Foss E.J., Lao U, Dalrymple E, Adrianse RL, Loe T, and Bedalov A. SIR2 Suppresses Replication Gaps and Genome Instability by Balancing Replication Between Repetitive and Unique Sequences. Proc. Natl. Acad. Sci. U S A., 2017. Abstract

Sripathy S, Leko V, Adrianse RL, Loe T, Foss EJ, Dalrymple E, Lao U, Gatbonton-Schwager T, Carter KT, Payer B, Patrick J. Paddison PJ, Grady WM, Lee JT, Bartolomei MS, and Bedalov A. A screen for reactivation of MeCP2 on the inactive X-chromosome in mouse identifies BMP/TGF-βsuperfamily as a regulator of XIST expression. Proc. Natl. Acad. Sci. U S A., 2017.


Lessing D, Dial TO, Wei C, Payer B, Carrette LLG, Kesner B, Szanto A, Jadhav A, Maloney DJ, Simeonov A, Theriault J, Hasaka T, Bedalov A, Bartolomei MS, and Lee JT. A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation Proc. Natl. Acad. Sci. U S A., 2016 113 (50) 14366-14371; published ahead of print November 23, 2016

Bedalov A., Chowdhury S., Simon J.A. “Biology, Chemistry and Pharmacology of Sirtuins.” In “Enzymes of Epigenetics Part B” Marmonstein R. (Editor) Elsevier series Methods in Enzymology. Volume 574. 2016.


Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Britt J, Starwalt R, McDaniel L, Ward , Parra D, Newcomb B, Lao U, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vigneau S, Kozlitina J, Sybille D. Reichardt SD, Holger M., Reichardt HM, Gärtner J, Bartolomei MS, Fang M, Loeb KC. Keene D, Bernstein I, Goodell M, Brat DJ, Peter Huppke P, Neul J, Bedalov A*, Pieper AA. Wild type microglia do not arrest pathology in mouse models of Rett syndrome. Nature. 2015 ;521(7552):E1-4. doi: 10.1038/nature14444. (*corresponding author). Abstract

Banfic H, Crljen V, Lukinovic-Skudar V, Dembitz V, Lalic H, Bedalov A, Visnjic D. Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length. Adv Biol Regul. 2016 Jan;60:22-8. doi: 10.1016/j.jbior.2015.09.003. Epub 2015 Sep 26


Mahajan SS, Scian M, Sripathy S, Posakony J, Lao U, Loe TK, Leko V, Thalhofer A, Schuler AD, Bedalov A, Simon JA. Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors. J Med Chem. 2014 Apr 24;57(8):3283-94. doi: 10.1021/jm4018064. Epub 2014 Apr 15. PMID: 24697269

Lucas JM, Heinlein C, Kim T, Hernandez SA, Malik MS, True LD, Morrissey C, Corey E, Montgomery B, Mostaghel E, Clegg N, Coleman I, Brown CM, Schneider EL, Craik C, Simon JA, Bedalov A, Nelson PS. The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis. Cancer Discov. 2014 Aug 13. [Epub ahead of print] PMID: 25122198


Banfic H, Bedalov A, York JD, Visnjic D. Inositol Pyrophosphates Modulate S Phase Progression after Pheromone-induced Arrest in Saccharomyces serevisiae. J Biol Chem. 2013; 288(3):1717-25. PMID: 23179856. PMCID: PMC3548482

Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS Genetics 2013, In Press. PMCID: PMC Journal - In Process  Abstract

Leko V, Park GJ, Lao U, Simon JA, Bedalov A. Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model. PLoS One. 2013 Jun 14;8(6):e66283. PMID: 24697269 Abstract

Tsuchiyama S, Kwan E, Dang W, Bedalov A, Kennedy BK. “Sirtuins in yeast: phenotypes and tools”. In Sirtuins. Springer Series Methods Mol. Biol. 2013;1077:11-37.


Leko V, Varnum-Finney B, Li H, Gu Y, Flowers D, Nourigat C, Bernstein ID, Bedalov A. SIRT1 is dispensable for function of hematopoietic stem cells in adult mice. Blood. 2012; 23;119(8):1856-60. PMID: 22219225. PMCID: PMC3293640

*Foss EJ, Radulovic D, Stirewalt DL, Radich J, Sala-Torra O, Pogosova-Agadijanyan EL, Hengel SM, Loeb KR, Deeg HJ, Meshinchi S, Goodlett DR, Bedalov A. Proteomic classification of acute lekemias by alignment-based quantitation of LC-MS/MS data sets. J Proteome Res. 2012; 11(10):5005-10. PMID: 22900933. PMCID: PMC3564549


