Nature Structural & Molecular Biology (2018) 25(3), pp. 270-278
- Scorpion Potassium Channel Toxin alpha-KTx 4.2 6ATL.pdb
- Scorpion Potassium Channel Toxin alpha-KTx 4.5 6ATN.pdb
- Scorpion Potassium Channel Toxin kappa-KTx 1.1 6ATS.pdb
- Human Elafin 6ATU.pdb
- Scorpion Chlorotoxin 6ATW.pdb
- Scorpion Potassium Channel Toxin gamma-KTx 2.2 6AU7.pdb
- Scorpion Potassium Channel Toxin gamma-KTx 2.2 6AUP.pdb
- Spider U5-theraphotoxin-Hs1b 1 6AV8.pdb
- Scorpion Insectotoxin-I1 6AVA.pdb
- Scorpion Potassium Channel Toxin alpha-KTx 1.5 6AVC.pdb
- Scorpion Potassium Channel Toxin alpha-KTx 6.9 6AVD.pdb
Crook, Z.R., Sevilla, G.P., Friend, D., Brusniak, M.-Y., Bandaranayake, A.D., Clarke, M., Gewe, M., Mhyre, A.J., Baker, D., Strong, R.K., Bradley, P., Olson, J.M.
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
Nature Communications (2017) 8:2244
Deblonde, G.J.P., Sturzbecher-Hoehne, M., Rupert, P.B., An, D.D., Illy, M.-C., Ralston, C.Y., Brabec, J., de Jong, W.A., Strong, R.K., Abergel, R.J.
Chelation and stabilization of berkelium in oxidation state +IV
Nature Chemistry (2017) 9(9), pp. 843-849
- Human Siderocalin + Californium 5KIC.pdb
Cai, X., Caballero-Benitez, A., Gewe, M.M., Jenkins, I.C., Drescher, C.W., Strong, R.K., Spies, T., Groh, V.
Control of tumor initiation by NKG2D naturally expressed on ovarian cancer cells
Neoplasia (2017) 19(6), pp. 471-82
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