The goal of the Hsieh Lab at the Fred Hutchinson Cancer Center is to comprehensively delineate the fundamental role of mRNA translation in normal cell physiology, cancer etiology, and cancer progression. Armed with this knowledge we are defining the next generation of therapeutic vulnerabilities in disorders associated with translation deregulation such as cancer.
Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression. Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang L, Depeille P, Smith E, Montgomery RB, Lee JK, Haffner MC, Vakar-Lopez F, Grivas P, Wright JL, Lam HM, Black PC, Roose JP, Ryazanov AG, Subramaniam AR, Henikoff S, Hsieh AC. (2023).
Defining cellular population dynamics at single cell resolution during prostate cancer progression. Germanos AA, Arora S, Zheng Y, Goddard E, Coleman I, Ku A, Wilkinson S, Song H, Brady NJ, Amezquita RA, Zager M, Long A, Yang C, Bielas J, Gottardo R, Rickman DS, Huang FW, Ghajar CM, Nelson PS, Sowalsky A, Setty M, Hsieh AC. (2022).
Multiplex functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer. Lim Y, Arora S, Schuster SL, Corey L, Fitzgibbon M, Wladyka CL, Wu X, Coleman IM, Delrow JJ, Corey E, True LD, Nelson PS, Ha G, Hsieh AC. (2021).
Androgen receptor regulates a druggable translational regulon in advanced prostate cancer. Liu Y, Horn JL, Banda K, Goodman AZ, Lim Y, Jana S, Arora S, Germanos AA, Wen L, Hardin WR, Yang YC, Coleman IM, Tharakan RG, Cai EY, Uo T, Pillai SPS, Corey E, Morrissey C, Chen Y, Carver BS, Plymate SR, Beronja S, Nelson PS, Hsieh AC. (2019).