Marshall GM, Liu PY, Gherardi S, Scarlett CJ, Bedalov A, Xu N, Iraci N, Valli E, Ling D, Thomas W, van Bekkum M, Sekyere E, Jankowski K, Trahair T, Mackenzie KL, Haber M, Norris MD, Biankin AV, Perini G, Liu T. SIRT1 Promotoes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability. PLoS Genet. 7(6):e1002135, 2011. PMCID: PMC3116909  Abstract

Nemecek ER, Guthrie KA, Sorror ML, Wood BL, Doney KC, Hilger RA, Scott BL, Kovacsovics TJ, Maziarz RT, Woolfrey AE, Bedalov A, Sanders JE, Pagel JM, Sickle EJ, Witherspoon R, Flowers ME, Appelbaum FR, Deeg HJ. Conditioning with treosulfan and fludarabine followed by allogeneic cell transplantation for high-risk hematologic malignancies. Biol Blood Marrow Transplant 17(3):341-50, 2011. PMCID: PMC2974965 Abstract

Mahajan SS, Leko V, Simon JA, Bedalov A. “Sirtuin modulators”. In Histone Deacetylases: the Biology and Clinical Implication. Tso-Pang Yao, Edward Seto (Editors). Springer Series Exp Pharmacol. Handbook 2011; 206:241-55. PMID: 21879453. PMCID:: PMC3419436


Newcomb B, Bedalov A. Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens. Methods Mol Biol. 548:145-60, 2009. PMCID: PMC2925398 Abstract

Van Gool F, Galli M, Gueydan C, Kruys V, Prevott PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O. Intracellualr NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent matter. Nat Med.15(2):206-10, 2009. PMCID: PMC2845476 Abstract

Li H., Simon J., Bedalov A. “NAD-dependent deacetylases as therapeutic targets”. in “Epigenetic Targets in Drug Discovery”. Wolfgang Sippl and Manfred Jung (Editors). Wiley-VCH series Methods and Principles in Medicinal Chemistry. Volume 42. 2009.


Chevillet JR, Park GJ, Bedalov A, Simon JA, Vasioukhin VI. Identification and characterization of small-molecule inhibitors of hepsin. Mol Cancer Ther. 7(10):3343-51, 2008. PMCID: PMC2659609 Abstract

Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, Sahebol-Amri M, Koscik B, Ljuma L, Roy PJ, Bedalov A, Giaever G, Nislow C, Merrill AR, Lory S, Stagljar I. Identification of small molecular inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. PLoS Genet. 4(2):e1000005, 2008. PMCID: PMC2265467 Abstract


Thaminy S, Newcomb B, Kim J, Gatbonton T, Foss E, Simon J, Bedalov A. Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56. J Biol Chem. 282(52):37805-14, 2007. Abstract

Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L. Genetic basis of proteome variation in yeast. Nat Genet. 39(11):1369-75, 2007. Abstract

Chang C, Storer BE, Scott BL, Bryant EM, Shulman HM, Flowers ME, Sandmaier BM, Witherspoon RP, Nash RA, Sanders JE, Bedalov A, Hansen JA, Clurman BE, Storb R, Appelbaum FR, Deeg HJ. Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patients with de novo disease and disease following prior therapy or antecedent hematological disorders. Blood 110(4):1379-87, 2007. PMCID: PMC1939908 Abstract


Foss E, Bedalov A. Pharmacogenetics: yeast lead the way. Chem Biol. 13(3):236-8, 2006. Abstract

Heltweg B, Gatbonston, Schuler AD, Posakony J, Li H, Goehle S, Kollipara R, Depinho RA, Gu Y, Simon JA, Bedalov A. Antitumor activity of a small-molecule inhibitor of human silent infromation regulator 2 enzymes. Cancer Res.66(8):4368-77, 2006. Abstract

Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A. Telomere lenght as a quantitative trait: genome-wide survey and genetic mapping of telomere legth-control genes in yeast. PLoS Genet.2(3):e35, 2006. PMCID: PMC1401499 Abstract


Kaeberlin M, McDonagh T, Heltweg B, Hixon J, Westmand EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Substrat-specific activation of sirtuins by resveratrol. J Biol Chem. 280(17):17038-45, 2005. Abstract


Posakony J, Hirao M, Bedalov A. Indentification an characterization of Sir2 inhibitors through phenotypic assays in yeast. Comb Chem High Throughput Screen. 7(7):661-8, 2004. Abstract

Bedalov A, Simon JA. Neuroscience. NAD to the rescue. Science 305(5686):954-5, 2004. Abstract

Simon JA, Bedalov A. Yeast as a model system for anticancer drug discovery. Nat Rev Cancer 4:(6):481-92, 2004. Abstract

