Publications
2022
- Szulzewsky, F Arora, S, Arakaki, A, Sievers, P, Bonin, D, Paddison, P, Sahm, F, Cimino, PJ, Gujral, TS, Holland, EC. 2022. Expression of YAP1-MAML2 and constitutively active YAP1 drive the formation of meningioma-like tumors in mice that resemble NF2-mutant meningiomas. Genes & Development. Pubmed.
- Sullivan, KM, Jiang, X, Guha, P, Lausted, C, Carter, JA, Hsu, C, Labadie, KP, Kohli, K, Kenerson, HL, Daniel, SK, Yan, X, Meng,C, Chan, M, Abbasi, A, Seo, D, Park, JO, Crispe, N, Yeung, RS, Kim, TS, Gujral, TS, Tian, Q, Katz, sc, and Pillarisetty, VG. 2022. Blockade of interleukin-10 potentiates antitumor immune function in human colorectal cancer liver metastases. Gut. Pubmed.
- Chan, M, Holland, E, and Gujral, TS. Olverembatinib inhibits SARS-CoV-2-Omicron variant-mediated cytokine release. EMBO molecular medicine. 2022. May 17. e15919. Pubmed
- Kang, Y, Vijay, S, and Gujral, TS. Deep Neural Network Modeling Identifies Biomarkers of Response to Immune-checkpoint Therapy. iScience. 2022. 25 (5) May 20, 104228. Pubmed
- Nishida-Aoki, N, and Gujral, TS. Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype. Cancer Research. 2022. Feb 1. 13:canres.1428.202. Pubmed
- Mossa, F, Robesti, D, Ramachandran, S, Corey, E, Titus, MA, Kang, Y, Zhang, J, Briganti, A, Montorsim F, Vellano, CP, Marszalek, JR, Frigo, DE, Logothetis, CJ, Gujral, TS, and Dondossola, E. Subtype and site specific-induced metabolic vulnerabilities in prostate cancer. Molecular Cancer Research. 2022. 2022 Sep 16;MCR-22-0250. Pubmed.
2021
- Bello T, Paindelli C, Diaz-Gomez LA, Melchiorri A , Mikos AG, Nelson PS, Dondossola E, and Gujral TS. Computational modeling identifies multi-targeted kinase inhibitors as effective therapies for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2021. October 5, 118 (40) e2103623118. Pubmed.
- Bello, T, Chan, M, Golkowski, M, Xue, AG, Khasnavis, N, Ceribelli, M, Ong,S, Thomas, C, and Gujral, TS. KiRNet: Kinase-centered network propagation of pharmacological screen results. Cell Reports Methods. 2021. 100007. Pubmed
- Chan, M, Vijay, S., McNevin, J, McElrath, JM, Holland, EC, and Gujral, TS. Machine Learning Identifies Molecular Regulators and Inhibitors for COVID19-induced Cytokine Release. Molecular Systems Biology. 2021. Sep;17 (9):e10426. Pubmed
- Arakaki, AKS, Szulzewsky, F, Gilbert, M, Gujral, TS, and Holland, EC. Utilizing Preclinical Models to Develop Targeted Therapies for Rare CNS Cancers. 2021. Neuro-Oncology. 23 (5) S4–S15. Pubmed
- Arakaki, AKS., Pan, W, Wedegaertner, H, Roca-Mercado, I, Chinn, L, Gujral, TS, and Trejo, J. α-arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis. Journal of Cell Science. 2021. Mar 15;jcs.254888. Pubmed
- Horowitz, LF, Rodriguez, AD, Au-Yeung, A, Bishop, KW, Barner, LA, Mishra, G, Raman, A, Delgado, P, Liu, JTC, Gujral, TS, Mehrabi, M, Yang, M, Pierce, R, and Folch, A. Microdissected “cuboids” for microfluidic drug testing of intact tissues. Lab on a Chip. 2021. Jan 5;21(1):122-142. Pubmed.
- Golkowski, M, Lau, HT, Chan, M, Kenerson, H, Vidadala,VN, Shoemaker, A, Maly, DJ, Yeung, RS, Gujral, TS.*, and Ong, S*.Pharmacoproteomics identifies kinase pathways that drive the epithelial-mesenchymal transition and drug resistance in hepatocellular carcinoma. *Co-corresponding. Cell Systems. 2020. S2405-4712(20)30249-0. Pubmed
- Szulzewsky, F, Arora, S, Hoellerbauer, P, King, C, Nathan, E, Chan, M., Cimino, P.J., Ozawa, T, Kawauchi, D, Pajtler, KW, Gilbertson, RJ, Paddison, PJ, Vasioukhin, V, Gujral, TS, and Holland, EC. Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis. Genes & Development. 2020. 34: 1051-1064. Pubmed
- Xue, A*, Chan, M*, and Gujral, TS. Pan-Cancer Analysis of the Developmental Pathways Reveals Non-canonocal Wnt signaling as a Driver of Mesenchymal-type Tumors. *Co-first. Translational Research. 2020. S1931-5244 (20 )30140-7. Featured New Investigator Article. Pubmed.
- Siddharth, V, and Gujral, TS. Non-linear Deep Neural Network for Rapid and Accurate Prediction of Phenotypic Responses to Kinase Inhibitors. iScience. 2020. 23 (5). 101129. Pubmed.
- Nishida-Aoki, N, Bondesson, AJ, and Gujral, TS. Measuring Real-time Drug Response in Organotypic Tumor Tissue Slices. J. Vis. Exp. 2020. (159), e61036. Pubmed
- Rata, S, Gruver, JS, Trikoz, N, Lukyanov, A, Vultaggio, J, Ceribelli, M, Thomas, C, Gujral, TS, Kirschner, MW, and Peshkin, L. An optimal set of inhibitors for Reverse Engineering via Kinase Regularization. 2020. bioRxiv.
