Our Research
The Hsieh Lab investigates how mRNA translation shapes cancer cell fate. Our research integrates molecular, cellular, and genomic approaches to uncover how translational regulation drives tumor initiation, lineage plasticity, heterogeneity, and disease progression. These discoveries provide a foundation for developing the next generation of therapies targeting cancers dependent on aberrant protein synthesis.
Select Publications
Nature
The evolution and heterogeneity of lethal metastatic bladder cancer subtypes. Itagi P*, Schuster SL*, Arora S, Persse TW, Waters JA, Yang M, Min A, Chandra P, Adil M, Galipeau PC, Rudoy D, Kreitman AS, Lin Y, Ko M, Sayar E, Patton RD, Kollath L, Meis A, Lindergren S, Ji N, Ali K, Venkatesh H, Wladyka CL, McDeed AP, Mills CB, Vashisth M, Kim JY, Nadal R, Hawley J, Yezefski T, Psutka SP, Gore JL, Lin DW, Nelson PS, Cheng HH, Schweizer MT, Fong L, Lee JK, Yu EY, Corey E, Morrissey C, Grivas P, Montgomery RB, Wright JL, Haffner MC, Vakar-Lopez F, Mian OY#, Lam HM#, Hsieh AC#, Ha G#. *co-first author, #co-corresponding author. (2026).
JCI
Therapeutic targeting of the eIF4E cap-binding domain reveals control of lineage fate in prostate cancer. Mishra R, Song S, Choradia D, Rudoy D, Wladyka CL, Hoang P, Kim JK, Coleman IM, Arora S, Dobersch S, Orellana AE, Dobersch S, Lin C, Gafken PR, Corey E, Nelson PS, Kugel S, Li H, Sengupta A, Hsieh AC. (2026).
Cancer Cell
Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression. Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang L, Depeille P, Smith E, Montgomery RB, Lee JK, Haffner MC, Vakar-Lopez F, Grivas P, Wright JL, Lam HM, Black PC, Roose JP, Ryazanov AG, Subramaniam AR, Henikoff S, Hsieh AC. (2023).
Nature Communications
Multiplex functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer. Lim Y, Arora S, Schuster SL, Corey L, Fitzgibbon M, Wladyka CL, Wu X, Coleman IM, Delrow JJ, Corey E, True LD, Nelson PS, Ha G, Hsieh AC. (2021).
Science Translational Medicine
Androgen receptor regulates a druggable translational regulon in advanced prostate cancer. Liu Y, Horn JL, Banda K, Goodman AZ, Lim Y, Jana S, Arora S, Germanos AA, Wen L, Hardin WR, Yang YC, Coleman IM, Tharakan RG, Cai EY, Uo T, Pillai SPS, Corey E, Morrissey C, Chen Y, Carver BS, Plymate SR, Beronja S, Nelson PS, Hsieh AC. (2019).