Posakony J, Hirao M, Stevens S, Simon JA, Bedalov A. Inhibitors of Sir2: evaluation of splitomicin analogues. J Med Chem. 47(10):2635-44, 2004. Abstract


Hirao M, Posakony J, Nelson M, Hruby H, Jung M, Simon JA, Bedalov A. Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast. J Biol Chem. 278(52):52773-82, 2003. Abstract

Bedalov A, Hirao M, Posakony J, Nelson M, Simon JA. NAD+-depenedent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Mol Cell Biol. 23(19):7044-54, 2003. PMCID: PMC193940 Abstract

Bedalov A, Simon JA. Sir2 flexes its muscle. Dev Cell 5(2):188-9, 2003. Abstract  


Bedalov A, Gatbonton T, Irvine WP, Gottschling DE, Simon JA. Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci USA 98(26):15113-8, 2001. Abstract


Bedalov A, Salvatori R, Dodig M, Kapural B, Pavlin D, Kream BE, Clark SH, Woody CO, Rowe DW, Lichtler AC. 1,25-Dihydroxyvitamin D3 inhibition of col1a1 promoter expression in calvariae from neonatal transgenic mice. Biochim Biophys Acta. 1398(3):285-93, 1998. Abstract


Bedalov A, Balasubramanyam A. Glucocorticoid-induced ketoacidosis in gestational diabetes: sequela of the acute treatment of preterm labor. A case report. Diabetes Care 20(6):922-4, 1997. Abstract


Dodig M, Kronenberg MS, Bedalov A, Kream BE, Gronowicz G, Clark SH, Mack K, Liu YH, Maxon R, Pan ZZ, Upholt WB, Rowe DW, Lichtler AC. Indentification of a TAAT-containing motif required for high level expression of the COL1A1 promoter in differentiated osteoblasted of transgenic mice. J Biol Chem 271(27):16422-9, 1996. Abstract


Bedalov A, Salvatori R, Dodgi M, Kronenberg MS, Kapural B, Bogdanovic Z, Kream BE, Woody CO, Clark SH, Mack K. Regulation of COL1A1 expression in type I collagen producing tissues: identification of a 49 base pair region which is required for transgene expression in bone of transgenic mice. J Bone Miner Res. 10(10):1443-51, 1995. Abstract

Bedalov A. Differences in regulation of alpha 1(I) collagen promoter in vascular smooth muscle cells in transfection studies and transgenic mice. Biochem Mol Biol Int. 37(1):159-66, 1995. Abstract

Kream BE, Harrison JR, Krebsbach PH, Bogdanovic Z, Bedalov A, Pavlin D, Woody CO, Clark SH, Rowe D, Lichlter AC. Regulation of type I collagen gene expression in bone. Connect Tissue Res. 31(4):261-4, 1995. Abstract

Thomas HF, Feldman JA, Bedalov A, Woody CO, Clark SH, Mack K, Lichtler AC. Indentification of regulatory elements necessary for the expression of the COL1A1 promoter in murine odontoblasts. Connect Tissue Res. 33(1-3):81-5, 1995. Abstract


Pavlin D, Bedalov A, Kronenberg MS, Kream BE, Rowe DW, Smith CL, Pike JW, Lichlter AC. Analysis of regulatory regions in the COL1A1 gene responsible for 1,25-dihydroxyvitamin D3-medicated transcriptional repression in osteoblastic cells. J Cell Biochem. 56(4):490-501, 1994. Abstract

Bedalov A, Breault DT, Sokolov BP, Lichler AC, Bedalov I, Clark SH, Mack K, Khillan JS, Woody CO, Kream BE. Regulation of the alpha 1(I) collagen promoter in vascular smooth muscle cells. Comparison with other alpha 1(I) Collagen-producing cells in transgenic animals and cultured cells. J Biol Chem. 269(7):4903-9, 1994. Abstract

Bogdanovic Z, Bedalov A, Krebsbach PH, Pavlin D, Woody CO, Clark SH, Thomas HF, Rowe DW, Kream BE, Lichtler AC. Upstream regulatory elements necessary for expression of the rat COL1A1 promoter in transgenic mice. J Bone Miner Res. 9(2):285-92, 1994. Abstract


Pavlin D, Lichtler AC, Bedalov A, Kream BE, Harssion JR, Thomas HF, Gronowicz GA, Clark SH, Woody CO, Rowe DW. Differential utilzation of regulatory domains within the alpha 1(I) collagen promoter in osseous and fibroblastic cells. J Cell Biol. 116(1):227-36, 1992. PMCID: PMC2289260  Abstract