News

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202120202019 | 2018 | 2017 | 2016 | 2015 | 2014


2021

Sep. 29, 2021
Welcome to Laura Baquero Galvis who joins the lab for her fall MCB rotation! We also welcome our new UW student intern Heidi Lee!

Sep. 17, 2021
Congratulations to Rashmi Mishra who was awarded a PNW Prostate Cancer SPORE Developmental Research Program award to study how translation modulation may eliminate enzalutamide resistance in advanced prostate cancer!

Sep. 10, 2021
Andrew gives a talk on delineating the functional relevance of somatic 5’ UTR mutations in human cancers at the Heidelberg EMBL Protein Synthesis and Translation Control meeting.

 

Aug. 2, 2021
New co-mentored postdoctoral fellow joins the Hsieh Lab!
Today we welcome Dr. Pushpa Itagi who will be co-mentored by Dr. Gavin Ha to study metastatic bladder cancer genomics. Welcome!

July 12, 2021
Congratulations to Yiting Lim for publishing our first functional genomics paper demonstrating that cancer associated mutations within the 5’ UTR can impact transcription levels and translational efficiency and are associated with differences in patient outcomes. Check out the paper at Nature Communications and highlighted by the Fred Hutch here.

Nature

May 25, 2021 
Congratulations to Sujata Jana for publishing a new piece of work demonstrating the importance of efficient mRNA translation on bladder transformation and cancer progression! This work highlights the importance of eIF4E phosphorylation in a subset of human bladder malignancies which represents a new druggable vulnerability. Check out this work at JCI Insight and highlighted by the Fred Hutch here.

JCI Image

Apr. 19, 2021
New postdoctoral fellow adds to the Hsieh Lab!
The Hsieh lab welcomes Dr. Yeon Soo Kim who will be studying UTR biology and the biology of advanced prostate cancer. 

Feb. 25, 2021
Congratulations to Samantha who was awarded a NRSA F31 grant! 

Happy to announce our new collaborative publication in Scientific Reports which describes the CoCaB 1 patient derived xenograft and organoid bladder cancer model system (co-senior authors Drs. Ming Lam and Jonathan Wright).

Jan. 6, 2021
Welcome to Jodiene Johnson who joins the lab for her winter MCB rotation!


2020

Nov. 18, 2020
New postdoctoral fellow joins the Hsieh Lab!
The Hsieh Lab welcomes Dr. Rashmi Mishra who will be starting her postdoc with us in December studying the role of mRNA translation in cell fate choice.

Sep. 30, 2020
Welcome to Sam Nutt who joins the lab for his fall MCB rotation!

Sep. 11, 2020
Yiting prepares to fly and we celebrate! 
A bitter sweet moment for the lab today as our outstanding postdoc Yiting Lim finishes up her last day with us. She has been instrumental in developing new technologies to study protein synthesis control in our lab and her footprint will be missed. She will be joining Just-Evotec Biologics as a senior scientist later this year. 

Yiting Lim

Sep. 3, 2020
Congratulations to Sujata Jana who presented her work on eIF4E activity in bladder cancer pathogenesis at the Cold Spring Harbor Translation Control Meeting.

Background Image
Background Image

Aug. 1, 2020 
The Hsieh Lab is awarded a multi-year grant from the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation.
These funds will be used to support a research program focused on understanding how mRNA translation is co-opted in bladder cancer. See Andrew’s In-Focus Fridays interview with Fred Hutch president Dr. Tom Lynch discussing the rationale, vision, and scope of the proposed work. 

Background Image
Background Image

July 2, 2020
Congratulations to Evan who just matriculated into medical school at St. Louis University. We are immensely proud of your accomplishment!

June 24, 2020
New summer interns in the Hsieh Lab!
The Hsieh lab welcomes Deepthi Mohanraj an undergraduate at the the University of Washington and Alla Kozubenko a first year UW medical student who will be working on bladder cancer related projects.

June 6, 2020
Congratulation to Alex, Samantha, and Sonali who contributed to the Beronja lab’s newest publication uncovering the role of eIF2B5 in cell fate choice published in Cell Stem Cell.

Farewell to Valentina Grilloa Alvarado who rotated in our lab during the pandemic no less! She gave a solid seminar at the UW MCB rotation talks and we were able to celebrate socially distanced. 

Socially distanced meeting

Mar. 27, 2020
Our undergraduate researcher Evan Anderson was recently awarded a Mary Gates Research Scholarship! Congratulations!