2019
- Sivakumar, R*., Chan, M*., Shin, J.S., Nishida-Aoki, N., Kenerson, H.L., Elemento, O., Beltran, H., Yeung, R and Gujral, T.S. Organotypic tumor tissue slice cultures provide a versatile platform for immuno-oncology and drug discovery. *Co-first. OncoImmunology. 2019. 8(12): e1670019. Pubmed
- Nishida-Aoki, N., and Gujral. T.S. Emerging approaches to study cell-cell interactions in tumor microenvironment. Oncotarget. 2019. 10:785-797. Pubmed
2018
- MacLeod, J., Gao, Y.,Hall, C.,Muller, W.J., Gujral, T.S and Greer, P.A. Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib. Oncotarget. 2018. 9:33382-33395. Pubmed.
- Bello, T., and Gujral. T.S. KInhibition: A Kinase Inhibitor Selection Portal. iScience. 2018. 8, 49–53. Pubmed.
2017
- Arang, N., Kain, H., Glennon, E., Bello, T., Dudgeon, D., Walter, E., Gujral, T.S. and Kaushansky, A. Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles. Nature Communications. 2017. 1;8(1):1232. Pubmed
- Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, Jao LE, Gygi SP, Greenberg ME, Ho HH. Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates. Elife. 2017. 8;6. pii: e26509. Pubmed.
- Gujral, T.S. and Kirschner M.W. The Hippo pathway mediates resistance to cytotoxic drugs. Proc Natl Acad Sci U S A. 2017. 114 (18) E3729-E3738. Pubmed
Pre-Gujral Lab Publications
2014
- Gujral, T.S., Chan, M.,Peshkin, L., Sorger, P.K., Kirschner, M.W. and MacBeath, G. "A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. " Cell. 2014. 159 (4), 844–856. Pubmed.
- Gujral, T.S*., Peshkin, L*., and Kirschner M.W. "Exploiting polypharmacology for drug target deconvolution." Proc Natl Acad Sci U S A. 2014. 111 (13) 5048-5053. Pubmed.
2013
- Gujral, T.S*., Karp, E.S*., Chan, M., Chang, B. and MacBeath, G. "Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates β-catenin in maintaining the integrity of tight junctions. " Chemistry & Biology. 2013. 20, 816-27. Pubmed.
- Hyndman, B.D*., Gujral, T.S*., Krieger, J.R., Cockburn, J.G. and Mulligan, L.M. "Multiple functional effects of RET kinase domain sequence variants in Hirschsprung disease." Human Mutation. 2013. 34, 132-42. Pubmed.
2012
- Gujral, T.S., Karp., R, Finski,A., Chan, M., MacBeath, G and Sorger, P. "Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays." Oncogene. 2012. Pubmed.
- Luckert, K*., Gujral, T.S.*, Chan, M., Joos, T.O., Sorger, P., MacBeath, G., and Potz, O. "A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins." Science Signaling. 2012. 5, pl1. Pubmed.
2011
- Chang, B.H*., Gujral, T.S*., Karp, E.S., BuKhalid, R., Grantcharova, V.P., and MacBeath, G. "A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactions." Chemistry & Biology . 2011. 18, 1143-52. Pubmed.
2010
- Cockburn, J.G., Richardson, D.S., Gujral, T.S. & Mulligan, L.M. "RET-mediated cell adhesion and migration require multiple integrin subunits." J Clin Endocrinol Metab. 2010. 95, E342-6. Pubmed.
- Shalek, A.K., Robinson, J.T., Karp, E., Seok Lee, J., Ahn, D., Yoon, M., Sutton, A., Jorgolli, M., Gertner, R., Gujral, T.S., MacBeath, G., Yang, E., and Park, H. "Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells." Proc Natl Acad Sci U S A. 2010. 107, 1870-5. Pubmed.
- Gujral, T.S. & Macbeath, G. "A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation." PLoS One. 2010. 5, e10024. Pubmed.
2009
- Richardson, D.S., Gujral, T.S., Peng, S., Asa, S.L. & Mulligan, L.M. "Transcript level modulates the inherent oncogenicity of RET/PTC oncoproteins." Cancer Research. 2009 69, 4861-9. Pubmed.
- Gujral, T.S. & Macbeath, G. "Emerging miniaturized proteomic technologies to study cell signaling in clinical samples." Science Signaling. 2009. 2, pe65.Pubmed.
2008
- Gujral, T.S., Van Veelen, W., Richardson, D., Myers, S, Meens, J., Acton, D., Duñach, M, Elliott, B.E., and Mulligan, L. M. "A novel RET kinase-beta-catenin signaling pathway contributes to tumorigenesis in thyroid carcinoma. " Cancer Research. 2008. 68, 1338-46. Pubmed.
2007
- Lai, A.Z., Gujral, T.S. & Mulligan, L.M. "RET signaling in endocrine tumors: delving deeper into molecular mechanisms." Endocr Pathol. 2007. 18, 57-67. Pubmed.
2006
- Gujral, T.S., Singh, V.K., Jia, Z. & Mulligan, L.M. "Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B." Cancer Research. 2006. 66, 10741-9. Pubmed.
- Gujral, T.S. & Mulligan, L.M. "Molecular implications of RET mutations for pheochromocytoma risk in multiple endocrine neoplasia 2. " Ann N Y Acad Sci. 2006. 1073, 234-40. Pubmed.
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© 2023 Fred Hutchinson Cancer Center, a 501(c)(3) nonprofit organization.