Mar. 12, 2020
Andrew is promoted to Associate Professor in the Division of Human Biology!

Jan. 1, 2020
Congratulations to Samantha who was awarded a CCEH Pilot and Feasibility Grant. Cheers!


2019

Dec. 13, 2019
Congratulations to Alex Germanos who is officially our lab’s second PhD candidate today after passing his UW MCB general exam!

Celebration for Alex

Nov. 11, 2019
Congratulations to Samantha Schuster who is officially our lab’s first PhD candidate today after passing her UW MCB general exam!

Celebration

Oct. 24, 2019
Congratulations to our intrepid graduate student Alex Germanos who successfully applied for the Interdisciplinary Training Grants T32. He will be co-mentored by Andrew and Dr. Raphael Gottardo.

Oct. 10, 2019
Our first collaborative paper with the Paddison Lab (Fred Hutch) hits the press today at Nature Communications! Read here about how m6A marks buttress mRNA specific translation in erythropoiesis. 

cover

Aug. 1, 2019
Congratulations to Yuzhen Liu and Jessie Horn for defining a new druggable interface between androgen receptor signaling and translation initiation, which was recently published in Science Translational Medicine. See Hutch News article.

Journal cover

July 31, 2019
The Hsieh lab has received funding from Obliteride which was highlighted on NBC's King5 Take 5.

 
The Hsieh Lab on King 5
 

June 24, 2019
Yuzhen and Jessie's AR and translation initiation paper was just accepted. Congratulations!

Lab members hold their papers

June 18, 2019
Congratulations to Brian Winters and Navonil De Sarkar for publishing the first UW/Fred Hutch bladder cancer rapid autopsy genomics paper in JCI Insight! Also see Hutch News article.

Lab members celebrate

May 21, 2019
Andrew gives a talk at the inaugural AACR Bladder Cancer: Transforming the Field conference in Denver about our work with the UW/Fred Hutch bladder cancer rapid autopsy program.

Dr. Hsieh speaks at a conference

Apr. 1, 2019
Congratulations to Yiting who was named an AACR NextGen Star today at the national meeting in Atlanta! Way to go! 

Welcome Rowan Hough our new UW undergraduate intern! She will be studying how the translation machinery is usurped in bladder cancer with Sujata.

Mar. 28, 2019
While there are very few somatic alterations to the protein components of the translation apparatus, there are a bunch of mutations in the RNA components such as the untranslated regions (UTRs) in cancer. Check out our new review written by Samantha Schuster that was just published in Trends in Cancer! 

Cell

Feb. 27, 2019
Congratulations to Sujata who has just been awarded a 2-year DoD PRCRP Horizon Award Fellowship!

Feb. 25, 2019
Sujata and Andrew attended the 2019 Translation Machinery in Health and Disease Gordon Research Conference, presented posters, and gave a talk. (They also took time to get in a picture. Can you find them in the crowd?)

Conference attendees
Translation Machinery in Health and Disease Gordon Research Conference | Feb. 17-22, 2019 | Hotel Galvez, Galveston, TX | Chair: Susan Ackerman Vice Chair: Tao Pan

2018

Oct. 31, 2018
mRNA specific translation strikes again!
The Hsieh and Paddison labs publish our new findings in bioRxiv on how N6-methyladenosine mRNA marks promote lineage specification in erythrocyte progenitors. Read more.

Oct. 17, 2018
Congratulations to Sujata for receiving one of two institutionally funded Interdisciplinary Training Grants as well as the HB Conference Travel Award.

Oct. 1, 2018
The Hsieh Lab welcomes our newest MCB graduate student Alex Germanos!

Sept. 12, 2018
Hsieh Lab presents our work at the Human Biology Division Retreat held at MOPOP!

MOPOP retreat

Sept. 7, 2018
Andrew gives a talk at the Cold Spring Harbor Translation Control meeting on a new transcriptional-translational interface in cancer.

 
 

Aug. 29, 2018
Congratulations to Samantha who was just awarded a 2-year fellowship through the UW Cell & Molecular Biology Training Grant!

July 25, 2018
The Hsieh Lab welcomes Alex Germanos an MCB student, who will be rotating into the lab over the summer!

June 5, 2018
Welcome to Samantha Schuster, who will join the Hsieh Lab in September 2018 as its very first UW MCB graduate student.

June 1, 2018
Welcome to our intrepid interns Lukas Corey (Yale), Rucha Deo (UW), and Sophia Chen (Lakeside HS) who will be plumbing the depths of translation control biology at the bench this summer.

May 12, 2018
Hsieh Lab participates in the 2018 BCAN Walk to End Bladder Cancer!

 
 

Apr. 9, 2018
tRNA fragment modifications regulate mRNA specific translation and stem cell function.

Congratulations to our colleague and collaborator Dr. Cristian Bellodi (Lund University) on publishing a paper in Cell this week demonstrating that pseudouridylation of tRNA fragments can control mRNA specific translation and stem cell function. Both Sonali and Yiting had a part in this beautiful work. Congratulations! Read more.

Apr. 3, 2018
Rucha was just selected to present her research at the UW 21st Annual Undergraduate Research Symposium. Congratulations!

Mar. 7, 2018
Hot off the press! The Hsieh Lab strikes again with another publication.

This one on the results from the Phase II MLN0128  trial in which we teamed up with Drs. Dana Rathkopf (MSKCC) and Tamara Lotan (JHMI) to determine the efficacy of this drug in patients with advanced prostate cancer. We conducted the correlative studies. Hard to believe we first started working with this compound almost a decade ago in cell lines and mice (Hsieh et al. Cancer Cell 2010 and Nature 2012). Read more.


2017

Oct. 26, 2017
Andrew selected to present at UW's Science in Medicine New Investigator Lecture Series. Watch video.

Oct. 19, 2017
Good News at Fred Hutch!
The Hsieh lab and Dr. Bruce Montgomery were awarded a bladder cancer precision medicine grant from the Seattle Translational Tumor Research program. Read more

Oct. 9, 2017
Welcome Bill Hardin, another cool addition to the lab!
Bill hails from the great state of Washington and just finished his PhD in the Department of Biology at UW. He has done some really great work imaging Giardia and molecularly dissecting regulators of cytokinesis with Alex Paredez, which was recently published in PNAS. Welcome aboard!

Oct. 6, 2017
Fresh off the press, Sujata’s PUS10 and apoptosis work was just published in Cell Death & Disease. 
Sujata reports that PUS10 nuclear translocation is necessary for TRAIL-mediated apoptosis and cleaved caspase 3 activity amplification. This work was started and primarily done in her PhD mentor’s laboratory (Dr. Ramesh Gupta) and finished in our laboratory. Way to go! Read more.

Oct. 2, 2017
Welcome Samantha Schuster, a UW MCB rotation student!
Samantha comes to us from UC Davis where she completed her undergraduate work. She has interned with both Neil Hunter at UC Davis and Dennis Slamon at UCLA and has a keen interest in translational research. She’s also an equestrian!

July 26, 2017
Yiting was accepted into the AACR Translational Cancer Research for Basic Scientists Workshop.
Yiting will be networking with instrumental players in the translational cancer field including Drs. George Demetri, Susan Band Horowitz, and Pasi Janne in Boston, MA this fall. Hurray, Yiting!

July 5, 2017
Welcome to Brian Winters, a UW Urology Fellow who has just joined the laboratory.
He has a background in translational cancer research with a focus in genitourinary malignancies and a special interest in bladder cancer. In addition, congratulations on getting the 2017 Bladder Cancer Advocacy Network (BCAN) John Quale Travel Fellowship and Young Investigator Awards.  Read more.

June 6, 2017
Congratulations to Kalyan who received an ASCO Young Investigator Award! Read more.

June 1, 2017
Jessie Horn our intrepid undergrad joins the Hsieh Lab as a technician today! Welcome Jessie, again!

May 2, 2017
Congratulations to Lukas who will be attending Yale University this fall!

Mar. 29, 2017
Congratulations to Asha! She will be matriculating into the Joint Doctoral program in Cell and Molecular Biology at San Diego State University and the University of California San Diego this fall.

Mar. 17, 2017
Hot off the press, the Hsieh Lab participated in a clinical trial of BEZ235 in patients with advanced prostate cancer.  

Mar. 6, 2017
Kalyan, Yiting, and Andrew presented the labs work at the 10th Annual Prostate Cancer Program Retreat in Fort Lauderdale, FL. Hooray for Yiting who won a $500 prize for her poster!

10th Annual Prostate Cancer Retreat
10th Annual Prostate Cancer Retreat

Jan. 1, 2017
This new year the Hsieh Lab is growing! We welcome Sujata Jana and Asha Goodman.
Sujata is a newly minted PhD from the Gupta Lab at Southern Illinois University and will be joining us as a postdoc in March 2017. As a graduate student she studied site specific modifications of tRNA, and the role of an RNA modifying enzyme on cellular homeostasis. Weclome! 

Asha recently graduated from San Diego State University and will be joining our laboratory as a technician. During undergrad she researched in the Deniz Lab at the Scripps Research Institute where she studied protein folding dynamics.


2016

Dec. 1, 2016
Congratulations to Kaylan who was awarded a CCEH Pilot and Feasibility Grant. Way to go!

Oct. 28, 2016
The Hsieh Lab is awarded a 2016 Movember Foundation PCF Challenge Award.
In this grant, the Hsieh Lab will be teaming up with Drs. Brett Carver and Yu Chen from Memorial Sloan Kettering to determine the role of protein synthesis control across of the spectrum of PI3K pathway mutations in prostate cancer. Also see Hutch News article.

Award winners
Award winners

Oct. 14, 2016
Yiting presented her work at the inaugural Human Biology Friday Science Talks alongside Dan Kuppers from the Paddison Lab!

Sept. 7, 2016
HB Retreat (Bainbridge, WA)
Postdocs Kalyan and Yiting, who gave oral presentations on their research at the Human Biology Retreat located at Islandwood, enjoy a moment with fellow lab members Yuzhen and Jessie who presented a poster.

Aug. 16, 2016
Kalyan presents his research at the inaugural Oncology T32 Retreat at the Fred Hutch! 

June 3, 2016
Fred Hutch/UW Cancer Consortium awards Hsieh Lab pilot research grant.
This grant, based on the work of postdoctoral fellow Li-Jie Wang, technician Yuzhen Liu, and UW undergraduate Jessie Horn, will support the very first preclinical trials testing protein synthesis inhibitors in bladder cancer models. Read more.

June 2, 2016
Welcome to our very first high school summer intern, Lukas Corey!
Lukas is currently a junior at Interlake High School and will be joining us this summer to work with Yiting. 

May 21, 2016
Jessie presents at the 2016 University of Washington Undergraduate Research Symposium.
Congratulations to our very own Jessie Horn who presented her research in an oral presentation at the 19th Annual University of Washington Undergraduate Research Symposium. Great job!

May 2, 2016
Kalyan just heard news from the AACR! His application was accepted for the 25th Annual AACR Workshop: Molecular Biology in Clinical Oncology.
Kalyan will be rubbing shoulders with big players in the field including Drs. Levi Garraway and Charles Sawyers in Snowmass, CO this summer. This will be a great opportunity to make valuable connections with current and future leaders in cancer research. Way to go! 

Apr. 27, 2016
The Hsieh Lab is recognized at the 2016 AACR Annual Meeting in New Orleans (and we got some grants too)!
Yiting was awarded the AACR Bristol-Myer Squibb Clinical and Translational Fellowship. Andrew was one of four recipients nationally to receive the inaugural NextGen Grant for Transformative Cancer Research. Go team! Read more.

AACR
Photo by © AACR/Todd Buchanan 2016
AACR
Photo by © AACR/Todd Buchanan 2016

Mar. 10, 2016
Andrew earns an ASCI Young Physican-Scientist Award.
He will be presenting research from the lab at the annual AAP/ASCI/APSA Joint Meeting in Chicago next month. Read more.

Feb. 11, 2016
Yiting has been awarded a DOD Prostate Cancer Research Program (PCRP) Postdoctoral Training Award!
Congratulations Yiting, great job! She will be co-mentored by Drs. Hsieh and Plymate. Read more.


2015

Nov. 17, 2015
Hot off the press: Cell type specific protein synthesis rates mark distinct prostate epithelial cell types for drug resistance.
In collaboration with colleagues at UCSF, utilizing a new genetic model, we demonstrate that aberrant translation initiation is necessary for prostate cancer formation and progression. However, resistance inevitably develops which is remarkably cell type specific. We have discovered that intrinsic protein synthesis rates of distinct prostate epithelial cell types and the levels of the translation inhibitor 4EBP1 are key elements which define sensitivity or resistance to PI3K-AKT-mTOR pathway inhibitors. Our mechanistic studies reveal that these are not only potential biomarkers which can be used in future clinical trials, but are functionally required for the drug resistance phenotype. Read story

Oct. 15, 2015
The Hsieh Lab is awarded a grant by the V Foundation for Cancer Research.
Andrew was named a 2015 V Foundation Scholar! The generous support provided by the foundation will be used to study the mechanisms by which aberrant protein synthesis control drives prostate cancer pathogenesis. Read more.

Oct. 1, 2015
The Hsieh Lab welcomes Kalyan Banda.
Kalyan is a clinical fellow in the division of Hematology and Oncology at the University of Washington and will be joining us as a postdoc in January 2016. He previously researched with Dr. Ajit Varki at UCSD and has a significant background in glycobiology. Welcome to the team!             

HB Retreat (Bainbridge Island, WA).
Postdocs Li-Jie and Yiting present their posters at the Human Biology Retreat.

Sept. 8, 2015
Stem Cell Center of Lund University (Sweden).
Andrew gives a seminar on protein synthesis control dynamics and cancer etiology at Lund University's Stem Cell Center in Lund, Sweden.

Aug. 28, 2015
The Hsieh Lab welcomes Funda Vakar-Lopez, MD.
Funda joins our lab as a pathologist. She is an assistant professor in the Department of Pathology at the University of Washington with a significant background in genitourinary malignancies. Welcome!

Aug. 24, 2015
Li-Jie has been awarded a Fred Hutch IDTG Dual Mentor Fellowship!
Congratulations Li-Jie, way to go! He will be co-mentored by Drs. Hsieh and Henikoff.

Aug. 10, 2015
The Hsieh Lab welcomes Sonali Arora.
Sonali joins our laboratory as our first computational biologist! She was previously a programmer for the R Bioconductor group at the Hutch and comes to our lab with significant bioinformatic experience. Welcome!

June 18, 2015
The Hsieh Lab welcomes Yuzhen Liu.
Yuzhen has just earned her bachelor of science in Pharmacology and Toxicology from the University of Toronto. She joins us as our new technician. Welcome to our grand adventure!

June 2, 2015
The Hsieh Lab welcomes Prachi Keni.
Prachi Keni, an undergraduate at Northwestern University, joins the lab as our first summer intern. Welcome! 

Apr. 15, 2015
The Hsieh Lab wins the inaugural 2015 Fast Pitch competition at the Fred Hutch. 

Hsieh Lab wins 2015 Fast Pitch Competition
Andrew was among 6 new investigators who gave 7-minute fast pitches to a number of generous donors and friends of the Fred Hutch.

Apr. 6, 2015
The Hsieh Lab welcomes Yiting Lim from Johns Hopkins.
Yiting earned her PhD studying hematopoietic stem cell biology and the cooperative and druggable nature of Hedgehog and FLT3/ITD signaling in myeloid malignancies. Welcome to the Fred Hutch!

Mar. 11, 2015
First rotating graduate student.
Joseph (Joey) Pangallo, a University of Washington MCB graduate student, will be rotating through the Hsieh Lab for the Spring quarter.

Mar. 3, 2015
Good News at Fred Hutch.
New type of biomarker shows promise in predicting prostate cancer recurrence. Dr. Andrew Hsieh, a researcher in the Fred Hutch Human Biology Division, has identified two biomarkers that may improve oncologists’ ability to predict which patients’ prostate cancer will recur after surgery, long before the development of visible cancer elsewhere in the body. Read more.   

First Paper out of Hsieh Lab.
In this paper, we extend our previous findings from the bench (Hsieh et al. Nature 2012) to the bedside (Sheridan et al. Oncotarget 2015). We show for the first time that translationally regulated protein products can be used as biomarkers to predict for future disease aggressiveness in prostate cancer. Read the paper.

Feb. 1, 2015
The Hsieh Lab welcomes our first postdoctoral researcher, Li-Jie Wang.
Li-Jie is a molecular biologist who earned his PhD interrogating the mechanisms by which AIM2 directs inflammasome formation and cancer etiology. He starts March 1st, welcome to the team! 


2014

Dec. 9, 2014
See the motivation behind why we fight.
Andrew is highlighted in a featured researcher piece written by Dr. Sabrina Richards published today at the Hutch.  Read the story

Nov. 20, 2014
Fred Hutch names new president and director.
Gary Gilliland, MD PhD has just been named the new president and director of the Fred Hutchinson Cancer Research Center. Read more.

Nov. 18, 2014
The Hsieh Lab welcomes our first member Ariana Marcassa.
Ariana hails from Canada and will be elucidating the role of aberrant translation control in bladder cancer. She holds a MSc. degree in bacterial genetics from the University of Waterloo and previously studied cytochrome P450 enzymes involved in biosynthesis of the phytohormone gibberellin.

Oct. 8, 2014
The Human Biology Division throws a welcome party for the Hsieh Lab.

Andrew Hsieh and colleague
Hsieh Lab warming party

Oct. 1, 2014
The Hsieh Lab is open.